Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice
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adipose tissue macrophages (ATMs) and their surrounding WAT microenvironment. Using targeted in vivo ATM ablation followed by transcriptional and metabolic WAT profiling, we found that ATMs protect WAT from the excessive pathological remodeling that occurs during obesity. As obesity progresses, ATMs control not only vascular integrity, adipocyte function, and lipid and metabolic derangements but also extracellular matrix accumulation and resultant fibrosis in the WAT. The protective role of ATMs during obesity-driven WAT dysfunction supports the notion that ATMs represent friends, rather than foes, as has previously assumed.
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Lipid droplet accumulation in macrophages occurs in lipid-rich microenvironments in the periphery.
“LD accumulation in macrophages has also been documented in lipid-rich microenvironments in the peripheral, such as atherosclerosis plaques (5), white adipose tissue (10), and tumors (9).”
From Reducing microglial lipid load enhances β amyloid phagocytosis in an Alzheimer’s disease mouse model (2025) · cites this paper as [10]
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CD169+ Macrophages Mediate the Immune Response of Allergic Rhinitis Through the Keap1/Nrf2/HO‐1 Axis
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Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling
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Turnover Kinetics of Pancreatic Macrophages in Lean and Obese Diabetic Mice
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The crosstalk between parenchymal cells and macrophages: A keeper of tissue homeostasis
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Perivascular Adipose Tissue Niches for Modulating Immune Cell Function
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Immunometabolism in obesity: Understanding the beneficial and detrimental roles of inflammation
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Unveiling the impact of TREM-2+ Macrophages in metabolic disorders
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Adipose Tissue Stromal Cells: Rheostats for Adipose Tissue Function and Metabolic Disease Risk
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CD9 regulates macrophage-mediated remodeling of adipose tissue in obesity
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Adipose tissue macrophage dysfunction in human MASLD – Cause or consequence?
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A closer look at adipose tissue lymphatics and their markers
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Banxia Baizhu Tianma Decoction attenuates obesity via regulating adipocyte-immune cell communication
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Metabolic inflammation, obesity, and cancer
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Regulatory Roles of Adipose Tissue Macrophages in Metabolic Health and Disease
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The role of adipose tissue macrophages in adipose tissue fibrosis
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SVEP1 couples adipose niche remodeling to macrophage activation and impaired metabolism in obesityPreprint
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- Authors
- Chen, Q., Lai, S. M., Xu, S., Tan, Y., Leong, K., Liu, D., Tan, J. C., Naik, R. R., Barron, A. M., Adav, S. S., Chen, J., Chong, S. Z., Ng, L. G., & Ruedl, C.
- Affiliations
- Nanyang Technological University (SG)
- Singapore Immunology Network (SG)
- Corresponding author
- Ruedl, Christiane
- ORCID
- Venue
- The EMBO Reports
- Published
- 2021-07-01
- Volume
- 22
- Issue
- 8
- Pages
- e52835-e52835
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- PMC
- PMC8339675
- OpenAlex
- W3159436991
- Cited by
- 56
- References
- 65
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 8 · 2023: 15 · 2022: 11 · 2021: 2
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- EMBO Reports (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DR-NTU (Nanyang Technological University) (submittedVersion, cc-by-nc-nd)
- Funders
- Ministry of Education-Singapore (MOE2018-T2-2-016)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- adipose tissue macrophages, obesity, adipose tissue remodeling, vascular integrity, adipose tissue fibrosis, extracellular matrix accumulation, adipocyte function, adipose tissue microenvironment, macrophage depletion, adipose tissue dysfunction
- MeSH terms
- Adipose Tissue, Animals, Macrophages, Mice, Inbred C57BL, Mice, Obese, Mice, Adipose Tissue, White
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