Cited by 221Adipokines, Inflammation, and Metabolic DiseasesGestational Diabetes Research and ManagementPregnancy and preeclampsia studies

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Obesity, pregnancy, inflammation, and vascular function

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Denison, F C, Roberts, K A, Barr, S M, Norman, J E·2010·Reproduction

DOI 10.1530/rep-10-0074

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Abstract

Maternal obesity is associated with increased morbidity and mortality for both mother and offspring. The mechanisms underlying the increased risk associated with maternal obesity are not well understood. In non-pregnant populations, many of the complications of obesity are thought to be mediated in part by inflammation and its sequelae. Recent studies suggest that a heightened inflammatory response may also be involved in mediating adverse clinical outcomes during pregnancy. This review summarizes our current knowledge about adipose tissue biology, and its role as an endocrine and inflammatory organ. The evidence for inflammation as a key mediator of adverse pregnancy outcome is also presented, focusing on the role of inflammation in adipose tissue, systemic inflammation, the placenta, and vascular endothelium.

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Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Hyperglycemia and adverse pregnancy outcomes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707943 · Cited by 5,563
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
Abdominal obesity and metabolic syndrome
Després, J.-P., & Lemieux, I. (2006) · Nature · doi:10.1038/nature05488 · Cited by 4,354
Dynamics of fat cell turnover in humans
Spalding, K. L., Arner, E., Westermark, P. O., Bernard, S., Buchholz, B. A., Bergmann, O., Blomqvist, L., Hoffstedt, J., Näslund, E., Britton, T., et al. (2008) · Nature · doi:10.1038/nature06902 · Cited by 2,357
Metabolic Syndrome in Childhood: Association With Birth Weight, Maternal Obesity, and Gestational Diabetes Mellitus
Boney, C. M., Verma, A., Tucker, R., & Vohr, B. R. (2005) · Pediatrics · doi:10.1542/peds.2004-1808 · Cited by 2,303
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L., & Kahn, B. B. (2005) · Nature · doi:10.1038/nature03711 · Cited by 2,086
Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
Kern, P. A., Ranganathan, S., Li, C., Wood, L., & Ranganathan, G. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.5.e745 · Cited by 1,883
Obesity-induced inflammatory changes in adipose tissue
Wellen, K. E., & Hotamisligil, G. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320514 · Cited by 1,823
Maternal obesity and pregnancy outcome: a study of 287 213 pregnancies in London
Sebire, N. J., Jolly, M., Harris, J. P., Wadsworth, J., Joffe, M., Beard, R. W., Regan, L., & Robinson, S. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801670 · Cited by 1,740
Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance
Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., Brechtel, G., & Baron, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118709 · Cited by 1,687 · cited 2×
“At a functional level, the vasodilatory response to endothelium-dependent vasodilators such as acetylcholine is attenuated (Steinberg et al. 1996), whereas the response to endothelium-independent vasodilators, such as sodium nitroprusside, remains intact (Van Guilder et al.”
Comparison of the Release of Adipokines by Adipose Tissue, Adipose Tissue Matrix, and Adipocytes from Visceral and Subcutaneous Abdominal Adipose Tissues of Obese Humans
Fain, J. N., Madan, A. K., Hiler, M. L., Cheema, P. S., & Bahouth, S. W. (2004) · Endocrinology · doi:10.1210/en.2003-1336 · Cited by 1,619
Normalization of obesity-associated insulin resistance through immunotherapy
Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., Dorfman, R., Wang, Y., Zielenski, J., Mastronardi, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2001 · Cited by 1,370
Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome
Maury, E., & Brichard, S. M. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.031 · Cited by 1,026
A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome
Boomsma, C. M., Eijkemans, M. J. C., Hughes, E. G., Visser, G. H. A., Fauser, B. C. J. M., & Macklon, N. S. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml036 · Cited by 852
Pregnancy complications and maternal cardiovascular risk: opportunities for intervention and screening?
Sattar, N. A., & Greer, I. A. (2002) · BMJ · doi:10.1136/bmj.325.7356.157 · Cited by 824
Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis
Sacks, G. P., Studená, K., Sargent, I. L., & Redman, C. W. G. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70254-6 · Cited by 823
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice
Liu, J., Divoux, A., Sun, J., Zhang, J., Clément, K., Glickman, J. N., Sukhova, G. K., Wolters, P. J., Du, J., Gorgun, C. Z., et al. (2009) · Nature Medicine · doi:10.1038/nm.1994 · Cited by 796
Adipocytokines and the Metabolic Complications of Obesity
Rasouli, N., & Kern, P. A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1613 · Cited by 751
TNF-α Is a Predictor of Insulin Resistance in Human Pregnancy
Kirwan, J. P., Hauguel-De Mouzon, S., Lepercq, J., Challier, J.-C., Huston-Presley, L., Friedman, J. E., Kalhan, S. C., & Catalano, P. M. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2207 · Cited by 738
Obesity prevalence from a European perspective: a systematic review
Berghöfer, A., Pischon, T., Reinhold, T., Apovian, C. M., Sharma, A. M., & Willich, S. N. (2008) · BMC Public Health · doi:10.1186/1471-2458-8-200 · Cited by 729
T-lymphocyte Infiltration in Visceral Adipose Tissue: A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin Resistance
Kintscher, U., Hartge, M., Hess, K., Foryst-Ludwig, A., Clemenz, M., Wabitsch, M., Fischer-Posovszky, P., Barth, T. F. E., Dragun, D., Skurk, T., et al. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.165100 · Cited by 692
Effect of body mass index on pregnancy outcomes in nulliparous women delivering singleton babies
Bhattacharya, S., Campbell, D. M., Liston, W. A., & Bhattacharya, S. (2007) · BMC Public Health · doi:10.1186/1471-2458-7-168 · Cited by 688
Maternal Obesity Is Associated with Dysregulation of Metabolic, Vascular, and Inflammatory Pathways
Ramsay, J. E., Ferrell, W. R., Crawford, L., Wallace, A. M., Greer, I. A., & Sattar, N. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020311 · Cited by 659
Fetuses of obese mothers develop insulin resistance in utero
Catalano, P. M., Presley, L., Minium, J., & Hauguel-de Mouzon, S. (2009) · Diabetes Care · doi:10.2337/dc08-2077 · Cited by 655
A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance
Sabio, G., Das, M., Mora, A., Zhang, Z., Jun, J. Y., Ko, H. J., Barrett, T., Kim, J. K., & Davis, R. J. (2008) · Science · doi:10.1126/science.1160794 · Cited by 604
Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production
Zeyda, M., Farmer, D., Todoric, J., Aszmann, O. C., Speiser, M., Györi, G., Zlabinger, G. J., & Stulnig, T. M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803632 · Cited by 575
Macrophage Infiltration into Omental Versus Subcutaneous Fat across Different Populations: Effect of Regional Adiposity and the Comorbidities of Obesity
Harman-Boehm, I., Blüher, M., Redel, H., Sion-Vardy, N., Ovadia, S., Avinoach, E., Shai, I., Klöting, N., Stumvoll, M., Bashan, N., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1811 · Cited by 574
Preadipocyte Conversion to Macrophage
Charrière, G. M., Cousin, B., Arnaud, E., André, M., Bacou, F., Pénicaud, L., & Casteilla, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210811200 · Cited by 556
Monocyte Chemoattractant Protein-1 Release Is Higher in Visceral than Subcutaneous Human Adipose Tissue (AT): Implication of Macrophages Resident in the AT
Bruun, J. M., Lihn, A. S., Pedersen, S. B., & Richelsen, B. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1696 · Cited by 555
Resistin and obesity-associated insulin resistance
Steppan, C. M., & Lazar, M. A. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00522-7 · Cited by 528
Hemostasis during normal pregnancy and puerperium
Hellgren, M. (2003) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2003-38897 · Cited by 492
A nationally representative study of maternal obesity in England, UK: trends in incidence and demographic inequalities in 619 323 births, 1989–2007
Heslehurst, N., Rankin, J. M., Wilkinson, J. R., & Summerbell, C. D. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.250 · Cited by 437
The growth of adipose tissue in children and adolescents. Cross-sectional and longitudinal studies of adipose cell number and size.
Knittle, J. L., Timmers, K. I., Ginsberg‐Fellner, F., Brown, R., & Katz, D. P. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109295 · Cited by 397
Adipose Macrophage Infiltration Is Associated With Insulin Resistance and Vascular Endothelial Dysfunction in Obese Subjects
Apovian, C. M., Bigornia, S., Mott, M. M., Meyers, M. R., Ulloor, J., Gagua, M., McDonnell, M. E., Hess, D. T., Joseph, L., & Gokce, N. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.170316 · Cited by 392
Gestational Diabetes Induces Placental Genes for Chronic Stress and Inflammatory Pathways
Radaelli, T., Varastehpour, A., Catalano, P., & Hauguel-de Mouzon, S. (2003) · Diabetes · doi:10.2337/diabetes.52.12.2951 · Cited by 390
Transdifferentiation properties of adipocytes in the adipose organ
Cinti, S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00183.2009 · Cited by 379
The emerging role of adipokines as mediators of inflammation and immune responses
Lago, F., Diéguez, C., Gómez-Reino, J. J., & Gualillo, O. (2007) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2007.04.007 · Cited by 373
Maternal Gestational Weight Gain and Offspring Weight in Adolescence
Oken, E., Rifas‐Shiman, S. L., Field, A. E., Frazier, A. L., & Gillman, M. W. (2008) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31818a5d50 · Cited by 368
CC Chemokine and CC Chemokine Receptor Profiles in Visceral and Subcutaneous Adipose Tissue Are Altered in Human Obesity
Huber, J., Kiefer, F. W., Zeyda, M., Ludvik, B. H., Silberhumer, G. R., Prager, G., Zlabinger, G. J., & Stulnig, T. M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2630 · Cited by 365
Expression of CD68 and Macrophage Chemoattractant Protein-1 Genes in Human Adipose and Muscle Tissues
Di Gregorio, G. B., Yao-Borengasser, A., Rasouli, N., Varma, V., Lu, T., Miles, L. M., Ranganathan, G., Peterson, C. A., McGehee, R. E., & Kern, P. A. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2305 · Cited by 362
Fatty acid‐induced induction of Toll‐like receptor‐4/nuclear factor‐κB pathway in adipocytes links nutritional signalling with innate immunity
Schaeffler, A., Gross, P., Buettner, R., Bollheimer, C., Buechler, C., Neumeier, M., Kopp, A., Schoelmerich, J., & Falk, W. (2009) · Immunology · doi:10.1111/j.1365-2567.2008.02892.x · Cited by 360
Association of Low Interleukin-10 Levels with the Metabolic Syndrome in Obese Women
Esposito, K., Pontillo, A., Giugliano, F., Giugliano, G., Marfella, R., Nicoletti, G., & Giugliano, D. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021437 · Cited by 355
Trends in maternal obesity incidence rates, demographic predictors, and health inequalities in 36 821 women over a 15‐year period
Heslehurst, N., Ells, L. J., Simpson, H., Batterham, A. M., Wilkinson, J. R., & Summerbell, C. (2006) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.01180.x · Cited by 349
Sympathetic nervous system and insulin resistance: from obesity to diabetes
Esler, M. (2001) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02236-1 · Cited by 344
Cytokines of the Placenta and Extra-placental Membranes: Roles and Regulation During Human Pregnancy and Parturition
Bowen, J. M., Chamley, L., Keelan, J. A., & Mitchell, M. D. (2002) · Placenta · doi:10.1053/plac.2001.0782 · Cited by 342
The Role of Growth Factors and Cytokines during Implantation: Endocrine and Paracrine Interactions
Guzeloglu‐Kayisli, O., Kayisli, U. A., & Taylor, H. S. (2009) · Seminars in Reproductive Medicine · doi:10.1055/s-0028-1108011 · Cited by 324
Resistin Gene Expression in Human Adipocytes Is Not Related to Insulin Resistance
Janke, J., Engeli, S., Gorzelniak, K., Luft, F. C., & Sharma, A. M. (2002) · Obesity Research · doi:10.1038/oby.2002.1 · Cited by 318
Adipose tissue macrophages
Zeyda, M., & Stulnig, T. M. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.07.003 · Cited by 316
Adipose Tissue Is a Major Source of Interleukin-1 Receptor Antagonist
Juge-Aubry, C. E., Somm, E., Giusti, V., Pernin, A., Chicheportiche, R., Verdumo, C., Rohner‐Jeanrenaud, F., Burger, D., Dayer, J., & Meier, C. A. (2003) · Diabetes · doi:10.2337/diabetes.52.5.1104 · Cited by 305
The American Journal of Clinical Nutrition
(2023) · American Journal of Clinical Nutrition · doi:10.3945/(issn)1938-3207 · Cited by 303
The Placenta Cytokine Network and Inflammatory Signals
Mouzon, S. H., & Guerre-Millo, M. (2005) · Placenta · doi:10.1016/j.placenta.2005.08.009 · Cited by 294
IL-1 receptor antagonist serum levels are increased in human obesity: a possible link to the resistance to leptin?
Meier, C. A., Bobbioni, E., Gabay, C., Assimacopoulos-Jeannet, F., Golay, A., & Dayer, J.-M. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8351 · Cited by 287
Plasma Interleukin-8 Concentrations Are Increased in Obese Subjects and Related to Fat Mass and Tumor Necrosis Factor-α System
Straczkowski, M., Dzienis-Straczkowska, S., Stêpieñ, A., Kowalska, I., Szelachowska, M., & Kinalska, I. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020135 · Cited by 280
Obesity is associated with increased arterial stiffness from adolescence until old age
Zebekakis, P. E., Nawrot, T. S., Thijs, L., Balkestein, E. J., Spek, J. J., Bortel, L. M. V., Struijker-Boudier, H. A. J., Safar, M. E., & Staessen, J. A. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000179511.93889.e9 · Cited by 276
Longitudinal Assessment of Maternal Endothelial Function and Markers of Inflammation and Placental Function throughout Pregnancy in Lean and Obese Mothers
Stewart, F. M., Freeman, D. J., Ramsay, J. E., Greer, I. A., CASLAKE, M. J., & Ferrell, W. R. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2083 · Cited by 274
The chronology of adipose tissue appearance and distribution in the human fetus
Poissonnet, C. M., Burdi, A. R., & Garn, S. M. (1984) · Early Human Development · doi:10.1016/0378-3782(84)90106-3 · Cited by 242
Leptin and Adiponectin Stimulate the Release of Proinflammatory Cytokines and Prostaglandins from Human Placenta and Maternal Adipose Tissue via Nuclear Factor-κB, Peroxisomal Proliferator-Activated Receptor-γ and Extracellularly Regulated Kinase 1/2
Lappas, M., Permezel, M., & Rice, G. E. (2005) · Endocrinology · doi:10.1210/en.2005-0406 · Cited by 241
Maternal obesity, length of gestation, risk of postdates pregnancy and spontaneous onset of labour at term
Denison, F. C., Price, J. F., Graham, C., Wild, S. H., & Liston, W. A. (2008) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2008.01694.x · Cited by 232
Self-citation
Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding
Heinonen, M. V., Purhonen, A. K., Miettinen, P., Pääkkönen, M., Pirinen, E., Alhava, E., Åkerman, K., & Herzig, K. H. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2005.05.003 · Cited by 232
Obesity and vascular dysfunction
Stapleton, P. A., James, M. E., Goodwill, A. G., & Frisbee, J. C. (2008) · Pathophysiology · doi:10.1016/j.pathophys.2008.04.007 · Cited by 221
Influence of the Menstrual Cycle, Pregnancy, and Preeclampsia on Arterial Stiffness
Robb, A. O., Mills, N. L., Din, J. N., Smith, I., Paterson, F., Newby, D. E., & Denison, F. C. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.130898 · Cited by 212
Self-citation
Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus
Magee, M., Permezel, M., Riley, C. B., Desoyé, G., & Lappas, M. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0031 · Cited by 207
Visceral adiposity and its anatomical distribution as predictors of the metabolic syndrome and cardiometabolic risk factor levels
Demerath, E. W., Reed, D., Rogers, N. L., Sun, S. S., Lee, M., Choh, A. C., Couch, W. P., Czerwinski, S. A., Chumlea, W. C., Siervogel, R. M., et al. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26546 · Cited by 206
Overexpression of placental leptin in diabetic pregnancy: a critical role for insulin.
Lepercq, J. A., Caüzac, M., Lahlou, N., Timsit, J., Girard, J. R., Auwerx, J. H., & Mouzon, S. H. (1998) · Diabetes · doi:10.2337/diabetes.47.5.847 · Cited by 200
Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia
Rusterholz, C., Hahn, S., & Holzgreve, W. (2007) · Seminars in Immunopathology · doi:10.1007/s00281-007-0071-6 · Cited by 198
Role of adipose tissue in haemostasis, coagulation and fibrinolysis
Faber, D. R., de Groot, P. G., & Visseren, F. L. J. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00593.x · Cited by 197
Intra‐adipose sex steroid metabolism and body fat distribution in idiopathic human obesity
Wake, D. J., Strand, M., Rask, E., Westerbacka, J., Livingstone, D. E. W., Söderberg, S., Andrew, R., Yki‐Järvinen, H., Olsson, T., & Walker, B. R. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02755.x · Cited by 182
Growth and development of human adipose tissue during early gestation
Poissonnet, C. M., Burdi, A. R., & Bookstein, F. L. (1983) · Early Human Development · doi:10.1016/0378-3782(83)90028-2 · Cited by 179
IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2
Jones, H. N., Jansson, T., & Powell, T. L. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00195.2009 · Cited by 168 · cited 3×
“org concentrations of the proinflammatory cytokines IL6 and TNF stimulate the activity of amino acid transporter system A (Jones et al. 2009).”
Visceral Obesity and Plasma Glucose-Insulin Homeostasis: Contributions of Interleukin-6 and Tumor Necrosis Factor-α in Men
Cartier, A., Lemieux, I., Alméras, N., Tremblay, A., Bergeron, J., & Després, J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2191 · Cited by 165
Maternal C-reactive protein levels are raised at 4 weeks gestation
Sacks, G. P. (2004) · Human Reproduction · doi:10.1093/humrep/deh179 · Cited by 165
T-ing up inflammation in fat
Lumeng, C. N.-K., Maillard, I. P., & Saltiel, A. R. (2009) · Nature Medicine · doi:10.1038/nm0809-846 · Cited by 162
Differential regulation of genes for fetoplacental lipid pathways in pregnancy with gestational and type 1 diabetes mellitus
Radaelli, T., Lepercq, J., Varastehpour, A., Basu, S., Catalano, P. M., & Hauguel-De Mouzon, S. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.04.019 · Cited by 156 · cited 2×
“Studies have also demonstrated major changes in the placental gene expression profile of inflammatory genes in women who have developed gestational diabetes mellitus (GDM; Radaelli et al. 2009).”
Obesity: a risk factor for preeclampsia
Walsh, S. W. (2007) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2007.09.003 · Cited by 155
Inflammation and Triglycerides Partially Mediate the Effect of Prepregnancy Body Mass Index on the Risk of Preeclampsia
Bodnar, L. M., Ness, R. B., Harger, G. F., & Roberts, J. M. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi334 · Cited by 148
Adipose tissue is a regulated source of interleukin-10
Juge-Aubry, C. E., Somm, E., Pernin, A., Alizadeh, N., Giusti, V., Dayer, J.-M., & Meier, C. A. (2005) · Cytokine · doi:10.1016/j.cyto.2004.10.017 · Cited by 144
Impairment of Dendritic Cell Functionality and Steady-State Number in Obese Mice
Macia, L., Delacre, M., Abboud, G., Ouk, T., Delanoye, A., Verwaerde, C., Saule, P., & Wolowczuk, I. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.5997 · Cited by 142
11β‐HSD Type 1 Expression in Human Adipose Tissue: Impact of Gender, Obesity, and Fat Localization
Paulsen, S. K., Pedersen, S. B., Fisker, S., & Richelsen, B. (2007) · Obesity · doi:10.1038/oby.2007.233 · Cited by 136
The Incidence of Placental Abnormalities, Maternal and Cord Plasma Malondialdehyde and Vascular Endothelial Growth Factor Levels in Women with Gestational Diabetes Mellitus and Nondiabetic Controls
Madazlı, R., Tüten, A., Calay, Z., Uzun, H., Uludağ, S., & Ocak, V. (2008) · Gynecologic and Obstetric Investigation · doi:10.1159/000113045 · Cited by 134
Obesity increases prostanoid-mediated vasoconstriction and vascular thromboxane receptor gene expression
Traupe, T., Lang, M., Göettsch, W., Münter, K., Morawietz, H., Vetter, W., & Barton, M. (2002) · Journal of Hypertension · doi:10.1097/00004872-200211000-00024 · Cited by 133
11&Bgr;-Hydroxysteroid Dehydrogenase Type 1 and Obesity
Morton, N. M., & Seckl, J. R. (2008) · KARGER eBooks · doi:10.1159/000115363 · Cited by 132
Inflammation is associated with a decrease of lipogenic factors in omental fat in women
Poulain‐Godefroy, O., Lecœur, C., Pattou, F. N., Frühbeck, G., & Froguel, P. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00926.2007 · Cited by 128
Infliximab Restores Glucose Homeostasis in an Animal Model of Diet-Induced Obesity and Diabetes
ARAUJO, E. P. D., de Souza, C. T., Ueno, M., Cintra, D. E., Bértolo, M. B., Carvalheira, J. B. C., Saad, M. J. A., & Velloso, L. A. (2007) · Endocrinology · doi:10.1210/en.2007-0132 · Cited by 128
Effect of Increasing Maternal Body Mass Index on Oxidative and Nitrative Stress in The Human Placenta
Roberts, V. H. J., Smith, J. E., McLea, S. A., Heizer, A., Richardson, J. L., & Myatt, L. (2008) · Placenta · doi:10.1016/j.placenta.2008.11.019 · Cited by 124
The umbilical coiling index, a review of the literature
de Laat, M. W. M., Franx, A., van Alderen, E. D., Nikkels, P. G. J., & Visser, G. H. A. (2005) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050400028899 · Cited by 123
Abdominal Visceral Adiposity in the First Trimester Predicts Glucose Intolerance in Later Pregnancy
Martin, A., Berger, H. M., Nisenbaum, R. A., Lausman, A. Y., MacGarvie, S., Crerar, C., & Ray, J. G. (2009) · Diabetes Care · doi:10.2337/dc09-0290 · Cited by 110
Modulation of placental vascular endothelial growth factor by leptin and hCG
Islami, D. (2003) · Molecular Human Reproduction · doi:10.1093/molehr/gag053 · Cited by 108
Association between omental adipose tissue macrophages and liver histopathology in morbid obesity: Influence of glycemic status
Tordjman, J., Poitou, C., Hugol, D., Bouillot, J., Basdevant, A., Bédossa, P., Guerre-Millo, M., & Clément, K. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.02.031 · Cited by 107
Feto-placental Adaptations to Maternal Obesity in the Baboon
Farley, D. R., Tejero, M. E., Comuzzie, A. G., Higgins, P. B., Cox, L. A., Werner, S. L., Jenkins, S. L., Li, C., Choi, J., Dick, E. J., et al. (2009) · Placenta · doi:10.1016/j.placenta.2009.06.007 · Cited by 104
Expression of adipokines and estrogen receptors in adipose tissue and placenta of patients with gestational diabetes mellitus
Kleiblová, P., Dostálová, I., Bártlová, M., Lacinová, Z., Tichá, I., Krejčí, V., Springer, D., Kleibl, Z., & Haluzı́k, M. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.002 · Cited by 104
Hypertension‐Independent Microvascular Rarefaction in the Obese Zucker Rat Model of the Metabolic Syndrome
Frisbee, J. C. (2005) · Microcirculation · doi:10.1080/10739680590960241 · Cited by 103
An Increase in the Circulating Concentration of Monocyte Chemoattractant Protein-1 Elicits Systemic Insulin Resistance Irrespective of Adipose Tissue Inflammation in Mice
Tateya, S., Tamori, Y., Kawaguchi, T., Kanda, H., & Kasuga, M. (2010) · Endocrinology · doi:10.1210/en.2009-0926 · Cited by 101
In response to oxidative stress, the expression of inflammatory cytokines and antioxidant enzymes are impaired in placenta, but not adipose tissue, of women with gestational diabetes
Lappas, M., Mittion, A., & Permezel, M. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0321 · Cited by 90
Activation of Phospholipase A2 Is Associated with Generation of Placental Lipid Signals and Fetal Obesity
Varastehpour, A., Radaelli, T., Minium, J., Ortega, H., Herrera, E., Catalano, P. M., & Mouzon, S. H. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0873 · Cited by 85
Interleukin-11 Promotes Migration, But Not Proliferation, of Human Trophoblast Cells, Implying a Role in Placentation
Paiva, P., Salamonsen, L. A., Manuelpillai, U., Walker, C., Tapia-Pizarro, A., Wallace, E. M., & Dimitriadis, E. (2007) · Endocrinology · doi:10.1210/en.2007-0517 · Cited by 83
Influence of Visceral Obesity and Liver Fat on Vascular Structure and Function in Obese Subjects
Sturm, W., Sandhofer, A., Engl, J., Laimer, M. W., Molnar, C., Kaser, S., Weiss, H. G., Tilg, H., Ebenbichler, C. F., & Patsch, J. R. (2009) · Obesity · doi:10.1038/oby.2009.81 · Cited by 73
Leptin Stimulates Protein Synthesis-Activating Translation Machinery in Human Trophoblastic Cells1
Pérez‐Pérez, A., Maymó, J. L., Gambino, Y. P., Dueñas, J. L., Goberna, R., Varone, C. L., & Sánchez‐Margalet, V. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.109.076513 · Cited by 68
Placental Structure in Type 1 Diabetes
Nelson, S. M., Coan, P. M., Burton, G. J., & Lindsay, R. S. (2009) · Diabetes · doi:10.2337/db09-0739 · Cited by 62
Impaired Endothelium-Dependent Vasodilation in Normotensive and Normoglycemic Obese Adult Humans
Guilder, G. P. V., Hoetzer, G. L., Dengel, D. R., Stauffer, B. L., & DeSouza, C. A. (2006) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000205097.29946.d3 · Cited by 61
Visfatin in gestational diabetes: Serum level and mRNA expression in fat and placental tissue
Telejko, B., Kuźmicki, M., Zonenberg, A., Szamatowicz, J., Wawrusiewicz‐Kurylonek, N., Nikołajuk, A., Kretowski, A. J., & Górska, M. (2009) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.12.017 · Cited by 58
Increase in normal placental weights related to increase in maternal body mass index
Swanson, L. D., Bewtra, C., Swanson, L. D., & Bewtra, C. (2008) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050701866963 · Cited by 52
Regulation of Microvascular Function by Adipose Tissue in Obesity and Type 2 Diabetes: Evidence of an Adipose-Vascular
Zhang, H., & Zhang, C. (2009) · American Journal of Biomedical Sciences · doi:10.5099/aj090200133 · Cited by 48
Increased expression of the macrophage markers and of 11β-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity
Makkonen, J., Westerbacka, J., Kolak, M., Sutinen, J., Cornér, A., Hamsten, A., Fisher, R. M., & Yki‐Järvinen, H. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803635 · Cited by 45
Developing dendritic cells become ‘lacy’ cells packed with fat and glycogen
Maroof, A., English, N. R., Bedford, P. A., Gabrilovich, D. I., & Knight, S. C. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02181.x · Cited by 44
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Pathophysiological significance of abnormal umbilical cord coiling index
Sebire, N. J. (2007) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.5180 · Cited by 40
Focus on leptin, a pleiotropic hormone.
Fietta, P. (2005) · PubMed · Cited by 37
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Hétu, P., & Riendeau, D. (2007) · Obesity · doi:10.1038/oby.2007.514 · Cited by 35
Vascular adrenergic tone and structural narrowing constrain reactive hyperemia in skeletal muscle of obese Zucker rats
Frisbee, J. C. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01251.2005 · Cited by 32
Insulin and fatty acids regulate the expression of the fat droplet-associated protein adipophilin in primary human trophoblasts
Elchalal, U., Schaiff, W. T., Smith, S. D., Rimon, E., Bildirici, İ., Nelson, D. M., & Sadovsky, Y. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.04.012 · Cited by 31
Acute endothelial tissue plasminogen activator release in pregnancy
Robb, A. O., Mills, N. L., Din, J. N., Cameron, S., Ludlam, C. A., Newby, D. E., & Denison, F. C. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.03207.x · Cited by 23
Self-citation
Stimulated nitric oxide release and nitric oxide sensitivity in forearm arterial vasculature during normotensive and preeclamptic pregnancy
Anumba, D. O. C., Ford, G. A., Boys, R. J., & Robson, S. C. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70394-7 · Cited by 23
ORIGINAL ARTICLE: Interleukin‐10 May Participate in Regulating Trophoblast Invasion in Human Placentae Throughout Gestation
Pang, Z.-J., Zhou, J., & Huang, L. (2008) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2008.00586.x · Cited by 21
Structural Remodeling in the Limb Circulation: Impact of Obesity and Diabetes
Stepp, D. W., & de Chantemèle, E. J. B. (2007) · Microcirculation · doi:10.1080/10739680701285609 · Cited by 16
Expression of resistin protein in normal human subcutaneous adipose tissue and pregnant women subcutaneous adipose tissue and placenta
Yong-ming, Z., Muxun, Z., Guo, W., Meixia, Y., Keying, X., Shiang, H., Chen, Y., Huanli, Z., Xu, L., & Tiecheng, G. (2006) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/bf02829553 · Cited by 16
The effect of maternal characteristics on endothelial-dependent relaxation of myometrial arteries
Myers, J., Hall, C., Wareing, M., Gillham, J. C., & Baker, P. N. (2005) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2005.05.017 · Cited by 10
Carboxypeptidase E in the mouse placenta
Singh, U., Yu, Y., Kalinina, E. V., Konno, T., Sun, T., Ohta, H., Wakayama, T., Soares, M. J., Hemberger, M., & Fundele, R. H. (2006) · Differentiation · doi:10.1111/j.1432-0436.2006.00093.x · Cited by 9

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Challier, 2008, Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta, Placenta, 29, 274, 10.1016/j.placenta.2007.12.010 · DOI · Paper page
Dorup, 1999, Normal pregnancy is associated with enhanced endothelium-dependent flow-mediated vasodilation, American Journal of Physiology, 276, H821
Gunderson, 2001, Does the pattern of postpartum weight change differ according to pregravid body size?, International Journal of Obesity and Related Metabolic Disorders, 25, 853, 10.1038/sj.ijo.0801631 · DOI

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Authors: Denison, F. C., Roberts, K. A., Barr, S. M., & Norman, J. E.
Affiliations: The Queen's Medical Research Institute (GB)
ORCID: Denison, F C
Roberts, K A
Norman, J E
Venue: Reproduction
Publisher: Oxford University Press (OUP)
Published: 2010-09-01
Volume: 140
Issue: 3
Pages: 373-385
ISSN: 1470-1626 (ISSN-L)
1741-7899
DOI: 10.1530/rep-10-0074
OpenAlex: W2116489286
Cited by: 221
References: 125
Citations by year: 2026: 8 · 2025: 9 · 2024: 8 · 2023: 15 · 2022: 12 · 2021: 9 · 2020: 20 · 2019: 16 · 2018: 16 · 2017: 21 · 2016: 12 · 2015: 15 · 2014: 18 · 2013: 18 · 2012: 13
FWCI: 9.70
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Reproduction (publishedVersion)
PubMed (publishedVersion)
Bristol Research (University of Bristol) (submittedVersion)
Explore Bristol Research (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords: maternal obesity, pregnancy complications, inflammation, vascular function, adipose tissue, adipokines, systemic inflammation, placenta, vascular endothelium, adverse pregnancy outcomes, maternal morbidity and mortality
MeSH terms: Adipose Tissue, Endothelium, Vascular, Female, Fibrinolysis, Humans, Inflammation, Obesity, Pregnancy, Pregnancy Complications, Pregnancy Complications, Cardiovascular, Pregnancy Outcome, Risk Factors, Inflammation Mediators

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Obesity, pregnancy, inflammation, and vascular function

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