Cited by 186Menstrual Health and DisordersHypothalamic control of reproductive hormonesOvarian function and disorders

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Allopregnanolone concentrations and premenstrual syndrome

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Monteleone, P, Luisi, S, Tonetti, A, Bernardi, F, Genazzani, AD, Luisi, M, Petraglia, F, Genazzani, AR·2000·European Journal of Endocrinology

DOI 10.1530/eje.0.1420269

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Abstract

OBJECTIVE: To evaluate basal allopregnanolone and progesterone in both phases of the menstrual cycle in women suffering from premenstrual syndrome (PMS) and their response to a GnRH test. DESIGN: We selected 56 women (28 patients with PMS and 28 controls) aged between 18 and 32 years. Blood samples were drawn in both follicular and phases. Twenty-eight women (14 patients with PMS and 14 controls) underwent a GnRH test in the luteal phase. METHODS: We evaluated allopregnanolone by RIA, using a specific antibody. Serum progesterone and oestradiol were determined using a commercially available RIA kit. RESULTS: Luteal phase allopregnanolone concentrations were significantly lower in patients with PMS than in controls. Progesterone concentrations were significantly lower in patients with PMS in both the follicular and the luteal phase. Serum oestradiol concentrations were in the normal range in both groups of women, although slightly greater in those with PMS. Allopregnanolone and progesterone responses to a GnRH test were significantly blunted in women with PMS. CONCLUSIONS: Diminished concentrations of allopregnanolone and progesterone, its precursor, and a blunted response to the GnRH test lead us to hypothesise that patients with PMS may suffer from an inadequate production of ovarian neuroactive steroids, especially in the luteal phase. This would lead to an impaired anxiolytic GABA(A)-mediated response in stressful physiological and psychological conditions, and may in part explain various psychoneuroendocrine symptoms that arise during PMS.

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Authors: Monteleone, P., Luisi, S., Tonetti, A., Bernardi, F., Genazzani, A., Luisi, M., Petraglia, F., & Genazzani, A.
Affiliations: University of Pisa (IT)
Corresponding author: Genazzani, AR
ORCID: Monteleone, P
Luisi, S
Bernardi, F
Venue: European Journal of Endocrinology
Publisher: Oxford University Press (OUP)
Published: 2000-03-01
Volume: 142
Issue: 3
Pages: 269-273
ISSN: 0804-4643 (ISSN-L)
1479-683X
DOI: 10.1530/eje.0.1420269
OpenAlex: W2119460554
Cited by: 186
References: 14
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 6 · 2013: 6 · 2012: 6
FWCI: 14.49
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by
Locations: European Journal of Endocrinology (publishedVersion)
PubMed (publishedVersion)
Florence Research (University of Florence) (submittedVersion)
IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
Use Siena air (University of Siena) (submittedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords: allopregnanolone, premenstrual syndrome, progesterone, GnRH stimulation test, luteal phase, neurosteroids, ovarian steroidogenesis, estradiol, menstrual cycle
MeSH terms: Adult, Estradiol, Female, Follicular Phase, Humans, Gonadotropin-Releasing Hormone, Luteal Phase, Menstrual Cycle, Pregnanolone, Premenstrual Syndrome, Progesterone, Radioimmunoassay, Case-Control Studies

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Allopregnanolone concentrations and premenstrual syndrome

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