Cited by 790Autism Spectrum Disorder ResearchBehavioral and Psychological StudiesChild Nutrition and Feeding Issues

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A Systematic Review of Early Intensive Intervention for Autism Spectrum Disorders

Warren, Zachary, McPheeters, Melissa L., Sathe, Nila, Foss-Feig, Jennifer H., Glasser, Allison, Veenstra-VanderWeele, Jeremy·2011·Pediatrics

DOI 10.1542/peds.2011-0426

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Abstract

CONTEXT: Early intensive behavioral and developmental interventions for young children with autism spectrum disorders (ASDs) may enhance developmental outcomes. OBJECTIVE: To systematically review evidence regarding such interventions for children aged 12 and younger with ASDs. METHODS: We searched Medline, PsycINFO, and ERIC (Education Resources Information Center) from 2000 to May 2010. Two reviewers independently assessed studies against predetermined inclusion/exclusion criteria. Two reviewers independently extracted data regarding participant and intervention characteristics, assessment techniques, and outcomes and assigned overall quality and strength-of-evidence ratings using predetermined criteria. RESULTS: Thirty-four unique studies met inclusion criteria. Seventeen studies were case series; 2 were randomized controlled trials. We rated 1 study as good quality, 10 as fair quality, and 23 as poor quality. The strength of the evidence overall ranged from insufficient to low. Studies of University of California Los Angeles/Lovaas–based interventions and variants reported clinically significant gains in language and cognitive skills in some children, as did 1 randomized controlled trial of an early intensive developmental intervention approach (the Early Start Denver Model). Specific parent-training approaches yielded gains in short-term language function and some challenging behaviors. Data suggest that subgroups of children displayed more prominent gains across studies, but participant characteristics associated with greater gains are not well understood. CONCLUSIONS: Studies of Lovaas-based approaches and early intensive behavioral intervention variants and the Early Start Denver Model resulted in some improvements in cognitive performance, language skills, and adaptive behavior skills in some young children with ASDs, although the literature is limited by methodologic concerns.

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Authors: Warren, Z., McPheeters, M. L., Sathe, N., Foss-Feig, J. H., Glasser, A., & Veenstra-VanderWeele, J.
Affiliations: Departments of Psychiatry and Pediatrics,
Vanderbilt University (US)
Vanderbilt Evidence-Based Practice Center, Institute for Medicine and Public Health, and
Department of Psychology and Human Development, and
ORCID: Warren, Zachary
McPheeters, Melissa L.
Sathe, Nila
Glasser, Allison
Veenstra-VanderWeele, Jeremy
Venue: Pediatrics
Publisher: American Academy of Pediatrics (AAP)
Published: 2011-05-01
Volume: 127
Issue: 5
Pages: e1303-e1311
ISSN: 0031-4005 (ISSN-L)
1098-4275
DOI: 10.1542/peds.2011-0426
OpenAlex: W2155277287
Cited by: 790
References: 49
Citations by year: 2026: 28 · 2025: 30 · 2024: 33 · 2023: 33 · 2022: 48 · 2021: 57 · 2020: 105 · 2019: 66 · 2018: 61 · 2017: 61 · 2016: 53 · 2015: 59 · 2014: 55 · 2013: 44 · 2012: 45
FWCI: 4.06
Type: journal article
Language: en
Open access: closed
Locations: PEDIATRICS (publishedVersion)
PubMed (publishedVersion)
Funders: National Research Council of Thailand
Agency for Healthcare Research and Quality
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Keywords: autism spectrum disorder, early intensive intervention, behavioral interventions, developmental intervention, Early Start Denver Model, parent training, language skills, cognitive performance, adaptive behavior, young children, intervention outcomes
MeSH terms: Behavior Therapy, Child, Child Development Disorders, Pervasive, Child, Preschool, Female, Humans, Male, Prognosis, Severity of Illness Index, United States, Randomized Controlled Trials as Topic, Treatment Outcome, Early Intervention, Educational, Early Diagnosis

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A Systematic Review of Early Intensive Intervention for Autism Spectrum Disorders

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