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Cited by 91RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancerCancer-related Molecular Pathways

Translate to divide: сontrol of the cell cycle by protein synthesis

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Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA, Polymenis, Michael, Aramayo, Rodolfo, Department of Biology, Texas A&M University, College Station, TX 77843, USA·2015·Microbial Cell
DOI 10.15698/mic2015.04.198PMC PMC5348972
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Abstract

Protein synthesis underpins much of cell growth and, consequently, cell multiplication. Understanding how proliferating cells commit and progress into the cell cycle requires knowing not only which proteins need to be synthesized, but also what determines their rate of synthesis during cell division.

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  • Inhibition of rRNA production can halt cell cycle activity with accompanying decreases in cell size.

    “inhibition of rRNA production can halt cell cycle activity (Polymenis and Aramayo, 2015) with accompanying decreases in cell size”

    From PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress (2021) · cites this paper as Polymenis and Aramayo, 2015

    In “INITIATE TO START?” (page unavailable), the table lists RNA polymerase I subunits with G1 arrest, supporting the claim that disrupting rRNA production can halt cell-cycle progression in yeast. “RIBOSOME MAKES PROTEIN MAKES CELLS?” (page unavailable) reports smaller cells for some ribosomal-protein mutants, but does not establish that inhibiting rRNA production itself causes the accompanying decrease in cell size. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • In eukaryotic cells, deletion and/or knockdown of key genes regulating protein synthesis, such as eIFs, results in delayed cell cycle entry.

    “Hence, in eukaryotic cells, deletion and/or knockdown of key genes regulating protein synthesis, such as translation elongation initiation factors (eIFs), several of which are repressed by IL-1 in our dataset, results in delayed cell cycle entry (Polymenis and Aramayo, 2015).”

    From PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress (2021) · cites this paper as Polymenis and Aramayo, 2015

    The “INITIATE TO START?” section (page unavailable) reports that inhibiting several eIFs causes G1 arrest and prevents initiation of a new round of division in yeast. This supports the knockdown-like part of the claim, but the cited genetic evidence is in yeast; it does not establish the stated result generally across eukaryotic cells or specifically for eIF gene deletion. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Department of Biochemistry and Biophysics, T. A. U., Polymenis, M., Aramayo, R., & Department of Biology, T. A. U.
Affiliations
Texas A&M University (US)
Corresponding author
  • Polymenis, Michael
  • Aramayo, Rodolfo
ORCID
Venue
Microbial Cell
Publisher
Shared Science Publishers OG
Published
2015-04-06
Volume
2
Issue
4
Pages
94-104
ISSN
2311-2638 (ISSN-L)
DOI
10.15698/mic2015.04.198
PMC
PMC5348972
OpenAlex
W2104240441
Cited by
91
References
5
Citations by year
2026: 5 · 2025: 11 · 2024: 8 · 2023: 8 · 2022: 8 · 2021: 6 · 2020: 21 · 2019: 9 · 2018: 4 · 2017: 8 · 2016: 3
FWCI
0.48
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Microbial Cell (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • OakTrust (Texas A&M University Libraries) (submittedVersion, cc-by)
Funders
  • National Science Foundation (0818248)
  • National Institutes of Health
  • National Institute of General Medical Sciences (R01GM058770)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords
cell cycle regulation, protein synthesis, cell proliferation, cell division, cell growth, translation rate, protein synthesis rate

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