Cited by 291Adipokines, Inflammation, and Metabolic DiseasesRedox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Oxidative stress and metabolic pathologies: from an adipocentric point of view

Open access
Le Lay, Soazig, Simard, Gilles, Martinez, Maria Carmen, Andriantsitohaina, Ramaroson·2014·Oxidative Medicine and Cellular Longevity

Abstract

Oxidative stress plays a pathological role in the development of various diseases including diabetes, atherosclerosis, or cancer. Systemic oxidative stress results from an imbalance between oxidants derivatives production and antioxidants defenses. Reactive oxygen species (ROS) are generally considered to be detrimental for health. However, evidences have been provided that they can act as second messengers in adaptative responses to stress. Obesity represents a major risk factor for deleterious associated pathologies such as type 2 diabetes, liver, and coronary heart diseases. Many evidences regarding obesity-induced oxidative stress accumulated over the past few years based on established correlations of biomarkers or end-products of free-radical-mediated oxidative stress with body mass index. The hypothesis that oxidative stress plays a significant role in the development of metabolic disorders, especially insulin-resistance state, is supported by several studies where treatments reducing ROS production reverse metabolic alterations, notably through improvement of insulin sensitivity, hyperlipidemia, or hepatic steatosis. In this review, we will develop the mechanistic links between oxidative stress generated by adipose tissue in the context of obesity and its impact on metabolic complications development. We will also attempt to discuss potential therapeutic approaches targeting obesity-associated oxidative stress in order to prevent associated-metabolic complications.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1155/2014/908539

Cites

199 of 199 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Numerous scientific investigations have substantiated a robust correlation between hyperlipidemia and oxidative stress, with oxidative stress assuming a pivotal role in the development of metabolic disorders.

    “Numerous scientific investigations have substantiated a robust correlation between hyperlipidemia and oxidative stress, with oxidative stress assuming a pivotal role in the development of metabolic disorders (Le Lay et al., 2014; Okuno et al., 2018; Raut and Khullar, 2023).”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Le Lay, S., Simard, G., Martinez, M. C., & Andriantsitohaina, R.
Affiliations
  • INSERM UMR 1063, “Stress Oxydant et Pathologies Métaboliques”, Institut de Biologie en Santé, 4 rue Larrey, 49933 Angers, France
  • Inserm (FR)
Corresponding author
Andriantsitohaina, Ramaroson
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2014
Volume
2014
Pages
1-18
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
OpenAlex
W2139770322
Cited by
291
References
197
Citations by year
2026: 6 · 2025: 13 · 2024: 25 · 2023: 28 · 2022: 25 · 2021: 35 · 2020: 16 · 2019: 29 · 2018: 21 · 2017: 30 · 2016: 33 · 2015: 24 · 2014: 4 · 2012: 2
FWCI
4.05
Type
journal article
Language
en
Open access
Locations
  • Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
oxidative stress, obesity, adipose tissue, reactive oxygen species, insulin resistance, metabolic disorders, type 2 diabetes, hepatic steatosis, hyperlipidemia, antioxidants, treatment options
MeSH terms
Antioxidants, Humans, Hyperglycemia, Hyperlipidemias, Obesity, Renin-Angiotensin System, Reactive Oxygen Species, Oxidative Stress, NADPH Oxidases, Adipose Tissue, White

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review