The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Obesity, insulin resistance, and pregnancy outcome
Open accessAbstract
There has been a significant increase over the past few decades in the number of reproductive age women who are either overweight or obese. Overweight and obese women are at increased risk for having decreased insulin sensitivity as compared with lean or average weight women. The combination of obesity and decreased insulin sensitivity increases the long-term risk of these individuals developing the metabolic syndrome and associated problems of diabetes, hypertension, hyperlipidemia, and cardiovascular disorders. Because of the metabolic alterations during normal pregnancy, particularly the 60% decrease in insulin sensitivity, overweight and obese women are at increased risk of metabolic dysregulation in pregnancy, i.e. gestational diabetes, preeclampsia, and fetal overgrowth. Hence, pregnancy can be considered as a metabolic stress test for the future risk of the metabolic syndrome. In this review, we will review the underlying pathophysiology related to these disorders. Most importantly, an understanding of these risks provides an opportunity for prevention. For example, a planned pregnancy offers an opportunity to address weight control prior to conception. At the very least, by avoiding excessive weight gain during pregnancy, this may prevent excessive weight retention post partum. Finally, based on the concept of in utero programming, these lifestyle measures may not only have short- and long-term benefits for the woman but also for her offspring as well.
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International Association of Diabetes and Pregnancy Study Groups Consensus Panel (2010) · Diabetes Care · doi:10.2337/dc09-1848 · Cited by 5,390
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“…methods include measures of fasting glucose and insulin (HOMA (homeostasis model assessment) and QUICKI (quantitative insulin sensitivity check index); Matthews et al. 1985, Katz et al. 2000) as well as models using the oral glucose tolerance test, e.g. as described by Matsuda & DeFronzo (1999).”
MethodBuchanan, T. A., & Xiang, A. H. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524531 · Cited by 2,123
Banting Lecture 1980. Of pregnancy and progeny
Freinkel, N. (1980) · Diabetes · doi:10.2337/diabetes.29.12.1023 · Cited by 1,366
Banting lecture 1980: of pregnancy and progeny.
Freinkel, N. (1980) · Diabetes · doi:10.2337/diab.29.12.1023 · Cited by 1,366
DeFronzo, R. A., Gunnarsson, R., Björkman, O., Olsson, M., & Wahren, J. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111938 · Cited by 1,167
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TNF-α Is a Predictor of Insulin Resistance in Human Pregnancy
Kirwan, J. P., Hauguel-De Mouzon, S., Lepercq, J., Challier, J.-C., Huston-Presley, L., Friedman, J. E., Kalhan, S. C., & Catalano, P. M. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2207 · Cited by 738
Self-citationPerinatal risk factors for childhood obesity and metabolic dysregulation
Catalano, P. M., Farrell, K., Thomas, A., Huston-Presley, L., Mencin, P., de Mouzon, S. H., & Amini, S. B. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27416 · Cited by 553
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Cited by
Preconceptional and maternal obesity: epidemiology and health consequences
Poston, L., Caleyachetty, R., Cnattingius, S., Corvalán, C., Uauy, R., Herring, S., & Gillman, M. W. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30217-0 · Cited by 1,111
Gestational Diabetes Mellitus and Macrosomia: A Literature Review
KC, K., Shakya, S., & Zhang, H. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000371628 · Cited by 917
Gut Microbiota Profiling: Metabolomics Based Approach to Unravel Compounds Affecting Human Health
Vernocchi, P., Del Chierico, F., & Putignani, L. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01144 · Cited by 426
Can food be addictive? Public health and policy implications
Gearhardt, A. N., Grilo, C. M., DiLeone, R. J., Brownell, K. D., & Potenza, M. N. (2011) · Addiction · doi:10.1111/j.1360-0443.2010.03301.x · Cited by 396
Normal Pregnancy- A State of Insulin Resistance
Sonagra, A. D. (2014) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2014/10068.5081 · Cited by 268
Metadata
- Authors
- Catalano, P. M.
- Venue
- Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-09-01
- Volume
- 140
- Issue
- 3
- Pages
- 365-371
- ISSN
- 1470-1626 (ISSN-L)
- 1741-7899
- OpenAlex
- W2071148488
- Cited by
- 447
- References
- 16
- FWCI
- 32.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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