Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorder and in control subjects
Abstract
A variety of hypotheses have been proposed to explain the premenstrual syndromes. These hypotheses serve as rationales for an equally diverse range of proposed treatments. To investigate these hypotheses, we obtained multiple blood samples across the menstrual cycle in women with well-characterized menstrually related mood disorder and in control subjects. No diagnosis-related differences were observed in the levels or patterns of secretion of progesterone, estradiol, follicle-stimulating hormone, luteinizing hormone, testosterone-estradiol-binding globulin, dehydroepiandrosterone sulfate, dihydrotestosterone, prolactin, or cortisol. Our data suggest that premenstrual syndrome does not represent a simple hormonal deficiency and that the cited rationales for several of the proposed treatments are of questionable merit.
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Three other studies failed to detect any significant differences between cortisol patterns in healthy controls and PMS/PMDD patients.
“Three other studies failed to detect any significant differences between cortisol patterns in healthy controls and PMS/PMDD patients [57, 66, 106].”
From Sleep, hormones, and circadian rhythms throughout the menstrual cycle in healthy women and women with premenstrual dysphoric disorder (2010) · cites this paper as [106]
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- Authors
- Rubinow, D. R., Hoban, M. C., Grover, G. N., Galloway, D. S., Roy-Byrne, P., Andersen, R., & Merriam, G. R.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Rubinow, David R.
- ORCID
- Rubinow, David R.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1988-01
- Volume
- 158
- Issue
- 1
- Pages
- 5-11
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2012067598
- Cited by
- 235
- References
- 18
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 7 · 2016: 5 · 2015: 3 · 2014: 6 · 2013: 9 · 2012: 15
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- premenstrual syndrome, menstrual cycle, plasma hormones, premenstrual dysphoric disorder, progesterone, estradiol, luteinizing hormone, follicle-stimulating hormone, testosterone, dehydroepiandrosterone sulfate, prolactin, cortisol, dihydrotestosterone
- MeSH terms
- Dehydroepiandrosterone, Estradiol, Female, Follicle Stimulating Hormone, Hormones, Humans, Hydrocortisone, Luteinizing Hormone, Menstrual Cycle, Premenstrual Syndrome, Prolactin, Sex Hormone-Binding Globulin, Dihydrotestosterone, Testosterone, Dehydroepiandrosterone Sulfate, Mood Disorders
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