New Insights into Adipokines in Gestational Diabetes Mellitus
Open accessAbstract
Gestational diabetes mellitus (GDM) is the most common metabolic disorder of pregnancy and has considerable short- and long-term consequences for the health of both the mother and the newborn. Within its pathophysiology, genetic, nutritional, epigenetic, immunological, and hormonal components have been described. Within the last two items, it is known that different hormones and cytokines secreted by adipose tissue, known collectively as adipokines, are involved in the metabolic alterations underlying GDM. Although the maternal circulating profile of adipokines in GDM has been extensively studied, and there are excellent reviews on the subject, it is in recent years that more progress has been made in the study of their expression in visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), placenta, and their concentrations in the umbilical circulation. Thus, this review compiles and organizes the most recent findings on the maternal and umbilical circulating profile and the levels of expression of adipokines in VAT, SAT, and placenta in GDM.
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A low adiponectin concentration in the first and second trimesters of pregnancy is a predictor of diabetes development in pregnancy.
“It was shown that a low adiponectin concentration in the first and second trimesters of pregnancy is a predictor of diabetes development in pregnancy [50].”
From Gestational Diabetes Mellitus—Recent Literature Review (2022) · cites this paper as [50]
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Peña-Cano, M. I., Valencia‐Ortega, J., Morales-Ávila, E., Díaz-Velázquez, M. F., Gómez-Díaz, R. A., & Saucedo, R. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01671-9 · Cited by 19 · see citing works
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Saucedo, R., Valencia‐Ortega, J., Moreno-González, L. E., Peña-Cano, M. I., Aranda-Martínez, A., García, Y., Díaz-Velázquez, M. F., & Hernández-Valencia, M. (2021) · Ginekologia Polska · doi:10.5603/gp.a2021.0083 · Cited by 18 · see citing works
Self-citationSerum nesfatin-1 levels are decreased in pregnant women newly diagnosed with gestational diabetes
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Şeyhanlı, Z., Şeyhanlı, A., Aksun, S., & Pamuk, B. Ö. (2021) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2021.1888919 · Cited by 15 · see citing works
High levels of growth hormone and human placental lactogen in pregnancy complicated by diabetes.
Lopez-Espinoza, I., Smith, R. F., Gillmer, M. D. G., Schidlmeir, A., & Hockaday, T. D. R. (1986) · PubMed · Cited by 15 · see citing works
Al-Musharaf, S., Sabico, S., Hussain, S. D., Al-Tawashi, F., Alwaily, H. B., Al‐Daghri, N. M., & McTernan, P. G. (2021) · Disease Markers · doi:10.1155/2021/8862494 · Cited by 14 · see citing works
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Serum Levels and Placental Expression of NGAL in Gestational Diabetes Mellitus
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Bulmuş, F. G., Melekoğlu, R., Gürsu, M. F., Bağcı, H., Kavak, E. Ç., & Akyol, A. (2020) · Journal of Turkish Society of Obstetric and Gynecology · doi:10.4274/tjod.galenos.2020.67026 · Cited by 10 · see citing works
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Ganancia de peso gestacional como factor de riesgo para desarrollar complicaciones obstétricas
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Gestational Diabetes Mellitus—Recent Literature Review
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Unveiling Gestational Diabetes: An Overview of Pathophysiology and Management
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Deep Insight of the Pathophysiology of Gestational Diabetes Mellitus
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Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review
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Gestational Diabetes Mellitus and Colostral Appetite-Regulating Adipokines
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Excessive Pregestational Weight and Maternal Obstetric Complications: The Role of Adipokines
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The role of adipogenic niche resident cells in colorectal cancer progression in relation to obesity
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Alshganbee, M. F. H., Nabatchian, F., Farrokhi, V., Fadaei, R., Moradi, N., & Afrisham, R. (2023) · The Journal of Physiological Sciences · doi:10.1186/s12576-023-00879-z · Cited by 7 · see citing works
Maternal Visceral Fat in Prediction of Gestational Diabetes Mellitus
Detsrisuwan, J., Luewan, S., Sirichotiyakul, S., & Tongsong, T. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020493 · Cited by 6 · see citing works
Li, J., Li, J., Jin, J., Zhang, R., Li, R., Xu, X., Wang, Y., Hu, X., Wang, L., & Yu, S. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1621932 · Cited by 5 · see citing works
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Diabetes Ketoacidosis and COVID-19: An Insight into the Pathophysiology
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Jiang, J., Wei, S., Chen, M., Tan, Y., Yang, Z., Yang, G., Feng, W., Han, Z., Wei, X., & Luo, X. M. (2024) · Biomedicines · doi:10.3390/biomedicines12051128 · Cited by 2 · see citing works
From Pregnancy to Postpartum: The Cardiovascular Risks Associated with Gestational Diabetes
Sharma, R., Singh, U., Kamal, R., & Kumar, R. (2025) · Current Cardiology Reviews · doi:10.2174/011573403x354645250329171327 · Cited by 3 · see citing works
Alrikabi, R., & Hussain, D. A. (2024) · Baghdad Science Journal · doi:10.21123/bsj.2024.10234 · Cited by 1 · see citing works
Dai, X.-W., Fan, X., Ye, Y., Yu, M., Li, T., & Yu, K. (2025) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-025-07873-w · Cited by 1 · see citing works
Lis-Kuberka, J., & Berghausen-Mazur, M. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1776904 · Cited by 1 · see citing works
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Challenges in the management of gestational diabetes mellitus in anorexia nervosa
Siddiqui, R., & McAdams, C. J. (2024) · Psychiatry Research Case Reports · doi:10.1016/j.psycr.2024.100215 · Cited by 1 · see citing works
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Adiposity-dependent adipokine-immunoglobulin interplay in mature breast milk
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Pathogenesis of gestational diabetes mellitus
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- Authors
- Valencia-Ortega, J., González-Reynoso, R., Ramos-Martínez, E. G., Ferreira-Hermosillo, A., Peña-Cano, M. I., Morales-Ávila, E., & Saucedo, R.
- Affiliations
- Unidad de Investigación Médica en Enfermedades Endocrinas, UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico
- Mexican Social Security Institute (MX)
- Universidad Nacional Autónoma de México (MX)
- Universidad Autónoma del Estado de México (MX)
- Corresponding author
- Saucedo, Renata
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2022-06-03
- Volume
- 23
- Issue
- 11
- Pages
- 6279
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC9181219
- OpenAlex
- W4281773150
- Cited by
- 39
- References
- 113
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 9 · 2023: 9 · 2022: 4
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Consejo Nacional de Ciencia y Tecnología
- Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- gestational diabetes mellitus, adipokines, adipose tissue, visceral adipose tissue, subcutaneous adipose tissue, placenta, umbilical cord blood, cytokines, hormonal regulation, epigenetics
- MeSH terms
- Adipose Tissue, Female, Humans, Infant, Newborn, Pregnancy, Diabetes, Gestational, Subcutaneous Fat, Intra-Abdominal Fat, Adipokines
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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