The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
The role of oxytocin in cardiovascular regulation
Open accessAbstract
Studies of body volume expansion have indicated that lesions of the anteroventral third ventricle and median eminence block the release of atrial natriuretic peptide (ANP) into the circulation. Detailed analysis of the lesions showed that activation of oxytocin (OT)-ergic neurons is responsible for ANP release, and it has become clear that activation of neuronal circuitry elicits OT secretion into the circulation, activating atrial OT receptors and ANP release from the heart. Subsequently, we have uncovered the entire functional OT system in the rat and the human heart. An abundance of OT has been observed in the early development of the fetal heart, and the capacity of OT to generate cardiomyocytes (CMs) has been demonstrated in various types of stem cells. OT treatment of mesenchymal stem cells stimulates paracrine factors beneficial for cardioprotection. Cardiovascular actions of OT include: i) lowering blood pressure, ii) negative inotropic and chronotropic effects, iii) parasympathetic neuromodulation, iv) vasodilatation, v) anti-inflammatory activity, vi) antioxidant activity, and vii) metabolic effects. OT actions are mediated by nitric oxide and ANP. The beneficial actions of OT may include the increase in glucose uptake by CMs and stem cells, reduction in CM hypertrophy, oxidative stress, and mitochondrial protection of several cell types. In experimentally induced myocardial infarction in rats, continuous in vivo OT delivery improves cardiac healing and cardiac work, reduces inflammation, and stimulates angiogenesis. Because OT plays anti-inflammatory and cardioprotective roles and improves vascular and metabolic functions, it demonstrates potential for therapeutic use in various pathologic conditions.
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“There has also been some suggestion that oxytocin has important effects in the periphery, moderating cardiovascular functioning and the peripheral cortisol response, which may influence social behaviour (Cardoso et al., 2014b;Gutkowska et al., 2014).”
From Meta-analysis of the effects of intranasal oxytocin on interpretation and expression of emotions (2017) · cites this paper as Gutkowska et al., 2014
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Cites
de Bold, A. J., Borenstein, H., Veress, A. T., & Sonnenberg, H. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90370-2 · Cited by 3,144 · cited 1×
“(17) who showed that the heart is the site of the synthesis of a potent diuretic and natriuretic hormone.”
BackgroundOxidative stress and heart failure
Tsutsui, H., Kinugawa, S., & Matsushima, S. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00554.2011 · Cited by 1,277
On some physiological actions of ergot
Dale, H. H. (1906) · The Journal of Physiology · doi:10.1113/jphysiol.1906.sp001148 · Cited by 1,011 · cited 1×
“Sir Henry Dale (2) reported in 1906 that intravenous injection of ox posterior pituitary gland extracts into a cat caused the animal’s uterus to contract.”
BackgroundThe immune system and cardiac repair
Frangogiannis, N. G. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.06.007 · Cited by 667 · cited 1×
“Furthermore, OT infusion has been shown to stimulate transforming growth factor (TGF)-b expression in injured heart tissue (36), pointing to improvement of LV function (68) as well as beneficial effects such as reduced apoptosis and increased cell proliferation (69).”
BackgroundAdult Cardiac Sca-1-positive Cells Differentiate into Beating Cardiomyocytes
Matsuura, K., Nagai, T., Nishigaki, N., Oyama, T., Nishi, J., Wada, H., Sano, M., Toko, H., Akazawa, H., Sato, T., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310822200 · Cited by 638
THE SEQUENCE OF AMINO ACIDS IN OXYTOCIN, WITH A PROPOSAL FOR THE STRUCTURE OF OXYTOCIN
du Vigneaud, V., Ressler, C., & Trippett, S. (1953) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)49238-1 · Cited by 594
Ovize, M., Baxter, G. F., Lisa, F. D., Ferdinandy, P., David Garcia-dorado, A., Hausenloy, D. J., Heusch, G., Vinten-Johansen, J., Yellon, D. M., & Schulz, R. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq129 · Cited by 502 · cited 2×
“Indeed, PKG inhibits the opening of mPTP through the prolongation of intracellular acidosis, resulting in Ca normalization and prevention of hypercontracture (51).”
BackgroundOxytocin and autistic disorder: alterations in peptide forms
Green, L., Fein, D., Modahl, C., Feinstein, C., Waterhouse, L., & Morris, M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01139-8 · Cited by 404 · cited 1×
“The deficit in processing of the extended forms in patients with autism might be implicated in the development of this syndrome (71).”
BackgroundOn the Physiological Action of Extracts of Pituitary Body and certain other Glandular Organs
Oliver, G. D., & Schäfer, E. A. (1895) · The Journal of Physiology · doi:10.1113/jphysiol.1895.sp000565 · Cited by 371
Anxiety and stress responses in female oxytocin deficient mice
Amico, J. A., Mantella, R. C., Vollmer, R. R., & Li, X. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.0953-8194.2004.01161.x · Cited by 327 · cited 1×
“OT-deficient mice exhibit increased stress responses associated with a significant hyperactivation of the hypothalamic-pituitaryadrenal (HPA) axis (63).”
Background
Research works printed but not linked: 3
- Woodbury AR, 1940, Blood pressure studies of the effects of pituitary preparations on the human, Am J Physiol, 129, 500
- von den Velden R, 1913, [Die Nierenwirkung von Hypophysenextrakten beim Menschen], Klin Wochschr, 50, 2083
- Ondrejcakova M, 2009, Oxytocin exerts protective effects on in vitro myocardial injury induced by ischemia and reperfusion, Can J Physiol Pharmacol, 87, 137
Cited by
Sorted by citations
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Is oxytocin “nature’s medicine”
Carter, C. S., Kenkel, W. M., MacLean, E. L., Wilson, S. R., Perkeybile, A. M., Yee, J. R., Ferris, C. F., Nazarloo, H. P., Porges, S. W., Davis, J. M., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019398 · Cited by 394
“Studies in mice also suggest that both oxytocin and the extended form have a critical role in tissue differentiation in the heart and in survival or restoration of heart tissue after damage (such as hypoxia) or disease (such as diabetes) (Gutkowska et al., 2014; Jankowski et al., 2016).”
BackgroundMeta-analysis of the effects of intranasal oxytocin on interpretation and expression of emotions
Leppanen, J., Ng, K. W., Tchanturia, K., & Treasure, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.010 · Cited by 188
“There has also been some suggestion that oxytocin has important effects in the periphery, moderating cardiovascular functioning and the peripheral cortisol response, which may influence social behaviour (Cardoso et al., 2014b; Gutkowska et al., 2014).”
The Role of Oxytocin in Cardiovascular Protection
Jankowski, M., Broderick, T. L., & Gutkowska, J. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.02139 · Cited by 101
The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans
Kerem, L., & Lawson, E. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147737 · Cited by 104
Metadata
- Authors
- Gutkowska, J., Jankowski, M., & Antunes-Rodrigues, J.
- Affiliations
- Centre Hospitalier de l’Université de Montréal (CA)
- Universidade de São Paulo, Brasil
- ORCID
- Jankowski, M.
- Venue
- Brazilian Journal of Medical and Biological Research
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2014-03-18
- Volume
- 47
- Issue
- 3
- Pages
- 206-214
- ISSN
- 0100-879X (ISSN-L)
- 1414-431X
- PMC
- PMC3982941
- OpenAlex
- W2167829495
- Cited by
- 131
- References
- 73
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 11 · 2023: 14 · 2022: 8 · 2021: 13 · 2020: 20 · 2019: 14 · 2018: 15 · 2017: 15 · 2016: 9 · 2015: 3
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Brazilian Journal of Medical and Biological Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, cardiovascular regulation, atrial natriuretic peptide, anteroventral third ventricle, median eminence, oxytocinergic neurons, cardiomyocyte development, mesenchymal stem cells, cardioprotection, nitric oxide, myocardial infarction, angiogenesis, oxidative stress, mitochondrial protection, anti-inflammatory activity, vasodilation, blood pressure, cardiomyocyte hypertrophy, glucose uptake
- MeSH terms
- Animals, Cardiotonic Agents, Cell Differentiation, Heart, Humans, Atrial Natriuretic Factor, Nitric Oxide, Oxytocin, Signal Transduction, Receptors, Oxytocin, Oxidative Stress, Myocytes, Cardiac, Rats
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