Oxidative stress and metabolic pathologies: from an adipocentric point of view
Open accessAbstract
Oxidative stress plays a pathological role in the development of various diseases including diabetes, atherosclerosis, or cancer. Systemic oxidative stress results from an imbalance between oxidants derivatives production and antioxidants defenses. Reactive oxygen species (ROS) are generally considered to be detrimental for health. However, evidences have been provided that they can act as second messengers in adaptative responses to stress. Obesity represents a major risk factor for deleterious associated pathologies such as type 2 diabetes, liver, and coronary heart diseases. Many evidences regarding obesity-induced oxidative stress accumulated over the past few years based on established correlations of biomarkers or end-products of free-radical-mediated oxidative stress with body mass index. The hypothesis that oxidative stress plays a significant role in the development of metabolic disorders, especially insulin-resistance state, is supported by several studies where treatments reducing ROS production reverse metabolic alterations, notably through improvement of insulin sensitivity, hyperlipidemia, or hepatic steatosis. In this review, we will develop the mechanistic links between oxidative stress generated by adipose tissue in the context of obesity and its impact on metabolic complications development. We will also attempt to discuss potential therapeutic approaches targeting obesity-associated oxidative stress in order to prevent associated-metabolic complications.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Numerous scientific investigations have substantiated a robust correlation between hyperlipidemia and oxidative stress, with oxidative stress assuming a pivotal role in the development of metabolic disorders.
“Numerous scientific investigations have substantiated a robust correlation between hyperlipidemia and oxidative stress, with oxidative stress assuming a pivotal role in the development of metabolic disorders (Le Lay et al., 2014; Okuno et al., 2018; Raut and Khullar, 2023).”
From Lactiplantibacillus plantarum N4 ameliorates lipid metabolism and gut microbiota structure in high fat diet-fed rats (2024) · cites this paper as Le Lay et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Lee, T. S., Saltsman, K., Ohashi, H., & King, G. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.13.5141 · Cited by 373 · see citing works
Retracted(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667 · see citing works
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207 · see citing works
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989 · see citing works
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508 · see citing works
The Pathobiology of Diabetic Complications
Brownlee, M. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1615 · Cited by 5,339 · see citing works
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664 · see citing works
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290 · see citing works
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277 · see citing works
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788 · see citing works
Inflammatory Mechanisms in Obesity
Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works
ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis
D'Autréaux, B., & Toledano, M. B. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2256 · Cited by 3,642 · see citing works
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359 · see citing works
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239 · see citing works
Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.
Griendling, K. K., Minieri, C. A., Ollerenshaw, J. D., & Alexander, R. W. (1994) · Circulation Research · doi:10.1161/01.res.74.6.1141 · Cited by 2,735 · see citing works
Reactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · see citing works
n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases
Calder, P. C. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1505s · Cited by 2,525 · see citing works
Dynamics of fat cell turnover in humans
Spalding, K. L., Arner, E., Westermark, P. O., Bernard, S., Buchholz, B. A., Bergmann, O., Blomqvist, L., Hoffstedt, J., Näslund, E., Britton, T., et al. (2008) · Nature · doi:10.1038/nature06902 · Cited by 2,357 · see citing works
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275 · see citing works
PPARγ signaling and metabolism: the good, the bad and the future
Ahmadian, M., Suh, J. M., Hah, N., Liddle, C., Atkins, A. R., Downes, M., & Evans, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3159 · Cited by 2,016 · see citing works
Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace
Förstermann, U., & Münzel, T. (2006) · Circulation · doi:10.1161/circulationaha.105.602532 · Cited by 1,957 · cited 1× · see citing works
“The transformation of eNOS from a protective enzyme to a contributor to oxidative stress has been well described in endothelial cells and observed in different models of cardiovascular diseases, including patients with cardiovascular risk factors [27].”
BackgroundIKK-β links inflammation to obesity-induced insulin resistance
Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773 · see citing works
Inoguchi, T., Li, P., Umeda, F., Yu, H. Y., Kakimoto, M., Imamura, M., Aoki, T., Etoh, T., Hashimoto, T., Naruse, M., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1939 · Cited by 1,577 · see citing works
Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
Vásquez-Vivar, J., Kalyanaraman, B., Martásek, P., Hogg, N., Masters, B. S. S., Karoui, H., Tordo, P., & Pritchard, K. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9220 · Cited by 1,484 · see citing works
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2003) · Diabetes · doi:10.2337/diabetes.52.1.1 · Cited by 1,482 · see citing works
Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase
Vickers, C., Hales, P., Kaushik, V. K., Dick, L. R., Gavin, J. M., Tang, J., Godbout, K., Parsons, T. F., Baronas, E., Hsieh, F., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200581200 · Cited by 1,406 · see citing works
Keaney, J. F., Larson, M. G., Vasan, R. S., Wilson, P. W. F., Lipinska, I., Corey, D., Massaro, J. M., Sutherland, P., Vita, J. A., & Benjamin, E. J. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000058402.34138.11 · Cited by 1,304 · see citing works
Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation
Hosogai, N., Fukuhara, A., Oshima, K., Miyata, Y., Tanaka, S., Segawa, K., Furukawa, S., Tochino, Y., Komuro, R., Matsuda, M., et al. (2007) · Diabetes · doi:10.2337/db06-0911 · Cited by 1,257 · cited 1× · see citing works
“Alteration of NOrelated angiogenic processes might therefore participate in inadequate vasculature observed upon fat expansion in obesity giving rise to hypoxia [99].”
BackgroundAnderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253 · see citing works
Reactive oxygen species in cancer cells: Live by the sword, die by the sword
Schumacker, P. T. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.015 · Cited by 1,242 · see citing works
Calnan, D. R., & Brunet, A. (2008) · Oncogene · doi:10.1038/onc.2008.21 · Cited by 1,170 · see citing works
Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor
Ishii, H., Jirousek, M. R., Koya, D., Takagi, C., Xia, P., Clermont, A. C., Bursell, S., Kern, T. S., Ballas, L. M., Heath, W. F., et al. (1996) · Science · doi:10.1126/science.272.5262.728 · Cited by 1,103 · see citing works
Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training
Gomez-Cabrera, M.-C., Domenech, E., & Viña, J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.02.001 · Cited by 1,020 · see citing works
Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications
Geraldes, P., & King, G. L. (2010) · Circulation Research · doi:10.1161/circresaha.110.217117 · Cited by 993 · see citing works
Apelin, a Newly Identified Adipokine Up-Regulated by Insulin and Obesity
Boucher, J., Masri, B., Daviaud, D., Gesta, S., Guigné, C., Mazzucotelli, A., Castan-Laurell, I., Tack, I., Knibiehler, B., Carpéné, C., et al. (2005) · Endocrinology · doi:10.1210/en.2004-1427 · Cited by 910 · see citing works
Du, X. L., Edelstein, D., Dimmeler, S., Ju, Q., Sui, C., & Brownlee, M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11235 · Cited by 907 · see citing works
Novel insights of dietary polyphenols and obesity
Wang, S. F., Moustaïd‐Moussa, N., Chen, L., Mo, H., Shastri, A. A., Su, R., Bapat, P., Kwun, I., & Shen, C. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.09.001 · Cited by 903 · see citing works
Oxidative stress and metabolic syndrome
Roberts, C. K., & Sindhu, K. K. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.02.026 · Cited by 865 · see citing works
Du, X., Matsumura, T., Edelstein, D., Rossetti, L., Zsengellér, Z. K., Szabó, C., & Brownlee, M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18127 · Cited by 832 · see citing works
Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ
Qiang, L., Wang, L., Kon, N., Zhao, W., Lee, S., Zhang, Y., ROSENBAUM, M. S., Zhao, Y., Gu, W. J., Farmer, S. R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.027 · Cited by 802 · see citing works
Cross talk between mitochondria and NADPH oxidases
Dikalov, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.033 · Cited by 783 · see citing works
Mechanisms of obesity-associated insulin resistance: many choices on the menuPreprint
Qatanani, M., & Lazar, M. A. (2007) · Genes & Development · doi:10.1101/gad.1550907 · Cited by 780 · see citing works
PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein
Ohno, H., Shinoda, K., Spiegelman, B. M., & Kajimura, S. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.019 · Cited by 749 · see citing works
The phagocytes: neutrophils and monocytes
Dale, D. C., Boxer, L. A., & Liles, W. C. (2008) · Blood · doi:10.1182/blood-2007-12-077917 · Cited by 740 · see citing works
Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans
Vincent, H. K., & Taylor, A. G. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803177 · Cited by 738 · see citing works
Therapeutic Targeting of Mitochondrial Superoxide in Hypertension
Dikalova, A., Bikineyeva, A. T., Budzyn, K., Nazarewicz, R. R., McCann, L. A., Lewis, W., Harrison, D. G., & Dikalov, S. (2010) · Circulation Research · doi:10.1161/circresaha.109.214601 · Cited by 737 · see citing works
Extending life span by increasing oxidative stress
Ristow, M., & Schmeisser, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.010 · Cited by 718 · see citing works
Adipocytokines in Obesity and Metabolic Disease
Cao, H. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0339 · Cited by 705 · see citing works
Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency
López-Lluch, G., Hunt, N., Jones, B., Zhu, M., Jamieson, H., Hilmer, S., Cascajo, M. V., Allard, J., Ingram, D. K., Navas, P., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510452103 · Cited by 699 · see citing works
Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols
Kuzkaya, N., Weissmann, N., Harrison, D. G., & Dikalov, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302227200 · Cited by 692 · see citing works
Kintscher, U., Hartge, M., Hess, K., Foryst-Ludwig, A., Clemenz, M., Wabitsch, M., Fischer-Posovszky, P., Barth, T. F. E., Dragun, D., Skurk, T., et al. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.165100 · Cited by 692 · see citing works
Influence of body fat distribution on free fatty acid metabolism in obesity.
Jensen, M. D., Haymond, M. W., Rizza, R. A., Cryer, P. E., & Miles, J. M. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113997 · Cited by 683 · see citing works
Leptin induces oxidative stress in human endothelial cells
Bouloumié, A., Marumo, T., Lafontan, M., & Busse, R. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.10.1231 · Cited by 679 · see citing works
Mitochondrial Complex III ROS Regulate Adipocyte Differentiation
Tormos, K. V., Ansó, E., Hamanaka, R. B., Eisenbart, J. D., Joseph, J., Kalyanaraman, B., & Chandel, N. S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.007 · Cited by 662 · see citing works
Yamagishi, S., Edelstein, D., Du, X.-L., Kaneda, Y., Guzmán, M., & Brownlee, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007383200 · Cited by 620 · see citing works
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.
Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M. A., Chui, P. C., Leszyk, J., Straubhaar, J., Czech, M. P., & Corvera, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21752 · Cited by 616 · see citing works
The role of mitochondria in insulin resistance and type 2 diabetes mellitus
Szendroedi, J., Phielix, E., & Roden, M. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.138 · Cited by 600 · cited 1× · see citing works
“Accordingly, oxidative stress has been shown to play critical roles in the development of pathologies such as diabetes, atherosclerosis, and hypertension [106, 107].”
BackgroundOmega-3 Fatty Acids and Cardiovascular Disease
Kris‐Etherton, P. M., Harris, W. S., & Appel, L. J. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000057393.97337.ae · Cited by 597 · see citing works
Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice
Ejaz, A., Wu, D., Kwan, P., & Meydani, M. (2009) · Journal of Nutrition · doi:10.3945/jn.108.100966 · Cited by 585 · see citing works
Reactive oxygen species enhance insulin sensitivity
Loh, K., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B. J., Skiba, B., Ooms, L. M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.009 · Cited by 581 · see citing works
González‐Périz, A., Horrillo, R., Ferré, N., Gronert, K., Dong, B., Morán‐Salvador, E., Titos, E., Martínez‐Clemente, M., López‐Parra, M., Arroyo, V., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-125674 · Cited by 556 · see citing works
Bierhaus, A. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00233-2 · Cited by 555 · see citing works
Perreault, M., & Marette, A. (2001) · Nature Medicine · doi:10.1038/nm1001-1138 · Cited by 540 · see citing works
Redox signaling in macrophages.
Forman, H., & Torres, M. (2001) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(01)00010-3 · Cited by 539 · see citing works
Apelin Stimulates Glucose Utilization in Normal and Obese Insulin-Resistant Mice
Dray, C., Knauf, C., Daviaud, D., Waget, A., Boucher, J., Buléon, M., Cani, P. D., Attané, C., Guigné, C., Carpéné, C., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.003 · Cited by 522 · see citing works
Obesity-Associated Oxidative Stress: Strategies Finalized to Improve Redox State
Savini, I., Catani, M. V., Evangelista, D., Gasperi, V., & Avigliano, L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140510497 · Cited by 514 · see citing works
Mahadev, K., Motoshima, H., Wu, X., Ruddy, J. M., Arnold, R. S., Cheng, G., Lambeth, J. D., & Goldstein, B. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.1844-1854.2004 · Cited by 513 · see citing works
The Hyperglycemia-induced Inflammatory Response in Adipocytes
Lin, Y., Berg, A. H., Iyengar, P., Lam, T. K. T., Giacca, A., Combs, T. P., Rajala, M. W., Du, X., Rollman, B., Li, W., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411863200 · Cited by 497 · see citing works
Periadventitial fat releases a vascular relaxing factor
Löhn, M., Dubrovska, G., Lauterbach, B., Luft, F. C., Gollasch, M., & Sharma, A. M. (2002) · The FASEB Journal · doi:10.1096/fj.02-0024com · Cited by 474 · see citing works
Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats
Rivera, L., Morón, R., Sánchez, M., Zarzuelo, A., & Galisteo, M. (2008) · Obesity · doi:10.1038/oby.2008.315 · Cited by 473 · see citing works
Wilson-Fritch, L., Burkart, A., Bell, G., Mendelson, K., Leszyk, J., Nicoloro, S., Czech, M., & Corvera, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.1085-1094.2003 · Cited by 459 · see citing works
Tao, L., Gao, E., Jiao, X., Yuan, Y., Li, S., Christopher, T. A., Lopez, B. L., Koch, W. J., Chan, L., Goldstein, B. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.666941 · Cited by 453 · see citing works
Tetrahydrobiopterin Improves Endothelium-Dependent Vasodilation in Chronic Smokers
Heitzer, T. A., Brockhoff, C. J., Mayer, B., Warnholtz, A., Mollnau, H., Henne, S., Meinertz, T., & Münzel, T. F. (2000) · Circulation Research · doi:10.1161/01.res.86.2.e36 · Cited by 449 · see citing works
Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?
Cantó, C., & Auwerx, J. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.003905 · Cited by 433 · see citing works
Lee, H., Lee, Y. J., Choi, H., Ko, E. H., & Kim, J. W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808742200 · Cited by 428 · see citing works
The adipose-tissue renin–angiotensin–aldosterone system: role in the metabolic syndrome?
Engeli, S., Schling, P., Gorzelniak, K., Boschmann, M., Janke, J., Ailhaud, G. P., Teboul, M., Massiéra, F., & Sharma, A. M. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00311-4 · Cited by 415 · see citing works
Sorbitol Pathway: Presence in Nerve and Cord with Substrate Accumulation in Diabetes
Gabbay, K. H., MEROLA, L. O., & Field, R. A. (1966) · Science · doi:10.1126/science.151.3707.209 · Cited by 400 · see citing works
Vascular NADPH oxidases: molecular mechanisms of activation
Brandes, R. P., & Kreuzer, J. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.08.007 · Cited by 396 · see citing works
Rivera, L., Morón, R., Zarzuelo, A., & Galisteo, M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.027 · Cited by 391 · see citing works
Dandona, P., Mohanty, P., Ghanim, H., Aljada, A., Browne, R. W., Hamouda, W., Prabhala, A., Afzal, A., & Garg, R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.1.7150 · Cited by 370 · see citing works
Blum, M., Dolnikowski, G. G., Seyoum, E., Harris, S. S., Booth, S. L., Peterson, J., Saltzman, E. J., & Dawson‐Hughes, B. (2008) · Endocrine · doi:10.1007/s12020-008-9051-4 · Cited by 366 · see citing works
Effect of fatty acids on energy coupling processes in mitochondria
Wojtczak, L., & Schönfeld, P. (1993) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(93)90004-y · Cited by 363 · see citing works
Effects of Exercise Training on Glucose Homeostasis
Boulé, N. G., Weisnagel, S. J., Lakka, T. A., Tremblay, A., Bergman, R. N., Rankinen, T., Leon, A. S., Skinner, J. S., Wilmore, J. H., Rao, D. C., et al. (2005) · Diabetes Care · doi:10.2337/diacare.28.1.108 · Cited by 356 · see citing works
Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis
Chun, H. J., Ali, Z. A., Kojima, Y., Kundu, R. K., Sheikh, A. Y., Agrawal, R., Zheng, L., Leeper, N. J., Pearl, N., Patterson, A. J., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34871 · Cited by 329 · see citing works
Shinozaki, K., Kashiwagi, A., Nishio, Y., Okamura, T., Yoshida, Y., Masada, M., Toda, N., & Kikkawa, R. (1999) · Diabetes · doi:10.2337/diabetes.48.12.2437 · Cited by 329 · see citing works
Toledo, F. G. S., Menshikova, E. V., Ritov, V. B., Azuma, K., Radikova, Z., DeLany, J., & Kelley, D. E. (2007) · Diabetes · doi:10.2337/db07-0141 · Cited by 321 · see citing works
Mahadev, K., Wu, X., Zilbering, A., Zhu, L., Lawrence, J. T. R., & Goldstein, B. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105061200 · Cited by 298 · see citing works
Systemic Oxidative Stress is Associated With Visceral Fat Accumulation and the Metabolic Syndrome
Fujita, K., Nishizawa, H., Funahashi, T., Shimomura, I., & Shimabukuro, M. (2006) · Circulation Journal · doi:10.1253/circj.70.1437 · Cited by 294 · see citing works
Mitochondria and Reactive Oxygen Species
Addabbo, F., Montagnani, M., & Goligorsky, M. S. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.130054 · Cited by 294 · see citing works
Fat cell enlargement is an independent marker of insulin resistance and ‘hyperleptinaemia’
Lundgren, M., Svensson, M. K. E., Lindmark, S., Renström, F., Ruge, T., & Eriksson, J. W. (2007) · Diabetologia · doi:10.1007/s00125-006-0572-1 · Cited by 278 · see citing works
Carotenoids in Human Blood and Tissues
Parker, R. S. (1989) · Journal of Nutrition · doi:10.1093/jn/119.1.101 · Cited by 276 · see citing works
Mitochondrial (Dys)function in Adipocyte (De)differentiation and Systemic Metabolic Alterations
Pauw, A. D., Tejerina, S., Raes, M. J., Keijer, J., & Arnould, T. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081155 · Cited by 270 · see citing works
Physical Activity and Insulin Sensitivity
Balkau, B., Mhamdi, L., Oppert, J., Nolan, J. J., Golay, A., Porcellati, F., Laakso, M., Ferrannini, E., & on behalf of the EGIR-RISC Study Group (2008) · Diabetes · doi:10.2337/db07-1605 · Cited by 260 · see citing works
Nox4 Acts as a Switch Between Differentiation and Proliferation in Preadipocytes
Schröder, K., Wandzioch, K., Helmcke, I., & Brandes, R. P. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.174219 · Cited by 258 · see citing works
Adiponectin, driver or passenger on the road to insulin sensitivity?
Ye, R., & Scherer, P. E. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.04.001 · Cited by 251 · see citing works
Carbonylation of Adipose Proteins in Obesity and Insulin Resistance
Grimsrud, P. A., Picklo, M. J., Griffin, T. J., & Bernlohr, D. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600120-mcp200 · Cited by 249 · see citing works
Han, C. Y., Kargi, A. Y., Omer, M., Chan, C. K., Wabitsch, M., O’Brien, K. D., Wight, T. N., & Chait, A. (2009) · Diabetes · doi:10.2337/db09-0925 · Cited by 246 · see citing works
Insulin-stimulated intracellular hydrogen peroxide production in rat epididymal fat cells
May, J. M., & de Haën, C. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30209-0 · Cited by 235 · see citing works
Reactive oxygen species mediate adipocyte differentiation in mesenchymal stem cells
Kanda, Y., Hinata, T., Kang, S. W., & Watanabe, Y. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.06.007 · Cited by 231 · see citing works
Reactive oxygen species at phospholipid bilayers: Distribution, mobility and permeation
Cordeiro, R. M. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.09.016 · Cited by 228 · see citing works
Higuchi, M., Dusting, G. J., Peshavariya, H., Jiang, F., Hsiao, S. T.-F., Chan, E. C., & Liu, G. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0306 · Cited by 227 · see citing works
Local adipose tissue renin-angiotensin system
Cassis, L. A., Police, S. B., Yiannikouris, F. B., & Thatcher, S. E. (2008) · Current Hypertension Reports · doi:10.1007/s11906-008-0019-9 · Cited by 224 · see citing works
Carrière, A., Carmona, M.-C., Fernandez, Y., Rigoulet, M., Wenger, R. H., Pénicaud, L., & Casteilla, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407258200 · Cited by 220 · see citing works
Kôno, T., Robinson, F. W., Blevins, T. L., & Ezaki, O. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33914-0 · Cited by 215 · see citing works
Molecular mechanisms of the cardiovascular protective effects of polyphenols
Andriantsitohaina, R., Auger, C., Chataigneau, T., Étienne-Selloum, N., Li, H., Martínez, M. C., Schini‐Kerth, V. B., & Laher, I. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003406 · Cited by 215 · see citing works
Self-citationKetonen, J., Jin, S., Martonen, E., & Mervaala, E. M. A. (2010) · Circulation Journal · doi:10.1253/circj.cj-09-0661 · Cited by 209 · see citing works
Czech, M., Lawrence, J. C., & Lynn, W. S. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.10.4173 · Cited by 208 · see citing works
Curtis, J., Grimsrud, P. A., Hahn, W. S., Xu, X. M., Foncea, R. E., Graham, D. W., Brestoff, J. R., Wiczer, B. M., Ilkayeva, O., Cianflone, K., et al. (2010) · Diabetes · doi:10.2337/db09-1105 · Cited by 207 · see citing works
Reactive oxygen species are downstream products of TRAF-mediated signal transduction
Chandel, N. S., Schumacker, P. T., & Arch, R. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103074200 · Cited by 203 · see citing works
Gao, C., Zhu, C., Zhao, Y., Chen, X.-H., Ji, C., Zhang, C., Zhu, J., Xia, Z., Tong, M., & Guo, X. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.01.039 · Cited by 203 · see citing works
Gut metabotypes govern health effects of dietary polyphenols
Bolca, S., de Wiele, T. V., & Possemiers, S. (2012) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2012.09.009 · Cited by 201 · see citing works
Du, X., Matsumura, T., Edelstein, D., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318127 · Cited by 200 · see citing works
Strauss, R. S. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70409-9 · Cited by 199 · see citing works
Chrysohoou, C., Panagiotakos, D. B., Pitsavos, C., Skoumas, I., Papademetriou, L., Economou, M., & Stefanadis, C. (2007) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.05.007 · Cited by 199 · see citing works
Effects of oxidative stress on adiponectin secretion and lactate production in 3T3-L1 adipocytes
Soares, A. F., Guichardant, M., Cozzone, D., Bernoud‐Hubac, N., Bouzaïdi-Tiali, N., Lagarde, M., & Géloën, A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.12.010 · Cited by 198 · see citing works
Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner
Fischer-Posovszky, P., Kukulus, V., Tews, D., Unterkircher, T., Debatin, K.-M., Fulda, S., & Wabitsch, M. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28435 · Cited by 195 · see citing works
Konrad, T., Vicini, P., Kusterer, K., Höflich, A., Assadkhani, A., Böhles, H. J., Sewell, A., Tritschler, H., Cobelli, C., & Usadel, K. H. (1999) · Diabetes Care · doi:10.2337/diacare.22.2.280 · Cited by 189 · see citing works
Oxidant stress reduces insulin responsiveness in 3T3-L1 adipocytes
Rudich, A., Kozlovsky, N., Potashnik, R., & Bashan, N. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.5.e935 · Cited by 188 · see citing works
Han, C. Y., Umemoto, T., Omer, M., Den Hartigh, L. J., Chiba, T., LeBoeuf, R., Buller, C. L., Sweet, I. R., Pennathur, S., Abel, E. D., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.304998 · Cited by 187 · see citing works
Li, L., Mamputu, J., Wiernsperger, N. F., & Renier, G. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2227 · Cited by 187 · see citing works
Omega-3 Fatty Acids Reduce Adipose Tissue Macrophages in Human Subjects With Insulin Resistance
Spencer, M. L., Finlin, B. S., Ünal, R., Zhu, B., Morris, A. J., Shipp, L. R., Lee, J. D., Walton, R. G., Adu, A. K., Erfani, R. A., et al. (2013) · Diabetes · doi:10.2337/db12-1042 · Cited by 179 · see citing works
Hyperglycemia Activates Caspase-1 and TXNIP-Mediated IL-1β Transcription in Human Adipose Tissue
Koenen, T. B., Stienstra, R., van Tits, L. J., Graaf, J. D., Stalenhoef, A. F. H., Joosten, L. A. B., Tack, C. J., & Netea, M. G. (2011) · Diabetes · doi:10.2337/db10-0266 · Cited by 172 · see citing works
Apelin Decreases Lipolysis via Gq, Gi, and AMPK-Dependent Mechanisms
Yue, P., Jin, H. H., Xu, S., Aillaud, M., Deng, A. C., Azuma, J., Kundu, R. K., Reaven, G. M., Quertermous, T., & Tsao, P. S. (2010) · Endocrinology · doi:10.1210/en.2010-0576 · Cited by 171 · see citing works
Dandona, P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.1.355 · Cited by 171 · see citing works
Necrosis of the Anterior Pituitary and Zona Glomerulosa of the Adrenal
Bradley, R. (1964) · The Lancet · doi:10.1016/s0140-6736(64)90874-8 · Cited by 170 · see citing works
Li, R., Wang, W., Zhang, H., Yang, X., Fan, Q., Christopher, T. A., Lopez, B. L., Tao, L., Goldstein, B. J., Gao, F., et al. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00462.2007 · Cited by 169 · see citing works
Bełtowski, J. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00236-3 · Cited by 168 · see citing works
Russell, A. P., Gastaldi, G., Bobbioni-Harsch, E., Arboit, P., Gobelet, C., Dériaz, O., Golay, A., Witztum, J. L., & Giacobino, J.-P. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00875-5 · Cited by 166 · see citing works
Kurata, A., Nishizawa, H., Kihara, S., Maeda, N., Sonoda, M., Okada, T., Ohashi, K., Hibuse, T., Fujita, K., Yasui, A., et al. (2006) · Kidney International · doi:10.1038/sj.ki.5001810 · Cited by 166 · see citing works
Wang, C., Wang, C., Huang, H., & Wei, Y. (2013) · The FEBS Journal · doi:10.1111/febs.12096 · Cited by 165 · see citing works
Neuhouser, M. L., Rock, C. L., Eldridge, A. L., Kristal, A. R., Patterson, R. E., Cooper, D. A., Neumark‐Sztainer, D., Cheskin, L. J., & Thornquist, M. D. (2001) · Journal of Nutrition · doi:10.1093/jn/131.8.2184 · Cited by 164 · see citing works
Plasma free fatty acid turnover rate in obesity
Björntorp, P., Bergman, H., & Varnauskas, E. (1969) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1969.tb07347.x · Cited by 161 · see citing works
Role of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxide.
Hayes, G. R., & Lockwood, D. H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.22.8115 · Cited by 155 · see citing works
Pillon, N. J., Croze, M. L., Vella, R., Soulère, L., Lagarde, M., & Soulage, C. O. (2012) · Endocrinology · doi:10.1210/en.2011-1957 · Cited by 154 · see citing works
Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons
Zeng, X. J., Yu, S. P., Zhang, L., & Wei, L. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.02.005 · Cited by 154 · see citing works
Krieger‐Brauer, H. I., Medda, P. K., & KATHER, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.10135 · Cited by 152 · see citing works
Activation of catalase by apelin prevents oxidative stress‐linked cardiac hypertrophy
Foussal, C., Lairez, O., Calise, D., Pathak, A., Guilbeau‐Frugier, C., Valet, P., Parini, A., & Kunduzova, O. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.04.025 · Cited by 151 · see citing works
Expression of nitric oxide synthases in subcutaneous adipose tissue of nonobese and obese humans
Elizalde, M., Rydén, M., van Harmelen, V., Eneroth, P. H. E., Gyllenhammar, H., Holm, C., Ramel, S., Ölund, A., Arner, P., & Andersson, K. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33432-5 · Cited by 150 · see citing works
Prevention of diet-induced obesity by dietary black tea polyphenols extract in vitro and in vivo
Uchiyama, S., Taniguchi, Y., Saka, A., Yoshida, A., & Yajima, H. (2010) · Nutrition · doi:10.1016/j.nut.2010.01.019 · Cited by 148 · see citing works
The Metabolism of Tritiated Glucose by Rat Adipose Tissue
Katz, J. J., & Rognstad, R. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99873-x · Cited by 140 · see citing works
Relationship of oxidative stress with obesity and its role in obesity induced metabolic syndrome.
Sankhla, M., Sharma, T. K., Mathur, K., Rathor, J. S., Butolia, V., Gadhok, A. K., Vardey, S. K., Sinha, M., & Kaushik, G. G. (2012) · PubMed · Cited by 131 · see citing works
Lipophilic Micronutrients and Adipose Tissue Biology
Landrier, J., Marcotorchino, J., & Tourniaire, F. (2012) · Nutrients · doi:10.3390/nu4111622 · Cited by 129 · see citing works
Maingrette, F., & Renier, G. (2003) · Diabetes · doi:10.2337/diabetes.52.8.2121 · Cited by 124 · see citing works
Regulation of the nitric oxide system in human adipose tissue
Engeli, S., Janke, J., Gorzelniak, K., Böhnke, J., Ghose, N., Lindschau, C., Luft, F. C., & Sharma, A. M. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300322-jlr200 · Cited by 123 · see citing works
ADIPOSE-CELL SIZE AND IMMUNOREACTIVE INSULIN LEVELS IN OBESE AND NORMAL-WEIGHT ADULTS
Stern, J., Hollander, N., Batchelor, B., Cohn, C., & Hirsch, J. (1972) · The Lancet · doi:10.1016/s0140-6736(72)92474-9 · Cited by 122 · see citing works
Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: Role of p38 MAPK
Archuleta, T. L., Lemieux, A. M., Saengsirisuwan, V., Teachey, M. K., Lindborg, K. A., Kim, J. S., & Henriksen, E. J. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.08.014 · Cited by 122 · see citing works
Talior, I., Tennenbaum, T., Kuroki, T., & Eldar-Finkelman, H. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00378.2004 · Cited by 120 · see citing works
Murdolo, G., Piroddi, M., Luchetti, F., Tortoioli, C., Canonico, B., Zerbinati, C., Galli, F., & Iuliano, L. (2012) · Biochimie · doi:10.1016/j.biochi.2012.12.014 · Cited by 120 · see citing works
Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways
Than, A., Cheng, Y., Foh, L.-C., Leow, M. K., Lim, S. C., Chuah, Y. J., Kang, Y., & Chen, P. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.07.002 · Cited by 120 · see citing works
Crujeiras, A. B., Parra, D., Milagro, F. I., Goyenechea, E., Larrarte, E., Margareto, J., & Martínez, J. A. (2008) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2008.0001 · Cited by 119 · see citing works
Wang, C., Ching-chū, W., & Wei, Y. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05625.x · Cited by 117 · see citing works
Iturrioz, X., Alvear‐Perez, R., Mota, N. D., Franchet, C., Guillier, F., Leroux, V., Dabiré, H., Jouan, M. L., Chabane, H., Gerbier, R., et al. (2009) · The FASEB Journal · doi:10.1096/fj.09-140715 · Cited by 112 · see citing works
Agouni, A., Lagrue-Lak-Hal, A.-H., Mostefai, H. A., Tesse, A., Mulder, P. G. H., Rouet, P., Desmoulin, F., Heymes, C., Martínez, M. C., & Andriantsitohaina, R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005557 · Cited by 111 · see citing works
Self-citationLu, B., Ennis, D., Lai, R., Bogdanovic, E., Nikolov, R., Salamon, L., Fantus, C., Le‐Tien, H., & Fantus, I. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106783200 · Cited by 105 · see citing works
Adipose Tissue Proadipogenic Redox Changes in Obesity
Galinier, A., Carrière, A., Fernandez, Y., Carpéné, C., André, M., Caspar‐Bauguil, S., Thouvenot, J.-P., Périquet, B., Pénicaud, L., & Casteilla, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506949200 · Cited by 104 · see citing works
Green Tea Polyphenols Reduced Fat Deposits in High Fat-Fed Rats via erk1/2-PPARγ-Adiponectin Pathway
Tian, C., Ye, X., Zhang, R., Long, J., Ren, W., Ding, S., Liao, D., Jin, X., Wu, H., Shun-qin, X., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053796 · Cited by 102 · see citing works
Tocopherol distribution and intracellular localization in human adipose tissue
Traber, M. G., & Kayden, H. J. (1987) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/46.3.488 · Cited by 101 · see citing works
Demozay, D., Mas, J.-C., Rocchi, S., & OBBERGHEN, E. V. (2008) · Diabetes · doi:10.2337/db07-0389 · Cited by 101 · see citing works
Meta‐analysis: antioxidant supplements for primary and secondary prevention of colorectal adenoma
Bjelaković, G., Nagorni, A. V., Nikolova, D., Simonetti, R. G., Bjelaković, M., & Gluud, C. N. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02970.x · Cited by 100 · see citing works
Esfahani, A., Wong, J. M., Truan, J., Villa, C., Mirrahimi, A., Srichaikul, K., & Kendall, C. W. C. (2011) · Journal of the American College of Nutrition · doi:10.1080/07315724.2011.10719971 · Cited by 97 · see citing works
Plasma GSH/GSSG affects glucose homeostasis in healthy subjects and non-insulin-dependent diabetics
Paolisso, G., di Maro, G., Pizza, G., D’Amore, A., Sgambato, S., Tesauro, P., Varricchio, M., & D'Onofrio, F. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.263.3.e435 · Cited by 97 · see citing works
Mammalian Antioxidant Defenses Are Not Inducible by H2O2
Desaint, S., Luriau, S., Aude, J.-C., Rousselet, G., & Tolédano, M. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401888200 · Cited by 96 · see citing works
楠知里, Liu, Y., Yoshizaki, T., Nakagawa, F., Ishikado, A., Kondo, M., Morino, K., Sekine, O., Ugi, S., Nishio, Y., et al. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.10.115 · Cited by 95 · see citing works
Du, X. L., Edelstein, D., Dimmeler, S., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200111235 · Cited by 91 · see citing works
Miwa, I., Ichimura, N., Sugiura, M., Hamada, Y., & Taniguchi, S. (2000) · Endocrinology · doi:10.1210/endo.141.8.7614 · Cited by 87 · see citing works
Blood vitamin and lipid levels in overweight and obese women.
de Burgos, A. M., Wartanowicz, M., & Ziemlański, Ś. (1992) · PubMed · Cited by 85 · see citing works
Long, E. K., Olson, D. M., & Bernlohr, D. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.030 · Cited by 83 · see citing works
Zhang, Y., & Chen, X. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00380.2010 · Cited by 82 · see citing works
Payne, G. A., Bohlen, H. G., Dinçer, Ü. D., Borbouse, L., & Tune, J. D. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00116.2009 · Cited by 80 · see citing works
Skeletal Muscle Lipid Peroxidation and Insulin Resistance in Humans
Ingram, K. H., Hill, H. S., Moellering, D. R., Hill, B. G., Lara‐Castro, C., Newcomer, B. R., Brandon, L. J., Ingalls, C. P., Penumetcha, M., Rupp, J. C., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2963 · Cited by 77 · see citing works
Little, S. A., & de Haën, C. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70390-1 · Cited by 74 · see citing works
Zarrouki, B., Soares, A. F., Guichardant, M., Lagarde, M., & Géloën, A. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.04.048 · Cited by 73 · see citing works
Hatia, S., Septembre‐Malaterre, A., Sage, F. L., Badiou, A., Baret, P., Payet, B., d’Hellencourt, C. L., & Gonthier, M. (2014) · Free Radical Research · doi:10.3109/10715762.2013.879985 · Cited by 70 · see citing works
Volk, T. J., Hensel, M., Schuster, H., & Kox, W. J. (2000) · Molecular and Cellular Biochemistry · doi:10.1023/a:1007059616914 · Cited by 69 · see citing works
The in vitro oxidizability of lipoprotein particles in obese and non-obese subjects
Gaal, L. F. V., Vertommen, J., & Leeuw, I. H. D. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(97)00316-x · Cited by 62 · see citing works
Involvement of Oxidative Stress and the JNK Pathway in Glucose Toxicity
Kaneto, H., Nakatani, Y., Kawamori, D., Miyatsuka, T., & Matsuoka, T. (2004) · The Review of Diabetic Studies · doi:10.1900/rds.2004.1.165 · Cited by 61 · see citing works
Park, H., Jung, U. J., Lee, M., Cho, S., Jung, H., Hong, J. H., Park, Y. B., Kim, S. R., Shim, S., Jung, J., et al. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200447 · Cited by 61 · see citing works
Frohnert, B. I., Long, E. K., Hahn, W. S., & Bernlohr, D. A. (2014) · Diabetes · doi:10.2337/db13-0777 · Cited by 60 · cited 1× · see citing works
“Furthermore, glutathionylated lipid aldehydes, by-products of oxidative stress found to be elevated in obeseWAT, are potent activators of macrophage inflammation [90].”
BackgroundAntioxidant Vitamin Levels in Plasma and Low Density Lipoprotein of Obese Girls
Kljno, T., Hozumi, M., Morinobu, T., Murata, T., Mingci, Z., & Tamai, H. (1998) · Free Radical Research · doi:10.3109/10715769809097878 · Cited by 59 · see citing works
Zhang, X., Wang, Z., Li, J., Gu, D., Li, S., Shen, C., & Song, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070663 · Cited by 56 · see citing works
Adipose tissue expandability, lipotoxicity and the metabolic syndrome
Vidal‐Puig, A. (2013) · Endocrinología y Nutrición · doi:10.1016/s1575-0922(13)70026-3 · Cited by 54 · see citing works
Frayn, K. N., Langin, D., & Karpe, F. (2008) · Diabetologia · doi:10.1007/s00125-007-0901-z · Cited by 54 · see citing works
n-3 fatty acids modulate adipose tissue inflammation and oxidative stress
Fan, C., Zirpoli, H., & Qi, K. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32835c02c8 · Cited by 50 · see citing works
Blockade of the Renin-Angiotensin System Ameliorates Apelin Production in 3T3-L1 Adipocytes
Hung, W., Hsieh, T., Lin, T. H., Chou, P.-C., Hsiao, P., Lin, K., & Shin, S. (2010) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-010-6274-4 · Cited by 48 · see citing works
Hormesis in Aging and Neurodegeneration—A Prodigy Awaiting Dissection
Mao, L., & Franke, J. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140713109 · Cited by 47 · see citing works
Eicosapentaenoic acid up‐regulates apelin secretion and gene expression in 3T3‐L1 adipocytes
Lorente‐Cebrián, S., Bustos, M., Martí, A., Martínez, J. A., & Moreno-Aliaga, M. J. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900522 · Cited by 45 · see citing works
Schmidt, S., Stahl, F., Mutz, K., Scheper, T., Hahn, A., & Schuchardt, J. (2012) · Nutrition and Metabolism · doi:10.1186/1743-7075-9-45 · Cited by 45 · see citing works
Alteration of Amine Oxidase Activity in the Adipose Tissue of Obese Subjects
Visentin, V., Prévot, D., Front, V. D. D. S., Morin‐Cussac, N., Thalamas, C., Galitzky, J., Valet, P., Zorzano, A., & Carpéné, C. (2004) · Obesity Research · doi:10.1038/oby.2004.62 · Cited by 43 · see citing works
Site specific changes of redox metabolism in adipose tissue of obese Zucker rats
Galinier, A., Carrière, A., Fernandez, Y., Caspar‐Bauguil, S., Périquet, B., Périquet, A., Pénicaud, L., & Casteilla, L. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.10.052 · Cited by 39 · see citing works
Systems biology of antioxidants
Andriantsitohaina, R., Duluc, L., Rodríguez, J., del Valle, L. G., Guevara-García, M., Simard, G., Soleti, R., Su, D., Velázquez‐Pérez, L., Wilson, J. X., et al. (2012) · Clinical Science · doi:10.1042/cs20110643 · Cited by 39 · see citing works
Self-citationTang, S., Le‐Tien, H., Goldstein, B. J., Shin, P., Lai, R., & Fantus, I. G. (2001) · Diabetes · doi:10.2337/diabetes.50.1.83 · Cited by 38 · see citing works
Perrot, V., & Rechler, M. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212750200 · Cited by 27 · see citing works
Diffusion of hydrogen peroxide across DPPC large unilamellar liposomes
Abuin, E., Lissi, E. A., & Ahumada, M. (2012) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2012.07.001 · Cited by 27 · see citing works
Miwa, I. (2000) · Endocrinology · doi:10.1210/en.141.8.2767 · Cited by 26 · see citing works
Nishikawa, T., Edelstein, D., Du, X., Yamagishi, S., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D. A., Oates, P. J., Hammes, H., et al. (2000) · Cited by 23 · see citing works
Demozay, A., Más, J. A. S., Rocchi, S., & OBBERGHEN, E. V. (2008) · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Oxidative stress, inflammation and treatment response in major depression
Lindqvist, D., Dhabhar, F. S., James, S. J., Hough, C. M., Jain, F. A., Bersani, F. S., Reus, V. I., Verhoeven, J. E., Epel, E. S., Mahan, L., et al. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.11.031 · Cited by 473 · see citing works
Srikanthan, K., Feyh, A., Visweshwar, H., Shapiro, J. I., & Sodhi, K. (2015) · International Journal of Medical Sciences · doi:10.7150/ijms.13800 · Cited by 443 · see citing works
Oxidative Stress, Plant Natural Antioxidants, and Obesity
Pérez-Torres, I., Castrejón-Téllez, V., Soto, M. E., Rubio-Ruiz, M. E., Manzano-Pech, L., & Guarner‐Lans, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041786 · Cited by 411 · see citing works
Nutrients and Oxidative Stress: Friend or Foe?
Tan, B. L., Norhaizan, M. E., & Liew, W.-P.-P. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9719584 · Cited by 437 · see citing works
Correlation between Oxidative Stress, Nutrition, and Cancer Initiation
Saha, S. K., Lee, S. B., Won, J., Choi, H. Y., Kim, K., Yang, G., Dayem, A. A., & Cho, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071544 · Cited by 399 · see citing works
Role of oxidative stress and antioxidants in daily nutrition and human health
Bjørklund, G., & Chirumbolo, S. (2016) · Nutrition · doi:10.1016/j.nut.2016.07.018 · Cited by 241 · see citing works
Gusti, A. M. T., Qusti, S. Y., Alshammari, E. M., Toraih, E. A., & Fawzy, M. S. (2021) · Antioxidants · doi:10.3390/antiox10040595 · Cited by 238 · see citing works
Higuchi, M., Dusting, G. J., Peshavariya, H., Jiang, F., Hsiao, S. T.-F., Chan, E. C., & Liu, G. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0306 · Cited by 227 · see citing works
Rajagopal, P., Shyamaladevi, B., Vijayalakshmi, P., & Jayaraman, S. (2018) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2018.1545815 · Cited by 222 · see citing works
Bonet, M. L., Canas, J. A., Ribot, J., & Palou, A. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.02.022 · Cited by 223 · see citing works
Ruiz, Á. H., García‐Villanova, B., Guerra-Hernández, E. J., Amiano, P., Ruiz‐Canela, M., & Molina‐Montes, E. (2019) · Nutrients · doi:10.3390/nu11040774 · Cited by 204 · see citing works
Guo, Y., Luo, S., Ye, Y., Yin, S., Fan, J., & Xia, M. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa644 · Cited by 198 · see citing works
Varra, F., Varras, M. N., Varra, V., & Theodosis‐Nobelos, P. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13219 · Cited by 194 · see citing works
Sripetchwandee, J., Chattipakorn, N., & Chattipakorn, S. C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00496 · Cited by 196 · see citing works
CD36 Mediated Fatty Acid-Induced Podocyte Apoptosis via Oxidative Stress
Hua, W., Huang, H., Tan, L.-T., Wan, J., Gui, H.-B., Zhao, L., Ruan, X. Z., Chen, X., & Du, X. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127507 · Cited by 163 · see citing works
Normal-weight obesity syndrome: diagnosis, prevalence, and clinical implications
Franco, L. P., de Morais, C. C., & Cominetti, C. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw019 · Cited by 157 · see citing works
Dietary Fat and Cancer—Which Is Good, Which Is Bad, and the Body of Evidence
Bojková, B., Winklewski, P. J., & Wszędybył-Winklewska, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114114 · Cited by 158 · see citing works
The two faces of reactive oxygen species (ROS) in adipocyte function and dysfunction
Castro, J. P., Grune, T., & Speckmann, B. (2016) · Biological Chemistry · doi:10.1515/hsz-2015-0305 · Cited by 152 · see citing works
Mechanistic aspects of carotenoid health benefits – where are we now?
Bohn, T., Bonet, M. L., Borel, P., Keijer, J., Landrier, J., Milisav, I., Ribot, J., Riso, P., Winklhofer-Roob, B., Sharoni, Y., et al. (2021) · Nutrition Research Reviews · doi:10.1017/s0954422421000147 · Cited by 151 · see citing works
Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome
Kokosar, M., Benrick, A., Perfilyev, A., Fornes, R., Nilsson, E., Maliqueo, M., Behre, C. J., Sazonova, A., Ohlsson, C., Ling, C., et al. (2016) · Scientific Reports · doi:10.1038/srep22883 · Cited by 137 · see citing works
Is immunosenescence influenced by our lifetime “dose” of exercise?
Turner, J. E. (2016) · Biogerontology · doi:10.1007/s10522-016-9642-z · Cited by 112 · see citing works
The Interplay Between Adipose Tissue and Vasculature: Role of Oxidative Stress in Obesity
Zhou, Y., Li, H., & Xia, N. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.650214 · Cited by 106 · see citing works
Remely, M., Ferk, F., Sterneder, S., Setayesh, T., Roth, S., Kepčija, T., Noorizadeh, R., Rebhan, I., Greunz, M., Beckmann, J., et al. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3079148 · Cited by 104 · see citing works
The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress
Włodarski, A., Strycharz, J., Wróblewski, A. M., Kasznicki, J., Drzewoski, J., & Śliwińska, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186902 · Cited by 99 · see citing works
A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats
Sandoval‐Salazar, C., Ramı́rez-Emiliano, J., Trejo-Bahena, A., Oviedo-Solís, C. I., & Ortíz, M. S. S. (2016) · Biological Research · doi:10.1186/s40659-016-0075-6 · Cited by 95 · see citing works
The role of lipotoxicity in kidney disease: From molecular mechanisms to therapeutic prospects
Ren, L., Cui, H., Wang, Y., Ju, F., Cai, Y., Gang, X., & Wang, G. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114465 · Cited by 99 · see citing works
The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease
Srikanthan, K., Shapiro, J., & Sodhi, K. (2016) · Molecules · doi:10.3390/molecules21091172 · Cited by 87 · see citing works
Lipid profiles in schizophrenia associated with clinical traits: a five year follow-up study
Solberg, D. K., Bentsen, H., Refsum, H., & Andreassen, O. A. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-1006-3 · Cited by 82 · see citing works
Obesity, altered oxidative stress, and clinical correlates in chronic schizophrenia patients
An, H., Du, X., Huang, X., Qi, L., Jia, Q., Yin, G., Xiao, C., Huang, X., Ning, Y., Cassidy, R. M., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0303-7 · Cited by 80 · see citing works
Esfandi, R., Seidu, I., Willmore, W. G., & Tsopmo, A. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13762 · Cited by 78 · see citing works
Carotenoids in Adipose Tissue Biology and Obesity
Bonet, M. L., Canas, J. A., Ribot, J., & Palou, A. (2016) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-319-39126-7_15 · Cited by 78 · see citing works
Fentoğlu, Ö., Kırzıoğlu, F. Y., Bulut, M. T., Doğuç, D. K., Kulaç, E., Önder, C., & Günhan, M. (2015) · Journal of Periodontology · doi:10.1902/jop.2015.140561 · Cited by 75 · see citing works
Xu, J., Kitada, M., Ogura, Y., & Koya, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.641852 · Cited by 72 · see citing works
The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases
Świątkiewicz, I., Wróblewski, M., Nuszkiewicz, J., Sutkowy, P., Wróblewska, J., & Woźniak, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076382 · Cited by 79 · see citing works
Elrayess, M. A., Almuraikhy, S., Kafienah, W., Al‐Menhali, A. S., Al‐Khelaifi, F., Bashah, M., Žarković, K., Žarković, N., Waeg, G., Alsayrafi, M., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.015 · Cited by 68 · see citing works
Yi, X., Tang, D., Cao, S., Li, T., Gao, H., Ma, T., Yao, T., Li, J., & Chang, B. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3071658 · Cited by 68 · see citing works
Remely, M., Ferk, F., Sterneder, S., Setayesh, T., Kepčija, T., Roth, S., Noorizadeh, R., Greunz, M., Rebhan, I., Wagner, K., et al. (2017) · Nutrients · doi:10.3390/nu9060607 · Cited by 67 · see citing works
Obiako, P., Ayisire, S., & Sayes, C. M. (2024) · Environment International · doi:10.1016/j.envint.2024.108864 · Cited by 65 · see citing works
Sakurai, T., Ogasawara, J., Shirato, K., Izawa, T., Oh‐ishi, S., Ishibashi, Y., Radak, Z. O., Ohno, H., & Kizaki, T. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9410954 · Cited by 66 · see citing works
Mizuno, H., Ekuni, D., Maruyama, T., Kataoka, K., Yoneda, T., Fukuhara, D., Sugiura, Y., Tomofuji, T., Wada, J., & Morita, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188171 · Cited by 67 · see citing works
Roh, H., & So, W.-Y. (2016) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2016.07.006 · Cited by 65 · see citing works
Sharma, S. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113528 · Cited by 65 · see citing works
Diomede, F., Marconi, G. D., Guarnieri, S., D’Attilio, M., Cavalcanti, M. F. X. B., Mariggiò, M. A., Pizzicannella, J., & Trubiani, O. (2019) · Materials · doi:10.3390/ma13010130 · Cited by 60 · see citing works
Alves, M. G., Jesus, T. T., Sousa, M., Goldberg, E., Silva, B. M., & Oliveira, P. F. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666151209151550 · Cited by 58 · see citing works
Alsanea, S., & Liu, D. (2017) · Pharmaceutical Research · doi:10.1007/s11095-017-2230-3 · Cited by 58 · see citing works
The Role of Reactive Oxygen Species in Adipogenic Differentiation
de Villiers, D., Potgieter, M., Ambele, M. A., Adam, L. T., Durandt, C., & Pepper, M. S. (2017) · Advances in experimental medicine and biology · doi:10.1007/5584_2017_119 · Cited by 59 · see citing works
Bays, H. E., Jones, P. H., Jacobson, T. A., Cohen, D. E., Orringer, C. E., Kothari, S. N., Azagury, D. E., Morton, J. M., Nguyen, N. T., Westman, E. C., et al. (2015) · Journal of clinical lipidology · doi:10.1016/j.jacl.2015.12.002 · Cited by 57 · see citing works
Redox Regulation of Lipid Mobilization in Adipose Tissues
Abou-Rjeileh, U., & Contreras, G. A. (2021) · Antioxidants · doi:10.3390/antiox10071090 · Cited by 56 · see citing works
Diamanti‐Kandarakis, E., Papalou, O., Kandaraki, E., & Kassi, G. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0616 · Cited by 55 · see citing works
Dludla, P. V., Mazibuko-Mbeje, S. E., Nyambuya, T. M., Mxinwa, V., Tiano, L., Marcheggiani, F., Cirilli, I., Louw, J., & Nkambule, B. B. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104332 · Cited by 54 · see citing works
Nutritional status of selenium in overweight and obesity: A systematic review and meta-analysis
Fontenelle, L. C., de Araújo, D. S. C., Soares, T. D. C., Cruz, K. J. C., Henriques, G. S., & Marreiro, D. D. N. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.02.007 · Cited by 56 · see citing works
Martino, H. S. D., Dias, M. M. D. S., Noratto, G. D., Talcott, S. T., & Mertens‐Talcott, S. U. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.02.037 · Cited by 52 · see citing works
Chen, R., Yan, J., Liu, P., Wang, Z., & Wang, C. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0007-3 · Cited by 52 · see citing works
Poblete-Aro, C., Russell‐Guzmán, J., Parra, P., Muñoz, M. E. S., González, B. E. V., Cofré-Bolados, C., & Herrera-Valenzuela, T. (2018) · Revista médica de Chile · doi:10.4067/s0034-98872018000300362 · Cited by 50 · see citing works
The Kidney in Obesity: Current Evidence, Perspectives and Controversies
Kounatidis, D. C., Vallianou, N. G., Stratigou, T., Voukali, M., Karampela, Ι., & Dalamaga, Μ. (2024) · Current Obesity Reports · doi:10.1007/s13679-024-00583-y · Cited by 51 · see citing works
Böhm, A., Keuper, M., Meile, T., Zdichavsky, M., Fritsche, A., Häring, H., de Angelis, M. H., Staiger, H., & Frankó, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-69016-9 · Cited by 49 · see citing works
Taherkhani, S., Suzuki, K., & Ruhee, R. T. (2021) · Antioxidants · doi:10.3390/antiox10040594 · Cited by 48 · see citing works
The role of glucose-6-phosphate dehydrogenase in adipose tissue inflammation in obesity
Park, Y. J., Choe, S. S., Sohn, J. H., & Kim, J. B. (2017) · Adipocyte · doi:10.1080/21623945.2017.1288321 · Cited by 48 · see citing works
Pleiotropic Effects of Eugenol: The Good, the Bad, and the Unknown
Aburel, O. M., Pavel, I. Z., Dănilă, M. D., Lelcu, T., Roi, A., Lighezan, R., Muntean, D. M., & Rusu, L. C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3165159 · Cited by 47 · see citing works
Sierżant, K., Perruchot, M., Merlot, É., Floc'H, N. L., & Gondret, F. (2019) · BMC Veterinary Research · doi:10.1186/s12917-019-2107-2 · Cited by 46 · see citing works
Current Status of Obesity: Protective Role of Catechins
Basu, T., Selman, A., Reddy, A. P., & Reddy, P. H. (2023) · Antioxidants · doi:10.3390/antiox12020474 · Cited by 45 · see citing works
Hssaini, L., Hernández, F., Viuda‐Martos, M., Charafi, J., Razouk, R., Houmanat, K., Ouaabou, R., Ennahli, S., Elothmani, D., Hmid, I., et al. (2021) · Molecules · doi:10.3390/molecules26092574 · Cited by 44 · see citing works
Hawthorn fruit acid consumption attenuates hyperlipidemia-associated oxidative damage in rats
Feng, Y., Gao, S., Zhu, T., Sun, G., Zhang, P., Huang, Y., Qu, S., Du, X., & Mou, D. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.936229 · Cited by 44 · see citing works
Effects of Hyperoxia on Oxygen‐Related Inflammation with a Focus on Obesity
González‐Muniesa, P., Garcia-Gerique, L., Quintero, P., Arriaza, S., López-Pascual, A., & Martínez, J. A. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8957827 · Cited by 44 · see citing works
Keijer, J., Escoté, X., Galmés, S., Palou-March, A., Serra, F. A., Aldubayan, M. A., Pigsborg, K., Magkos, F., Baker, E. J., Calder, P. C., et al. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2198605 · Cited by 46 · see citing works
Oxidative Stress and Vascular Damage in the Context of Obesity: The Hidden Guest
Martínez‐Martínez, E., Souza‐Neto, F. V., Jiménez‐González, S., & Cachofeiro, V. (2021) · Antioxidants · doi:10.3390/antiox10030406 · Cited by 42 · see citing works
Allium schoenoprasumL.: a review of phytochemistry, pharmacology and future directions
Singh, V., Chauhan, G., Krishan, P., & Shri, R. (2017) · Natural Product Research · doi:10.1080/14786419.2017.1367783 · Cited by 45 · see citing works
Herroon, M. K., Rajagurubandara, E. N., Diedrich, J. D., Heath, E. I., & Podgorski, I. (2018) · Scientific Reports · doi:10.1038/s41598-017-17800-5 · Cited by 41 · see citing works
Spiegeleer, M. D., Paepe, E. D., Meulebroek, L. V., Gies, I., Schepper, J. D., & Vanhaecke, L. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00394-0 · Cited by 40 · see citing works
Ampawong, S., Isarangkul, D., & Aramwit, P. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216681553 · Cited by 40 · see citing works
Savini, I., Gasperi, V., & Catani, M. (2016) · Springer eBooks · doi:10.1007/978-3-319-19821-7_6 · Cited by 34 · see citing works
Lewis, N., Newell, J., Burden, R., Howatson, G., & Pedlar, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149927 · Cited by 39 · see citing works
Gonzalez‐Mañán, D., D’Espessailles, A., Dossi, C. G., Martín, M. S., Mancilla, R. A., & Tapia, G. (2017) · Journal of Nutrition · doi:10.3945/jn.116.243261 · Cited by 37 · see citing works
Mega, C., Teixeira‐Lemos, E., Fernandes, R., & Reis, F. (2017) · Journal of Diabetes Research · doi:10.1155/2017/5164292 · Cited by 37 · see citing works
Seong, E., Bose, S., Han, S.-Y., Song, E., Lee, M.-J., Nam, Y., & Kim, H. (2021) · The EPMA Journal · doi:10.1007/s13167-021-00243-4 · Cited by 37 · see citing works
Hypomagnesemia and its relation with chronic low-grade inflammation in obesity
de Oliveira, A. R. S., Cruz, K. J. C., Severo, J. S., Morais, J. B. S., de Freitas, T. E. C., Araújo, R. S., & Marreiro, D. D. N. (2017) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.63.02.156 · Cited by 35 · see citing works
Kim, H., & Kwon, O. (2019) · Nutrients · doi:10.3390/nu11071487 · Cited by 35 · see citing works
Yin, C., Luo, X., Duan, Y., Duan, W., Zhang, H., He, Y., Sun, G., & Sun, X. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.05.032 · Cited by 35 · see citing works
Goguet-Rubio, P., Klug, R. L., Sharma, D. L., Srikanthan, K., Puri, N., Lakhani, V., Nichols, A., O'Hanlon, K. M., Abraham, N. G., Shapiro, J. I., et al. (2017) · International Journal of Medical Sciences · doi:10.7150/ijms.18988 · Cited by 35 · see citing works
John, C. M., & Arockiasamy, S. (2019) · Natural Product Research · doi:10.1080/14786419.2019.1573820 · Cited by 34 · see citing works
Environmental toxicants, oxidative stress and health adversities: interventions of phytochemicals
Dwivedi, S., Kushalan, S., Paithankar, J. G., D’Souza, L. C., Hegde, S., & Sharma, A. (2021) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgab044 · Cited by 34 · see citing works
Dong, Y., Gao, G., Fan, H., Li, S., Li, X., & Liu, W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124778 · Cited by 34 · see citing works
Histone Carbonylation Is a Redox-Regulated Epigenomic Mark That Accumulates with Obesity and Aging
Hauck, A. K., Zhou, T., Upadhyay, A., Sun, Y., O’Connor, M. B., Chen, Y., & Bernlohr, D. (2020) · Antioxidants · doi:10.3390/antiox9121210 · Cited by 33 · see citing works
Anthocyanins ameliorate obesity-associated metainflammation: Preclinical and clinical evidence
Santamarina, A. B., Calder, P. C., Estadella, D., & Pisani, L. P. (2023) · Nutrition Research · doi:10.1016/j.nutres.2023.04.004 · Cited by 37 · see citing works
Goudarzi, M., Weber, W., Chung, J., Doyle‐Eisele, M., Melo, D. R., Mak, T. D., Strawn, S. J., Brenner, D. J., Guilmette, R. A., & Fornace, A. J. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00576 · Cited by 32 · see citing works
Ju, J., Zheng, Z., Xu, Y., Cao, P., Li, J., Li, Q., & Liu, Y. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-0980-0 · Cited by 32 · see citing works
Zhou, Y., Jiang, Q., Zhao, S., Yan, B., & Zhou, X. (2019) · Journal of Food Science · doi:10.1111/1750-3841.14958 · Cited by 31 · see citing works
Pregnancy as a model for aging
Giller, A., Andrawus, M., Gutman, D., & Atzmon, G. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101093 · Cited by 30 · see citing works
Kuczmarski, M. F., Pohlig, R. T., Stave Shupe, E., Zonderman, A. B., & Evans, M. K. (2018) · The Journal of nutrition, health and aging · doi:10.1007/s12603-018-1006-8 · Cited by 30 · see citing works
Lütfioğlu, M., Aydoğdu, A., Atabay, V. E., Sakallıoğlu, E. E., & Avcı, B. (2017) · Brazilian Oral Research · doi:10.1590/1807-3107bor-2017.vol31.0110 · Cited by 30 · see citing works
Zhang, D., Cheng, C., Cao, M., Wang, T., Chen, X., Zhao, Y., Wang, B., Ren, Y., Liu, D., Liu, L., et al. (2020) · Journal of Diabetes · doi:10.1111/1753-0407.13021 · Cited by 30 · see citing works
Baban, B., Khodadadi, H., Salles, É. L., Costigliola, V., Morgan, J. C., Hess, D. C., Vaibhav, K., Dhandapani, K. M., & Yu, J. C.-K. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101487 · Cited by 31 · see citing works
Menezes, E. F., Peixoto, L. G., Teixeira, R. R., Justino, A. B., Puga, G. M., & Espíndola, F. S. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7218936 · Cited by 29 · see citing works
Urm1: an essential regulator of JNK signaling and oxidative stress in Drosophila melanogaster
Khoshnood, B., Dacklin, I., & Grabbe, C. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2121-x · Cited by 29 · see citing works
Vivarelli, F., Canistro, D., Sapone, A., Nicola, G. R. D., Marquillas, C. B., Iori, R., Antonazzo, I. C., Gentilini, F., & Paolini, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150913 · Cited by 28 · see citing works
Visceral Fat Dysfunctions in the Rat Social Isolation Model of Psychosis
Schiavone, S., Camerino, G. M., Mhillaj, E., Zotti, M., Colaianna, M., Giorgi, A. D., Trotta, A., Cantatore, F. P., Conte, E., Bové, M., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00787 · Cited by 28 · see citing works
Metabolic modulation predicts heart failure tests performance
Contaifer, D., Buckley, L. F., Wohlford, G. F., Kumar, N. G., Morriss, J. M., Ranasinghe, A. D., Carbone, S., Canada, J. M., Trankle, C. R., Abbate, A., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218153 · Cited by 27 · see citing works
Chama, M. K. H., Liang, H., Huang, D., Ge, X., Ren, M., Zhang, L., Wu, L., & Ji, K. (2021) · Aquaculture Reports · doi:10.1016/j.aqrep.2021.100872 · Cited by 26 · see citing works
Roy, J. R., Janaki, C. S., Jayaraman, S., Vijayalakshmi, P., Balaji, T., Vijayamalathi, M., & Veeraraghavan, V. P. (2022) · Antioxidants · doi:10.3390/antiox11102081 · Cited by 28 · see citing works
Maity, J., Dey, T., Banerjee, A., Chattopadhyay, A., Das, A. R., & Bandyopadhyay, D. (2022) · Journal of Pineal Research · doi:10.1111/jpi.12847 · Cited by 26 · see citing works
- Authors
- Le Lay, S., Simard, G., Martinez, M. C., & Andriantsitohaina, R.
- Affiliations
- INSERM UMR 1063, “Stress Oxydant et Pathologies Métaboliques”, Institut de Biologie en Santé, 4 rue Larrey, 49933 Angers, France
- Inserm (FR)
- Corresponding author
- Andriantsitohaina, Ramaroson
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-18
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC4131099
- OpenAlex
- W2139770322
- Cited by
- 291
- References
- 197
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 25 · 2023: 28 · 2022: 25 · 2021: 35 · 2020: 16 · 2019: 29 · 2018: 21 · 2017: 30 · 2016: 33 · 2015: 24 · 2014: 4 · 2012: 2
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- oxidative stress, obesity, adipose tissue, reactive oxygen species, insulin resistance, metabolic disorders, type 2 diabetes, hepatic steatosis, hyperlipidemia, antioxidants, treatment options
- MeSH terms
- Antioxidants, Humans, Hyperglycemia, Hyperlipidemias, Obesity, Renin-Angiotensin System, Reactive Oxygen Species, Oxidative Stress, NADPH Oxidases, Adipose Tissue, White
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review