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Cited by 17Dental Implant Techniques and Outcomesdental development and anomaliesDental materials and restorations

Restoration of Oral Function for Adult Edentulous Patients with Ectodermal Dysplasia: A Prospective Preliminary Clinical Study

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Wu, Yiqun, Wang, Xu Dong, Wang, Feng, Huang, Wei, Zhang, Zhiyong, Zhang, Zhiyuan, Kaigler, Darnell, Zou, Duohong·2015·Clinical Implant Dentistry and Related Research
DOI 10.1111/cid.12296
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Abstract

Background: Therapy with zygomatic implants (ZIs) or conventional implants (CIs) has proven to be an effective method to restore oral function for systemically healthy patients. However, it is still a major challenge to fully restore oral function to edentulous adult patients with ectodermal dysplasia (ED). Purpose: The aim of this study was to determine an effective treatment protocol for restoring oral function using ZIs and CIs to edentulous adult ED patients. Materials and Methods: Ten edentulous adult ED patients were treated in this study. The treatment protocol involved the following: (1) bone augmentation in the region of the anterior teeth; (2) placement of two ZIs and four CIs in the maxilla, and four CIs in the mandible; (3) fabrication of dental prosthesis; and (4) psychological and oral education. Following treatment of these patients, implant success rates, biological complications, patient satisfaction, and psychological changes were recorded. Results: Although there was evidence of bone graft resorption in the maxilla, bone augmentation of the mandible was successful in all patients. Nine CIs in the maxilla failed and were removed. All ZIs were successful, and the CIs success rates were 77.50% in the maxilla and 100% in the mandible, with a mean of 88.75%. The mean peri‐implant bone resorption for the CIs ranged from 1.3 ± 0.4 mm to 1.8 ± 0.6 mm, and four cases exhibited gingival hyperplasia in the maxilla and mandible. One hundred percent of the patients were satisfied with the restoration of their oral function, and >50% of the patients exhibited enhanced self‐confidence and self‐esteem. Conclusions: This study demonstrates that oral function can be restored in edentulous adult ED patients using a comprehensive and systematic treatment protocol involving psychological and oral education, bone augmentation, implant placement, and denture fabrication. Despite these positive outcomes, bone augmentation remains challenging in the anterior region of the maxilla for edentulous adult ED patients.

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  • ED patients are prone to rapid bone resorption and impaired soft tissue healing postoperatively.

    “ED patients are prone to rapid bone resorption and impaired soft tissue healing postoperatively [32].”

    From Implant-supported fixed prosthodontic treatment for ectodermal dysplasia: a case report (2026) · cites this paper as [32]

    The Results report significant maxillary bone-graft resorption in four of ten edentulous ED patients. The paper does not establish that ED patients generally experience rapid postoperative bone resorption, and it does not report impaired postoperative soft-tissue healing. (LLM, conf=0.86)

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  • Previous studies report long-term implant survival rates in ED patients ranging from 88.5% to 97.6%, with mean marginal bone loss at 1 year of approximately 1.3-1.8 mm.

    “Previous studies report long-term implant survival rates in ED patients ranging from 88.5% to 97.6%, with mean marginal bone loss at 1 year of approximately 1.3–1.8 mm [31, 32].”

    From Implant-supported fixed prosthodontic treatment for ectodermal dysplasia: a case report (2026) · cites this paper as [32]

    The Results and Table 3 (page not supplied) report a mean conventional-implant success rate of 88.75% over three years and mean bone loss of 1.3 mm at one year. They do not report 97.6% survival, and the 1.8 mm bone-loss figure is for three years, not one year. (LLM, conf=0.90)

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Authors
Wu, Y., Wang, X. D., Wang, F., Huang, W., Zhang, Z., Zhang, Z., Kaigler, D., & Zou, D.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • University of Michigan (US)
  • Anhui Medical University (CN)
Corresponding author
  • Wu, Yiqun
  • Zou, Duohong
ORCID
Venue
Clinical Implant Dentistry and Related Research
Publisher
Wiley
Published
2015-03-02
Volume
17
Issue
S2
Pages
e633-42
ISSN
  • 1523-0899 (ISSN-L)
  • 1708-8208
DOI
10.1111/cid.12296
OpenAlex
W2130039123
Cited by
17
References
40
Citations by year
2026: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1
FWCI
2.15
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Implant Dentistry and Related Research (publishedVersion)
  • PubMed (publishedVersion)
  • Deep Blue (University of Michigan) (submittedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders
  • Shanghai Jiao Tong University (YG2012MS32)
  • Science and Technology Commission of Shanghai Municipality (13ZR1424000)
  • National Natural Science Foundation of China (31370983, 81371190)
  • Chinese Ministry of Education (212080)
  • BSKY (XJ201109)
  • Anhui Medical University
Topics
  • Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
  • Health Sciences › Dentistry › Orthodontics › Dental materials and restorations
Keywords
ectodermal dysplasia, zygomatic implants, oral rehabilitation, bone augmentation, implant success rate, peri-implant bone loss, gingival hyperplasia, patient satisfaction, self-esteem, psychoeducation, denture fabrication
MeSH terms
Alveolar Ridge Augmentation, Dental Implantation, Endosseous, Ectodermal Dysplasia, Female, Humans, Male, Mouth, Edentulous, Zygoma, Treatment Outcome, Young Adult

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