Treatment of invasive candidiasis: between guidelines and daily clinical practice
Open accessAbstract
Invasive candidiasis, including candidemia (IC/C), is a major cause of morbidity and mortality among hospitalized patients. While incidence is higher in intensive care units, the majority of cases of candidemia are documented in medical wards. Although Candida albicans is still the most frequently isolated species, IC/C due to non-albicans species, usually less susceptible to fluconazole, is increasing. Early identification of patients at risk, knowledge of local epidemiology and prompt efforts to define etiologic diagnosis play a pivotal role for appropriateness. Starting therapy with an echinocandin, switching then to fluconazole when possible, seems to represent a potentially useful strategy for the management of IC/C. The choice between the three echinocandins should be based on the specific indications, pharmacokinetic/pharmacodynamic profile, clinical experience and relative cost.
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Yeoh, S. F., Lee, T. J., Chew, K. L., Lin, S., Yeo, D., & Setia, S. (2018) · Infection and Drug Resistance · doi:10.2147/idr.s165676 · Cited by 20 · see citing works
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- Authors
- Tagliaferri, E., & Menichetti, F.
- Affiliations
- Azienda Ospedaliera Universitaria Pisana (IT)
- Corresponding author
- Tagliaferri, Enrico
- Venue
- Expert Review of Anti-infective Therapy
- Publisher
- Informa UK Limited
- Published
- 2015-03-27
- Volume
- 13
- Issue
- 6
- Pages
- 685-689
- ISSN
- 1478-7210 (ISSN-L)
- 1744-8336
- OpenAlex
- W2088458792
- Cited by
- 14
- References
- 38
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 1
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Expert Review of Anti-infective Therapy (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Keywords
- invasive candidiasis, candidemia, echinocandins, fluconazole, non-albicans Candida, Candida albicans, antifungal therapy, treatment guidelines, clinical practice, intensive care unit, internal medicine ward, pharmacokinetics/pharmacodynamics
- MeSH terms
- Antifungal Agents, Candida, Humans, Intensive Care Units, Fluconazole, Disease Management, Echinocandins, Candidiasis, Invasive, Candidemia
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