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Functional Abdominal Pain in Childhood and Long-term Vulnerability to Anxiety Disorders
Open accessAbstract
BACKGROUND: Cross-sectional studies link functional abdominal pain (FAP) to anxiety and depression in childhood, but no prospective study has evaluated psychiatric status in adulthood or its relation to pain persistence. METHODS: Pediatric patients with FAP (n = 332) and control subjects (n = 147) were tracked prospectively and evaluated for psychiatric disorders and functional gastrointestinal disorders (FGIDs) at follow-up in adolescence and young adulthood (mean age = 20.01 years). Participants were classified according to presence (FGID-POS) or absence (FGID-NEG) of FGIDs at follow-up. RESULTS: Lifetime and current risk of anxiety disorders was higher in FAP than controls (lifetime: 51% vs 20%; current: 30% vs 12%). Controlling for gender and age, the odds ratio was 4.9 (confidence interval = 2.83–7.43) for lifetime anxiety disorder and 3.57 (confidence interval = 2.00–6.36) for current anxiety disorder at follow-up for FAP versus controls. Lifetime risk of depressive disorder was significantly higher in FAP versus controls (40% vs. 16%); current risk did not differ. In most cases, initial onset of anxiety disorders was before pediatric FAP evaluation; onset of depressive disorders was subsequent to FAP evaluation. Within the FAP group, risk of current anxiety disorders at follow-up was significantly higher for FGID-POS versus FGID-NEG (40% vs 24%), and both were higher than controls (12%); current depressive disorders did not differ across FGID-POS, FGID-NEG, and controls. CONCLUSIONS: Patients with FAP carry long-term vulnerability to anxiety that begins in childhood and persists into late adolescence and early adulthood, even if abdominal pain resolves.
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“More specifically, studies show elevated anxiety levels in pediatric populations diagnosed with diabetes (Ducat et al., 2014), functional abdominal pain (Shelby et al., 2013), coronary heart disease (Oliver et al., 2020), and asthma (Pateraki et al., 2018).”
From Intolerance of Uncertainty and Health-Related Anxiety in Youth amid the COVID-19 Pandemic: Understanding and Weathering the Continuing Storm (2022) · cites this paper as Shelby et al., 2013
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Cites
Four Factor Index of Social Status
Paschou, R. (1975) · Cited by 6,989
Four Factor Index of Social Status [1975]
Hollingshead, A. B. (1975) · Cited by 5,151
Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.
Vlaeyen, J. W. S., & Linton, S. J. (2000) · Pain · doi:10.1016/s0304-3959(99)00242-0 · Cited by 4,931
Childhood and adolescent depression: a review of the past 10 years, Part I
BIRMAHER, B., RYAN, N. D., WILLIAMSON, D. E., BRENT, D. A., KAUFMAN, J., DAHL, R. E., PEREL, J., & NELSON, B. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199611000-00011 · Cited by 2,076
Childhood Functional Gastrointestinal Disorders: Child/Adolescent
Rasquin, A., Lorenzo, C. D., Forbes, D., Guiraldes, E., Hyams, J. S., Staiano, A., & Walker, L. S. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.08.063 · Cited by 1,804
Self-citationPain demands attention: A cognitive–affective model of the interruptive function of pain.
Eccleston, C., & Crombez, G. (1999) · Psychological Bulletin · doi:10.1037/0033-2909.125.3.356 · Cited by 1,718
Outline of a fear-avoidance model of exaggerated pain perception--I.
Lethem, J., Slade, P. D., Troup, J. D. G., & Bentley, G. (1983) · Behaviour Research and Therapy · doi:10.1016/0005-7967(83)90009-8 · Cited by 1,327
SILVERMAN, W. K., SAAVEDRA, L. M., & PINA, A. A. (2001) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200108000-00016 · Cited by 1,190
Whitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116
Brown, T. A., Di Nardo, P. A., Lehman, C. L., & Campbell, L. A. (2001) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.110.1.49 · Cited by 887
Understanding the co-occurrence of anxiety disorders and chronic pain: state-of-the-art
Asmundson, G. J. G., & Katz, J. (2009) · Depression and Anxiety · doi:10.1002/da.20600 · Cited by 756
Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions
Öhman, L., & Simrén, M. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.4 · Cited by 617
Rome III: New standard for functional gastrointestinal disorders.
Drossman, D. A., & Dumitrascu, D. L. (2006) · PubMed · Cited by 584
Abdominal pain and irritable bowel syndrome in adolescents: a community-based study
Hyams, J. S., Burke, G., Davis, P. M., Rzepski, B., & Andrulonis, P. A. (1996) · The Journal of Pediatrics · doi:10.1016/s0022-3476(96)70246-9 · Cited by 532
Recurrent abdominal pain, anxiety, and depression in primary care
Campo, J. V., Bridge, J., Ehmann, M., Altman, S., Lucas, A., Birmaher, B., Lorenzo, C. D., Iyengar, S., & Brent, D. A. (2004) · Pediatrics · doi:10.1542/peds.113.4.817 · Cited by 467
Idiopathic pain disorders – Pathways of vulnerability
Diatchenko, L., Nackley, A. G., Slade, G. D., Fillingim, R. B., & Maixner, W. (2006) · Pain · doi:10.1016/j.pain.2006.04.015 · Cited by 398
The Epidemiology of Childhood Recurrent Abdominal Pain in Western Countries: A Systematic Review
Chitkara, D. K., Rawat, D. J., & Talley, N. J. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41893.x · Cited by 359
Childhood and Adolescent Depression: A Review of the Past 10 Years. Part II
Birmaher, B. B., Ryan, N. D., Williamson, D. E., Brent, D. A., & Kaufman, J. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199612000-00008 · Cited by 335
Salim, S., Chugh, G., & Asghar, M. (2012) · Advances in protein chemistry and structural biology · doi:10.1016/b978-0-12-398314-5.00001-5 · Cited by 331
A Prospective School-based Study of Abdominal Pain and Other Common Somatic Complaints in Children
Saps, M., Seshadri, R., Sztainberg, M., Schaffer, G., Marshall, B. M., & Di Lorenzo, C. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2008.09.047 · Cited by 330
LYNEHAM, H. J., ABBOTT, M. J., & RAPEE, R. M. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3180465a09 · Cited by 307
Functional abdominal pain in childhood and adolescence increases risk for chronic pain in adulthood
Walker, L. S., Crish, S. D., Rippel, S., & Bruehl, S. P. (2010) · Pain · doi:10.1016/j.pain.2010.06.018 · Cited by 264
Self-citationAdult Outcomes of Pediatric Recurrent Abdominal Pain: Do They Just Grow Out of It?
Campo, J. V., Lorenzo, C. D., Chiappetta, L., Bridge, J. A., Colborn, D. K., Gartner, J. C., Gaffney, P., Kocoshis, S. A., & Brent, D. A. (2001) · PEDIATRICS · doi:10.1542/peds.108.1.e1 · Cited by 259
Labus, J. S., Mayer, E. A., Chang, L., Bolus, R., & Naliboff, B. D. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31802e2f24 · Cited by 257
Walker, L. S., Guite, J. W., Duke, M., Barnard, J. A., & Greene, J. W. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70400-7 · Cited by 246
Self-citationRecurrent Abdominal Pain in Children: Psychiatric Diagnoses and Parental Psychopathology
Garber, J., Zeman, J. L., & Walker, L. S. (1990) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199007000-00021 · Cited by 238
Self-citationWalker, L. S., Sherman, A. L., Bruehl, S. P., Garber, J., & Smith, C. A. (2012) · Pain · doi:10.1016/j.pain.2012.03.026 · Cited by 232
Self-citationWalker, L. S., Garber, J., Smith, C. A., Slyke, D. A. V., & Claar, R. L. (2001) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.69.1.85 · Cited by 213
Self-citationWalker, L. S., Garber, J., Smith, C. A., Slyke, D. A. V., & Claar, R. L. (2001) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.69.1.85 · Cited by 213
Self-citationWorrying about chronic pain: vigilance to threat and misdirected problem solving
Aldrich, S., Eccleston, C., & Crombez, G. (2000) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(99)00062-5 · Cited by 208
Anxiety Disorders Interview for DSM-IV: Client Interview Schedule
Brown, T. A., DiNardo, P. A., Barlow, D. H., & Mercier, M. A. (1999) · Journal of Cognitive Psychotherapy · doi:10.1891/0889-8391.13.4.380d · Cited by 203
Children with Recurrent Abdominal Pain: How Do They Grow Up?
Apley, J., & Hale, B. (1973) · BMJ · doi:10.1136/bmj.3.5870.7 · Cited by 196
Campbell, C. M., & Edwards, R. R. (2009) · Translational research · doi:10.1016/j.trsl.2008.12.002 · Cited by 175
Advances in Protein Chemistry and Structural Biology
(2021) · Advances in protein chemistry and structural biology · doi:10.1016/s1876-1623(21)00003-1 · Cited by 174
Too sick for school? Parent influences on school functioning among children with chronic pain
Logan, D. E., Simons, L. E., & Carpino, E. A. (2012) · Pain · doi:10.1016/j.pain.2011.11.004 · Cited by 174
O’Donovan, A., Slavich, G. M., Epel, E. S., & Neylan, T. C. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.10.013 · Cited by 156
Anxiety and somatic complaints in children with recurrent abdominal pain and anxiety disorders
Dufton, L. M., Dunn, M. J., & Compas, B. E. (2008) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsn064 · Cited by 151
Testing a Model of Pain Appraisal and Coping in Children With Chronic Abdominal Pain.
Walker, L. S., Smith, C. A., Garber, J., & Claar, R. L. (2005) · Health Psychology · doi:10.1037/0278-6133.24.4.364 · Cited by 140
Self-citationLife events and family history in children with recurrent abdominal pain
ROBINSON, J. O., Alverez, J. H., & DODGE, J. A. (1990) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(90)90051-5 · Cited by 135
Advances in Protein Chemistry and Structural Biology
(2020) · Advances in protein chemistry and structural biology · doi:10.1016/s1876-1623(20)30068-7 · Cited by 120
Baber, K. F., Anderson, J., Puzanovova, M., & Walker, L. S. (2008) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31816c4372 · Cited by 113
Self-citationPrognosis of Chronic or Recurrent Abdominal Pain in Children
Gieteling, M. J., Bierma‐Zeinstra, S. M., Passchier, J., & Berger, M. Y. (2008) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31815bc1c1 · Cited by 108
A typology of pain coping strategies in pediatric patients with chronic abdominal pain
Walker, L. S., Baber, K. F., Garber, J., & Smith, C. A. (2008) · Pain · doi:10.1016/j.pain.2007.08.038 · Cited by 107
Self-citationAttentional Biases to Pain and Social Threat in Children with Recurrent Abdominal Pain
Boyer, M. C., Compas, B. E., Stanger, C., Colletti, R. B., Konik, B. S., Morrow, S., & Thomsen, A. H. (2005) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsj015 · Cited by 99
Crombez, G., Beirens, K., Damme, S. V., Eccleston, C., & Fontaine, J. R. J. (2009) · Pain · doi:10.1016/j.pain.2009.04.006 · Cited by 91
Voigt, K., Wollburg, E., Weinmann, N., Herzog, A., Meyer, B., Langs, G., & Löwe, B. (2012) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2012.08.020 · Cited by 86
The relation of social functioning to school impairment among adolescents with chronic pain
Simons, L. E., Logan, D. E., Chastain, L., & Stein, M. (2010) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e3181b511c2 · Cited by 70
Knook, L. M. E., Konijnenberg, A. Y., van der Hoeven, J., Kimpen, J. L. L., Buitelaar, J. K., van Engeland, H., & de Graeff-Meeder, E. R. (2010) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-010-0146-0 · Cited by 68
Functional gastrointestinal symptoms in children with anxiety disorders
Waters, A. M., Schilpzand, E., Bell, C., Walker, L. S., & Baber, K. (2013) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-012-9657-0 · Cited by 61
Self-citationBeck, J. E., Lipani, T. A., Baber, K. F., Dufton, L. M., Garber, J., Smith, C. A., & Walker, L. S. (2011) · Pain · doi:10.1016/j.pain.2011.01.029 · Cited by 49
Self-citationIncreased wind-up to heat pain in women with a childhood history of functional abdominal pain
Crish, S. D., Bruehl, S. P., & Walker, L. S. (2011) · Pain · doi:10.1016/j.pain.2010.12.032 · Cited by 39
Self-citationNaliboff, B. D., Munakata, J., Chang, L., & Mayer, E. A. (1998) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(98)00049-x · Cited by 32
Increased Auditory Startle Reflex in Children with Functional Abdominal Pain
Bakker, M. J., Boer, F., Benninga, M. A., Koelman, J. H. T. M., & Tijssen, M. A. J. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.08.045 · Cited by 31
The importance of emotional processes in the modulation of pain
Rhudy, J. L. (2009) · Pain · doi:10.1016/j.pain.2009.07.003 · Cited by 15
Research works printed but not linked: 2
- Silverman, 1996, The Anxiety Disorders Interview Schedule for Children for DSM-IV: Child and Parent Versions
- Naliboff, 1998, Toward a biobehavioral model of visceral hypersensitivity in irritable bowel syndrome., J Psychosom Res, 45, 485
Cited by
Sorted by citations
Chambers, C. T., Dol, J., Tutelman, P. R., Langley, C., Parker, J. A., Cormier, B., Macfarlane, G. J., Jones, G. T., Chapman, D., Proudfoot, N. A., et al. (2024) · Pain · doi:10.1097/j.pain.0000000000003267 · Cited by 311
Prevalence of Functional Gastrointestinal Disorders in Children and Adolescents
Lewis, M. L., Palsson, O. S., Whitehead, W. E., & van Tilburg, M. A. L. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.04.008 · Cited by 290
Fisher, E., Law, E. F., Palermo, T. M., & Eccleston, C. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011118.pub2 · Cited by 244
Systematic review on intensive interdisciplinary pain treatment of children with chronic pain
Hechler, T., Kanstrup, M., Holley, A. L., Simons, L. E., Wicksell, R., Hirschfeld, G., & Zernikow, B. (2015) · Pediatrics · doi:10.1542/peds.2014-3319 · Cited by 230
Paediatric functional abdominal pain disorders
Thapar, N., Benninga, M. A., Crowell, M. D., Di Lorenzo, C., Mack, I., Nurko, S., Saps, M., Shulman, R. J., Szajewska, H., van Tilburg, M. A. L., et al. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-00222-5 · Cited by 221
Metadata
- Authors
- Shelby, G. D., Shirkey, K. C., Sherman, A. L., Beck, J. E., Haman, K., Shears, A. R., Horst, S. N., Smith, C. A., Garber, J., & Walker, L. S.
- Affiliations
- Vanderbilt University (US)
- Departments of Pediatrics,
- Medicine, and
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2013-09-01
- Volume
- 132
- Issue
- 3
- Pages
- 475-482
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- PMC
- PMC3876748
- OpenAlex
- W2136729608
- Cited by
- 272
- References
- 53
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 25 · 2023: 20 · 2022: 26 · 2021: 33 · 2020: 24 · 2019: 28 · 2018: 12 · 2017: 17 · 2016: 20 · 2015: 19 · 2014: 14 · 2013: 3
- FWCI
- 17.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- PEDIATRICS (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (T32MH018921)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK058404)
- National Center for Research Resources (UL1RR024975)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD015052, R01HD023264)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- functional abdominal pain, anxiety disorders, depressive disorders, functional gastrointestinal disorders, childhood, pain persistence
- MeSH terms
- Adolescent, Anxiety Disorders, Mental Disorders, Child, Chronic Disease, Depressive Disorder, Female, Follow-Up Studies, Gastrointestinal Diseases, Humans, Interview, Psychological, Male, Prospective Studies, Recurrence, Risk, Somatoform Disorders, Tennessee, Abdominal Pain
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