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Neuroinflammation in the pathophysiology of Parkinson’s disease and therapeutic evidence of anti-inflammatory drugs

Bassani, Taysa Bervian, Vital, Maria A.B.F., Rauh, Laryssa K.·2015·Arquivos de Neuro-Psiquiatria
DOI 10.1590/0004-282x20150057
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Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disease affecting approximately 1.6% of the population over 60 years old. The cardinal motor symptoms are the result of progressive degeneration of substantia nigra pars compacta dopaminergic neurons which are involved in the fine motor control. Currently, there is no cure for this pathology and the cause of the neurodegeneration remains unknown. Several studies suggest the involvement of neuroinflammation in the pathophysiology of PD as well as a protective effect of anti-inflammatory drugs both in animal models and epidemiological studies, although there are controversial reports. In this review, we address evidences of involvement of inflammatory process and possible therapeutic usefulness of anti-inflammatory drugs in PD.

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Metadata

Authors
Bassani, T. B., Vital, M. A. B. F., & Rauh, L. K.
Affiliations
  • Pontifícia Universidade Católica do Paraná, Brazil; Universidade Federal do Paraná, Brazil
  • Universidade Federal do Paraná, Brazil
  • Pontifícia Universidade Católica do Paraná, Brazil
Venue
Arquivos de Neuro-Psiquiatria
Publisher
FapUNIFESP (SciELO)
Published
2015-07
Volume
73
Issue
7
Pages
616-623
ISSN
0004-282X
DOI
10.1590/0004-282x20150057
Cited by
78
References
2

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