Plasma endotoxin level of healthy donors
Abstract
The plasma level of endotoxin was determined in 116 healthy blood donors. After a routine physical and laboratory investigations the endotoxin level was determined with Limulus amebocyte lysate assay (LAL-test) by the chromogenic kinetic method of Bio-Whittaker Co. (USA). Its sensitivity was 0.005-50 EU/ml. The plasma level of endotoxin in most of the healthy donors was less than 1 EU/ml (in the range of 0.01-1.0 EU/ml), but always measurable. The average ±S.D. was 0.128±0.215 EU/ml. Because of the high standard deviation and high range of values, the data were distributed into two groups with the means of 0.05±0.022 EU/ml and 0.294±0.186 EU/ml. The difference between the groups was significant (p<0.001). In conclusion, endotoxin can be measured in plasma of healthy individuals.
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Blood plasma endotoxin levels are normally low in healthy humans.
“Blood plasma levels of endotoxin are normally low”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [7]
Endotoxin is present in plasma of all healthy humans at very variable levels between 0.01 and 0.5 EU/ml (mean 0.1 ± 0.2 EU/ml), equivalent to about 1 and 50 pg/ml.
“Endotoxin is present in plasma of all healthy humans at very variable levels between 0.01 and 0.5 EU/ml (mean 0.1 ± 0.2 EU/ml), equivalent to about 1 and 50 pg/ml [7, 8].”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [7]
Average resting endotoxin units in the current study were comparable to values observed for healthy volunteers with similar fitness levels.
“Average resting endotoxin units in the current study remained within normal limits (<10 pg·mL−1), and were comparable to values observed (~11.0 ± 5.0 pg·mL−1) for healthy volunteers with similar fitness levels [14,39,40].”
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- Authors
- Nádházi, Z., Takáts, A., Offenmüller, K., & Bertók, L.
- Affiliations
- Semmelweis University (HU)
- Institute for Small Animal Research 2100 Gödöllő, P.O. Box 417. Hungary
- Frédéric Joliot-Curie National Research Institute for Radiobiology and Radiohygiene (HU)
- Venue
- Acta Microbiologica et Immunologica Hungarica
- Publisher
- Akademiai Kiado Zrt.
- Published
- 2002-03-01
- Volume
- 49
- Issue
- 1
- Pages
- 151-157
- ISSN
- 1217-8950 (ISSN-L)
- 1588-2640
- OpenAlex
- W2097210429
- Cited by
- 60
- References
- 18
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 4 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Microbiologica et Immunologica Hungarica (publishedVersion)
- PubMed (publishedVersion)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Keywords
- plasma endotoxin, healthy blood donors, Limulus amebocyte lysate assay, endotoxin measurement
- MeSH terms
- Animals, Blood Donors, Chromogenic Compounds, Endotoxins, Female, Humans, Limulus Test, Male, Sensitivity and Specificity
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