Cited by 45Hypothalamic control of reproductive hormonesSexual Differentiation and DisordersNeuroendocrine regulation and behavior

Prenatal programming of the female reproductive neuroendocrine system by androgens

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Robinson, Jane·2006·Reproduction

Abstract

It has been clear for several decades that the areas of the brain that control reproductive function are sexually dimorphic and that the 'programming actions' of the male gonadal steroids are responsible for sex-specific release of the gonadotrophins from the pituitary gland. The administration of exogenous steroids to fetal/neonatal animals has pinpointed windows of time in an animals' development when the reproductive neuroendocrine axis is responsive to the organisational influences of androgens. These 'critical' periods for sexual differentiation of the brain are trait- and species-specific. The neural network regulating the activity of the gonadotrophin releasing hormone (GnRH) neurones is vital to the control of reproductive function. It appears that early exposure to androgens does not influence the migratory pathway of the GnRH neurone from the olfactory placode or the size of the population of neurones that colonise the postnatal hypothalamus. However, androgens do influence the number and the nature of connections that these neurones make with other neural phenotypes. Gonadal steroid hormones play key roles in the regulation of GnRH release acting largely via steroid-sensitive intermediary neurones that impinge on the GnRH cells. Certain populations of hormonally responsive neurones have been identified that are sexually dimorphic and project from hypothalamic areas known to be involved in the regulation of GnRH release. These neurones are excellent candidates for the programming actions of male hormones in the reproductive neuroendocrine axis of the developing female.

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Crossref · 10.1530/rep.1.00064

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  • The ovulation-inducing LH surge is impaired in PCOS, resulting in lengthened or absent menstrual cycles.

    “The ovulation‐inducing LH surge is also impaired, resulting in lengthened or absent menstrual cycles (Foecking et al., 2005; Robinson, 2006).”

    From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Robinson, 2006

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Authors
Robinson, J.
Affiliations
University of Glasgow (GB)
Corresponding author
Robinson, Jane
Venue
Reproduction
Published
2006-10-01
Volume
132
Issue
4
Pages
539-547
ISSN
  • 1470-1626 (ISSN-L)
  • 1741-7899
OpenAlex
W1964708317
Cited by
45
References
79
Citations by year
2023: 1 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 2 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 3
FWCI
0.54
Type
journal article
Language
en
Open access
Locations
  • Reproduction (publishedVersion)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Funders
Biotechnology and Biological Sciences Research Council
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
prenatal programming, androgens, sexual differentiation of the brain, hypothalamus, critical period, sex steroids, olfactory placode
MeSH terms
Androgens, Animals, Brain, Female, Gestational Age, Humans, Infertility, Female, Gonadotropin-Releasing Hormone, Male, Neurosecretory Systems, Sex Characteristics, Species Specificity, Fetal Development, Endocrine Disruptors

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