Cited by 221Adipokines, Inflammation, and Metabolic DiseasesGestational Diabetes Research and ManagementPregnancy and preeclampsia studies

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Obesity, pregnancy, inflammation, and vascular function

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Denison, F C, Roberts, K A, Barr, S M, Norman, J E·2010·Reproduction

DOI 10.1530/rep-10-0074

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Abstract

Maternal obesity is associated with increased morbidity and mortality for both mother and offspring. The mechanisms underlying the increased risk associated with maternal obesity are not well understood. In non-pregnant populations, many of the complications of obesity are thought to be mediated in part by inflammation and its sequelae. Recent studies suggest that a heightened inflammatory response may also be involved in mediating adverse clinical outcomes during pregnancy. This review summarizes our current knowledge about adipose tissue biology, and its role as an endocrine and inflammatory organ. The evidence for inflammation as a key mediator of adverse pregnancy outcome is also presented, focusing on the role of inflammation in adipose tissue, systemic inflammation, the placenta, and vascular endothelium.

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Authors: Denison, F. C., Roberts, K. A., Barr, S. M., & Norman, J. E.
Affiliations: The Queen's Medical Research Institute (GB)
ORCID: Denison, F C
Roberts, K A
Norman, J E
Venue: Reproduction
Publisher: Oxford University Press (OUP)
Published: 2010-09-01
Volume: 140
Issue: 3
Pages: 373-385
ISSN: 1470-1626 (ISSN-L)
1741-7899
DOI: 10.1530/rep-10-0074
OpenAlex: W2116489286
Cited by: 221
References: 125
Citations by year: 2026: 8 · 2025: 9 · 2024: 8 · 2023: 15 · 2022: 12 · 2021: 9 · 2020: 20 · 2019: 16 · 2018: 16 · 2017: 21 · 2016: 12 · 2015: 15 · 2014: 18 · 2013: 18 · 2012: 13
FWCI: 9.70
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Reproduction (publishedVersion)
PubMed (publishedVersion)
Bristol Research (University of Bristol) (submittedVersion)
Explore Bristol Research (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords: maternal obesity, pregnancy complications, inflammation, vascular function, adipose tissue, adipokines, systemic inflammation, placenta, vascular endothelium, adverse pregnancy outcomes, maternal morbidity and mortality
MeSH terms: Adipose Tissue, Endothelium, Vascular, Female, Fibrinolysis, Humans, Inflammation, Obesity, Pregnancy, Pregnancy Complications, Pregnancy Complications, Cardiovascular, Pregnancy Outcome, Risk Factors, Inflammation Mediators

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