Imaging of microglia in patients with neurodegenerative disorders

Politis, Marios

doi:10.3389/fphar.2012.00096

Cited by 112Neuroinflammation and Neurodegeneration MechanismsMedical Imaging Techniques and ApplicationsNeurological Disease Mechanisms and Treatments

Imaging of microglia in patients with neurodegenerative disorders

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Politis, Marios·2012·Frontiers in Pharmacology

DOI 10.3389/fphar.2012.00096PMC PMC3361961

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Abstract

Microglia constitute the main immune defense in the central nervous system. In response to neuronal injury, microglia become activated, acquire phagocytic properties, and release a wide range of pro-inflammatory mediators that are essential for the annihilation of the neuronal insult. Although the role of microglial activation in acute neuronal damage is well defined, the pathophysiological processes underlying destructive or protective role to neurons following chronic exposure to microglial activation is still a subject of debate. It is likely that chronic exposure induces detrimental effects by promoting neuronal death through the release of neurotoxic factors. Positron emission tomography (PET) imaging with the use of translocator protein (TSPO) radioligands provides an in vivo tool for tracking the progression and severity of neuroinflammation in neurodegenerative disease. TSPO expression is correlated to the extent of microglial activation and the measurement of TSPO uptake in vivo with PET is a useful indicator of active disease. Although understanding of the interaction between radioligands and TSPO is not completely clear, there is a wide interest in application of TSPO imaging in neurodegenerative disease. In this article, we aim to review the applications of in vivo microglia imaging in neurodegenerative disorders such as Parkinson's disease, Huntington's disease, Dementias, and Multiple Sclerosis.

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Current PET imaging ligands, including TSPO, are not selective for microglia and are better markers of neuroinflammation.
“Current PET imaging ligands, including TSPO, are not selective for microglia and are better markers of neuroinflammation (Politis et al., 2012).”
From Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain (2018) · cites this paper as Politis et al., 2012
Methods to image microglia exist and are being used to test treatment effects on microglia.
“Methods to image microglia exist and are being used to test the effect of treatments on microglia205–210.”
From Microglial signatures and their role in health and disease (2018) · cites this paper as [210]

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Authors: Politis, M.
Affiliations: Hammersmith Hospital (GB)
Corresponding author: Politis, Marios
ORCID: Politis, Marios
Venue: Frontiers in Pharmacology
Publisher: Frontiers Media SA
Published: 2012
Volume: 3
Pages: 96-96
ISSN: 1663-9812 (ISSN-L)
DOI: 10.3389/fphar.2012.00096
PMC: PMC3361961
OpenAlex: W2077735428
Cited by: 111
References: 118
Citations by year: 2026: 2 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 9 · 2021: 4 · 2020: 14 · 2019: 8 · 2018: 5 · 2017: 11 · 2016: 8 · 2015: 11 · 2014: 16 · 2013: 10 · 2012: 3
FWCI: 6.44
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
Locations: Frontiers in Pharmacology (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (publishedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Michael J. Fox Foundation for Parkinson's Research
Parkinson's UK (J-0704)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: microglial activation, neuroinflammation, translocator protein (TSPO), positron emission tomography, neurodegenerative diseases, Parkinson's disease, Huntington's disease, dementia, multiple sclerosis, neurotoxicity

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