Oxytocin revisited: Its role in cardiovascular regulation

Gutkowska, J.; Jankowski, M.

doi:10.1111/j.1365-2826.2011.02235.x

Cited by 208Neuroendocrine regulation and behaviorCardiovascular, Neuropeptides, and Oxidative Stress ResearchNeuropeptides and Animal Physiology

Oxytocin revisited: Its role in cardiovascular regulation

Gutkowska, J., Jankowski, M.·2012·Journal of Neuroendocrinology

DOI 10.1111/j.1365-2826.2011.02235.x

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Abstract

Traditionally associated with female reproduction, oxytocin (OT) was revisited recently and was revealed to have several new roles in the cardiovascular system. Functional OT receptors have been discovered in the rat and human heart, as well as in vascular beds. The cardiovascular activities of OT include: (i) lowering blood pressure; (ii) negative cardiac inotropy and chronotropy; (iii) parasympathetic neuromodulation; (iv) vasodilatation; (v) anti-inflammatory; (vi) antioxidative; and (vii) metabolic effects. These outcomes are mediated, at least in part, by stimulating cardioprotective mediators, such as nitric oxide and atrial natriuretic peptide. OT and its extended form OT-Gly-Lys-Arg have been shown to be abundant in the foetal mouse heart. OT has the capacity to generate cardiomyocytes from various types of stem cells, including the cardiac side population. Mesenchymal cells transfected with OT-Gly-Lys-Arg, or preconditioned with OT, are resistant to apoptosis and express endothelial cell markers. OT increases glucose uptake in cultured cardiomyocytes from newborn and adult rats, in normal, hypoxic and even insulin resistance conditions. In rats with experimentally-induced myocardial infarction, continuous in vivo OT delivery improves the cardiac healing process, as well as cardiac work, reduces inflammation and stimulates angiogenesis. Therefore, in pathological conditions, OT exerts anti-inflammatory and cardioprotective properties, and improves vascular and metabolic functions. Thus, OT has potential for therapeutic use.

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Oxytocin receptors are present in the heart and linked to natriuretic hormone secretion; oxytocin has direct cardiac effects, and intranasal oxytocin in humans increases heart rate variability.
“Oxytocin receptors are expressed in the heart, coupled to secretion of natriuretic hormone (48).Oxytocin has direct cardiac effects, and intranasal application in man increases heart rate variability (49).”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [48]
Oxytocin has been reported to reduce heart rate.
“oxytocin has been reported to reduce HR [24]”
From Intranasal oxytocin reduces provoked symptoms in female patients with posttraumatic stress disorder despite exerting sympathomimetic and positive chronotropic effects in a randomized controlled trial (2017) · cites this paper as [24]
Oxytocin has an undisputed role in cardiovascular regulation.
“apart from oxytocin’s undisputed role in cardiovascular regulation [24]”
From Intranasal oxytocin reduces provoked symptoms in female patients with posttraumatic stress disorder despite exerting sympathomimetic and positive chronotropic effects in a randomized controlled trial (2017) · cites this paper as [24]

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The oxytocin receptor: from intracellular signaling to behavior
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Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans
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A comparison of methods to measure central and peripheral oxytocin concentrations in human and non-human primates
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The role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis
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Vasopressin and Oxytocin in Control of the Cardiovascular System
Japundžić‐Žigon, N. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311020008 · Cited by 89 · see citing works
Positive Interpersonal Processes
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Body temperature and cardiac changes induced by peripherally administered oxytocin, vasopressin and the non‐peptide oxytocin receptor agonist <scp>WAY</scp> 267,464: a biotelemetry study in rats
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Peripheral vasopressin but not oxytocin relates to severity of acute psychosis in women with acutely-ill untreated first-episode psychosis
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Chronic Postnatal Stress Induces Depressive-like Behavior in Male Mice and Programs second-Hit Stress-Induced Gene Expression Patterns of OxtR and AvpR1a in Adulthood
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Molecular mechanisms underlying oxytocin-induced cardiomyocyte protection from simulated ischemia–reperfusion
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Effects of lactation on postpartum blood pressure among women with gestational hypertension and preeclampsia
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Oxytocin and cardioprotection in diabetes and obesity
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The modulation of emotional and social behaviors by oxytocin signaling in limbic network
Triana-Del Rio, R., Ranade, S., Guardado, J., LeDoux, J., Klann, E., & Shrestha, P. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1002846 · Cited by 58 · see citing works
Intranasal oxytocin reduces provoked symptoms in female patients with posttraumatic stress disorder despite exerting sympathomimetic and positive chronotropic effects in a randomized controlled trial
Sack, M., Spieler, D., Wizelman, L., Epple, G., Stich, J., Zaba, M., & Schmidt, U. (2017) · BMC Medicine · doi:10.1186/s12916-017-0801-0 · Cited by 57 · see citing works
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An overview of the oxytocin-oxytocin receptor signaling network
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The interplay of oxytocin and sex hormones
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Epigenetic Programming of Synthesis, Release, and/or Receptor Expression of Common Mediators Participating in the Risk/Resilience for Comorbid Stress-Related Disorders and Coronary Artery Disease
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Oxytocin has therapeutic effects on cancer, a hypothesis
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Association between the oxytocin receptor ( OXTR ) gene and children's social cognition at 18 months
Wade, M., Hoffmann, T. J., Wigg, K., & Jenkins, J. M. (2014) · Genes Brain & Behavior · doi:10.1111/gbb.12148 · Cited by 47 · see citing works
Protective effect of oxytocin on ovarian ischemia-reperfusion injury in rats
Akdemir, A., Erbaş, O., Göde, F., Ergenoglu, M. A., Yeniel, Ö., Oltulu, F., Yavaşoğlu, A., & Taşkıran, D. (2014) · Peptides · doi:10.1016/j.peptides.2014.02.015 · Cited by 46 · see citing works
Oxytocin and Related Peptide Hormones: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis
Mehdi, S. F., Pusapati, S., Khenhrani, R. R., Farooqi, M. S., Sarwar, S., Alnasarat, A., Mathur, N., Metz, C. N., LeRoith, D., Tracey, K. J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.864007 · Cited by 44 · see citing works
The Physiological Function of Oxytocin in Humans and Its Acute Response to Human-Dog Interactions: A Review of the Literature
Powell, L., Guastella, A. J., McGreevy, P., Bauman, A., Edwards, K. M., & Stamatakis, E. (2019) · Journal of Veterinary Behavior · doi:10.1016/j.jveb.2018.10.008 · Cited by 63 · see citing works
Lipo-oxytocin-1, a Novel Oxytocin Analog Conjugated with Two Palmitoyl Groups, Has Long-Lasting Effects on Anxiety-Related Behavior and Social Avoidance in CD157 Knockout Mice
Mizuno, A., Михайлович, Ч. С., Kikuchi, Y., Fakhrul, A. A. K. M., Akther, S., Deguchi, K., Yoshihara, T., Ishihara, K., Shuto, S., & Higashida, H. (2015) · Brain Sciences · doi:10.3390/brainsci5010003 · Cited by 43 · see citing works
Oxytocin Receptor Signaling in Vascular Function and Stroke
McKay, E. C., & Counts, S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.574499 · Cited by 41 · see citing works
Oxytocin and vasopressin signaling in health and disease
Perisic, M., Woolcock, K., Hering, A., Mendel, H. C., & Muttenthaler, M. (2024) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2024.01.010 · Cited by 40 · see citing works
Oxytocin promotes functional coupling between paraventricular nucleus and both sympathetic and parasympathetic cardioregulatory nuclei
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Oxytocin Signaling Pathway: From Cell Biology to Clinical Implications
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Intranasal application of vasopressin fails to elicit changes in brain immediate early gene expression, neural activity and behavioural performance of rats
Ludwig, M., Tobin, V. A., Callahan, M. F., Papadaki, E., Becker, A., Engelmann, M., & Leng, G. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12046 · Cited by 37 · see citing works
Heart and brain: Cortical representation of cardiac signals is disturbed in borderline personality disorder, but unaffected by oxytocin administration
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The localization of oxytocin receptors in the islets of Langerhans in the rat pancreas
Suzuki, M., Honda, Y., Li, M., Masuko, S., & Murata, Y. (2013) · Regulatory Peptides · doi:10.1016/j.regpep.2013.03.019 · Cited by 36 · see citing works
Oxytocin alters cell fate selection of rat neural progenitor cells in vitro
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Association of Oxytocin with Glucose Intolerance and Inflammation Biomarkers in Metabolic Syndrome Patients with and without Prediabetes
Akour, A. A., Kasabri, V. N., Bulatova, N., AlMuhaissen, S. A., Naffa, R. G., Fahmawi, H. A., Momani, M. S., Zayed, A. A., & Bustanji, Y. K. (2017) · The Review of Diabetic Studies · doi:10.1900/rds.2017.14.364 · Cited by 35 · see citing works
Large household reduces dementia mortality: A cross-sectional data analysis of 183 populations
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Factors associated with social participation amongst elders in rural Sri Lanka: a cross-sectional mixed methods analysis
Marsh, C., Agius, P. A., Jayakody, G., Shajehan, R., Abeywickrema, C., Durrant, K., Luchters, S. M. F., & Holmes, W. R. (2018) · BMC Public Health · doi:10.1186/s12889-018-5482-x · Cited by 35 · see citing works
Anti-hypertrophic effects of oxytocin in rat ventricular myocytes
Ménaouar, A., Florian, M., Wang, D., Danalache, B. A., Jankowski, M., & Gutkowska, J. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.04.174 · Cited by 33 · see citing works
Oxytocin and oxygen: the evolution of a solution to the ‘stress of life’
Carter, C. S., & Kingsbury, M. A. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0054 · Cited by 32 · see citing works
Cardiac Effects of Vasopressin
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A Sedentary and Unhealthy Lifestyle Fuels Chronic Disease Progression by Changing Interstitial Cell Behaviour: A Network Analysis
Huston, P. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.904107 · Cited by 34 · see citing works
Oxytocin and microglia in the development of social behaviour
Gonzalez, A. M., & Hammock, E. A. D. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0059 · Cited by 32 · see citing works
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Authors: Gutkowska, J., & Jankowski, M.
Affiliations: Centre Hospitalier de l’Université de Montréal (CA)
Corresponding author: Gutkowska, J.
ORCID: Jankowski, M.
Venue: Journal of Neuroendocrinology
Publisher: Wiley
Published: 2012-03-26
Volume: 24
Issue: 4
Pages: 599-608
ISSN: 0953-8194 (ISSN-L)
1365-2826
DOI: 10.1111/j.1365-2826.2011.02235.x
OpenAlex: W1601819842
Cited by: 208
References: 101
Citations by year: 2026: 5 · 2025: 10 · 2024: 14 · 2023: 17 · 2022: 12 · 2021: 19 · 2020: 12 · 2019: 20 · 2018: 13 · 2017: 16 · 2016: 13 · 2015: 17 · 2014: 18 · 2013: 20 · 2012: 2
FWCI: 1.68
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Heart and Stroke Foundation of Canada
Canadian Institutes of Health Research
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, cardiovascular regulation, oxytocin receptor, blood pressure, negative inotropic effect, negative chronotropic effect, vasodilation, anti-inflammatory activity, antioxidant activity, nitric oxide, atrial natriuretic peptide, cardiomyocyte differentiation, mesenchymal stem cells, myocardial infarction, angiogenesis, cardioprotection, hypoxia, insulin resistance
MeSH terms: Animals, Cardiovascular System, Cell Differentiation, Disease Models, Animal, Humans, Models, Biological, Myocardial Infarction, Atrial Natriuretic Factor, Oxytocin, Receptors, Oxytocin, Myocytes, Cardiac

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Oxytocin revisited: Its role in cardiovascular regulation

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