Adipokines in healthy skeletal muscle and metabolic disease

Obesity is associated with macrophage accumulation in adipose tissue

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

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The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

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Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

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Weight-Reducing Effects of the Plasma Protein Encoded by the <i>obese</i> Gene

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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

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Effects of the <i>obese</i> Gene Product on Body Weight Regulation in <i>ob</i> / <i>ob</i> Mice

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The anti-inflammatory effect of exercise

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Congenital leptin deficiency is associated with severe early-onset obesity in humans

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

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IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

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The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.

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AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

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Protection from obesity-induced insulin resistance in mice lacking TNF-α function

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The Metabolic Syndrome: Prevalence and Associated Risk Factor Findings in the US Population From the Third National Health and Nutrition Examination Survey, 1988-1994

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Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

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Recent advances in the relationship between obesity, inflammation, and insulin resistance.

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Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

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Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1

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Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

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Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance

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Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

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Comparison of the Release of Adipokines by Adipose Tissue, Adipose Tissue Matrix, and Adipocytes from Visceral and Subcutaneous Abdominal Adipose Tissues of Obese Humans

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Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes

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Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

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Interleukin-6-deficient mice develop mature-onset obesity

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Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation

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Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

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Adiponectin and Metabolic Syndrome

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Disruption of adiponectin causes insulin resistance and neointimal formation

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Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight Loss

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Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6

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Transient increase in obese gene expression after food intake or insulin administration

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Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys

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Endocrine Regulation of Energy Metabolism: Review of Pathobiochemical and Clinical Chemical Aspects of Leptin, Ghrelin, Adiponectin, and Resistin

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Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF

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Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation

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Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

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Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

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Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

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Adipokines and Insulin Resistance

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Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects.

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Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex

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Interleukin-6 stimulates lipolysis and fat oxidation in humans

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Diet-induced obese mice develop peripheral, but not central, resistance to leptin.

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Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

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Adipocytokines in Obesity and Metabolic Disease

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Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running

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Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

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Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists

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Adipose Tissue IL-6 Content Correlates with Resistance to Insulin Activation of Glucose Uptake both in Vivo and in Vitro

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A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

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Effect of exercise training on chronic inflammation

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Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production

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Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator–Activated Receptor α

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Intramuscular lipid content is increased in obesity and decreased by weight loss

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Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content

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Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3

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Chronic Exposure to Interleukin-6 Causes Hepatic Insulin Resistance in Mice

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Skeletal Muscle Lipid Metabolism in Exercise and Insulin Resistance

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Adipocyte dysfunction, inflammation and metabolic syndrome

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Adipocytokines: leptin—the classical, resistin—the controversical, adiponectin—the promising, and more to come

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Leptin Directly Alters Lipid Partitioning in Skeletal Muscle

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Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese mice

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IL-6 and TNF-α expression in, and release from, contracting human skeletal muscle

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