The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
Maternal modifiers of the infant gut microbiota: metabolic consequences
Open accessAbstract
Transmission of metabolic diseases from mother to child is multifactorial and includes genetic, epigenetic and environmental influences. Evidence in rodents, humans and non-human primates support the scientific premise that exposure to maternal obesity or high-fat diet during pregnancy creates a long-lasting metabolic signature on the infant innate immune system and the juvenile microbiota, which predisposes the offspring to obesity and metabolic diseases. In neonates, gastrointestinal microbes introduced through the mother are noted for their ability to serve as direct inducers/regulators of the infant immune system. Neonates have a limited capacity to initiate an immune response. Thus, disruption of microbial colonization during the early neonatal period results in disrupted postnatal immune responses that highlight the neonatal period as a critical developmental window. Although the mechanisms are poorly understood, increasing evidence suggests that maternal obesity or poor diet influences the development and modulation of the infant liver and other end organs through direct communication via the portal system, metabolite production, alterations in gut barrier integrity and the hematopoietic immune cell axis. This review will focus on how maternal obesity and dietary intake influence the composition of the infant gut microbiota and how an imbalance or maladaptation in the microbiota, including changes in early pioneering microbes, might contribute to the programming of offspring metabolism with special emphasis on mechanisms that promote chronic inflammation in the liver. Comprehension of these pathways and mechanisms will elucidate our understanding of developmental programming and may expand the avenue of opportunities for novel therapeutics.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, the healthy diet of a pregnant woman rich in dietary fiber shapes the gut microbiota of her offspring [100].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [100]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · cited 1×
“In adults, the transmissibility of obesity and related disorders by gut bacteria is likely mediated specifically by cells of the innate immune system, a phenomenon that is observed in Rag1 mice lacking all cells of the adaptive immune system (Bäckhed et al. 2004).”
BackgroundHepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774 · cited 1×
“Regardless, the first major seeding of the gut microbiota is thought to occur during the birthing process following exposure to bacteria residing in the mother's vaginal canal and gut during vaginal birth or the mother’s skin during a cesarean section (Dominguez-Bello et al. 2010).”
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010.
Ogden, C., Carroll, M., Kit, B., & Flegal, K. (2012) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2012.40 · Cited by 4,128 · cited 2×
“A particularly alarming statistic is the prevalence of obesity in children, affecting 10% of infants and toddlers and 17% of children and adolescents in the United States (Ogden et al. 2012).”
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788
Development of the Human Infant Intestinal Microbiota
Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650
Cited by
Sorted by citations
Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing
Gantenbein, K. V., & Kanaka-Gantenbein, C. (2021) · Nutrients · doi:10.3390/nu13061951 · Cited by 288
The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD
Soderborg, T. K., Clark, S. E., Mulligan, C. E., Janssen, R. C., Babcock, L. R., Ir, D., Young, B. E., Krebs, N. F., Lemas, D. J., Johnson, L. K., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06929-0 · Cited by 292
Xie, R., Sun, Y., Wu, J., Huang, S., Jin, G., Guo, Z., Zhang, Y., Liu, T., Liu, X., Cao, X., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02608 · Cited by 126
Development and Function of the Intestinal Microbiome and Potential Implications for Pig Production
Nowland, T. L., Plush, K. J., BARTON, M. D., & Kirkwood, R. N. (2019) · Animals · doi:10.3390/ani9030076 · Cited by 136
Hsu, C., & Tain, Y. (2019) · Nutrients · doi:10.3390/nu11040894 · Cited by 108
“Emerging evidence shows that gut microbiota dysbiosis in early-life might be correlated with adverse offspring outcomes including obesity [120], metabolic syndrome [120], diabetes [120], hypertension [121], allergy [122], and neurological disorder [123].”
BackgroundJian, C., Carpén, N., Helve, O., de Vos, W. M., Korpela, K., & Salonen, A. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103475 · Cited by 111
Maternal Microbiome and Metabolic Health Program Microbiome Development and Health of the Offspring
Calatayud, M., Koren, O., & Collado, M. C. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.021 · Cited by 102
Nutrition therapy within and beyond gestational diabetes
Hernandez, T. L., Mande, A., & Barbour, L. A. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.04.004 · Cited by 86
Dai, X., Guo, Z., Chen, D., Li, L., Song, X., Liu, T., Jin, G., Li, Y., Liu, Y., Ajiguli, A., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1738187 · Cited by 89
“Three-weekold is the key point for gut barrier formation and intestinal microbiota colonization, and microbes in early-life play a key role in body weight gain.(13,37) We may presume the effect of MS on offspring body weight through its impact on gut barrier and gut microbiota.”
BackgroundThe microbiota composition of the offspring of patients with gestational diabetes mellitus (GDM)
Ponzo, V., Ferrocino, I., Zarovska, A., Amenta, M. B., Leone, F., Monzeglio, C., Rosato, R., Pellegrini, M., Gambino, R., Cassader, M., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226545 · Cited by 86
Gestational Diabetes Is Uniquely Associated With Altered Early Seeding of the Infant Gut Microbiota
Soderborg, T. K., Carpenter, C. M., Janssen, R. C., Weir, T. L., Robertson, C. E., Ir, D., Young, B. E., Krebs, N. F., Hernandez, T. L., Barbour, L. A., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.603021 · Cited by 82
“The development of several essential biological systems depends on proper infant gut microbe seeding and expansion; these systems include energy extraction from the diet, gut barrier function, and immune system maturation/education (3, 4).”
BackgroundEpigenetics and neurodegeneration: role of early-life nutrition
Gabbianelli, R., & Damiani, E. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.01.014 · Cited by 84
Air Pollution, Early Life Microbiome, and Development
Vallès, Y., & Francino, M. P. (2018) · Current Environmental Health Reports · doi:10.1007/s40572-018-0215-y · Cited by 65
Paul, H. A., Collins, K. H., Nicolucci, A. C., Urbanski, S. J., Hart, D. A., Vogel, H. J., & Reimer, R. A. (2019) · The FASEB Journal · doi:10.1096/fj.201801551r · Cited by 60
Abbasi, A., Aghebati‐Maleki, A., Yousefi, M., & Maleki, L. A. (2020) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2020.103244 · Cited by 59
Pre-Eclampsia: Microbiota possibly playing a role
Ahmadian, E., Saadat, Y. R., Khatibi, S. M. H., Nariman‐Saleh‐Fam, Z., Bastami, M., Vahed, F. Z., Ardalan, M., & Vahed, S. Z. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104692 · Cited by 54
Wang, X., Chen, D., Li, Y., Zhao, S., Chen, C., & Ning, D. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.11.022 · Cited by 52
Hsu, C., Hou, C., Lee, C., Chan, J. Y. H., & Tain, Y. (2019) · Nutrients · doi:10.3390/nu11091982 · Cited by 51
“During pregnancy, the diet–gut microbiota interactions can mediate epigenetic regulation of gene expression not only in mother but also in the fetus via the contact with their metabolites [10].”
BackgroundMicrobiome‐immune‐metabolic axis in the epidemic of childhood obesity: Evidence and opportunities
Kincaid, H. J., Nagpal, R., & Yadav, H. (2019) · Obesity Reviews · doi:10.1111/obr.12963 · Cited by 47
“Almost two‐thirds of American child‐bearing agedwomen have obesity.(29)Maternal obesity and diabetes are known to pose high risks of developing these ailments in their children(30,31) (Figure 3).”
BackgroundWang, M., Xie, Z., Li, L., Chen, Y., Yuan, L., Wang, Y., Lu, B., Zhang, S., Ma, F., Ma, C., et al. (2019) · Food & Function · doi:10.1039/c8fo02565g · Cited by 45
Alves, J. L. D. B., de Oliveira, Y., Carvalho, N., Cavalcante, R. G. S., Lira, M. M. P., do Nascimento, L. C. P., Magnani, M., Vidal, H., Braga, V. A., & de Souza, E. L. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104252 · Cited by 43
Aloisio, I., Prodam, F., Giglione, E., Cionci, N. B., Solito, A., Bellone, S., Baffoni, L., Mogna, L., Pane, M., Bona, G., et al. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00039 · Cited by 38
“Some Authors suggest that the sudden modification of the initial conditions may disrupt the physiological process predisposing to certain diseases (46, 56, 57) and alterations in the precocious colonization have a role (54, 55).”
BackgroundMicrobiome Profiles of Ligature-Induced Periodontitis in Nonhuman Primates across the Life Span
Kirakodu, S. S., Chen, J., González‐Martínez, J., González, O. A., & Ebersole, J. L. (2019) · Infection and Immunity · doi:10.1128/iai.00067-19 · Cited by 36
Alsharairi, N. A. (2020) · Microorganisms · doi:10.3390/microorganisms8081119 · Cited by 34
“This has profound clinical implications for maternal diet-induced alterations to the maternal gut microbiota which, in turn, could have a lasting impact on the infant gut microbiota composition, thus making children more susceptible to inflammatory diseases [65].”
Alabduljabbar, S., Zaidan, S. A., Lakshmanan, A. P., & Terranegra, A. (2021) · Life · doi:10.3390/life11060467 · Cited by 34
Host Factors of Favorable Intestinal Microbial Colonization
Pirr, S. M., & Viemann, D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.584288 · Cited by 30
Chleilat, F., Schick, A., Deleemans, J. M., Ma, K., Alukic, E., Wong, J., Tuplin, E. W. N., Nettleton, J. E., & Reimer, R. A. (2021) · The FASEB Journal · doi:10.1096/fj.202100198rr · Cited by 36
Nazzari, S., Grumi, S., Mambretti, F., Villa, M., Giorda, R., Provenzi, L., MOM-COPE Study Group, Borgatti, R., Biasucci, G., Decembrino, L., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02160-0 · Cited by 36
“Available evidence shows that the methylation status of NR3C1 gene in cord blood was predicted by maternal psychological distress [15–17], experiences of war-related stress [18, 19] and partner violence [20] during pregnancy.”
BackgroundKhine, W. W. T., Rahayu, E. S., See, T. Y., Kuah, S., Salminen, S., Nakayama, J., & Lee, Y. K. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1761240 · Cited by 32
Gaukroger, C. H., Edwards, S. A., Walshaw, J., Nelson, A., Adams, I. P., Stewart, C. J., & Kyriazakis, I. (2020) · animal · doi:10.1016/j.animal.2020.100135 · Cited by 30
“The development of themicrobiota during early life is now recognised as having a significant impact on host metabolism (Mulligan and Friedman, 2017) and health”
BackgroundCarter, S., Lin, J. C., Chow, T., Yu, X., Rahman, M. M., Martinez, M. P., Feldman, K., Eckel, S. P., Chen, J., Chen, Z., et al. (2022) · Autism · doi:10.1177/13623613221118430 · Cited by 28
“Studies also have established that the presence of conditions associated with MIA during pregnancy, including the ones in the present study, can influence the gut microbiota of both mothers and their children (Mulligan & Friedman, 2017).”
BackgroundPreconception helminth infection alters offspring microbiota and immune subsets in a mouse model
Nyangahu, D. D., Darby, M., Havyarimana, E., Brown, B. P., Horsnell, W. G. C., & Jaspan, H. B. (2020) · Parasite Immunology · doi:10.1111/pim.12721 · Cited by 27
“…accession number for the 16SrRNA sequences reported in this paper is PRJNA609138. uthor M anuscript A uthor M anuscript A uthor M anuscript Background Various factors influence gut colonisation in infants, most of which are maternally-derived (Mulligan & Friedman, 2017; Tanaka & Nakayama, 2017).”
BackgroundRole of Maternal Microbiota and Nutrition in Early-Life Neurodevelopmental Disorders
Daliry, A., & Pereira, E. N. G. D. S. (2021) · Nutrients · doi:10.3390/nu13103533 · Cited by 31
Zhang, H., Wang, Y., Zhang, X., Zhang, L. R., Zhao, X., Xu, Y., Wang, P., Liang, X., Xue, M., & Liang, H. (2023) · Nutrients · doi:10.3390/nu15224726 · Cited by 28
Nutrition, Gut Microbiota, and Allergy Development in Infants
Rey-Mariño, A., & Francino, M. P. (2022) · Nutrients · doi:10.3390/nu14204316 · Cited by 31
Conta, G., CHIERICO, F. D., Reddel, S., Marini, F., Sciubba, F., Capuani, G., Tomassini, A., Cocco, M. E. D., Laforgia, N., Baldassarre, M. E., et al. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.688440 · Cited by 25
“The gut microbiota plays a major role in health and disease in humans by transforming the dietary compounds that are not directly digestible by the host enzymes, as well as by providing intestinal protection from pathogen colonization, inducing cell differentiation and modulation of the immune system of the host (Lync…”
BackgroundEcoevolutionary processes structure milk microbiomes across the mammalian tree of life
Keady, M., Jiménez, R. R., Bragg, M., Wagner, J. C. P., Bornbusch, S. L., Power, M. L., & Muletz‐Wolz, C. R. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2218900120 · Cited by 25
“The enteromammary pathway is hypothesized to be a mode by which specific bacterial taxa move from the maternal gut to the mammary gland and then to infant gut postnatally (49–51).”
BackgroundRadford‐Smith, D. E., & Anthony, D. C. (2023) · Metabolites · doi:10.3390/metabo13030455 · Cited by 23
“While the consequences of maternal obesity on offspring metabolism, obesity, and cardiovascular health have been widely reported [7,8], only more recently are thorough investigations being made into how maternal diet and obesity affect maternal and offspring behaviour, including the transmission of psychiatric disease…”
BackgroundCarson, K. E., Alvarez, J., Mackley, J., Travagli, R. A., & Browning, K. N. (2023) · The Journal of Physiology · doi:10.1113/jp284726 · Cited by 26
“…(Shrestha et al., 2020), anxiety and mood disorders (Rivera et al., 2015; DeCapo et al., 2019), as well as gastrointestinal (GI) dysfunction (Mulligan & Friedman, 2017; McMenamin et al., 2018; Clyburn et al., 2019) underscoring the importance of understanding the impact of diet itself on…”
BackgroundDai, X., Wang, C., Guo, Z., Li, Y., Liu, T., Jin, G., Wang, S., Wang, B., Jiang, K., & Cao, H. (2021) · Food & Function · doi:10.1039/d1fo02921e · Cited by 21
Gawlik, A., Salonen, A., Jian, C., Yanover, C., Antosz, A., Shmoish, M., Wasniewska, M. G., Bereket, A., Wudy, S. A., Hartmann, M. F., et al. (2021) · Pediatric Obesity · doi:10.1111/ijpo.12835 · Cited by 20
“This raises a hypothesis that the dynamic mother-infant microbiota exchange during early life may relate to childhood obesity.(60) A recent study(33) found that infants born both vaginally (adjusted odds ratio, OR, 3.”
BackgroundMaternal Gut Dysbiosis Alters Offspring Microbiota and Social Interactions
Zhang, Z., Xue, C., Ju, M., Guo, J., Wang, M., Yi, S., & Yi, X. (2021) · Microorganisms · doi:10.3390/microorganisms9081742 · Cited by 19
Free threonine in human breast milk is related to infant intestinal microbiota composition
Riederer, M., Schweighofer, N., Trajanoski, S., Stelzer, C., Zehentner, M., Fuchs‐Neuhold, B., Kashofer, K., Mayr, J. A., Hörmann-Wallner, M., Holasek, S. J., et al. (2021) · Amino Acids · doi:10.1007/s00726-021-03057-w · Cited by 19
Consequences of colonialism: A microbial perspective to contemporary Indigenous health
Skelly, E., Kapellas, K., Cooper, A., & Weyrich, L. S. (2018) · American Journal of Physical Anthropology · doi:10.1002/ajpa.23637 · Cited by 17
Rodriguez‐Caro, H., & Williams, S. A. (2018) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174418000569 · Cited by 17
The role of gut micorbiome in obesity and diabetes
Górowska‐Kowolik, K., & Chobot, A. P. (2019) · World Journal of Pediatrics · doi:10.1007/s12519-019-00267-x · Cited by 18
Snow, S. J., Broniowska, K. A., Karoly, E. D., Henriquez, A. R., Phillips, P. M., Ledbetter, A. D., Schladweiler, M. C. J., Miller, C. N., Gordon, C. J., & Kodavanti, U. P. (2020) · Scientific Reports · doi:10.1038/s41598-020-73361-0 · Cited by 15
Cömert, T. K., Akpınar, F., Erkaya, S., Durmaz, B., & Durmaz, R. (2022) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2022.2148098 · Cited by 16
The influence of maternal diet on offspring’s gut microbiota in early life
Peng, L., Tan, Y., & Bajinka, O. (2023) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-023-07305-0 · Cited by 15
“For instance, maternal obesity or low diet influences the process and transition of offspring liver and other end organs directly via the portal system [40].”
Li, J.-M., Wan, Y., Zheng, Z., Zhang, H.-Q., Li, Y., Guo, X.-F., Li, K.-L., & Li, D. (2021) · Food & Function · doi:10.1039/d1fo00906k · Cited by 12
Bianco, I., Ferrara, C., Romano, F., Loperfido, F., Sottotetti, F., Masri, D. E., Vincenti, A., Cena, H., & Giuseppe, R. D. (2024) · Biomedicines · doi:10.3390/biomedicines12112423 · Cited by 15
“…to several exposure factors, such as maternal health (presence of certain pathologies including obesity, allergies, celiac disease, mastitis) [15–17], maternal dietary habits and lifestyle factors [18], gestational age (term vs. preterm birth) [19], delivery mode (vaginal birth vs. C-section…”
Tang, M. H., Ligthart, I., Varga, S., Lebeer, S., van Overveld, F. J., & Rijkers, G. T. (2025) · Biology · doi:10.3390/biology14030299 · Cited by 16
“As indicated above, microbe–host interactions during the neonatal period determine the immune mechanisms that maintain homeostasis and tolerance [144–146].”
Bioinformatics and machine learning in gastrointestinal microbiome research and clinical application
Hopson, L. M., Singleton, S. S., David, J. A., Basuchoudhary, A., Prast‐Nielsen, S., Klein, P., Sen, S., & Mazumder, R. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.08.011 · Cited by 15
Gut Injury and the Microbiome in Neonates
Pammi, M., Hollister, E. B., & Neu, J. (2020) · Clinics in Perinatology · doi:10.1016/j.clp.2020.02.010 · Cited by 13
Melo, G. M., Capucho, A. M., Sacramento, J. F., Ponce-de-Leão, J., Fernandes, M. V., Almeida, I. F., Martins, F. O., & Conde, S. V. (2023) · Nutrients · doi:10.3390/nu16010067 · Cited by 13
“Recent evidence indicates that many components of a mother’s diet are pivotal in shaping aspects of the offspring’s health, including the microbiome and the neonatal immune system [8].”
BackgroundJiang, L., Du, L.-D., Zeng, J., Chu, H., Peng, Z., & Fan, J. (2025) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2025.0718 · Cited by 12
Zhang, Q., Dong, Y., & Fan, J. (2023) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2023.12.007 · Cited by 11
Barnett, J. A., Josephson, J. K., Yuzbashian, E., Haskey, N., Hart, M. M., Soma, K. K., Verdugo, A., McComb, C. J., Bandy, M. L., Ghosh, S., et al. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.180437 · Cited by 13
Mouse Chow Composition Influences Immune Responses and Food Allergy Development in a Mouse Model
Weidmann, E., Samadi, N., Klems, M., Heiden, D., Seppova, K., Ret, D., & Untersmayr, E. (2018) · Nutrients · doi:10.3390/nu10111775 · Cited by 10
Breast feeding, obesity, and asthma association: clinical and molecular views
Kian, N., Bagheri, A., Salmanpour, F., Soltani, A., Mohajer, Z., Samieefar, N., Barekatain, B., & Kelishadi, R. (2023) · Clinical and Molecular Allergy · doi:10.1186/s12948-023-00189-0 · Cited by 12
“These modifications may put the child at a high risk of inflammatory diseases such as asthma [129].”
BackgroundDevelopmental Contributions to Obesity
Wu, A. J., & Oken, E. (2023) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2023.02.001 · Cited by 9
Kebbe, M., Shankar, K., Redman, L. M., & Andres, A. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.02.029 · Cited by 13
Mukherjee, A. M. (2025) · Infection and Immunity · doi:10.1128/iai.00502-25 · Cited by 11
“Perturbations in these microbial communities, due to antibiotic exposure or dysbiosis, correlate with aberrant metabolic imprinting, predisposing infants to obesity, insulin resistance, and dyslipidemia in later childhood (43).”
The benefits of probiotic interventions in maternal-fetal health: An appraise review
Dhillon, P., Singh, K., & Kaur, K. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100211 · Cited by 9
The neonatal microbiome in utero and beyond: perinatal influences and long-term impacts
Hill, L., Sharma, R., Hart, L., Popov, J., Moshkovich, M., & Pai, N. (2021) · Journal of Laboratory Medicine · doi:10.1515/labmed-2021-0131 · Cited by 11
“Body composition and dietary habits of the mother have been shown to have several effects on neonatal development, including neonatal microbial colonization, immune function, and the development of obesity and metabolic syndrome [73].”
BackgroundNovel Perspective on the Regulation of Offspring Food Allergy by Maternal Diet and Nutrients
Bai, T., Wang, Z., Shao, H., Zhang, X., Lorenz, A., Meng, X., Wu, Y., Chen, H., & Li, X. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c09108 · Cited by 11
Gut ecosystem during infancy: The role of “biotics”
Toca, M. D. C., Burgos, F., Fernández, A., Giglio, N., Orsi, M., Sosa, P., Tabacco, O., Ursino, F., Ussher, F., & Vinderola, G. (2020) · Archivos Argentinos de Pediatria · doi:10.5546/aap.2020.eng.278 · Cited by 8
Activation of Proneuronal Transcription Factor Ascl1 in Maternal Liver Ensures a Healthy Pregnancy
Lee, J., Garcia, V., Nambiar, S. M., Jiang, H., & Dai, G. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.08.009 · Cited by 8
“It is known that the microbiome shows adaptive changes to accommodate the physiological and immunologic alterations of the host during pregnancy.(22,46,47) Here, we found that 8 bacteria species in maternal ceca responded to the deficiency of”
BackgroundDjekkoun, N., Dépeint, F., Guibourdenche, M., Sabbouri, H. E. K. E., Corona, A., Rhazi, L., Gay‐Queheillard, J., Rouabah, L., Biendo, M., Al‐Salameh, A., et al. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-03063-y · Cited by 8
Hypertension and renal disease programming: focus on the early postnatal period
Borghese, M. F. A., Oronel, L. H., Ortiz, M. D. C., & Majowicz, M. P. (2022) · Clinical Science · doi:10.1042/cs20220293 · Cited by 6
Metabolic Programming and Nutrition
Brasiel, P. G. D. A., & Luquetti, S. C. P. D. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.92201 · Cited by 6
“In children, metabolic diseases, including obesity, insulin resistance, and NAFLD, along with other related immune-based diseases, are associated with modifications in infant gut bacterial composition; however, the mechanisms involved are not entirely clear [43, 56].”
Gut Microbiome of a Multiethnic Community Possessed No Predominant Microbiota
Khine, W. W. T., Teo, A. H. T., Loong, L. W. W., Tan, J. J. H., Ang, C. G. H., Ng, W., Lee, C. N., Zhu, C., Lau, Q. C., & Lee, Y. K. (2021) · Microorganisms · doi:10.3390/microorganisms9040702 · Cited by 6
“Indeed, gut microbiome has been reported to play vital roles in the physiological functions and wellbeing of people [1,2].”
BackgroundGut microbiota and the ways to correct it in chronic kidney disease
Стуров, Н. В., Popov, S. V., & Belikov, I. (2023) · Indian Journal of Nephrology · doi:10.4103/ijn.ijn_469_21 · Cited by 5
“[13] It is known that the first colonizers of the GIT are aerophilous representatives of the Proteobacteria and Actinobacteria phyla, which form a favorable microenvironment for further colonization by representatives of Firmicutes and Bacteroides.”
BackgroundCecchini, L., Barmaz, C., Coloma, M. J., Baeschlin, H., Etter, J., Netzer, S., Bregy, L., Marchukov, D., Trigo, N. F., Meier, R., et al. (2023) · BMC Pediatrics · doi:10.1186/s12887-023-04198-5 · Cited by 4
“…study the analysis of the trajectory of the gut microbiota maturation and its influencing environmental factors (breastfeeding, maternal and infant nutrition, lifestyle) may confirm specific correlations between clinical and microbiota data [10, 11, 13, 98, 99] but also identify new associations.”
BackgroundRelationship of maternal high-fat diet to intestinal barrier integrity and disease in offspring
Zhang, C., Zhong, W., Miao, L., Lin, Z., Sun, S., Jiang, M., Jin, C., & Shi, L. (2025) · Nutrition Research · doi:10.1016/j.nutres.2025.06.003 · Cited by 4
Nutrient metabolism and requirements in lactation
Francis, J., & Egdorf, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818460-8.00004-6 · Cited by 4
Bayaga, C. L. T., Tanguilig, K. M. N., Aba, R. P. M., Pico, M. B., & Gabriel, A. A. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14974 · Cited by 4
“Other than diet, maternal weight, prepregnancy health, mode of delivery, antibiotic exposure and geographical location have all been found to play roles in bacterial profiles of human milk (Mart ın et al. 2007; Li et al. 2017; Mulligan and Friedman 2017; Chen et al. 2018; Lundgren et al. 2019; Padilha et al. 2019; Her…”
BackgroundNutrigenomics as a Strategy for Neuronal Health
Damiani, E., & Gabbianelli, R. (2019) · Healthy ageing and longevity · doi:10.1007/978-3-030-24958-8_9 · Cited by 4
Alterations in Gut Microbiota of Infants Born to Mothers with Obesity
Meiirmanova, Z., Mukhanbetzhanov, N., Jarmukhanov, Z., Vinogradova, E. B., Kozhakhmetova, S., Morenko, M., Duisebayeva, A., Poddighe, D., Kushugulova, A. R., & Kozhakhmetov, S. (2025) · Biomedicines · doi:10.3390/biomedicines13040838 · Cited by 4
“Unlike previous works proposing general strategies for microbiome modulation [30], our data on specific metabolic pathways allow the development of more targeted approaches.”
Exploring the Vital Role of Microbiota Metabolites in Early-Life Health
Zhang, B., Lin, Y., Song, S., & Guo, H. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.04.025 · Cited by 3
Zhao, M., Li, X., Li, Y., Ma, L., Liu, Y., Wang, S., Tian, J., Liang, Y., Shen, C., Ma, X., et al. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s534551 · Cited by 3
“33–35 Their observed association with lipid-and amino acid-related metabolites in our study, such as palmitoylcarnitine and N2-acetyl-L-ornithine, suggests a functional link between microbial metabolic output and host immunometabolism pathways.”
Xixi, N. A., Karamanolis, G. P., Vlachogianni, E.-E., Voulgaris, T. A., Sokou, R., Volaki, P., Paliatsiou, S., Iliodromiti, Z., Iacovidou, N. M., & Boutsikou, Τ. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1751708 · Cited by 2
Lipski, E. A. (2020) · Springer eBooks · doi:10.1007/978-3-030-30730-1_23 · Cited by 2
Wang, Q., Lu, X., Hu, W., Zhang, C., Liu, K., Tong, K., Chen, K., & Wang, H. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2023.9250035 · Cited by 2
“Molecular aspects of dietary polyphenols in pregnancy”
Santangelo, C., & Masella, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813862-5.00010-4 · Cited by 2
Early Life Events and Development of Gut Microbiota in Infancy
Jeong, S. (2021) · Korean Journal of Gastroenterology · doi:10.4166/kjg.2021.408 · Cited by 2
Ecosistema intestinal en la infancia: rol de los “bióticos”
(2020) · Archivos Argentinos de Pediatria · doi:10.5546/aap.2020.278 · Cited by 3
Heinecke, F., Fornes, D. D., Capobianco, E., Quiroga, J. P. F., Labiano, M., Faletti, A. G., Jawerbaum, A., & White, V. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112201 · Cited by 1
Experience-dependent development of vagal circuitry in rodents and humans
Panvini, S., Kamitakahara, A. K., Rinaman, L., & Levitt, P. R. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106728 · Cited by 2
Microbiota intestinal en pediatría
Camacho, J. H., Pinilla, L. R., Peña, D. S., Dueñas, S. S., Carvajal, D. R., Castillo, N. B., Peña, R. R., Saenz, I. P., Quesada, S. M., Salazar, A. G., et al. (2020) · Revista Repertorio de Medicina y Cirugía · doi:10.31260/repertmedcir.01217372.1100 · Cited by 1
Comment on G. N. Vallianatou et al.
Hu, Q., Lv, Z., & Niu, H. (2025) · Pediatric Allergy and Immunology · doi:10.1111/pai.70023 · Cited by 1
Hart, D. A., Herzog, W., Rios, J. L., Reimer, R. A., & Collins, K. H. (2020) · Springer eBooks · doi:10.1007/978-3-030-35358-2_7 · Cited by 1
Sleep Apnoea and Early Antecedents of Adult Disease
Gozal, D. (2018) · Barcelona Respiratory Network · doi:10.23866/brnrev:2017-0030
Molecular Regulation of Maternal Hepatic Adaptations to Pregnancy
Lee, J. (2020) · Purdue e-Pubs (Purdue University System) · doi:10.25394/pgs.12221951.v1
Profil Mikrobiota Saluran Cerna Pada Anak, Dewasa, Berbagai Suku dan Ras
Kurniawan, D., Makmun, A., Zulfahmidah, Z., & Aisyah, W. N. (2020) · Indonesian Journal of Health · doi:10.33368/inajoh.v0i0.6
Lavine, J. E. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734302582.793574474
Dietary Fiber Intake and Chronic Diseases Outcome During Pregnancy
Guo, C., Luo, X., Xiao, M., & Zhao, Y. (2022) · Highlights in Science Engineering and Technology · doi:10.54097/hset.v2i.553
Microbiome Applications for Sustainable Food Systems
Trif, M., Alexandru Vasile, R. U. S. U., Francino, M. P., Delgado, G., & Rufián‐Henares, J. Á. (2022) · Springer eBooks · doi:10.1007/978-3-031-07434-9_8
Enaud, R. (2023) · Perfectionnement en Pédiatrie · doi:10.1016/s2588-932x(23)00149-3
Maternal thyroid-gut dynamics during pregnancy and cognitive trajectories in children
Yadav, A., Wankhede, N. L., Sangamwar, S., Taksande, B. G., Aglawe, M. M., Rahangdale, S. R., Umekar, M., & Kale, M. (2026) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2026.101254
Metadata
- Authors
- Mulligan, C. M., & Friedman, J. E.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Friedman, Jacob E
- ORCID
- Friedman, Jacob E
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2017-10-01
- Volume
- 235
- Issue
- 1
- Pages
- R1-R12
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- PMC
- PMC5568816
- OpenAlex
- W2739563526
- Cited by
- 101
- References
- 106
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 5 · 2023: 12 · 2022: 8 · 2021: 15 · 2020: 25 · 2019: 12 · 2018: 11
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NIH-R01, DK048520)
- Nutrition Obesity Research Center, University of North Carolina
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078590, P30DK048520)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- maternal obesity, maternal high-fat diet, infant gut microbiota, developmental programming, metabolic disorders, neonatal innate immunity, intestinal barrier integrity, offspring obesity risk
- MeSH terms
- Gastrointestinal Microbiome, Animals, Female, Humans, Infant, Metabolic Diseases, Pregnancy, Prenatal Exposure Delayed Effects
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
