Further understanding of tau phosphorylation: implications for therapy

Medina, Miguel; Avila, Jesús

doi:10.1586/14737175.2015.1000864

Cited by 41Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment Research

Further understanding of tau phosphorylation: implications for therapy

Medina, Miguel, Avila, Jesús·2015·Expert Review of Neurotherapeutics

DOI 10.1586/14737175.2015.1000864

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Abstract

Tau is a brain microtubule-associated protein that regulates microtubule structure and function. Prominent tau neurofibrillary pathology is a common feature in a number of neurodegenerative disorders collectively referred to as tauopathies, the most common of which is Alzheimer's disease. Beyond its classical role as a microtubule-associated protein, recent advances in our understanding of tau cellular functions have unveiled novel important tau cellular functions that may also play a pivotal role in pathogenesis and render novel targets for therapeutic intervention. Regulation of tau behavior and function under physiological and pathological conditions is mainly achieved through post-translational modifications, especially phosphorylation, which has significant implications for the development of novel therapeutic approaches in a number of neurodegenerative disorders.

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Different disease stages may involve unique activation of different kinases that preferentially phosphorylate tau at specific sites.
“Rather, it might suggest that with different stages of the disease (Fig. 1), there are unique activations of the different kinases responsible for phosphorylating the tau protein preferentially at specific sites41.”
From A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease (2020) · cites this paper as [41]

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Authors: Medina, M., & Avila, J.
Affiliations: Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
ORCID: Medina, Miguel
Venue: Expert Review of Neurotherapeutics
Publisher: Informa UK Limited
Published: 2015-01-02
Volume: 15
Issue: 1
Pages: 115-122
ISSN: 1473-7175 (ISSN-L)
1744-8360
DOI: 10.1586/14737175.2015.1000864
OpenAlex: W1968219915
Cited by: 41
References: 91
Citations by year: 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 13 · 2015: 4
FWCI: 0.98
Type: journal article
Language: en
Open access: closed
Locations: Expert Review of Neurotherapeutics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: tau phosphorylation, tau protein, tauopathy, Alzheimer's disease, neurofibrillary tangles, microtubule-associated proteins, post-translational modification, neurodegenerative diseases, therapeutic target
MeSH terms: Humans, Phosphorylation, Antipsychotic Agents, tau Proteins, Tauopathies

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Further understanding of tau phosphorylation: implications for therapy

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