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Cited by 39Acute Lymphoblastic Leukemia researchChildhood Cancer Survivors' Quality of LifeEthics in Clinical Research

Treatment Setting, Clinical Trial Enrollment, and Subsequent Outcomes Among Adolescents With Cancer: A Literature Review

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Tai, Eric, Buchanan, Natasha, Westervelt, Lauren, Elimam, Dena, Lawvere, Silvana·2014·Pediatrics
DOI 10.1542/peds.2014-0122cPMC PMC6075704
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Abstract

BACKGROUND: There has been an overall improvement in survival rates for persons with cancer over the past 35 years. However, these gains are less prevalent among adolescents with cancer aged 15 to 19 years, which may be due to lower clinical trial enrollment among adolescents with cancer. METHODS: We conducted a literature review to assess current research regarding clinical trial enrollment and subsequent outcomes among adolescents with cancer. The search included English-language publications that reported original data from January 1985 to October 2011. RESULTS: The search identified 539 records. Of these 539 records, there were 30 relevant original research articles. Multiple studies reported that adolescents with cancer are enrolled in clinical trials at lower rates compared with younger children and older adults. Treatment setting, physician type, and institution type may all be factors in the low enrollment rate among adolescents. Few data focused solely on adolescents, with many studies combining adolescents with young adults. The number of available studies related to this topic was limited, with significant variability in study design, methods, and outcomes. CONCLUSIONS: This literature review suggests that adolescents with cancer are not treated at optimal settings and are enrolled in clinical trials at low rates. This may lead to inferior treatment and poor subsequent medical and psychosocial outcomes. The scarcity in data further validates the need for additional research focusing on this population.

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Research works printed but not linked: 2

  1. [4]Adolescent and Young Adult Oncology Press Review Group; National Cancer Institute; LiveStrong Young Adult Alliance. Closing the Gap: Research and Care Imperatives for Adolescents and Young Adults With Cancer. Bethesda, MD: National Institutes of Health; 2006 NIH Publication 06-6067
  2. [17]Paulussen M, Ahrens S, Juergens HF. Cure rates in Ewing tumor patients aged over 15 years are better in pediatric oncology units: Results of GPOH CESS/EICESS studies [abstract]. Proc Am Soc Clin Oncol. 2003; 22(816): 3279

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Authors
Tai, E., Buchanan, N., Westervelt, L., Elimam, D., & Lawvere, S.
Affiliations
  • Centers for Disease Control and Prevention (US)
  • SciMetrika LLC, Research Triangle Park, North Carolina; and
  • University of North Carolina at Chapel Hill (US)
Corresponding author
Tai, Eric
ORCID
Tai, Eric
Venue
Pediatrics
Publisher
American Academy of Pediatrics (AAP)
Published
2014-06-01
Volume
133
Issue
Supplement_3
Pages
S91-S97
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.2014-0122c
PMC
PMC6075704
OpenAlex
W2121542492
Cited by
39
References
47
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 8 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 1
FWCI
0.47
Type
journal article
Language
en
Open access
Locations
  • PEDIATRICS (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (CC999999)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
Keywords
adolescent cancer, clinical trial recruitment, treatment setting, institutional type, psychosocial outcomes, medical outcomes, young adult cancer, clinical trial access
MeSH terms
Adolescent, Clinical Trials as Topic, Humans, Neoplasms, Survival Rate, Treatment Outcome, Patient Selection, Young Adult

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