A Retrospective 3- to 5-Year Study of the Reconstruction of Oral Function Using Implant-Supported Prostheses in Patients With Hypohidrotic Ectodermal Dysplasia
Open accessAbstract
The aim of this study was to evaluate oral function rehabilitation in patients with hypohidrotic ectodermal dysplasia (HED) using implant-supported prostheses based on bone augmentation. From September 2005 and March 2009, 25 HED patients were chosen for clinical data analysis in this study. The criteria for patient selection included the following: the display of clinical features of HED, the number of congenitally missing teeth (>5), the patient age (>16 years), the patient's willingness, and the patient's tolerance for bone graft surgery and implant placement. Follow-up evaluations were initiated from the time of implant prosthetic placement and scheduled annually for 3-5 years. The effects of oral function reconstruction were assessed based on the cumulative survival and success rates of implants, the health of the peri-implant area, and the degree of patient satisfaction. Twenty-five HED patients received 169 conventional implants and 10 zygomatic implants (179 total implants). During 3-5 years of post-loading evaluations, 5 of the 179 implants failed and 3 implants were removed. The 3-year success and cumulative survival rates were 97.2% and 98.3%, respectively. Furthermore, periodontal probing and radiographic assessments showed that the 3-year incidence of peri-implantitis was 4.5%. Finally, HED patients expressed high degrees of satisfaction with their facial contours, masticatory function, pronunciation ability, and comfort with the implant-supported prostheses. The results of this 3- to 5-year retrospective study indicate that the oral function of HED patients can be effectively reconstructed using bone augmentation and implant-supported prostheses; however, longer term results are warranted in the future.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
All but two studies provided demographic and clinical features for each affected individual; these two cohort studies were excluded from standard descriptive analysis.
“All but two studies provided demographic and clinical features for each affected individual; for standard descriptive analysis, these two cohort studies were excluded.26,32”
From Prosthetic rehabilitation of patients with hypohidrotic ectodermal dysplasia: A systematic review (2018) · cites this paper as [32]
Cites
The long-term efficacy of currently used dental implants: a review and proposed criteria of success.
Albrektsson, T. O., Zarb, G. A., Worthington, P., & Eriksson, A. R. (1986) · PubMed · Cited by 3,691 · see citing works
Bone augmentation procedures in implant dentistry.
Chiapasco, M., Casentini, P., & Zaniboni, M. (2009) · PubMed · Cited by 658 · see citing works
Surgical treatment of peri‐implantitis
Claffey, N. M., Clarke, E., Polyzois, I., & Renvert, S. (2008) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2008.01277.x · Cited by 328 · see citing works
Microbiology and antimicrobial therapy of peri‐implantitis
Mombelli, A. (2002) · Periodontology 2000 · doi:10.1034/j.1600-0757.2002.280107.x · Cited by 267 · see citing works
Conventional Versus Laser-Assisted Therapy of Periimplantitis
Bach, G., Neckel, C. P., Mall, C., & Krekeler, G. (2000) · Implant Dentistry · doi:10.1097/00008505-200009030-00010 · Cited by 242 · see citing works
Treatment of severe hypodontia–oligodontia—an interdisciplinary concept
Worsaae, N., Jensen, B., Holm, B., & Holsko, J. (2007) · International Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.ijom.2007.01.021 · Cited by 146 · see citing works
Prospective clinical trial of dental implants in persons with ectodermal dysplasia
Guckes, A. (2002) · The Journal of Prosthetic Dentistry · doi:10.1016/s0022-3913(02)00043-4 · Cited by 139 · see citing works
Prospective clinical trial of dental implants in persons with ectodermal dysplasia
Guckes, A. D., Scurria, M. S., King, T. S., McCarthy, G. R., & Brahim, J. S. (2002) · The Journal of Prosthetic Dentistry · doi:10.1067/mpr.2002.127099 · Cited by 138 · see citing works
Salvi, G. E., Persson, G. R., Heitz‐Mayfield, L. J. A., Frei, M., & Lang, N. P. (2007) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2007.01377.x · Cited by 124 · see citing works
Jensen, T., Schou, S., Svendsen, P. A., Forman, J. L., Gundersen, H. J. G., Terheyden, H., & Holmstrup, P. (2011) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2011.02245.x · Cited by 123 · see citing works
Schwarz, F., Sculean, A., Bieling, K., Ferrari, D., Rothamel, D., & Becker, J. C. (2007) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2007.01168.x · Cited by 111 · see citing works
Implants in children with ectodermal dysplasia: a case report and literature review.
Kramer, F., Baethge, C., & Tschernitschek, H. (2007) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2006.01180.x · Cited by 106 · see citing works
(2010) · The Journal of Prosthetic Dentistry · doi:10.1016/s0022-3913(10)60099-6 · Cited by 75 · see citing works
Sclar, A. G., Kannikal, J., Ferreira, C. F., Kaltman, S., & Parker, W. B. (2009) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2009.06.016 · Cited by 37 · see citing works
Interdisciplinary Management of Patients With Ectodermal Dysplasia
Sickels, J. E. V., Raybould, T. P., & Hicks, E. P. (2010) · Journal of Oral Implantology · doi:10.1563/aaid-joi-d-09-00043r1 · Cited by 37 · see citing works
Bayat, M., Khobyari, M. M., Dalband, M., & Momen‐Heravi, F. (2011) · The Journal of Advanced Prosthodontics · doi:10.4047/jap.2011.3.2.96 · Cited by 35 · see citing works
Osseointegration and Guided Bone Regeneration in Ectodermal Dysplasia Patients
Garagiola, U. M., Maiorana, C., Ghiglione, V., Marzo, G., Santoro, F., & Szabó, G. (2007) · Journal of Craniofacial Surgery · doi:10.1097/01.scs.0000246497.62065.5a · Cited by 30 · see citing works
Grecchi, F., Zingari, F., Bianco, R., Zollino, I., Casadio, C., & Carinci, F. (2010) · Implant Dentistry · doi:10.1097/id.0b013e3181e40609 · Cited by 26 · see citing works
Li, D., Liu, Y., Ma, W., & Song, Y. (2011) · Implant Dentistry · doi:10.1097/id.0b013e31822f7b24 · Cited by 21 · see citing works
Baig, M. R., Rajan, G., & Rajan, M. (2009) · Journal of Oral Implantology · doi:10.1563/aaid-joi-d-09-00012r1.1 · Cited by 17 · see citing works
Mutation p.Leu354Pro in EDA causes severe hypohidrotic ectodermal dysplasia in a Chinese family
Liu, Y., Yu, X., Wang, L., Li, C., Archacki, S. R., Huang, C., Liu, J. Y., Wang, Q. K., Liu, M., & Tang, Z. (2011) · Gene · doi:10.1016/j.gene.2011.10.009 · Cited by 14 · see citing works
Al‐Ibrahim, H. A., Al‐Hadlaq, S. M., Abduljabbar, T. S., Al‐Hamdan, K. S., & Abdin, H. A. (2012) · Special Care in Dentistry · doi:10.1111/j.1754-4505.2011.00222.x · Cited by 13 · see citing works
Immediate Loading in Ectodermal Dysplasia: Clinical Case
D'Ambrosio, A., Cioffi, A., Cirillo, A., & Sammartino, G. (2011) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2011.03.027 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Survival and Complications of Zygomatic Implants: An Updated Systematic Review.
Chrcanovic, B., Albrektsson, T., & Wennerberg, A. (2016) · Journal of oral and maxillofacial surgery · doi:10.1016/j.joms.2016.06.166 · Cited by 238 · see citing works
Clinical outcomes of implant therapy in ectodermal dysplasia patients: a systematic review
Wang, Y., He, J., Decker, A. M., Hu, J. C. ‐., & Zou, D. (2016) · International Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.ijom.2016.03.011 · Cited by 72 · see citing works
Self-citationProsthetic rehabilitation of patients with hypohidrotic ectodermal dysplasia: A systematic review
Schnabl, D., Grunert, I., Schmuth, M., & Kapferer‐Seebacher, I. (2018) · Journal of Oral Rehabilitation · doi:10.1111/joor.12638 · Cited by 63 · see citing works
Terheyden, H., & WÜSTHOFF, F. (2015) · International Journal of Implant Dentistry · doi:10.1186/s40729-015-0025-z · Cited by 60 · see citing works
Moraschini, V., de Queiroz, T. R., Sartoretto, S. C., de Almeida, D. C. F., Calasans‐Maia, M. D., & Louro, R. S. (2022) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.13153 · Cited by 41 · see citing works
Prosthetic treatment outcome in patients with severe hypodontia: a systematic review
Filius, M. A. P., Cune, M. S., Raghoebar, G. M., Vissink, A., & Visser, A. (2016) · Journal of Oral Rehabilitation · doi:10.1111/joor.12384 · Cited by 39 · see citing works
Attia, S., Schaaf, H., Khassawna, T. E., Malhan, D., Mausbach, K., Howaldt, H., & Streckbein, P. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101687 · Cited by 31 · see citing works
Early implant placement for a patient with ectodermal dysplasia: Thirteen years of clinical care
Knobloch, L. A., Larsen, P. E., Saponaro, P. C., & L’Homme-Langlois, E. (2017) · Journal of Prosthetic Dentistry · doi:10.1016/j.prosdent.2017.08.015 · Cited by 29 · see citing works
Long-term implant performance and patients’ satisfaction in oligodontia
Filius, M. A. P., Vissink, A., Cune, M. S., Raghoebar, G. M., & Visser, A. (2018) · Journal of Dentistry · doi:10.1016/j.jdent.2018.01.007 · Cited by 24 · see citing works
Attia, S., Narberhaus, C., Schaaf, H., Streckbein, P., Pons‐Kühnemann, J., Schmitt, C. M., Neukam, F. W., Howaldt, H., & Böttger, S. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020391 · Cited by 21 · see citing works
Wu, Y., Wang, X. D., Wang, F., Huang, W., Zhang, Z., Zhang, Z., Kaigler, D., & Zou, D. (2015) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.12296 · Cited by 17 · see citing works
Self-citationWu, Y., Zhang, C., SQUARIZE, C. H., & Zou, D. (2015) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2015.03.065 · Cited by 15 · see citing works
Self-citationFilius, M. A. P., Cune, M. S., Koopmans, P. C., Vissink, A., Raghoebar, G. M., & Visser, A. (2018) · Journal of Prosthetic Dentistry · doi:10.1016/j.prosdent.2017.12.009 · Cited by 14 · see citing works
Casaña-Ruiz, M. D., Catalá‐Pizarro, M., Borrás-Aviñó, C., Sanchis, M. E., & Bellot‐Arcís, C. (2023) · Journal of Clinical and Experimental Dentistry · doi:10.4317/jced.60168 · Cited by 10 · see citing works
Perez, E., Salinas, L., Mendoza, R., Guerrero, M., Oliva, J., & Mayta-Tovalino, F. (2023) · Journal of International Society of Preventive and Community Dentistry · doi:10.4103/jispcd.jispcd_51_22 · Cited by 6 · see citing works
Maiorana, C., Poli, P. P., Poggio, C. E., Barbieri, P., & Beretta, M. (2017) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2017.01.010 · Cited by 10 · see citing works
Laventure, A., Raoul, G., Nicot, R., Ferri, J., & Lauwers, L. (2021) · International Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.ijom.2021.01.014 · Cited by 10 · see citing works
Complex Rehabilitation for an Adolescent with Ectodermal Dysplasia—A 10‐Year Follow‐Up
Sun, X., Yang, J., Ma, X., Liu, S., & Zhang, J. (2020) · Journal of Prosthodontics · doi:10.1111/jopr.13238 · Cited by 8 · see citing works
Evaluation of Implant Success in Patients with Dental Aplasia
Attia, S., Schaper, E., Schaaf, H., Pons‐Kühnemann, J., Schlenz, M. A., Streckbein, P., Böttger, S., Howaldt, H., & Wilbrand, J.-F. (2019) · BioMed Research International · doi:10.1155/2019/1680158 · Cited by 7 · see citing works
Pre-implant and implant management of oligodontia patients: A 10-year retrospective study
Lauwers, L., Raoul, G., Lauwers, R., Antunes, D., Bovis, M., & Nicot, R. (2023) · Journal of Stomatology Oral and Maxillofacial Surgery · doi:10.1016/j.jormas.2023.101425 · Cited by 5 · see citing works
Prosthodontic Treatment for Severe Oligodontia with Long-term Follow-up.
Zhang, X. X., Peng, D., & Feng, H. L. (2015) · PubMed · Cited by 4 · see citing works
Thuaire, A., Nicot, R., Raoul, G., & Lauwers, L. (2022) · Journal of Stomatology Oral and Maxillofacial Surgery · doi:10.1016/j.jormas.2022.101370 · Cited by 4 · see citing works
McMillan, K. B., McMillan, D. C., Arce, K., & Salinas, T. J. (2022) · Oral and Maxillofacial Surgery · doi:10.1007/s10006-022-01107-5 · Cited by 2 · see citing works
Tomar, S., Srivastava, N., Rana, V., Goswami, R., Kaushik, N., Saxena, D., Pruthi, T., Rawat, P., & Kaur, N. (2025) · European Archives of Paediatric Dentistry · doi:10.1007/s40368-025-01125-3 · Cited by 1 · see citing works
Yavuz, Ì., Callea, M., Yavuz, Y., Goncharuk-Khomyn, M., & Biley, A. (2023) · Ukrainian Dental Journal · doi:10.56569/udj.2.1.2023.71-77 · Cited by 1 · see citing works
Complications of Implant Rehabilitation in Ectodermal Dysplasia Patients: A Review Study
Hassani, A., Kakoienejad, M., Dentist, Bahmani, P., Bahrani, H., & Dentist (2018) · Journal of Research in Dental and Maxillofacial Sciences · doi:10.29252/jrdms.3.4.1
Hypohidrotic hereditary ectodermal dysplasia: A case report
Sachdev, S. S., Padawe, D., Khade, A., Takate, V. S., & Dighe, K. (2023) · IP International Journal of Medical Paediatrics and Oncology · doi:10.18231/j.ijmpo.2022.039
Current Evidence on the Rehabilitation of Ectodermal Dysplasia Patients with Dental Implants
Mishra, S. K., & Chowdhary, R. (2024) · International Journal of Prosthodontics and Restorative Dentistry · doi:10.5005/jp-journals-10019-1460
Periodontal Architecture in Ectodermal Dysplasia: An Observational Clinical and Histological Study
Montevecchi, M., Liguori, M. G., Santini, I., Sforza, N. M., Querzoli, G., & Valeriani, L. (2026) · Oral Diseases · doi:10.1111/odi.70196
- Authors
- Zou, D., Wu, Y., Wang, X. D., Huang, W., Zhang, Z., & Zhang, Z.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Wu, Yiqun
- Venue
- Journal of Oral Implantology
- Published
- 2014-10
- Volume
- 40
- Issue
- 5
- Pages
- 571-580
- ISSN
- 0160-6972 (ISSN-L)
- 1548-1336
- OpenAlex
- W2137814742
- Cited by
- 29
- References
- 22
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 4
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Oral Implantology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81100788)
- Anhui Medical University
- Shanghai Jiao Tong University
- Topics
- Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
- Health Sciences › Dentistry › Orthodontics › Dental materials and restorations
- Keywords
- hypohidrotic ectodermal dysplasia, implant-supported prostheses, zygomatic implants, bone augmentation, implant survival and success rates, peri-implantitis, patient satisfaction, tooth agenesis, mastication
- MeSH terms
- Adolescent, Adult, Alveolar Ridge Augmentation, Anodontia, Dental Implantation, Endosseous, Female, Follow-Up Studies, Humans, Male, Mastication, Mouth Rehabilitation, Periodontal Index, Retrospective Studies, Speech, Dental Implants, Survival Analysis, Bone Transplantation, Treatment Outcome, Patient Satisfaction, Bone Substitutes, Dental Prosthesis, Implant-Supported, Dental Restoration Failure, Osteogenesis, Distraction, Device Removal, Ectodermal Dysplasia 1, Anhidrotic, Young Adult, Peri-Implantitis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review