The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Neuroprotection With Prolonged Head Cooling Started Before Postischemic Seizures in Fetal Sheep
Abstract
Objective.: Cerebral hypothermia has been shown to reduce damage from experimental hy-poxia-ischemia if started shortly after reperfusion. However, in the newborn infant it may not be feasible to determine prognosis so soon after exposure to asphyxia. The aim of this study was to determine whether head cooling, delayed until shortly before the onset of postasphyxial seizure activity, is neuroprotective. Methods.: Unanesthetized near-term fetal sheep in utero were subjected to 30 minutes of cerebral ischemia. Later, at 5.5 hours, they were randomized to either cooling (n = 7) or sham cooling (n = 10) for 72 hours. Intrauterine cooling was induced by circulating cold water through a coil around the fetal head. The water temperature was titrated to reduce fetal extradural temperature from 39.1 ± 0.1°C to between 30°C and 33°C, while maintaining esophageal temperature >37°C. Results.: Cerebral cooling suppressed the secondary rise in cortical impedance (a measure of cytotoxic edema), but did not prevent delayed seizures, 8 to 30 hours after ischemia. Transient metabolic changes including increased plasma lactate and glucose levels were seen with a moderate sustained rise in blood pressure. This severe cerebral insult resulted in depressed residual parietal electroencephalographic activity after 5 days recovery (−14.2 ± 1.5 decibels), associated with a watershed distribution of neuronal loss (eg, 94 ± 4% in parasagittal cortex and 77 ± 4% in the lateral cortex). Hypothermia was associated with better recovery of electroencephalographic activity (−8.9% ± 1.8 decibels) and substantially reduced neuronal loss in the parasagittal cortex (46 ± 13%), the lateral cortex (9 ± 4%), and other regions except the cornu ammonis sectors 1 and 2 of the hippocampus. Conclusions.: Delayed selective head cooling begun before the onset of postischemic seizures and continued for 3 days may have potential to significantly improve the outcome of moderate to severe hypoxic-ischemic encephalopathy.
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Cites
Treatment of Traumatic Brain Injury with Moderate Hypothermia
Marion, D. W., Penrod, L. E., Kelsey, S. F., Obrist, W. D., Kochanek, P. M., Palmer, A. M., Wisniewski, S. R., & DeKosky, S. T. (1997) · New England Journal of Medicine · doi:10.1056/nejm199702203360803 · Cited by 1,296
Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs.
Gunn, A. J., Gunn, T. R., de Haan, H. H., Williams, C. E., & Gluckman, P. D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119153 · Cited by 622
Self-citationColbourne, F., & Corbett, D. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07250.1995 · Cited by 497
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Delayed and prolonged post-ischemic hypothermia is neuroprotective in the gerbil
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Thoresen, M., Penrice, J., Lorek, A., Cady, E. B., Wylezinska, M., Kirkbride, V, Cooper, C. E., Brown, G. C., Edwards, A. D., Wyatt, J. S., et al. (1995) · Pediatric Research · doi:10.1203/00006450-199505000-00019 · Cited by 400
Status epilepticus in well–oxygenated rats causes neuronal necrosis
Nevander, G., Ingvar, M., Auer, R., & Siesjö, B. K. (1985) · Annals of Neurology · doi:10.1002/ana.410180303 · Cited by 310
Specific Inhibition of Apoptosis after Cerebral Hypoxia-Ischemia by Moderate Post-Insult Hypothermia
Edwards, A. D., Yue, X., Squier, M. V., Thoresen, M., Cady, E. B., Penrice, J., Cooper, C. E., Wyatt, J. S., Reynolds, E. O. R., & Mehmet, H. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2895 · Cited by 284
Posthypoxic cooling of neonatal rats provides protection against brain injury.
Thoresen, M., Bågenholm, R., Løberg, E. M., Apricena, F., & Kjellmer, I. (1996) · Archives of Disease in Childhood - Fetal and Neonatal Edition · doi:10.1136/fn.74.1.f3 · Cited by 232
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Cited by
Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy
Shankaran, S., Laptook, A. R., Ehrenkranz, R. A., Tyson, J. E., McDonald, S. A., Donovan, E. F., Fanaroff, A. A., Poole, W. K., Wright, L. L., Higgins, R. D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmcps050929 · Cited by 2,862
European Resuscitation Council Guidelines for Resuscitation 2010 Section 1. Executive summary
Nolan, J. P., Soar, J., Zideman, D. A., Biarent, D., Bossaert, L. L., Deakin, C., Koster, R. W., Wyllie, J., & Böttiger, B. (2010) · Resuscitation · doi:10.1016/j.resuscitation.2010.08.021 · Cited by 1,375
Lee, A. C., Kozuki, N., Blencowe, H., Vos, T., Bahalim, A., Darmstadt, G. L., Niermeyer, S., Ellis, M., Robertson, N. J., Cousens, S., et al. (2013) · Pediatric Research · doi:10.1038/pr.2013.206 · Cited by 665
Perinatal brain injury: From pathogenesis to neuroprotection
Volpe, J. J. (2001) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/1098-2779(200102)7:1<56::aid-mrdd1008>3.0.co;2-a · Cited by 438
Perinatal brain injury in the preterm and term newborn
du Plessis, A. J., & Volpe, J. J. (2002) · Current Opinion in Neurology · doi:10.1097/00019052-200204000-00005 · Cited by 295
Metadata
- Authors
- Gunn, A. J., Gunn, T. R., Gunning, M. I., Williams, C. E., & Gluckman, P. D.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 1998-11-01
- Volume
- 102
- Issue
- 5
- Pages
- 1098-1106
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2017984625
- Cited by
- 324
- References
- 30
- FWCI
- 9.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gunn, A. J., Gunn, T. R., Gunning, M. I., Williams, C. E., & Gluckman, P. D. (1998). Neuroprotection With Prolonged Head Cooling Started Before Postischemic Seizures in Fetal Sheep. Pediatrics. https://doi.org/10.1542/peds.102.5.1098
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