Predictors of early adult outcomes in pediatric-onset obsessive-compulsive disorder
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OBJECTIVE: The aim of this study was to determine the childhood clinical predictors of early adult outcomes in pediatric-onset obsessive-compulsive disorder (OCD) and to assess whether dimensional subtypes of OCD and the presence of comorbid tic symptoms influence long-term outcomes. METHODS: We conducted a longitudinal cohort study in which 45 of 62 eligible children with OCD were reassessed an average of 9 years later, in early adulthood. Main outcome measures included expert-rated, obsessive-compulsive (OC) symptom severity and time to remission of OC symptoms. Baseline clinical characteristics were evaluated in terms of their influence on OCD severity in adulthood and time to remission of OC symptoms. RESULTS: Forty-four percent of subjects were determined to have subclinical OC symptoms at the follow-up evaluation. The absence of a comorbid tic disorder and the presence of prominent hoarding symptoms were associated with the persistence of OCD symptoms. Female gender, earlier age at childhood assessment, later age of OCD onset, more-severe childhood OCD symptoms, and comorbid oppositional defiant disorder also were associated with persistence of OCD symptoms into adulthood. CONCLUSIONS: These results confirm that a significant proportion of treated children with OCD experience remission by adulthood. The presence of comorbid tics heralds a positive outcome, whereas primary hoarding symptoms are associated with persistent OCD.
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Pediatric-onset obsessive-compulsive disorder may remit in up to 40% of cases.
“In addition, pediatric onset OCD may remit in up to 40% of cases30”
From Developmental alterations of frontal-striatal-thalamic connectivity in obsessive-compulsive disorder (2011) · cites this paper as [30]
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- Authors
- Bloch, M. H., Craiglow, B. G., Landeros-Weisenberger, A., Dombrowski, P. A., Panza, K. E., Peterson, B. S., & Leckman, J. F.
- Affiliations
- Yale University (US)
- Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut
- New York State Psychiatric Institute (US)
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2009-10-01
- Volume
- 124
- Issue
- 4
- Pages
- 1085-1093
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- PMC
- PMC3974608
- OpenAlex
- W2118328164
- Cited by
- 129
- References
- 39
- Citations by year
- 2025: 2 · 2024: 7 · 2023: 4 · 2022: 4 · 2021: 9 · 2020: 4 · 2019: 11 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 10 · 2014: 17 · 2013: 8 · 2012: 15
- FWCI
- 12.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- PEDIATRICS (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5k02mh074677-05)
- National Institute of Mental Health (R01MH068318, K05MH076273, K23MH091240, K02-MH-074677)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- symptom remission, hoarding symptoms, oppositional defiant disorder, predictors of persistence, age of onset, gender differences
- MeSH terms
- Adolescent, Adult, Child, Child, Preschool, Female, Follow-Up Studies, Tourette Syndrome, Humans, Longitudinal Studies, Male, Monitoring, Physiologic, Obsessive-Compulsive Disorder, Predictive Value of Tests, Risk Factors, Severity of Illness Index, Tic Disorders, Time Factors, Cohort Studies, Incidence, Multivariate Analysis, Proportional Hazards Models, Age of Onset, Age Distribution, Sex Distribution, Disease Progression, Young Adult
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