p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Pankiv, S., Clausen, T. H., Lamark, T., Brech, A., Bruun, J.-A., Outzen, H., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702824200 · Cited by 4,578 · see citing works

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882 · see citing works

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500 · see citing works

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y., Ueno, I., Sakamoto, A., Tong, K. I., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2021 · Cited by 2,422 · see citing works

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347 · see citing works

In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker

Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0704 · Cited by 2,323 · see citing works

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.

Komatsu, M., Waguri, S., Koike, M., Sou, Y.-S., Ueno, T., Hara, T., Mizushima, N., Iwata, J.-I., Ezaki, J., Murata, S., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.035 · Cited by 2,124 · see citing works

Aggresomes, inclusion bodies and protein aggregation

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Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

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Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

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Chapter 12 Monitoring Autophagic Degradation of p62/SQSTM1

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Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

Boland, B., Kumar, A., Lee, S., Platt, F. M., Wegiel, J., Yu, W. H., & Nixon, R. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0800-08.2008 · Cited by 1,119 · see citing works

p62 at the crossroads of autophagy, apoptosis, and cancer

Moscat, J., & Diaz-Meco, M. T. (2009) · Cell · doi:10.1016/j.cell.2009.05.023 · Cited by 1,073 · see citing works

Role and Regulation of Starvation-Induced Autophagy in the Drosophila Fat Body

Scott, R. C., Schuldiner, O., & Neufeld, T. P. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.07.009 · Cited by 963 · see citing works

Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

Hwangbo, D., Gersham, B., Tu, M., Palmer, M., & Tatar, M. (2004) · Nature · doi:10.1038/nature02549 · Cited by 954 · see citing works

Autophagy and aging: The importance of maintaining "clean" cells

Cuervo, A. M., Bergamini, E., Brunk, U. T., Dröge, W., Ffrench, M., & Terman, A. (2005) · Autophagy · doi:10.4161/auto.1.3.2017 · Cited by 792 · see citing works

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

Hansen, M., Chandra, A., Mitic, L. L., Onken, B., Driscoll, M., & Kenyon, C. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040024 · Cited by 766 · see citing works

Autophagy, amyloidogenesis and Alzheimer disease

Nixon, R. A. (2007) · Journal of Cell Science · doi:10.1242/jcs.019265 · Cited by 749 · see citing works

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

Simonsen, A., Cumming, R. C., Brech, A., Isakson, P., Schubert, D. R., & Finley, K. D. (2008) · Autophagy · doi:10.4161/auto.5269 · Cited by 716 · see citing works

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

Filimonenko, M., Stuffers, S., Raiborg, C., Yamamoto, A., Malerød, L., Fisher, E. M. C., Isaacs, A., Brech, A., Stenmark, H., & Simonsen, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200702115 · Cited by 626 · see citing works

p62 Is a Common Component of Cytoplasmic Inclusions in Protein Aggregation Diseases

Zatloukal, K., Stumptner, C., Fuchsbichler, A., Heid, H., Schnoelzer, M., Kenner, L., Kleinert, R., Prinz, M., Aguzzi, A., & Denk, H. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64369-6 · Cited by 624 · see citing works

The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus

Hoozemans, J. J. M., van Haastert, E. S., Nijholt, D. A. T., Rozemuller, A. J. M., Eikelenboom, P., & Scheper, W. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080814 · Cited by 600 · see citing works

The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway

Zheng, Y. T., Shahnazari, S., Brech, A., Lamark, T., Johansen, T., & Brumell, J. H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900441 · Cited by 581 · see citing works

Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

Simonsen, A., & Tooze, S. A. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200907014 · Cited by 500 · see citing works

ESCRT-III Dysfunction Causes Autophagosome Accumulation and Neurodegeneration

Lee, J., Beigneux, A. P., Ahmad, S. T., Young, S. G., & Gao, F. (2007) · Current Biology · doi:10.1016/j.cub.2007.07.029 · Cited by 490 · see citing works

Programmed Autophagy in the Drosophila Fat Body Is Induced by Ecdysone through Regulation of the PI3K Pathway

Rusten, T. E., Lindmo, K., Juhász, G., Sass, M., Seglen, P. O., Brech, A., & Stenmark, H. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.07.005 · Cited by 487 · see citing works

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

Lamark, T., Kirkin, V., Dikic, I., & Johansen, T. (2009) · Cell Cycle · doi:10.4161/cc.8.13.8892 · Cited by 464 · see citing works

Listeria monocytogenes ActA-mediated escape from autophagic recognition

Yoshikawa, Y., Ogawa, M., Hain, T., Yoshida, M., Fukumatsu, M., Kim, M., Mimuro, H., Nakagawa, I., Yanagawa, T., Ishii, T., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1967 · Cited by 449 · see citing works

The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy

Filimonenko, M., Isakson, P., Finley, K. D., Anderson, M. R., Jeong, H., Melia, T. J., Bartlett, B. J., Myers, K. M., Birkeland, H. C. G., Lamark, T., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.04.007 · Cited by 432 · see citing works

Interaction Codes within the Family of Mammalian Phox and Bem1p Domain-containing Proteins

Lamark, T., Perander, M., Outzen, H., Kristiansen, K., Øvervatn, A., Michaelsen, E., Bjørkøy, G., & Johansen, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303221200 · Cited by 396 · see citing works

The role of TOR in autophagy regulation from yeast to plants and mammals

Díaz‐Troya, S., Pérez‐Pérez, M. E., Florencio, F. J., & Crespo, J. L. (2008) · Autophagy · doi:10.4161/auto.6555 · Cited by 394 · see citing works

Hassles with Taking Out the Garbage: Aggravating Aggresomes

García‐Mata, R., Gao, Y., & Sztul, E. S. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.30602.x · Cited by 387 · see citing works

Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

Ding, W., & Yin, X.-M. (2008) · Autophagy · doi:10.4161/auto.5190 · Cited by 383 · see citing works

Ref(2)P, the <i>Drosophila melanogaster</i> homologue of mammalian p62, is required for the formation of protein aggregates in adult brain

Nezis, I. P., Simonsen, A., Sagona, A. P., Finley, K., Gaumer, S., Contamine, D., Rusten, T. E., Stenmark, H., & Brech, A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200711108 · Cited by 370 · see citing works

Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway

Yamamoto, A., Cremona, M. L., & Rothman, J. E. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200510065 · Cited by 355 · see citing works

Oxidative Stress Induces a Form of Programmed Cell Death with Characteristics of Both Apoptosis and Necrosis in Neuronal Cells

Tan, S., Wood, M. R., & Maher, P. A. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71010095.x · Cited by 337 · see citing works

ESCRTs and Fab1 Regulate Distinct Steps of Autophagy

Rusten, T. E., Vaccari, T., Lindmo, K., Rodahl, L. M., Nezis, I. P., Sem-Jacobsen, C., Wendler, F., Vincent, J., Brech, A., Bilder, D. H., et al. (2007) · Current Biology · doi:10.1016/j.cub.2007.09.032 · Cited by 332 · see citing works

Shigella Phagocytic Vacuolar Membrane Remnants Participate in the Cellular Response to Pathogen Invasion and Are Regulated by Autophagy

Dupont, N., Lacas‐Gervais, S., Bertout, J., Paz, I., Frêche, B., Nhieu, G. T. V., van der Goot, F. G., Sansonetti, P. J., & Lafont, F. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.07.005 · Cited by 322 · see citing works

p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy

Clausen, T. H., Lamark, T., Isakson, P., Finley, K. D., Larsen, K. B., Brech, A., Øvervatn, A., Stenmark, H., Bjørkøy, G., Simonsen, A., et al. (2010) · Autophagy · doi:10.4161/auto.6.3.11226 · Cited by 321 · see citing works

Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes

Simonsen, A., Birkeland, H. C. G., Gillooly, D. J., Mizushima, N., Kuma, A., Yoshimori, T., Slagsvold, T., Brech, A., & Stenmark, H. (2004) · Journal of Cell Science · doi:10.1242/jcs.01287 · Cited by 282 · see citing works

Mutations in insulin signaling pathway alter juvenile hormone synthesis in Drosophila melanogaster

Tu, M., Yin, C., & Tatar, M. (2005) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2005.02.009 · Cited by 244 · see citing works

Cytoplasmic dynein/dynactin mediates the assembly of aggresomes

Johnston, J. A., Illing, M., & Kopito, R. R. (2002) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.10057 · Cited by 226 · see citing works

Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation

Kuusisto, E., Salminen, A., & Alafuzoff, I. I. (2002) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2002.00394.x · Cited by 213 · see citing works

Increased expression of p62 in expanded polyglutamine‐expressing cells and its association with polyglutamine inclusions

Nagaoka, U., Kim, K., Jana, N. R., Doi, H., Maruyama, M., Mitsui, K., Oyama, F., & Nukina, N. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02692.x · Cited by 183 · see citing works

Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection

Riley, B. E., Kaiser, S. E., Shaler, T. A., Ng, A., Hara, T., Hipp, M. S., Lage, K., Xavier, R. J., Ryu, K., Taguchi, K., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201005012 · Cited by 162 · see citing works

Abeta42-Induced Neurodegeneration via an Age-Dependent Autophagic-Lysosomal Injury in Drosophila

Ling, D., Song, H., Garza, D., Neufeld, T. P., & Salvaterra, P. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004201 · Cited by 160 · see citing works

Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration

Seelaar, H., Klijnsma, K. Y., de Koning, I., van der Lugt, A., Chiu, W. Z., Azmani, A., Rozemüller, A. J. M., & Swieten, J. C. V. (2009) · Journal of Neurology · doi:10.1007/s00415-009-5404-z · Cited by 155 · see citing works

How Shall I Eat Thee?

Klionsky, D. J., Cuervo, A. M., Dunn, W. A., Levine, B., van der Klei, I. J., & Seglen, P. O. (2007) · Autophagy · doi:10.4161/auto.4377 · Cited by 149 · see citing works

Amyloid‐β induces disulfide bonding and aggregation of GAPDH in Alzheimer's disease

Cumming, R. C., & Schubert, D. A. (2005) · The FASEB Journal · doi:10.1096/fj.05-4195fje · Cited by 147 · see citing works

The cell biology of autophagy in metazoans: a developing story

Meléndez, A., & Neufeld, T. P. (2008) · Development · doi:10.1242/dev.016105 · Cited by 143 · see citing works

The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically

Bergamini, E., Cavallini, G., Donati, A., & Gori, Z. (2003) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(03)00048-9 · Cited by 134 · see citing works

Nutrient Deprivation Induces Neuronal Autophagy and Implicates Reduced Insulin Signaling in Neuroprotective Autophagy Activation

Young, J. E., Martinez, R. A., & Spada, A. R. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806088200 · Cited by 129 · see citing works

Thinking globally and acting locally with TOR

Arsham, A. M., & Neufeld, T. P. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.09.005 · Cited by 127 · see citing works

Inhibition of Autophagy Induction Delays Neuronal Cell Loss Caused by Dysfunctional ESCRT-III in Frontotemporal Dementia

Lee, J., & Gao, F. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0924-09.2009 · Cited by 124 · see citing works

The demography of slow aging in male and female Drosophila mutant for the insulin‐receptor substrate homologue chico

Tu, M., Epstein, D., & Tatar, M. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00010.x · Cited by 117 · see citing works

ESCRT functions in autophagy and associated disease

Rusten, T. E., & Simonsen, A. (2008) · Cell Cycle · doi:10.4161/cc.7.9.5784 · Cited by 114 · see citing works

blue cheeseMutations Define a Novel, Conserved Gene Involved in Progressive Neural Degeneration

Finley, K. D., Edeen, P. T., Cumming, R. C., Mardahl‐Dumesnil, M., Taylor, B. J., Rodriguez, M. H., Hwang, C. E., Benedetti, M., & McKeown, M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01254.2003 · Cited by 113 · see citing works

The Drosophila homolog of Aut1 is essential for autophagy and development

Juhász, G., Csikós, G., Sinka, R., Erdélyi, M., & Sass, M. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00431-9 · Cited by 105 · see citing works

Regional distribution of TDP‐43 inclusions in Alzheimer disease (AD) brains: Their relation to AD common pathology

Kadokura, A., Yamazaki, T., Lemere, C. A., Takatama, M., & Okamoto, K. (2009) · Neuropathology · doi:10.1111/j.1440-1789.2009.01017.x · Cited by 104 · see citing works

Dimerisation of the UBA Domain of p62 Inhibits Ubiquitin Binding and Regulates NF-κB Signalling

Long, J., Garner, T. P., Pandya, M. J., Craven, C. J., Chen, P., Shaw, B., Williamson, M. P., Layfield, R., & Searle, M. S. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.11.032 · Cited by 102 · see citing works

Ubiquitin-protein conjugates in Alzheimer's lesions

Cole, G. M., & Timiras, P. S. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90698-7 · Cited by 101 · see citing works

A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body

Lindmo, K., Simonsen, A., Brech, A., Finley, K. D., Rusten, T. E., & Stenmark, H. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.03.002 · Cited by 78 · see citing works

The PI 3-kinase regulator Vps15 is required for autophagic clearance of protein aggregates

Lindmo, K., Brech, A., Finley, K. D., Gaumer, S., Contamine, D., Rusten, T. E., & Stenmark, H. (2008) · Autophagy · doi:10.4161/auto.5829 · Cited by 76 · see citing works

Genetic Modifiers of the Drosophila <i>Blue Cheese</i> Gene Link Defects in Lysosomal Transport With Decreased Life Span and Altered Ubiquitinated-Protein Profiles

Simonsen, A., Cumming, R. C., Lindmo, K., Galaviz, V., Cheng, S., Rusten, T. E., & Finley, K. D. (2007) · Genetics · doi:10.1534/genetics.106.065011 · Cited by 67 · see citing works

Eating on the fly: Function and regulation of autophagy during cell growth, survival and death in Drosophila

Neufeld, T. P., & Baehrecke, E. H. (2008) · Autophagy · doi:10.4161/auto.5782 · Cited by 56 · see citing works

A grading system of Alzheimer disease lesions in neocortical areas

Metsaars, W. P., Hauw, J., Welsem, M. E. V., & Duyckaerts, C. J. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00134-3 · Cited by 50 · see citing works

Chapter 9 Biochemical and Morphological Detection of Inclusion Bodies in Autophagy‐Deficient Mice

Waguri, S., & Komatsu, M. (2009) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)04009-3 · Cited by 47 · see citing works

ESCRTing autophagic clearance of aggregating proteins

Rusten, T. E., Filimonenko, M., Rodahl, L. M., Stenmark, H., & Simonsen, A. (2008) · Autophagy · doi:10.4161/auto.5396 · Cited by 44 · see citing works

Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degeneration

Rollinson, S. J., Rizzu, P., Sikkink, S. K., Baker, M., Halliwell, N. A., Snowden, J. S., Traynor, B. J., Ruano, D., Cairns, N. J., Rohrer, J. D., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.01.009 · Cited by 39 · see citing works

Chapter 6 Monitoring Autophagy in Alzheimer's Disease and Related Neurodegenerative Diseases

Yang, D., Lee, J., & Nixon, R. A. (2009) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)04006-8 · Cited by 34 · see citing works

Protein Conformational Pathology in Alzheimers and Other Neurodegenerative Diseases; New Targets for Therapy

Žerovnik, E. (2010) · Current Alzheimer Research · doi:10.2174/156720510790274437 · Cited by 23 · see citing works

Drosophila Atg7: Required for stress resistance, longevity and neuronal homeostasis, but not for metamorphosis

Juhász, G., & Neufeld, T. P. (2008) · Autophagy · doi:10.4161/auto.5572 · Cited by 23 · see citing works

Chapter Thirty‐Five Quantitative Analysis of Autophagic Activity in Drosophila Neural Tissues by Measuring the Turnover Rates of Pathway Substrates

Cumming, R. C., Simonsen, A., & Finley, K. D. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)03235-7 · Cited by 21 · see citing works

Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice

Papaconstantinou, J., DeFord, J. H., Gerstner, Á., Hsieh, C.-C., Boylston, W. H., Guigneaux, M. M., Flurkey, K., & Harrison, D. E. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.01.002 · Cited by 18 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) ¹

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,622 · see citing works

Oxidative stress response and Nrf2 signaling in aging

Zhang, H., Davies, K. J. A., & Forman, H. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.036 · Cited by 804 · see citing works

Huntingtin functions as a scaffold for selective macroautophagy

Rui, Y.-N., Xu, Z., Patel, B., Chen, Z., Chen, D., Tito, A., David, G., Sun, Y., Stimming, E. F., Bellen, H. J., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3101 · Cited by 423 · see citing works

Biological aging processes underlying cognitive decline and neurodegenerative disease

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Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

Gupta, V., Scheunemann, L., Eisenberg, T., Mertel, S., Bhukel, A., Koemans, T. S., Kramer, J. M., Liu, K. S. Y., Schroeder, S., Stunnenberg, H. G., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3512 · Cited by 374 · see citing works

Autophagy in Huntington disease and huntingtin in autophagy

Martin, D. D. O., Ladha, S., Ehrnhoefer, D. E., & Hayden, M. R. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.09.003 · Cited by 344 · see citing works

Insect Antiviral Innate Immunity: Pathways, Effectors, and Connections

Kingsolver, M. B., Huang, Z., & Hardy, R. W. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.10.006 · Cited by 350 · see citing works

Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy

Tanik, S. A., Schultheiss, C. E., Volpicelli-Daley, L. A., Brunden, K. R., & Lee, V. M. Y. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.457408 · Cited by 326 · see citing works

The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy

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Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance inDrosophila

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Subcellular Hsp70 Inhibitors Promote Cancer Cell Death via Different Mechanisms

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Mitochondrial Autophagy Involving Renal Injury and Aging Is Modulated by Caloric Intake in Aged Rat Kidneys

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Therapeutic Intervention in Cancer by Isoliquiritigenin from Licorice: A Natural Antioxidant and Redox Regulator

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Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy

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The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila

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p62 works as a hub modulation in the ageing process

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ALDH2 and Stroke: A Systematic Review of the Evidence

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UM-6 induces autophagy and apoptosis via the Hippo-YAP signaling pathway in cervical cancer

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Lazarillo-related Lipocalins confer long-term protection against type I Spinocerebellar Ataxia degeneration contributing to optimize selective autophagy

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Autophagy and Akt-mTOR signaling display periodic oscillations during torpor-arousal cycles in oxidative skeletal muscle of Daurian ground squirrels (Spermophilus dauricus)

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