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The role of oxytocin in cardiovascular regulation
Open accessAbstract
Studies of body volume expansion have indicated that lesions of the anteroventral third ventricle and median eminence block the release of atrial natriuretic peptide (ANP) into the circulation. Detailed analysis of the lesions showed that activation of oxytocin (OT)-ergic neurons is responsible for ANP release, and it has become clear that activation of neuronal circuitry elicits OT secretion into the circulation, activating atrial OT receptors and ANP release from the heart. Subsequently, we have uncovered the entire functional OT system in the rat and the human heart. An abundance of OT has been observed in the early development of the fetal heart, and the capacity of OT to generate cardiomyocytes (CMs) has been demonstrated in various types of stem cells. OT treatment of mesenchymal stem cells stimulates paracrine factors beneficial for cardioprotection. Cardiovascular actions of OT include: i) lowering blood pressure, ii) negative inotropic and chronotropic effects, iii) parasympathetic neuromodulation, iv) vasodilatation, v) anti-inflammatory activity, vi) antioxidant activity, and vii) metabolic effects. OT actions are mediated by nitric oxide and ANP. The beneficial actions of OT may include the increase in glucose uptake by CMs and stem cells, reduction in CM hypertrophy, oxidative stress, and mitochondrial protection of several cell types. In experimentally induced myocardial infarction in rats, continuous in vivo OT delivery improves cardiac healing and cardiac work, reduces inflammation, and stimulates angiogenesis. Because OT plays anti-inflammatory and cardioprotective roles and improves vascular and metabolic functions, it demonstrates potential for therapeutic use in various pathologic conditions.
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“There has also been some suggestion that oxytocin has important effects in the periphery, moderating cardiovascular functioning and the peripheral cortisol response, which may influence social behaviour (Cardoso et al., 2014b;Gutkowska et al., 2014).”
From Meta-analysis of the effects of intranasal oxytocin on interpretation and expression of emotions (2017) · cites this paper as Gutkowska et al., 2014
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Oxytocin is present in islets and plays a role in beta-cell function and survival
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ΔMST and the Regulation of Cardiac CSE and OTR Expression in Trauma and Hemorrhage
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“OTR and CSE are constitutively expressed in the heart [15,33] and are reported to be cardioprotective [32,33,35–37].”
BackgroundOxytocin in The Prevention of Injury Due to Testicular Torsion/Detorsion in Rats
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“ASDH primarily induces mechanical brain injury due to an increase in ICP as a consequence of subdural accumulation of blood (Hamahata and Nakagawa, 2020) and can lead to distortions, shifts and herniation of the brain parenchyma (Nyanzu et al., 2017).”
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“OT and OXTR were found in the atria and ventricles of rat hearts and in the large blood vessels, indicating a possible autocrine and paracrine role played by OT, regulating the vascular tone and the atrial and ventricular load [80,81].”
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“…oxytocin primarily acts on receptors on parasympathetic postganglionic fibres, stimulating the release of acetylcholine (Mukaddam-Daher et al., 2001), which activates muscarinic receptors in the sinoatrial nodal tissue, resulting in reduced heart rate and contractility (Gutkowska et al., 2014).”
BackgroundAdrenomedullin as a Protein with Multifunctional Behavior and Effects in Various Organs and Tissues
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Optimization of Mesenchymal Stem Cells to Increase Their Therapeutic Potential
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“Cardioprotective activities of oxytocin are lowering of blood pressure (BP), parasympathetic neuromodulation, anti-inflammatory activity and vasodilatation [6,7].”
A functional selective effect of oxytocin secreted under restraint stress in rats
Belém-Filho, I. J. A., Brasil, T. F. S., Fortaleza, E. A. T., Antunes‐Rodrigues, J., & Corrêa, F. M. D. A. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174182 · Cited by 7
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“It has pleiotropic effects and is expressed in numerous organ systems: the gastrointestinal tract [93], kidney [94], heart [94,95], and the cardiovascular system, wherein it has been shown to be cardioprotective [96–99] by improving glucose utilization [100,101], stimulating the NO system [102,103], and having negativ…”
BackgroundOxytocin: an expansive review of its mechanisms, functions, and therapeutic potential
Ueda, Y. (2023) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2023.19.1.1499 · Cited by 5
“Oxytocin has been found to modulate cardiovascular parameters, including blood pressure and heart rate, suggesting a potential role in cardiovascular homeostasis [8].”
BackgroundNeuroendocrine Regulation of Hydrosaline Metabolism
Ruginsk, S. G., Elias, L. L. K., Antunes‐Rodrigues, J., & Mecawi, A. S. (2022) · Endocrinology · doi:10.1007/978-3-030-44628-4_1-1 · Cited by 5
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Intranasal oxytocin has sympathoexcitatory effects on vascular tone in healthy males
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“The hemodynamic effects accompanied by an infusion or bolus of oxytocin are welldocumented (25).”
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The Role of Central Oxytocin in Autonomic Regulation
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Özer, Ö. F. (2017) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2017.65 · Cited by 4
“Recent evidence suggests that OT is involved in the regulation of cardiovascular functions (10, 11).”
BackgroundProtein/ Hormone Based Nanoparticles as Carriers for Drugs Targeting Protein-Protein Interactions
Al-Suhaimi, E. A., Ravinayagam, V., Jermy, B. R., Tarhini, M., & Elaı̈ssari, A. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666190304152320 · Cited by 4
Effects of oxytocin administration on the hydromineral balance of median eminence‐lesioned rats
Mahía, J., Bernal, A., & Puerto, A. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12778 · Cited by 4
“Male Wistar rats (300‐370 g) were obtained from a breeding colony of the University of Granada.”
InfluentialBlood oxytocin levels are not associated with ADHD tendencies and emotionality in healthy adults
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THE HEART OF STRENGTH: THE STRONG BLACK WOMAN SCHEMA AND CARDIOVASCULAR DISEASE RISK
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The Brain, Explained: A Comprehensive Theory of Brain FunctionPreprint
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Oxytocin-Induced Acute Pulmonary Edema: A Case Report and Literature Review
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“Oxytocin also exerts a transient negative chronotropic and ionotropic effect on the heart [12].”
BackgroundNeuroendocrine Control of the Vascular System
Dalmasso, C., & Loria, A. S. (2023) · Masterclass in neuroendocrinology · doi:10.1007/978-3-031-39995-4_3 · Cited by 2
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Oxytocin, the Love Hormone, in Stem Cell Differentiation
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Potential use in cellular treatment of oxytocin
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McCook, O., Denoix, N., & Merz, T. (2021) · Trauma Care · doi:10.3390/traumacare1030016 · Cited by 2
Neuroendocrine Regulation of Hydrosaline Metabolism
Ruginsk, S. G., Elias, L. L. K., Antunes‐Rodrigues, J., & Mecawi, A. S. (2023) · Endocrinology · doi:10.1007/978-3-031-27119-9_1 · Cited by 2
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Changes in peripheral oxytocin and vasopressin during a silent month-long Insight meditation retreat
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“This view helps to explain oxytocin ’ s involvement in processes like digestion (101), metabolism (102), the immune system (103), and cardiovascular function (104).”
BackgroundMünz, F., Abele, N., Zink, F., Wolfschmitt, E.-M., Hogg, M., Barck, C., Anetzberger, J., Hoffmann, A., Gröger, M., Calzia, E., et al. (2024) · Biomolecules · doi:10.3390/biom14111385 · Cited by 1
“It also has cardioprotective properties by enhancing glucose utilization [13,14], stimulating the nitric oxide system [15,16], and exerting a negative chronotropic effect [15].”
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“Oxytocin has shown promising anti-inflammatory and angiogenic properties, contributing to improved cardiac function after MI [14 ].”
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Oxytocin modulates glucose metabolism to protect against cardiac remodeling via the STAT3/eNOS Axis
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Metadata
- Authors
- Gutkowska, J., Jankowski, M., & Antunes-Rodrigues, J.
- Affiliations
- Centre Hospitalier de l’Université de Montréal (CA)
- Universidade de São Paulo, Brasil
- ORCID
- Jankowski, M.
- Venue
- Brazilian Journal of Medical and Biological Research
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2014-03-18
- Volume
- 47
- Issue
- 3
- Pages
- 206-214
- ISSN
- 0100-879X (ISSN-L)
- 1414-431X
- PMC
- PMC3982941
- OpenAlex
- W2167829495
- Cited by
- 131
- References
- 73
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 11 · 2023: 14 · 2022: 8 · 2021: 13 · 2020: 20 · 2019: 14 · 2018: 15 · 2017: 15 · 2016: 9 · 2015: 3
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Brazilian Journal of Medical and Biological Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, cardiovascular regulation, atrial natriuretic peptide, anteroventral third ventricle, median eminence, oxytocinergic neurons, cardiomyocyte development, mesenchymal stem cells, cardioprotection, nitric oxide, myocardial infarction, angiogenesis, oxidative stress, mitochondrial protection, anti-inflammatory activity, vasodilation, blood pressure, cardiomyocyte hypertrophy, glucose uptake
- MeSH terms
- Animals, Cardiotonic Agents, Cell Differentiation, Heart, Humans, Atrial Natriuretic Factor, Nitric Oxide, Oxytocin, Signal Transduction, Receptors, Oxytocin, Oxidative Stress, Myocytes, Cardiac, Rats
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