[The Role of Reactive Oxygen Species in the Pathogenesis of Adipocyte Dysfunction in Metabolic Syndrome. Prospects of Pharmacological Correction]
Open accessAbstract
It is established that oxidative stress induces insulin resistance of adipocytes, increases secretion leptin, IL-6, TNF-α by adipocytes. Adiponectin secretion by adipocytes is reduced after the action of reactive oxygen species. Metabolic syndrome contributes to oxidative stress in adipose tissue, on the one hand due to the activation of production of reactive oxygen species by adipocyte NADPH-oxidase, and on the other hand by reducing the antioxidant defense adipocytes. It is found that obesity itself can induce oxidative stress. Chronic stress, glucocorticoids, mineralocorticoids, angiotensin-II, TNF-α play an important role in the pathogenesis of oxidative stress of adipocytes. Metformin remains the cure for the treatment of insulin resistance. The positive results in the treatment of metabolic syndrome by losartan were obtained. Antioxidants and flavonoids exhibit a positive impact on the course of the experimental metabolic syndrome.
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Phycocyanin in Arthrospira platensis suppresses oxidative stress and leads to anti-inflammatory and insulin-sensitizing effects.
“Phycocyanin in Arthrospira platensis suppresses oxidative stress and leads to anti-inflammatory and insulin-sensitizing effects [106,107,108].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [107]
The Abstract links oxidative stress to adipocyte insulin resistance and discusses antioxidants generally. The pharmacological-correction section discusses other antioxidants and flavonoids, but searches for phycocyanin, Arthrospira platensis, and spirulina found no passage addressing the claimed effects of phycocyanin. (LLM, conf=0.77)
Experimental — accuracy not yet measuredBy suppressing adipocyte oxidative stress, spirulina may lead to systemic anti-inflammatory and insulin-sensitising effects.
“Thus, by suppressing adipocyte oxidative stress, spirulina may lead to systemic anti-inflammatory and insulin-sensitising effects.12–20”
From Effects of spirulina on weight loss and blood lipids: A review (2020) · cites this paper as [20]
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- Authors
- Prokudina, E. S., Maslov, L. N., Ivanov, V. V., Bespalova, I. D., Pismennyi, D. S., & Voronkov, N. S.
- Affiliations
- Siberian State Medical University (RU)
- Russian Academy of Sciences (RU)
- Venue
- Annals of the Russian academy of medical sciences
- Publisher
- Paediatrician Publishers LLC
- Published
- 2017-02-19
- Volume
- 72
- Issue
- 1
- Pages
- 11-16
- ISSN
- 0869-6047 (ISSN-L)
- 2414-3545
- OpenAlex
- W2591956869
- Cited by
- 17
- References
- 52
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 4
- FWCI
- 0.25
- Type
- journal article
- Language
- ru
- Open access
- hybrid
- doi.org
- Locations
- Annals of the Russian academy of medical sciences (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- reactive oxygen species, oxidative stress, adipocyte dysfunction, metabolic syndrome, insulin resistance, adipose tissue, NADPH oxidase, adiponectin, leptin, adipokines, obesity, glucocorticoids, angiotensin II, metformin, losartan, antioxidants, flavonoids
- MeSH terms
- Humans, Hypoglycemic Agents, Insulin Resistance, Metformin, Adipocytes, Oxidative Stress, Metabolic Syndrome
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