The DOI matches its Crossref record; 76 of the 82 references it cites were found in a registry or an index.
Improvement of Tumor Response by Manipulation of Tumor Oxygenation During Photodynamic Therapy¶
Abstract
Photodynamic therapy (PDT) requires molecular oxygen during light irradiation to generate reactive oxygen species. Tumor hypoxia, either preexisting or induced by PDT, can severely hamper the effectiveness of PDT. Lowering the light irradiation dose rate or fractionating a light dose may improve cell kill of PDT-induced hypoxic cells but will have no effect on preexisting hypoxic cells. In this study hyperoxygenation technique was used during PDT to overcome hypoxia. C3H mice with transplanted mammary carcinoma tumors were injected with 12.5 mg/kg Photofrin and irradiated with 630 nm laser light 24 h later. Tumor oxygenation was manipulated by subjecting the animals to 3 atp (atmospheric pressure) hyperbaric oxygen or normobaric oxygen during PDT light irradiation. The results show a significant improvement in tumor response when PDT was delivered during hyperoxygenation. With hyperoxygenation up to 80% of treated tumors showed no regrowth after 60 days. In comparison, when animals breathed room air, only 20% of treated tumors did not regrow. To explore the effect of hyperoxygenation on tumor oxygenation, tumor partial oxygen pressure was measured with microelectrodes positioned in preexisting hypoxic regions before and during the PDT. The results show that hyperoxygenation may oxygenate preexisting hypoxic cells and compensate for oxygen depletion induced by PDT light irradiation. In conclusion, hyperoxygenation may provide effective ways to improve PDT efficiency by oxygenating both preexisting and treatment-induced cell hypoxia.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The availability of molecular oxygen during PDT has been shown to have a profound effect on treatment outcomes. 433 , 434”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [433]
Citations
Cites
Dougherty, T. J., Gomer, C. J., Henderson, B. W., Jori, G., Kessel, D., Korbelik, M., Moan, J., & Peng, Q. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.12.889 · Cited by 4,716
Gomer, C. J. (1988) · Cited by 4,169
Oxygen Consumption and Diffusion Effects in Photodynamic Therapy
Foster, T. H., Murant, R. S., Bryant, R. G., Knox, R. S., Gibson, S. L., & Hilf, R. (1991) · Radiation Research · doi:10.2307/3577919 · Cited by 400
Kawasaki, K., & Shimizu, N. (2000) · Lasers in Surgery and Medicine · doi:10.1002/(sici)1096-9101(2000)26:3 · Cited by 367
Relationship of tumor hypoxia and response to photodynamic treatment in an experimental mouse tumor.
Henderson, B. W., & Fingar, V. H. (1987) · PubMed · Cited by 339
Braun, R. D., Lanzen, J. L., Snyder, S. A., & Dewhirst, M. W. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.6.h2533 · Cited by 285
Koukourakis, M. I., Giatromanolaki, A. N., Skarlatos, J., Corti, L., Blandamura, S., Piazza, M., Gatter, K. C., & Harris, A. L. (2001) · PubMed · Cited by 271
Sitnik, T., Hampton, J., & Henderson, B. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.231 · Cited by 260
Tumor tissue oxygenation as evaluated by computerized-po2-histography
Kallinowski, F., Zander, R., Hoeckel, M., & Vaupel, P. W. (1990) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(90)90018-f · Cited by 256
Antiangiogenic treatment enhances photodynamic therapy responsiveness in a mouse mammary carcinoma.
Ferrario, A., von Tiehl, K., Rucker, N., Schwarz, M. A., Gill, P. S., & Gomer, C. J. (2000) · PubMed · Cited by 253
Research works printed but not linked: 2
- Nias, 1991, New Developments in Fundamental and Applied Radiobiology, 318
- Tubiana, 1990, Introduction to Radiobiology
Cited by
Sorted by citations
Items 101–124 of 124
Николаевич, Л. С., Николаевич, П. С., Алиджанов, Э. К., Lantukh, Y. D., Анатольевич, Р. Д., Чакак, А. А., & Ишемгулов, А. Т. (2019) · Optics and Spectroscopy · doi:10.1134/s0030400x19120129 · Cited by 3
Physics of Photodynamic Therapy
Madsen, S. J. (2016) · Springer eBooks · doi:10.1007/978-1-4939-1758-7_18 · Cited by 4
Nonlinear photodynamic therapy. Method of pulsed oxygen depletion
Kogan, B. Y. (2005) · Photochemical & Photobiological Sciences · doi:10.1039/b500345h · Cited by 3
Model of photodynamic therapy of skin tumors
Gubarev, S. A., Makhanek, A. A., & Shulman, Z. P. (2007) · Journal of Engineering Physics and Thermophysics · doi:10.1007/s10891-007-0011-2 · Cited by 2
Oxygen Effects in Photodynamic Therapy
Juzeniene, A. (2012) · doi:10.1002/9783527643981.bphot028 · Cited by 2
Biological and physical strategies to improve the therapeutic index of photodynamic therapy.
Rendon, C. A. (2008) · TSpace (University of Toronto) · Cited by 2
Optimization of tumor photodynamic therapy strategies based on nanotechnology
Liu, Q., & Yu, R. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107202 · Cited by 1
Photodynamic Therapy in Combination with Antiangiogenic Approaches Improve Tumor Inhibition
Ramaswamy, B., Olivo, M., Gan, Y., & Soo, K. C. (2011) · InTech eBooks · doi:10.5772/24827 · Cited by 1
Principes d’application clinique de la photothérapie dynamique
Stepp, H. G. (2003) · Acta Endoscopica · doi:10.1007/bf03002415 · Cited by 1
Finlay, J. C., Cengel, K. A., Busch, T. M., & Zhu, T. C. (2011) · CRC Press eBooks · doi:10.1201/b10951-41 · Cited by 1
Savari, M.-N., & Jabali, A. (2023) · Nanomedicine and nanotoxicology · doi:10.1007/978-981-99-6507-6_7 · Cited by 1
Barrionuevo, W. R., Filho, E. C. M., & Bagnato, V. S. (2008) · Microscopy Research and Technique · doi:10.1002/jemt.20560 · Cited by 1
Activity of Psoralen-Functionalized Nanoscintillators against Cancer Cells upon X-Ray Excitation
Vo‐Dinh, T. (2014) · CRC Press eBooks · doi:10.1201/b17288-16 · Cited by 1
Oxygen saturation and perfusion changes during photodynamic therapy: use of noninvasive monitoring
Ibbotson, S. H. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10653.x
Solban, N. (2006) · Defense Technical Information Center (DTIC)
A Complementary Cancer Treatment Protocol
Westman, J. C. (2015) · Alternative and Complementary Therapies · doi:10.1089/act.2015.29019.jcw
Portable two linearly polarized beams absorption biometric system
Chen, D. (2012) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2012.31007
Duarte, J., Hage, R., Tedesco, A. C., Pazos, M. D. C., Martin, A. A., & Plapler, H. (2006) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.644973
HYPERBARIC OXYGENT HERAPY AND CANCER - A REVIEW
Moen, I. N. (2015) · NORA - Norwegian Open Research Archives
(2010) · The Internet Journal of Alternative Medicine · doi:10.5580/14aa
Regulation of Cells Functions by Light Technology and Its Feasibility
Kushibiki, T. (2009) · The Review of Laser Engineering · doi:10.2184/lsj.37.43
ГИПЕРБАРИЧЕСКАЯ ОКСИГЕНАЦИЯ И РАК – ОБЗОР (ПЕРЕВОД С АНГЛ. МИТРОХИНА А.А.)
Моэн, И., & Стур, Л. (2015) · Research and Practical Medicine Journal · doi:10.17709/2409-2231-2015-1-84-94
Oxidative Stress and Photodynamic Therapy for Prostate Cancer
Du, K. L., Finlay, J. C., Zhu, T. C., & Busch, T. M. (2011) · Humana Press eBooks · doi:10.1007/978-1-61779-397-4_14
Metadata
- Authors
- Chen, Q., Huang, Z., Chen, H., Shapiro, H., Beckers, J., & Hetzel, F. W.
- Affiliations
- HealthONE (US)
- Venue
- Photochemistry and Photobiology
- Publisher
- American Society for Photobiology
- Published
- 2007-05-01
- Volume
- 76
- Issue
- 2
- Pages
- 197-203
- ISSN
- 0031-8655 (ISSN-L)
- OpenAlex
- W1958679672
- Cited by
- 124
- References
- 82
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 1 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 4 · 2015: 9 · 2014: 4 · 2013: 5 · 2012: 5
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photochemistry and Photobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (P01CA043892)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- photodynamic therapy, tumor hypoxia, tumor oxygenation, hyperbaric oxygen therapy, normobaric oxygen, hyperoxygenation, reactive oxygen species, Photofrin, breast cancer
- MeSH terms
- Animals, Female, Male, Mammary Neoplasms, Experimental, Mice, Inbred C3H, Oxygen, Photochemotherapy, Photobiology, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
