The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
Obesity, pregnancy, inflammation, and vascular function
Open accessAbstract
Maternal obesity is associated with increased morbidity and mortality for both mother and offspring. The mechanisms underlying the increased risk associated with maternal obesity are not well understood. In non-pregnant populations, many of the complications of obesity are thought to be mediated in part by inflammation and its sequelae. Recent studies suggest that a heightened inflammatory response may also be involved in mediating adverse clinical outcomes during pregnancy. This review summarizes our current knowledge about adipose tissue biology, and its role as an endocrine and inflammatory organ. The evidence for inflammation as a key mediator of adverse pregnancy outcome is also presented, focusing on the role of inflammation in adipose tissue, systemic inflammation, the placenta, and vascular endothelium.
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“Gestational diabetes is associated with high aerobic fetal metabolism and hypoxia, stimulating the placenta to in crease angiogenesis, resulting in increased number of capillaries. The placentas also show abnormal endocrine function, increased inflam mation, and changes in placental transporters (Bedell et al., 2021; Denison et al., 2010; Gaither et al., 1999; Segura et al., 2017”
From Pregnancy-related maternal physiological adaptations and fetal chemical exposure (2023) · cites this paper as Denison et al., 2010
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Cites
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Cited by
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Maternal and child undernutrition and overweight in low-income and middle-income countries
Black, R. E., Victora, C. G., Walker, S. P., Bhutta, Z. A., Christian, P., de Onis, M., Ezzati, M., Grantham-McGregor, S., Katz, J., Martorell, R., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60937-x · Cited by 8,475
Genetic, hormonal and metabolic aspects of PCOS: an update
De Leo, V., Musacchio, M. C., Cappelli, V., Massaro, M. G., Morgante, G., & Petraglia, F. (2016) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-016-0173-x · Cited by 484
Vannuccini, S., Clifton, V. L., Fraser, I. S., Taylor, H. S., Critchley, H., Giudice, L. C., & Petraglia, F. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmv044 · Cited by 379
Placental structure and inflammation in pregnancies associated with obesity
Roberts, K., Riley, S. C., Reynolds, R. M., Barr, S., Evans, M., Statham, A., Hor, K., Jabbour, H. N., Norman, J. E., & Denison, F. C. (2011) · Placenta · doi:10.1016/j.placenta.2010.12.023 · Cited by 281
Self-citationAye, I. L. M. H., Lager, S., Ramirez, V. I., Gaccioli, F., Dudley, D. J., Jansson, T., & Powell, T. L. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.113.116186 · Cited by 285
Metadata
- Authors
- Denison, F. C., Roberts, K. A., Barr, S. M., & Norman, J. E.
- Affiliations
- The Queen's Medical Research Institute (GB)
- Venue
- Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-09-01
- Volume
- 140
- Issue
- 3
- Pages
- 373-385
- ISSN
- 1470-1626 (ISSN-L)
- 1741-7899
- OpenAlex
- W2116489286
- Cited by
- 221
- References
- 125
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 8 · 2023: 15 · 2022: 12 · 2021: 9 · 2020: 20 · 2019: 16 · 2018: 16 · 2017: 21 · 2016: 12 · 2015: 15 · 2014: 18 · 2013: 18 · 2012: 13
- FWCI
- 9.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Explore Bristol Research (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- maternal obesity, pregnancy complications, inflammation, vascular function, adipose tissue, adipokines, systemic inflammation, placenta, vascular endothelium, adverse pregnancy outcomes, maternal morbidity and mortality
- MeSH terms
- Adipose Tissue, Endothelium, Vascular, Female, Fibrinolysis, Humans, Inflammation, Obesity, Pregnancy, Pregnancy Complications, Pregnancy Complications, Cardiovascular, Pregnancy Outcome, Risk Factors, Inflammation Mediators
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