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Cited by 115Neonatal Health and BiochemistryAutism Spectrum Disorder ResearchMaternal Mental Health During Pregnancy and Postpartum

Neonatal jaundice, autism, and other disorders of psychological development

Maimburg, Rikke Damkjær, Bech, Bodil Hammer, Væth, Michael, Møller-Madsen, Bjarne, Olsen, Jørn·2010·Pediatrics
DOI 10.1542/peds.2010-0052
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Abstract

OBJECTIVES: The goals were to study the association between neonatal jaundice and disorders of psychological development in a national, population-based cohort and to study whether gestational age, parity, and season of birth influenced that association. METHODS: A population-based, follow-up study of all children born alive in Denmark between 1994 and 2004 (N = 733 826) was performed, with data collected from 4 national registers. Survival analysis was used to calculate hazard ratios (HRs). RESULTS: Exposure to jaundice in neonates was associated with increased risk of disorders of psychological development for children born at term. The excess risk of developing a disorder in the spectrum of psychological development disorders after exposure to jaundice as a neonate was between 56% (HR: 1.56 [95% confidence interval [CI]: 1.05–2.30]) and 88% (HR: 1.88 [95% CI: 1.17–3.02]). The excess risk of infantile autism was 67% (HR: 1.67 [95% CI: 1.03–2.71]). This risk for infantile autism was higher if the child was conceived by a parous woman (HR: 2.71 [95% CI: 1.57–4.66]) or was born between October and March (HR: 2.21 [95% CI: 1.24–3.94]). The risk for infantile autism disappeared if the child was conceived by a primiparous woman (HR: 0.58 [95% CI: 0.18–1.83]) or was born between April and September (HR: 1.02 [95% CI: 0.41–2.50]). Similar risk patterns were found for the whole spectrum of autistic disorders. CONCLUSIONS: Neonatal jaundice in children born at term is associated with disorders of psychological development. Parity and season of birth seem to play important roles.

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  • March birth as a risk factor for autism has been reported by several studies from Canada, Denmark, the US and Israel.

    “March birth as a risk factor for autism has also been reported by several studies from Canada [92], Denmark [80,88], the US [85] and Israel [87].”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [80]

  • Maimburg et al. (2010) reported increased risk for infantile autism in those born in winter (October to March).

    “In contrast, Maimburg et al. (2010) reported increased risk for infantile autism in those born in winter (October to March) [80].”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [80]

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Authors
Maimburg, R. D., Bech, B. H., Væth, M., Møller-Madsen, B., & Olsen, J.
Affiliations
  • Departments of Epidemiology and
  • Aarhus University (DK)
  • Orthopedic Surgery, Aarhus University Hospital, Aarhus, Denmark; and
  • University of California, Los Angeles (US)
ORCID
Venue
Pediatrics
Publisher
American Academy of Pediatrics (AAP)
Published
2010-11-01
Volume
126
Issue
5
Pages
872-878
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.2010-0052
OpenAlex
W2155816875
Cited by
115
References
35
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 9 · 2019: 8 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 10 · 2014: 13 · 2013: 7 · 2012: 8
FWCI
7.24
Type
journal article
Language
en
Open access
closed
Locations
  • PEDIATRICS (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords
neonatal jaundice, infantile autism, autism spectrum disorder, gestational age, parity, season of birth, term birth, primiparity, birth cohort
MeSH terms
Adult, Birth Weight, Child, Developmental Disabilities, Child Development Disorders, Pervasive, Child, Preschool, Cross-Sectional Studies, Denmark, Female, Follow-Up Studies, Gestational Age, Humans, Infant, Infant, Newborn, Jaundice, Neonatal, Male, Intellectual Disability, Parity, Pregnancy, Registries, Risk Factors, Seasons, Causality, Proportional Hazards Models

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