Early Developmental Processes and the Continuity of Risk for Underage Drinking and Problem Drinking

Zucker, Robert A.; Donovan, John E.; Masten, Ann S.; Mattson, Margaret E.; Moss, Howard B.

doi:10.1542/peds.2007-2243b

Cited by 276Substance Abuse Treatment and OutcomesChild and Adolescent Psychosocial and Emotional DevelopmentCrime Patterns and Interventions

Early Developmental Processes and the Continuity of Risk for Underage Drinking and Problem Drinking

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Zucker, Robert A., Donovan, John E., Masten, Ann S., Mattson, Margaret E., Moss, Howard B.·2008·Pediatrics

DOI 10.1542/peds.2007-2243bPMC PMC2581879

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Abstract

Developmental pathways to underage drinking emerge before the second decade of life. Many scientists, however, as well as the general public, continue to focus on proximal influences surrounding the initiation of drinking in adolescence, such as social, behavioral, and genetic variables related to availability and ease of acquisition of the drug, social reinforcement for its use, and individual differences in drug responses. In the past 20 years, a considerable body of evidence has accumulated on the early (often much earlier than the time of the first drink) predictors and pathways of youthful alcohol use and abuse. These early developmental influences involve numerous risk, vulnerability, promotive, and protective processes. Some of these factors are not related directly to alcohol use, whereas others involve learning and expectancies about later drug use that are shaped by social experience. The salience of these factors (identifiable in early childhood) for understanding the course and development of adult alcohol and other drug use disorders is evident from the large and growing body of findings on their ability to predict adult clinical outcomes. This review summarizes the evidence on early pathways toward and away from underage drinking, with a particular focus on the risk and protective factors and the mediators and moderators of risk for underage drinking that become evident during the preschool and early school years. It is guided by a developmental perspective on the aggregation of risk and protection and examines the contributions of biological, psychological, and social processes within the context of normal development. Implications of this evidence for policy, intervention, and future research are discussed.

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Aggressive traits, emotional dysregulation, and externalizing psychopathology frequently precede problematic drinking.
“longitudinal studies reveal that aggressive traits, emotional dysregulation, and externalizing psychopathology frequently precede problematic drinking”
From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Zucker et al. 2008
Antisocial tendencies, irritability, and poor impulse control often emerge during childhood and adolescence and predict the later development of AUD.
“Longitudinal studies further support this view, showing that antisocial tendencies, irritability, and poor impulse control often emerge during childhood and adolescence and predict the later development of AUD (White et al. 1993; Iacono et al. 2008; Zucker et al. 2008; Cho et al. 2014).”
From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Zucker et al. 2008

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Authors: Zucker, R. A., Donovan, J. E., Masten, A. S., Mattson, M. E., & Moss, H. B.
Affiliations: University of Michigan (US)
University of Pittsburgh (US)
University of Minnesota (US)
National Institute on Alcohol Abuse and Alcoholism (US)
Office of the Director (US)
ORCID: Zucker, Robert A.
Masten, Ann S.
Moss, Howard B.
Venue: Pediatrics
Publisher: American Academy of Pediatrics (AAP)
Published: 2008-04-01
Volume: 121
Issue: Supplement_4
Pages: S252-S272
ISSN: 0031-4005 (ISSN-L)
1098-4275
DOI: 10.1542/peds.2007-2243b
PMC: PMC2581879
OpenAlex: W2100712677
Semantic Scholar: 0e0ba59570c980fd320cfce840c7c8762e025123
Cited by: 276
References: 182
Citations by year: 2026: 3 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 12 · 2021: 12 · 2020: 8 · 2019: 10 · 2018: 18 · 2017: 20 · 2016: 31 · 2015: 15 · 2014: 18 · 2013: 35 · 2012: 20
FWCI: 2.06
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: PEDIATRICS (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Deep Blue (University of Michigan) (submittedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (R37AA007065, R01AA012342)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Sociology and Political Science › Crime Patterns and Interventions
Keywords: underage drinking, adolescent alcohol use, problem drinking, early childhood development, risk factors, protective factors, developmental pathways, alcohol expectancies, social learning, biological risk factors, preschool children, early school years
MeSH terms: Age Factors, Alcohol Drinking, Alcoholic Beverages, Alcoholism, Child, Child Behavior, Child Development, Child, Preschool, Humans, Risk Factors, Social Environment

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Early Developmental Processes and the Continuity of Risk for Underage Drinking and Problem Drinking

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