Reduced risk of reinfection with SARS-CoV-2 after COVID-19 vaccination—Kentucky, May–June 2021
Open accessAbstract
Although laboratory evidence suggests that antibody responses following COVID-19 vaccination provide better neutralization of some circulating variants than does natural infection (1,2), few real-world epidemiologic studies exist to support the benefit of vaccination for previously infected persons. This report details the findings of a case-control evaluation of the association between vaccination and SARS-CoV-2 reinfection in Kentucky during May-June 2021 among persons previously infected with SARS-CoV-2 in 2020. Kentucky residents who were not vaccinated had 2.34 times the odds of reinfection compared with those who were fully vaccinated (odds ratio [OR] = 2.34; 95% confidence interval [CI] = 1.58-3.47). These findings suggest that among persons with previous SARS-CoV-2 infection, full vaccination provides additional protection against reinfection. To reduce their risk of infection, all eligible persons should be offered vaccination, even if they have been previously infected with SARS-CoV-2.
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Studies suggest that vaccination of previously infected individuals leads to increased protection compared with vaccination of naive individuals.
“although studies37, 38 suggest that vaccination of previously infected individuals leads to increased protection compared with vaccination of naive individuals.”
From Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysis (2022) · cites this paper as [38]
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Protection against SARS-CoV-2 after Covid-19 Vaccination and Previous Infection
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- Authors
- Cavanaugh, A. M., Spicer, K. B., Thoroughman, D., Glick, C., & Winter, K.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Cavanaugh, Alyson M.
- Venue
- MMWR Morbidity and Mortality Weekly Report
- Published
- 2021-08-13
- Volume
- 70
- Issue
- 32
- Pages
- 1081-1083
- ISSN
- 0149-2195 (ISSN-L)
- 1545-861X
- PMC
- PMC8360277
- OpenAlex
- W3192403639
- Cited by
- 240
- References
- 7
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 27 · 2023: 37 · 2022: 134 · 2021: 34
- FWCI
- 18.37
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- MMWR Morbidity and Mortality Weekly Report (publishedVersion)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Funders
- Department for Public Health, Cabinet for Health and Family Services
- Centers for Disease Control and Prevention
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Keywords
- SARS-CoV-2, COVID-19 vaccination, reinfection, vaccine effectiveness, antibody response, natural infection
- MeSH terms
- Reinfection, COVID-19, COVID-19 Vaccines, Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Kentucky, Male, Middle Aged, Risk Assessment, Young Adult
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