The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
Maternal modifiers of the infant gut microbiota: metabolic consequences
Open accessAbstract
Transmission of metabolic diseases from mother to child is multifactorial and includes genetic, epigenetic and environmental influences. Evidence in rodents, humans and non-human primates support the scientific premise that exposure to maternal obesity or high-fat diet during pregnancy creates a long-lasting metabolic signature on the infant innate immune system and the juvenile microbiota, which predisposes the offspring to obesity and metabolic diseases. In neonates, gastrointestinal microbes introduced through the mother are noted for their ability to serve as direct inducers/regulators of the infant immune system. Neonates have a limited capacity to initiate an immune response. Thus, disruption of microbial colonization during the early neonatal period results in disrupted postnatal immune responses that highlight the neonatal period as a critical developmental window. Although the mechanisms are poorly understood, increasing evidence suggests that maternal obesity or poor diet influences the development and modulation of the infant liver and other end organs through direct communication via the portal system, metabolite production, alterations in gut barrier integrity and the hematopoietic immune cell axis. This review will focus on how maternal obesity and dietary intake influence the composition of the infant gut microbiota and how an imbalance or maladaptation in the microbiota, including changes in early pioneering microbes, might contribute to the programming of offspring metabolism with special emphasis on mechanisms that promote chronic inflammation in the liver. Comprehension of these pathways and mechanisms will elucidate our understanding of developmental programming and may expand the avenue of opportunities for novel therapeutics.
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“Moreover, the healthy diet of a pregnant woman rich in dietary fiber shapes the gut microbiota of her offspring [100].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [100]
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Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
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“In adults, the transmissibility of obesity and related disorders by gut bacteria is likely mediated specifically by cells of the innate immune system, a phenomenon that is observed in Rag1 mice lacking all cells of the adaptive immune system (Bäckhed et al. 2004).”
BackgroundHepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
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Items 101–101 of 101
Martins-Silva, A. F., de Abreu, A. R. R., Freitas, N. N., de Deus, I. J., Fagundes, M. M. D. A., Rosse, I. C., de Moraes, L. Â. G., Breguez, G. S., Medeiros, J. D., Azevedo, V., et al. (2026) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2026.110486
Metadata
- Authors
- Mulligan, C. M., & Friedman, J. E.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Friedman, Jacob E
- ORCID
- Friedman, Jacob E
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2017-10-01
- Volume
- 235
- Issue
- 1
- Pages
- R1-R12
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- PMC
- PMC5568816
- OpenAlex
- W2739563526
- Cited by
- 101
- References
- 106
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 5 · 2023: 12 · 2022: 8 · 2021: 15 · 2020: 25 · 2019: 12 · 2018: 11
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NIH-R01, DK048520)
- Nutrition Obesity Research Center, University of North Carolina
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078590, P30DK048520)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- maternal obesity, maternal high-fat diet, infant gut microbiota, developmental programming, metabolic disorders, neonatal innate immunity, intestinal barrier integrity, offspring obesity risk
- MeSH terms
- Gastrointestinal Microbiome, Animals, Female, Humans, Infant, Metabolic Diseases, Pregnancy, Prenatal Exposure Delayed Effects
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