Perinatal risk factors and infantile autism
Abstract
Objective: Suboptimal conditions during pregnancy and birth have been suggested as a cause of infantile autism. We have studied the association between obstetric factors and infantile autism. Method: A population‐based, matched case–control study of infantile autism. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI). Results: The risk of infantile autism was increased for mothers aged >35 years, with foreign citizenship, and mothers who used medicine during pregnancy. A higher risk of infantile autism was seen among children with low birth weight and with congenital malformations. Birth interventions, pathological cardiotocography, green amnion fluid and acidosis during delivery were not associated with increased risk for infantile autism. Conclusion: Our findings suggest that suboptimal birth conditions are not an independent risk factor for infantile autism. A high prevalence of low birth weight and birth defects among autism cases seems to explain the suboptimal birth outcome.
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Most studies showed increased risk of ASD among children of migrant parents, while some reported no association or even decreased risk.
“Most studies showed increased risk of ASD among children of migrant parents [61,62,63,64,65,66,67,69,70], while some reported no association [61,65,68,69] or even decreased risk [61,68,69,70].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [62]
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- Authors
- Maimburg, R. D., & Væth, M.
- Affiliations
- Aarhus University (DK)
- Corresponding author
- Maimburg, R. D.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2006-05-05
- Volume
- 114
- Issue
- 4
- Pages
- 257-264
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2087122753
- Cited by
- 192
- References
- 37
- Citations by year
- 2025: 4 · 2024: 8 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 11 · 2018: 10 · 2017: 6 · 2016: 15 · 2015: 12 · 2014: 21 · 2013: 14 · 2012: 17
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Augustinus Fonden
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Psychology › Clinical Psychology › Family and Disability Support Research
- Keywords
- infantile autism, perinatal risk factors, obstetric factors, maternal age, maternal medication use, low birth weight, congenital malformations, childbirth interventions, cardiotocography, amniotic fluid
- MeSH terms
- Acidosis, Amniotic Fluid, Autistic Disorder, Child, Female, Humans, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Perinatology, Population Surveillance, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Registries, Risk Factors, Intensive Care, Neonatal, Case-Control Studies
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