Cited by 705Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

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Adipocytokines in obesity and metabolic disease

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Cao, Haiming·2014·Journal of Endocrinology

DOI 10.1530/joe-13-0339PMC PMC3887367

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Abstract

The current global obesity pandemic is the leading cause for the soaring rates of metabolic diseases, especially diabetes, cardiovascular disease, hypertension, and non-alcoholic hepatosteatosis. Efforts devoted to find cures for obesity and associated disorders in the past two decades have prompted intensive interest in adipocyte biology, and have led to major advances in the mechanistic understanding of adipose tissue as an essential endocrine organ. Adipose tissue secretes an array of hormones (adipokines) that signal key organs to maintain metabolic homeostasis, and their dysfunction has been causally linked to a wide range of metabolic diseases. In addition, obesity induces production of inflammatory cytokines (often referred to together with adipokines as adipocytokines) and infiltration of immune cells into adipose tissue, which creates a state of chronic low-grade inflammation. Metabolic inflammation has been increasingly recognized as a unifying mechanism linking obesity to a broad spectrum of pathological conditions. This review focuses on classic examples of adipocytokines that have helped to form the basis of the endocrine and inflammatory roles of adipose tissue, and it also details a few newly characterized adipocytokines that provide fresh insights into adipose biology. Studies of adipocytokines in clinical settings and their therapeutic potential are also discussed.

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Authors: Cao, H.
Affiliations: National Institutes of Health (US)
Corresponding author: Cao, Haiming
ORCID: Cao, Haiming
Venue: Journal of Endocrinology
Publisher: Bioscientifica
Published: 2014-02
Volume: 220
Issue: 2
Pages: T47-T59
ISSN: 0022-0795 (ISSN-L)
1479-6805
DOI: 10.1530/joe-13-0339
PMC: PMC3887367
OpenAlex: W2159748100
Cited by: 705
References: 154
Citations by year: 2026: 19 · 2025: 28 · 2024: 42 · 2023: 57 · 2022: 66 · 2021: 80 · 2020: 83 · 2019: 58 · 2018: 67 · 2017: 53 · 2016: 63 · 2015: 61 · 2014: 27
FWCI: 9.08
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Endocrinology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (HL006103-02, ZIAHL006103, ZIAHL006159)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: adipokines, obesity, metabolic disorders, adipose tissue endocrine function, metabolic inflammation, low-grade inflammation, adipocyte biology, inflammatory cytokines, immune cell infiltration, diabetes mellitus, cardiovascular disease, hypertension, non-alcoholic fatty liver disease, adipose tissue hormones, therapeutic target
MeSH terms: Adipose Tissue, Animals, Endocrine System, Humans, Inflammation, Metabolic Diseases, Obesity, Adipokines

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