Genetic, hormonal and metabolic aspects of PCOS: an update

De Leo, V.; Musacchio, M. C.; Cappelli, V.; Massaro, M. G.; Morgante, G.; Petraglia, F.

doi:10.1186/s12958-016-0173-x

Cited by 484Ovarian function and disordersReproductive Biology and FertilityGenetic and Kidney Cyst Diseases

Genetic, hormonal and metabolic aspects of PCOS: an update

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De Leo, V., Musacchio, M. C., Cappelli, V., Massaro, M. G., Morgante, G., Petraglia, F.·2016·Reproductive Biology and Endocrinology

DOI 10.1186/s12958-016-0173-xPMC PMC4947298

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Abstract

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting 5-10 % of women of reproductive age. It generally manifests with oligo/anovulatory cycles, hirsutism and polycystic ovaries, together with a considerable prevalence of insulin resistance. Although the aetiology of the syndrome is not completely understood yet, PCOS is considered a multifactorial disorder with various genetic, endocrine and environmental abnormalities. Moreover, PCOS patients have a higher risk of metabolic and cardiovascular diseases and their related morbidity, if compared to the general population.

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Hyperinsulinemia and insulin resistance play important roles in the pathophysiology of PCOS for both normal-weight women and women with obesity.
“Hyperinsulinemia and insulin resistance play important roles in the pathophysiology of PCOS for both normal-weight women and women with obesity (2, 3, 73, 77).”
From Metformin and Combined Oral Contraceptive Pills in the Management of Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis (2024) · cites this paper as [73]

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Authors: De Leo, V., Musacchio, M. C., Cappelli, V., Massaro, M. G., Morgante, G., & Petraglia, F.
Affiliations: University of Siena (IT)
ORCID: Massaro, M. G.
Morgante, G.
Petraglia, F.
Venue: Reproductive Biology and Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2016-07-16
Volume: 14
Issue: 1
Pages: 38-38
ISSN: 1477-7827 (ISSN-L)
DOI: 10.1186/s12958-016-0173-x
PMC: PMC4947298
OpenAlex: W2468221982
Cited by: 484
References: 116
Citations by year: 2026: 20 · 2025: 49 · 2024: 64 · 2023: 76 · 2022: 61 · 2021: 68 · 2020: 47 · 2019: 32 · 2018: 36 · 2017: 25 · 2016: 4
FWCI: 4.64
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Reproductive Biology and Endocrinology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Florence Research (University of Florence) (submittedVersion, other-oa)
Use Siena air (University of Siena) (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords: polycystic ovary syndrome, insulin resistance, genetic susceptibility, endocrine disorders, metabolic disorders, cardiovascular risk, anovulation, hirsutism, multifactorial etiology, reproductive endocrinology
MeSH terms: Animals, Female, Hirsutism, Humans, Insulin Resistance, Obesity, Polycystic Ovary Syndrome, Gonadal Steroid Hormones, Hyperandrogenism, Epigenesis, Genetic

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Genetic, hormonal and metabolic aspects of PCOS: an update

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