Genetic Modifiers of the Drosophila Blue Cheese Gene Link Defects in Lysosomal Transport With Decreased Life Span and Altered Ubiquitinated-Protein Profiles
Open accessAbstract
Defects in lysosomal trafficking pathways lead to decreased cell viability and are associated with progressive disorders in humans. Previously we have found that loss-of-function (LOF) mutations in the Drosophila gene blue cheese (bchs) lead to reduced adult life span, increased neuronal death, and widespread CNS degeneration that is associated with the formation of ubiquitinated-protein aggregates. To identify potential genes that participate in the bchs functional pathway, we conducted a genetic modifier screen based on alterations of an eye phenotype that arises from high-level overexpression of Bchs. We found that mutations in select autophagic and endocytic trafficking genes, defects in cytoskeletal and motor proteins, as well as mutations in the SUMO and ubiquitin signaling pathways behave as modifiers of the Bchs gain-of-function (GOF) eye phenotype. Individual mutant alleles that produced viable adults were further examined for bchs-like phenotypes. Mutations in several lysosomal trafficking genes resulted in significantly decreased adult life spans and several mutants showed changes in ubiquitinated protein profiles as young adults. This work represents a novel approach to examine the role that lysosomal transport and function have on adult viability. The genes characterized in this study have direct human homologs, suggesting that similar defects in lysosomal transport may play a role in human health and age-related processes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Atg6 and Dlic2 were recently identified as modifiers of lysosomal/autophagic vacuole trafficking.
“Two modifiers of tau toxicity—Atg6 and Dlic2 (dynein light chain 2)—were also recently identified as modifiers of lysosomal/autophagic vacuole trafficking (193)”
From Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation (2011) · cites this paper as [193]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882 · see citing works
Autophagy as a regulated pathway of cellular degradation.
Klionsky, D., & Emr, S. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,794 · see citing works
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500 · see citing works
Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Øvervatn, A., Stenmark, H., & Johansen, T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507002 · Cited by 3,276 · see citing works
Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347 · see citing works
Impairment of starvation-induced and constitutive autophagy in <i>Atg7</i> -deficient mice
Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412022 · Cited by 2,331 · see citing works
Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study
Nixon, R. A., Wegiel, J., Kumar, A., Yu, W. H., Peterhoff, C., Cataldo, A., & Cuervo, A. M. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.2.113 · Cited by 1,588 · see citing works
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.059 · Cited by 1,293 · see citing works
A Unified Nomenclature for Yeast Autophagy-Related Genes
Klionsky, D. J., Cregg, J. M., Dunn, W. A., Emr, S. D., Sakai, Y., Sandoval, I. V., Sibirny, A. А., Subramani, S. E., Thumm, M., Marten Veenhuis, A., et al. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00296-x · Cited by 1,267 · see citing works
Molecular dissection of autophagy: two ubiquitin-like systems
Ohsumi, Y. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35056522 · Cited by 1,240 · cited 1× · see citing works
“Atg8/LC3 remains bound to autophagic membranes until degradation in lysosomes, thus serving as a useful marker of autophagy (Ohsumi 2001).”
BackgroundProteolysis: from the lysosome to ubiquitin and the proteasome
Ciechanover, A. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1552 · Cited by 1,133 · see citing works
Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
Yu, W. H., Cuervo, A. M., Kumar, A., Peterhoff, C. M., Schmidt, S. D., Lee, J.-H., Mohan, P. S., Mercken, M., Farmery, M. R., Tjernberg, L. O., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505082 · Cited by 967 · see citing works
Role and Regulation of Starvation-Induced Autophagy in the Drosophila Fat Body
Scott, R. C., Schuldiner, O., & Neufeld, T. P. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.07.009 · Cited by 963 · see citing works
Autophagy: in sickness and in health
Cuervo, A. M. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2003.12.002 · Cited by 816 · see citing works
The mitochondrial‐lysosomal axis theory of aging
Brunk, U. T., & Terman, A. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02869.x · Cited by 729 · see citing works
SUMO Modification of Huntingtin and Huntington's Disease Pathology
Steffan, J. S., Agrawal, N., Pallos, J., Rockabrand, E., Trotman, L. C., Slepko, N., Illes, K., Lukácsovich, T., Zhu, Y., Cattaneo, E. F., et al. (2004) · Science · doi:10.1126/science.1092194 · Cited by 713 · see citing works
Identification of genes that modify ataxin-1-induced neurodegeneration
Fernandez-Funez, P., Nino-Rosales, M. L., de Gouyon, B., She, W.-C., Luchak, J. M., Martinez, P., Turiegano, E., Benito, J., Capovilla, M., Skinner, P. J., et al. (2000) · Nature · doi:10.1038/35040584 · Cited by 661 · see citing works
Genetic Suppression of Polyglutamine Toxicity in Drosophila
Kazemi‐Esfarjani, P., & Benzer, S. (2000) · Science · doi:10.1126/science.287.5459.1837 · Cited by 562 · see citing works
A modular misexpression screen in Drosophila detecting tissue-specific phenotypes.
Rørth, P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12418 · Cited by 553 · see citing works
Dell’Angelica, E. C., Mullins, C., Caplan, S., & Bonifacino, J. S. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.10.1265 · Cited by 503 · see citing works
Protein sorting into multivesicular endosomes
Raiborg, C., Rusten, T. E., & Stenmark, H. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00080-2 · Cited by 500 · see citing works
Self-citationReggiori, F., Tucker, K. A., Stromhaug, P. E., & Klionsky, D. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(03)00402-7 · Cited by 476 · see citing works
Dynein mutations impair autophagic clearance of aggregate-prone proteins
Ravikumar, B., Acevedo‐Arozena, A., Imarisio, S., Berger, Z., Vacher, C., O’Kane, C. J., Brown, S. D. M., & Rubinsztein, D. C. (2005) · Nature Genetics · doi:10.1038/ng1591 · Cited by 458 · see citing works
Gunawardena, S., & Goldstein, L. S. B. (2001) · Neuron · doi:10.1016/s0896-6273(01)00496-2 · Cited by 428 · see citing works
Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis
Shih, S. C., Katzmann, D. J., Schnell, J. D., Sutanto, M. A., Emr, S. D., & Hicke, L. (2002) · Nature Cell Biology · doi:10.1038/ncb790 · Cited by 418 · see citing works
Hassles with Taking Out the Garbage: Aggravating Aggresomes
García‐Mata, R., Gao, Y., & Sztul, E. S. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.30602.x · Cited by 387 · see citing works
Cataldo, A., Hamilton, D. J., Barnett, J. L., Paskevich, P. A., & Nixon, R. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00186.1996 · Cited by 350 · see citing works
Gissen, P., Johnson, C. A., Morgan, N. V., Stapelbroek, J. M., Forshew, T., Cooper, W. N., McKiernan, P. J., Klomp, L. W. J., Morris, A. A. M., Wraith, J. E., et al. (2004) · Nature Genetics · doi:10.1038/ng1325 · Cited by 341 · see citing works
Rieder, S., & Emr, S. D. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.11.2307 · Cited by 305 · see citing works
Simonsen, A., Birkeland, H. C. G., Gillooly, D. J., Mizushima, N., Kuma, A., Yoshimori, T., Slagsvold, T., Brech, A., & Stenmark, H. (2004) · Journal of Cell Science · doi:10.1242/jcs.01287 · Cited by 282 · see citing works
Self-citationSatoh, A. K., O’Tousa, J. E., Ozaki, K., & Ready, D. F. (2005) · Development · doi:10.1242/dev.01704 · Cited by 274 · see citing works
Genetic modifiers of tauopathy in Drosophila
Shulman, J. M., & Feany, M. B. (2003) · Genetics · doi:10.1093/genetics/165.3.1233 · Cited by 256 · see citing works
A Role for the deep orange and carnation Eye Color Genes in Lysosomal Delivery in Drosophila
Sevrioukov, E. A., He, J.-P., Moghrabi, N. N., Sunio, A., & Krämer, H. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80199-9 · Cited by 208 · see citing works
Torroja, L., Chu, H., Kotovsky, I., & White, K. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80215-2 · Cited by 203 · see citing works
Trafficking through Rab11 Endosomes Is Required for Cellularization during Drosophila Embryogenesis
Pelissier, A., Chauvin, J., & Lecuit, T. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.023 · Cited by 195 · see citing works
A gain-of-function screen for genes controlling motor axon guidance and synaptogenesis in Drosophila
Kraut, R. S., Menon, K. P., & Zinn, K. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00124-5 · Cited by 183 · see citing works
Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery
Lloyd, V. K., Ramaswami, M., & Krämer, H. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01270-7 · Cited by 165 · see citing works
Genetic analyses of adaptin function from yeast to mammals
Boehm, M., & Bonifacino, J. S. (2002) · Gene · doi:10.1016/s0378-1119(02)00422-5 · Cited by 163 · see citing works
Krämer, H., & Phistry, M. M. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.133.6.1205 · Cited by 154 · see citing works
Dermaut, B., Norga, K., Kania, A., Verstreken, P., Pan, H., Zhou, Y., Callaerts, P., & Bellen, H. J. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412001 · Cited by 136 · see citing works
Connecting vesicle transport to the cytoskeleton
Kamal, A., & Goldstein, L. S. B. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00123-x · Cited by 134 · see citing works
Nakano, Y., Fujitani, K., Kurihara, J., Ragan, J., Usui‐Aoki, K., Shimoda, L. M. N., Lukácsovich, T., Suzuki, K., Sezaki, M., Sano, Y., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.11.3775-3788.2001 · Cited by 132 · see citing works
Rebay, I., Chen, F., Hsiao, F. C., Kolodziej, P. A., Kuang, B. H., Laverty, T., Suh, C., Voas, M. G., Williams, A., & Rubin, G. M. (2000) · Genetics · doi:10.1093/genetics/154.2.695 · Cited by 126 · see citing works
blue cheeseMutations Define a Novel, Conserved Gene Involved in Progressive Neural Degeneration
Finley, K. D., Edeen, P. T., Cumming, R. C., Mardahl‐Dumesnil, M., Taylor, B. J., Rodriguez, M. H., Hwang, C. E., Benedetti, M., & McKeown, M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01254.2003 · Cited by 113 · see citing works
Self-citationKouno, T., Mizuguchi, M., Tanida, I., Ueno, T., Kanematsu, T., Mori, Y., Shinoda, H., Hirata, M., Kominami, E., & Kawano, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413565200 · Cited by 103 · see citing works
Genetic Analysis of hook, a Gene Required for Endocytic Trafficking in Drosophila
Krämer, H., & Phistry, M. M. (1999) · Genetics · doi:10.1093/genetics/151.2.675 · Cited by 102 · see citing works
Khodosh, R., Augsburger, A., Schwarz, T. L., & Garrity, P. (2006) · Development · doi:10.1242/dev.02650 · Cited by 101 · see citing works
Finley, K. D., Edeen, P. T., Foss, M., Gross, E., Ghbeish, N., Palmer, R. H., Taylor, B. J., & McKeown, M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80655-8 · Cited by 95 · see citing works
Self-citationYanagisawa, H., Miyashita, T., Nakano, Y., & Yamamoto, D. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401246 · Cited by 92 · see citing works
Analysis of Dominant Enhancers and Suppressors of Activated Notch in Drosophila
Verheyen, E. M., Purcell, K. J., Fortini, M., & Artavanis‐Tsakonas, S. (1996) · Genetics · doi:10.1093/genetics/144.3.1127 · Cited by 90 · see citing works
Sriram, V., Krishnan, K. S., & Mayor, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200210166 · Cited by 90 · see citing works
Ma, J., Plesken, H., Treisman, J. E., Edelman‐Novemsky, I., & Ren, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401926101 · Cited by 84 · see citing works
A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body
Lindmo, K., Simonsen, A., Brech, A., Finley, K. D., Rusten, T. E., & Stenmark, H. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.03.002 · Cited by 78 · see citing works
Self-citationMunc18-1 Regulates Early and Late Stages of Exocytosis via Syntaxin-independent Protein Interactions
Ciufo, L. F., Barclay, J. W., Burgoyne, R. D., & Morgan, A. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0685 · Cited by 67 · see citing works
Membrane traffic to and from lysosomes.
Luzio, J. P., Pryor, P. R., Gray, S. R., Gratian, M. J., Piper, R. C., & Bright, N. A. (2005) · Biochemical Society Symposia · doi:10.1042/bss0720077 · Cited by 61 · see citing works
A Screen for Identifying Genes Interacting With Armadillo, the Drosophila Homolog of β-Catenin
Greaves, S., Sanson, B., White, P., & Vincent, J. (1999) · Genetics · doi:10.1093/genetics/153.4.1753 · Cited by 53 · see citing works
Encore facilitates SCF-Ubiquitin-proteasome-dependent proteolysis duringDrosophilaoogenesis
Ohlmeyer, J. T., & Schüpbach, T. (2003) · Development · doi:10.1242/dev.00855 · Cited by 47 · see citing works
Babcock, M. C., Macleod, G. T., Leither, J., & Pallanck, L. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5259-03.2004 · Cited by 46 · see citing works
Ditch, L. M., Shirangi, T. R., Pitman, J. L., Latham, K. L., Finley, K. D., Edeen, P. T., Taylor, B. J., & McKeown, M. (2004) · Development · doi:10.1242/dev.01568 · Cited by 36 · see citing works
Self-citationSohrabji, F., Peeples, K. W., & Marroquin, O. A. (2000) · Journal of Neurobiology · doi:10.1002/1097-4695(20001105)45:2 · Cited by 35 · see citing works
DSF Nuclear Receptor Acts As a Repressor in Culture and in Vivo
Pitman, J. L., Tsai, C., Edeen, P. T., Finley, K. D., Evans, R. M., & McKeown, M. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0648 · Cited by 18 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Simonsen, A., Cumming, R. C., Brech, A., Isakson, P., Schubert, D. R., & Finley, K. D. (2008) · Autophagy · doi:10.4161/auto.5269 · Cited by 716 · see citing works
Self-citationFilimonenko, M., Isakson, P., Finley, K. D., Anderson, M. R., Jeong, H., Melia, T. J., Bartlett, B. J., Myers, K. M., Birkeland, H. C. G., Lamark, T., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.04.007 · Cited by 432 · see citing works
Self-citationKaplan, J., Domenico, I. D., & Ward, D. M. (2008) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3282f2bcce · Cited by 360 · see citing works
Wittkopp, P. J., & Beldade, P. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.10.002 · Cited by 335 · see citing works
Bartlett, B. J., Isakson, P., Lewerenz, J., Sanchez, H., Kotzebue, R. W., Cumming, R. C., Harris, G. L., Nezis, I. P., Schubert, D. R., Simonsen, A., et al. (2011) · Autophagy · doi:10.4161/auto.7.6.14943 · Cited by 215 · see citing works
Self-citationNavajas, M., Migeon, A., Alaux, C., Martin‐Magniette, M., Robinson, G. E., Evans, J. D., Cros‐Arteil, S., Crauser, D., & Conte, Y. L. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-301 · Cited by 203 · see citing works
All-you-can-eat: autophagy in neurodegeneration and neuroprotection
Jaeger, P. A., & Wyss‐Coray, T. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-16 · Cited by 175 · see citing works
AP-3-dependent trafficking and disease: the first decade
Dell’Angelica, E. C. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.04.014 · Cited by 168 · see citing works
The role of ALFY in selective autophagy
Isakson, P., Holland, P., & Simonsen, A. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.66 · Cited by 129 · see citing works
Self-citationAutophagy in Drosophila melanogaster
Kary, C. S., & Baehrecke, E. H. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.02.009 · Cited by 121 · see citing works
Ambegaokar, S. S., & Jackson, G. R. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr432 · Cited by 113 · see citing works
“Two modifiers of tau toxicity—Atg6 and Dlic2 (dynein light chain 2)—were also recently identified as modifiers of lysosomal/autophagic vacuole trafficking (193), and dynein appears to be the motor protein most responsible for this trafficking (194,195).”
BackgroundA fruitful endeavor: Modeling ALS in the fruit fly
Casci, I., & Pandey, U. B. (2014) · Brain Research · doi:10.1016/j.brainres.2014.09.064 · Cited by 98 · see citing works
Autophagic pathways in Parkinson disease and related disorders
Xilouri, M., & Stefanis, L. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411001803 · Cited by 98 · see citing works
Akbar, M. A., Ray, S., & Krämer, H. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-03-0282 · Cited by 87 · see citing works
Autophagy inDrosophila: From Historical Studies to Current Knowledge
Mulakkal, N. C., Nagy, P., Takáts, S., Tusco, R., Juhász, G., & Nezis, I. P. (2014) · BioMed Research International · doi:10.1155/2014/273473 · Cited by 89 · see citing works
Azad, P., Zhou, D., Heinrichsen, E. T., & Haddad, G. G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005371 · Cited by 84 · see citing works
Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy
Napoli, E., Song, G., Panoutsopoulos, A. A., Riyadh, M. A., Kaushik, G., Halmai, J. A. N. M., Levenson, R., Zarbalis, K. S., & Giulivi, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-29421-7 · Cited by 70 · see citing works
Impaired proteasomal degradation enhances autophagy via hypoxia signaling in Drosophila
Lőw, P., Varga, Á., Pircs, K., Nagy, P., Szatmári, Z., Sass, M., & Juhász, G. (2013) · BMC Cell Biology · doi:10.1186/1471-2121-14-29 · Cited by 70 · see citing works
Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging
Kim, M., Park, H. L., Park, H., Ro, S., Nam, S., Reed, J. M., Guan, J., & Lee, J. H. (2013) · Autophagy · doi:10.4161/auto.24811 · Cited by 57 · see citing works
Differential Gene Expression Associated with Honey Bee Grooming Behavior in Response to Varroa Mites
Hamiduzzaman, M. M., Emsen, B., Hunt, G. J., Subramanyam, S., Williams, C. E., Tsuruda, J. M., & Guzmán‐Novoa, E. (2017) · Behavior Genetics · doi:10.1007/s10519-017-9834-6 · Cited by 56 · see citing works
Kim, M., Semple, I. A., Kim, B. Y., Kiers, A., Nam, S., Park, H., Park, H., Ro, S., Kim, J.-S., Juhász, G., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1063766 · Cited by 48 · see citing works
Lim, A. P. C., & Kraut, R. S. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2582-08.2009 · Cited by 45 · see citing works
Regulation of contractile vacuole formation and activity in Dictyostelium
Du, F., Edwards, K. M., Shen, Z., Sun, B., Lozanne, A. D., Briggs, S. P., & Firtel, R. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.131 · Cited by 44 · see citing works
Uptake of the Necrotic Serpin in Drosophila melanogaster via the Lipophorin Receptor-1
Soukup, S., Culí, J., & Gubb, D. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000532 · Cited by 43 · see citing works
Functional analysis of the SUMOylation pathway in Drosophila
Talamillo, A., Sánchez, J., & Barrio, R. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360868 · Cited by 42 · see citing works
Aging and Autophagic Function Influences the Progressive Decline of Adult Drosophila Behaviors
Ratliff, E. P., Mauntz, R. E., Kotzebue, R. W., Gonzalez, A., Achal, M., Barekat, A., Finley, K. A., Sparhawk, J. M., Robinson, J. E., Herr, D. R., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132768 · Cited by 40 · see citing works
Self-citationLinking Lysosomal Trafficking Defects with Changes in Aging and Stress Response in<i>Drosophila</i>
Simonsen, A., Cumming, R. C., & Finley, K. D. (2007) · Autophagy · doi:10.4161/auto.4604 · Cited by 37 · see citing works
Self-citationKim, Y., Ryu, T., Lee, J., Heo, Y.-S., Ahnn, J., Lee, S., & Yoo, O.-J. (2010) · BMC Cell Biology · doi:10.1186/1471-2121-11-9 · Cited by 37 · see citing works
Autophagy and Human Neurodegenerative Diseases—A Fly’s Perspective
Kim, M., Ho, A., & Lee, J. H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071596 · Cited by 35 · see citing works
Elevated oxidative membrane damage associated with genetic modifiers of Lyst-mutant phenotypes
Trantow, C. M., Hedberg-Buenz, A., Iwashita, S., Moore, S. A., & Anderson, M. G. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001008 · Cited by 32 · see citing works
Spinster Controls Dpp Signaling during Glial Migration in theDrosophilaEye
Yuva-Aydemir, Y., Bauke, A.-C., & Klämbt, C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0459-11.2011 · Cited by 30 · see citing works
Molecular mechanisms of selective autophagy in Drosophila
Gohel, R., Kournoutis, A., Petridi, S., & Nezis, I. P. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2019.08.003 · Cited by 27 · see citing works
Highfill, C., Reeves, G. A., & Macdonald, S. J. (2016) · BMC Genetics · doi:10.1186/s12863-016-0419-9 · Cited by 25 · see citing works
Hebbar, S., Sahoo, I., Matysik, A. S., García, I. A., Osborne, K. A., Papan, C., Torta, F. T., Narayanaswamy, P., Fun, X. H., Wenk, M. R., et al. (2015) · Scientific Reports · doi:10.1038/srep15926 · Cited by 25 · see citing works
Everman, E. R., McNeil, C. L., Hackett, J. L., Bain, C. L., & Macdonald, S. J. (2019) · Genetics · doi:10.1534/genetics.119.301930 · Cited by 25 · see citing works
Zhang, S., Ratliff, E. P., Molina, B., El-Mecharrafie, N., Mastroianni, J., Kotzebue, R. W., Achal, M., Mauntz, R. E., Gonzalez, A., Barekat, A., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041140 · Cited by 23 · see citing works
Self-citationQuantitative trait loci for longevity in heat-stressed Drosophila melanogaster
Defays, R., Gómez, F. H., Sambucetti, P., Scannapieco, A. C., Loeschcke, V., & Norry, F. M. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.07.003 · Cited by 22 · see citing works
Cipressa, F., & Cenci, G. (2013) · Fly · doi:10.4161/fly.26567 · Cited by 20 · see citing works
Selective Autophagy inDrosophila
Nezis, I. P. (2012) · International Journal of Cell Biology · doi:10.1155/2012/146767 · Cited by 20 · see citing works
Hortsch, R., Lee, E., Erathodiyil, N., Hebbar, S., Steinert, S., Lee, J. Y., Chua, D. S. K., & Kraut, R. S. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-01-0005 · Cited by 20 · see citing works
Hasanagic, M., van Meel, E., Luan, S., Aurora, R., Kornfeld, S. A., & Eissenberg, J. C. (2015) · Biology Open · doi:10.1242/bio.013334 · Cited by 19 · see citing works
Molina, B., Mastroianni, J., Suarez, E., Soni, B., Forsberg, E. M., & Finley, K. D. (2021) · Cells · doi:10.3390/cells10040900 · Cited by 17 · see citing works
Self-citationKasumovic, M. M., Chen, Z., & Wilkins, M. R. (2016) · BMC Genomics · doi:10.1186/s12864-016-3119-y · Cited by 17 · see citing works
Ratliff, E. P., Kotzebue, R. W., Molina, B., Mauntz, R. E., Gonzalez, A., Barekat, A., El-Mecharrafie, N., Garza, S., Gurney, M. A., Achal, M., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164239 · Cited by 16 · see citing works
Self-citationHall, B. S., Barnett, Y., Crofts, J. J., & Chuzhanova, N. A. (2019) · Aging · doi:10.18632/aging.102527 · Cited by 13 · see citing works
iFly: The eye of the fruit fly as a model to study autophagy and related trafficking pathways
Lőrincz, P., Takáts, S., Kárpáti, M., & Juhász, G. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.06.013 · Cited by 13 · see citing works
Atg2 Regulates Cellular and Humoral Immunity in Drosophila
Qin, B., Yu, S., Chen, Q., & Jin, L. H. (2023) · Insects · doi:10.3390/insects14080706 · Cited by 9 · see citing works
Rodriguez‐Fernandez, I. A., & Dell’Angelica, E. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143026 · Cited by 9 · see citing works
Macroautophagy and normal aging of the nervous system: Lessons from animal models
Kallergi, E., & Nikoletopoulou, V. (2021) · Cell Stress · doi:10.15698/cst2021.10.257 · Cited by 10 · see citing works
What do we mean by “aging”? Questions and perspectives revealed by studies in Drosophila
Wodrich, A. P. K., Scott, A. W., & Giniger, E. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111839 · Cited by 9 · see citing works
The BEACH Domain Is Critical for Blue Cheese Function in a Spatial and Epistatic Autophagy Hierarchy
Sim, J. P. L., Osborne, K. A., García, I. A., Matysik, A. S., & Kraut, R. S. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00129 · Cited by 8 · see citing works
Drosophila GGA Model: An Ultimate Gateway to GGA Analysis
Eissenberg, J. C., Ilvarsonn, A. M., Sly, W. S., Waheed, A., Krzyžánek, V., Pohlmann, R., Waschkau, D., Kretzschmar, D., & Dennes, A. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01285.x · Cited by 8 · see citing works
Chan, C., Epstein, D. J., & Hiesinger, P. R. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20940 · Cited by 7 · see citing works
The Unique GGA Clathrin Adaptor of Drosophila melanogaster Is Not Essential
Luan, S., Ilvarsonn, A. M., & Eissenberg, J. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045163 · Cited by 4 · see citing works
Kumarasamy, S. K., Wang, Y., Viswanathan, V., & Kraut, R. S. (2008) · BioData Mining · doi:10.1186/1756-0381-1-10 · Cited by 4 · see citing works
Molecular Machinery and Genetics of the Autophagy Pathway
Herr, D. R., & Finley, K. D. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-385101-7.00002-4 · Cited by 2 · see citing works
Self-citationTHE GENETIC BASIS OF VARIATION IN THERMAL PLASTICITY IN DROSOPHILA MELANOGASTER
Crawford, P. J. (2013) · K-State Research Exchange (Kansas State University) · Cited by 2 · see citing works
Kotzebue, R. W. (2013) · CSUN ScholarWorks (California State University, Northridge) · Cited by 1 · see citing works
Miller, G. S. (2010) · Human Biology · Cited by 1 · see citing works
Autophagy in Nonmammalian Systems
Hill, J. H., & Baehrecke, E. (2009) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0021582 · Cited by 1 · see citing works
Sim, J. P. L., Osborne, K. A., García, I. A., Matysik, A. S., & Kraut, R. S. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/084434 · Cited by 1 · see citing works
An evolutionarily conserved metallophosphodiesterase is a determinant of lifespan in DrosophilaPreprint
Gupta, K., Janardan, V., Banerjee, S., Chakrabarti, S., Srinivas, S., Mahishi, D., Raghu, P., & Visweswariah, S. S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.08.084137 · Cited by 1 · see citing works
Pinto, E. R. (2012) · QSpace (Queen's University Library)
history, and behavioral plasticity
Kasumovic, M. M., Chen, Z., & Wilkins, M. R. (2016)
Identifying Potential Binding Partners of VPS16B and VPS33B in Mammalian Cells
Chen, S. Z. (2013) · TSpace (University of Toronto)
Drosophila WDFY3 / Bchs overexpression impairs neural function
Körner, M. B., Velluva, A., Bundalian, L., Krohn, K., Schön, K., Schumann, I., Kromp, J., Thum, A. S., Garten, A., Hentschel, J., et al. (2025) · Journal of Neurogenetics · doi:10.1080/01677063.2025.2465536
Nervous system integrity in Drosophila : essential and dosage-sensitive roles of Hsp110
Rios, B., Xu, S., Farmer, S. M., Ye, X., Ye, L., Morano, K. A., & Zhang, S. (2026) · Genetics · doi:10.1093/genetics/iyag240
- Authors
- Simonsen, A., Cumming, R. C., Lindmo, K., Galaviz, V., Cheng, S., Rusten, T. E., & Finley, K. D.
- Affiliations
- Salk Institute for Biological Studies (US)
- Department of Biochemistry , Center for Cancer Biomedicine, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
- Corresponding author
- Finley, Kim D
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-06-01
- Volume
- 176
- Issue
- 2
- Pages
- 1283-1297
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- PMC
- PMC1894590
- OpenAlex
- W2148013240
- Cited by
- 67
- References
- 61
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 2 · 2013: 6 · 2012: 5
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Genetics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kreftforeningen
- Norges Forskningsråd
- National Institutes of Health
- National Institute on Aging
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- lysosomal trafficking, genetic modifiers, Drosophila, adult lifespan, ubiquitinated protein aggregates, autophagy, endosomal trafficking, neuronal cell death, ubiquitin signaling, age-related decline
- MeSH terms
- Animals, DNA Transposable Elements, Drosophila, Larva, Life Expectancy, Mutation, Nerve Degeneration, Nerve Tissue Proteins, Pupa, Gene Expression Regulation, Developmental, Microscopy, Confocal, Protein Transport, Ubiquitin, Drosophila Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review