Anxiety and stress responses in female oxytocin deficient mice

Amico, J. A.; Mantella, R. C.; Vollmer, R. R.; Li, X.

doi:10.1111/j.0953-8194.2004.01161.x

Cited by 327Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

Anxiety and stress responses in female oxytocin deficient mice

Amico, J. A., Mantella, R. C., Vollmer, R. R., Li, X.·2004·Journal of Neuroendocrinology

DOI 10.1111/j.0953-8194.2004.01161.x

Open this paper in CoChat — free account

Abstract

Oxytocin is believed to attenuate the response of the hypothalamic-pituitary-adrenal axis to stress and to be anxiolytic. Stressors with a psychological component evoke both central and peripheral secretion of oxytocin in laboratory rodents. Oxytocin gene deletion mice provide a novel way to understand the role of oxytocin in stress and anxiety-related behaviours. We present our experience with female oxytocin deficient mice that were tested in an elevated plus maze (EPM), a behavioural test of anxiety, or exposed to psychogenic stressors (platform shaker or novel environment). Oxytocin-deficient mice not only displayed more anxiety-related behaviour, but also released more corticosterone after a psychogenic stressor and manifested greater stress-induced hyperthermia compared to wild-type mice. The diurnal variation of corticosterone and the response of corticosterone to corticotropin-releasing factor were not significantly different between genotypes. We also measured Fos-immunoreactive protein, an index of neuronal activation, in the medial amygdala of female mice after EPM testing. The medial amygdala is important for processing of psychogenic stress and anxiety and also contains oxytocin pathways and oxytocin receptors. The expression of Fos in the medial amygdala of mice not exposed to the EPM was not different between genotypes. Following EPM exposure, Fos expression was greater in oxytocin null compared to wild-type mice. Our findings support the hypothesis that central oxytocin is anxiolytic, and attenuates the stress response to psychogenic provocation in female mice.

Integrity signals

Registry

Crossref · 10.1111/j.0953-8194.2004.01161.x

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Female mice lacking the oxytocin gene exhibit enhanced corticosteroid responses to psychogenic stressors and enhanced anxiety on the elevated plus-maze compared to wildtype controls.
“Similarly, female mice lacking the oxytocin gene exhibit enhanced corticosteroid responses to psychogenic stressors and enhanced anxiety on the elevated plus-maze compared to wildtype controls (Amico et al., 2004; Mantella et al., 2003).”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Amico et al., 2004
The anxiolytic, approach-promoting, and tolerance-enhancing roles of OT may serve as foundational substrates that promote social exploration and interaction while suppressing social avoidance.
“The anxiolytic, approach-promoting, and tolerance-enhancing roles of OT (Amico et al., 2004; Averbeck, 2010; Heinrichs et al., 2003; Kemp and Guastella, 2010; Neumann et al., 2000a; Riem et al., 2011; Ring et al., 2006; Uvnäs-Moberg et al., 1994; Waldherr and Neumann, 2007; Yoshida et al., 2009; Young, 2002) may serve as foundational substrates that promote social exploration and interaction while”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Amico et al., 2004

Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270 · see citing works
The Role of the Hippocampus in Feedback Regulation of the Hypothalamic-Pituitary-Adrenocortical Axis*
JACOBSON, L., & SAPOLSKY, R. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-118 · Cited by 1,739 · see citing works
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130 · see citing works
Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043 · see citing works
Efferent projections of the infralimbic cortex of the rat
Hurley, K. M., Herbert, H., Moga, M. M., & Saper, C. B. (1991) · Journal of Comparative Neurology · doi:10.1002/cne.903080210 · Cited by 777 · see citing works
Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system
Whitnall, M. H. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90035-q · Cited by 582 · see citing works
Ventral subicular interaction with the hypothalamic paraventricular nucleus: Evidence for a relay in the bed nucleus of the stria terminalis
Cullinan, W. E., Herman, J. P., & Watson, S. J. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903320102 · Cited by 541 · see citing works
Mapping of Glucocorticoid Receptor Immunoreactive Neurons in the Rat Tel- and Diencephalon Using a Monoclonal Antibody against Rat Liver Glucocorticoid Receptor*
Fuxé, K., Wikström, A., Okret, S., Agnati, L. F., Härfstrand, A., Yu, Z., Granholm, L., Zoli, M., Vale, W., & Gustafsson, J.-Α. (1985) · Endocrinology · doi:10.1210/endo-117-5-1803 · Cited by 507 · see citing works
Brain Oxytocin Inhibits Basal and Stress‐Induced Activity of the Hypothalamo‐Pituitary‐Adrenal Axis in Male and Female Rats: Partial Action Within the Paraventricular Nucleus
Neumann, Wigger, Torner, Holsboer, & Landgraf (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00442.x · Cited by 452 · see citing works
CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior
Bale, T. L., Davis, A. M., Auger, A. P., Dorsa, D. M., & McCarthy, M. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02546.2001 · Cited by 446 · see citing works
Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems
Joëls, M., & de Kloet, E. R. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90014-0 · Cited by 389 · see citing works
Chapter 12 Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis
Neumann, I. D. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39014-9 · Cited by 387 · see citing works
Neuronal Circuit Regulation of the Hypothalamo-Pituitary-Adrenocortical Stress Axis
Herman, J. P., Prewitt, C. M.-F., & Cullinan, W. E. (1996) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v10.i3-4.50 · Cited by 357 · see citing works
Infant vocalization, adult aggression, and fear behavior of an oxytocin null mutant mouse
Winslow, J. T., Hearn, E. F., Ferguson, J., Young, L. J., Matzuk, M. M., & Insel, T. R. (2000) · Hormones and Behavior · doi:10.1006/hbeh.1999.1566 · Cited by 348 · see citing works
Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: New insights into the secretory capacities of peptidergic neurons
Wotjak, C. T., Ganster, J., Kohl, G., Holsboer, F., Landgraf, R., & Engelmann, M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00683-0 · Cited by 345 · see citing works
Direct Projections from the Central Amygdaloid Nucleus to the Hypothalamic Paraventricular Nucleus: Possible Role in Stress-Induced Adrenocorticotropin Release
Gray, T. S., Carney, M. E., & Magnuson, D. J. (2008) · Neuroendocrinology · doi:10.1159/000125260 · Cited by 331 · see citing works
An Anxiolytic Action of Oxytocin is Enhanced by Estrogen in the Mouse
MCCARTHY, M. M., MCDONALD, C. H., BROOKS, P. J., & GOLDMAN, D. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00212-0 · Cited by 328 · see citing works
Chapter 12 The paraventricular nucleus of the hypothalamus and the functional neuroanatomy of visceromotor responses to stress
Sawchenko, P. E., Brown, E. R., Chan, R. K. W., Ericsson, A. B., Li, H.-Y., Roland, B. L., & Kovács, K. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)61866-x · Cited by 323 · see citing works
Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition
Young III, W. S., Shepard, E., Amico, J., Hennighausen, L., Wagner, K., LaMarca, M. E., McKinney, C., & Ginns, E. I. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.05266.x · Cited by 308 · see citing works
Self-citation
Neuroendocrine responses to an emotional stressor: evidence for involvement of the medial but not the central amygdala
Dayas, C. V., Buller, K. M., & Day, T. A. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00645.x · Cited by 303 · see citing works
Stress increases oxytocin release within the hypothalamic paraventricular nucleus
Nishioka, T., Anselmo-Franci, J. A., Li, P., Callahan, M. F., & Morris, M. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01159-1 · Cited by 214 · see citing works
Anatomical interactions between the central amygdaloid nucleus and the hypothalamic paraventricular nucleus of the rat: a dual tract-tracing analysis
Prewitt, C. M., & Herman, J. P. (1998) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(98)00045-3 · Cited by 205 · see citing works
Female oxytocin-deficient mice display enhanced anxiety-related behavior
Mantella, R. C., Vollmer, R. R., Li, X., & Amico, J. A. (2003) · Endocrinology · doi:10.1210/en.2002-0197 · Cited by 200 · see citing works
Stress-Induced Hyperthermia in Singly Housed Mice
Heyden, J. V. D. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00157-1 · Cited by 194 · see citing works
Central Oxytocin Administration Reduces Stress-Induced Corticosterone Release and Anxiety Behavior in Rats1
Windle, R. J., Shanks, N., Lightman, S. L., & Ingram, C. D. (1997) · Endocrinology · doi:10.1210/en.138.7.2829 · Cited by 170 · see citing works
A model to measure anticipatory anxiety in mice?
Borsini, F., Lecci, A., Volterra, G., & Meli, A. (1989) · Psychopharmacology · doi:10.1007/bf00444693 · Cited by 153 · see citing works
Oxytocin mediates stress‐induced analgesia in adult mice
Robinson, D. A., Wei, F., Wang, G. D., Li, P., Kim, S. J., Vogt, S. K., Muglia, L. J., & Zhuo, M. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013492 · Cited by 148 · see citing works
Colonic temperature of rats during handling.
Briese, E., & Mg, D. Q. (1970) · PubMed · Cited by 134 · see citing works
A single social defeat experience selectively stimulates the release of oxytocin, but not vasopressin, within the septal brain area of male rats
Ebner, K., Wotjak, C. T., Landgraf, R., & Engelmann, M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02464-1 · Cited by 129 · see citing works
Behavioural impact of intraseptally released vasopressin and oxytocin in rats
Englemann, M., Wotjak, C. T., Ebner, K., & Landgraf, R. (2000) · Experimental Physiology · doi:10.1111/j.1469-445x.2000.tb00015.x · Cited by 94 · see citing works
Central Administration of Corticotropin-Releasing Factor Modulates Oxytocin Secretion in the Rat*
BRUHN, T. O., Sutton, S. W., Plotsky, P. M., & Vale, W. (1986) · Endocrinology · doi:10.1210/endo-119-4-1558 · Cited by 90 · see citing works
Forced swimming stimulates the expression of vasopressin and oxytocin in magnocellular neurons of the rat hypothalamic paraventricular nucleus
Wotjak, C. T., Naruo, T., Muraoka, S., Simchen, R., Landgraf, R., & Engelmann, M. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01613.x · Cited by 85 · see citing works
Histoautoradiographic detection of oxytocin‐ and vasopressin‐binding sites in the telencephalon of the rat
Krémarik, P., Freund‐Mercier, M. J., & Stoeckel, M. E. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903330304 · Cited by 80 · see citing works
Single and Repeated Environmental Stress: Effect on Plasma Oxytocin, Corticosterone, Catecholamines, and Behavior
Hashiguchi, H., Ye, S., Morris, M., et al. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00527-6 · Cited by 80 · see citing works
Effects of Diurnal Variation in Plasma Corticosterone Levels on Adrenocortical Response to Stress.
Zimmermann, E., & CRITCHLOW, V. (1967) · Experimental Biology and Medicine · doi:10.3181/00379727-125-32172 · Cited by 78 · see citing works
Endogenous opioid regulation of stress-induced oxytocin release within the hypothalamic paraventricular nucleus is reversed in late pregnancy: a microdialysis study
Wigger, A., & Neumann, I. D. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00068-4 · Cited by 74 · see citing works
Enhanced Salt Intake in Oxytocin Deficient Mice
Puryear, R., Rigatto, K., Amico, J. A., & Morris, M. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7776 · Cited by 58 · see citing works
Self-citation
Oxytocin-containing pathway to the bed nuclei of the stria terminalis of the lactating rat brain: Immunocytochemical and in vitro electrophysiological evidence
Ingram, C. D., & Moos, F. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90258-4 · Cited by 56 · see citing works
Mice deficient in oxytocin manifest increased saline consumption following overnight fluid deprivation
Amico, J. A., Morris, M., & Vollmer, R. R. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.5.r1368 · Cited by 55 · see citing works
Self-citation
Correlation between oxytocin neuronal sensitivity and oxytocin-binding sites in the amygdala of the rat: electrophysiological and histoautoradiographic study
Condés‐Lara, M., Veinante, P., Rabai, M., & Freund‐Mercier, M. J. (1994) · Brain Research · doi:10.1016/0006-8993(94)91245-9 · Cited by 54 · see citing works
Systemic oxytocin treatment modulates glucocorticoid and mineralocorticoid receptor mRNA in the rat hippocampus
Petersson, M., & Uvnäs‐Moberg, K. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00334-3 · Cited by 47 · see citing works
Cholecystokinin and D-fenfluramine inhibit food intake in oxytocin-deficient mice
Mantella, R. C., Rinaman, L., Vollmer, R. R., & Amico, J. A. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00383.2002 · Cited by 44 · see citing works
Self-citation
The daily rhythm of the secretion of corticotrophin and corticosterone in rats and mice.
Pn, C. (1971) · PubMed · Cited by 41 · see citing works
Cardiovascular change and hypothalamic norepinephrine release in response to environmental stress
Nakata, T., Berard, W., Kogosov, E., et al. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.264.4.r784 · Cited by 39 · see citing works
Consumption of solutions containing sodium chloride is enhanced in female oxytocin-deficient mice.
Amico, J. A., Mantella, R. C., & Vollmer, R. R. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.1.32 · Cited by 13 · see citing works
Self-citation

Flagged first, then by citations

Sorted by citations

The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954 · see citing works
Social Bonds and Posttraumatic Stress Disorder
Charuvastra, A., & Cloitre, M. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.58.110405.085650 · Cited by 911 · see citing works
Psychosocial and psychophysiological effects of human-animal interactions: the possible role of oxytocin
Beetz, A., Uvnäs-Moberg, K., Julius, H., & Kotrschal, K. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00234 · Cited by 904 · see citing works
“It has also an anxiolytic effect (Uvnäs-Moberg et al., 1994; Neumann et al., 2000; Amico et al., 2004; Jonas et al., 2008; Guastella et al., 2009), in particular in relation to social threats (Kirsch et al., 2005).”
The social role of touch in humans and primates: Behavioural function and neurobiological mechanisms
Dunbar, R. I. M. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.07.001 · Cited by 798 · see citing works
Intranasal Oxytocin Increases Positive Communication and Reduces Cortisol Levels During Couple Conflict
Ditzen, B., Schaer, M., Gabriel, B., Bodenmann, G., Ehlert, U., & Heinrichs, M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.011 · Cited by 784 · see citing works
Brain oxytocin: A key regulator of emotional and social behaviours in both females and males
Neumann, I. D. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01726.x · Cited by 743 · see citing works
Anxiety, depression, and the microbiome: A role for gut peptides
Lach, G., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0585-0 · Cited by 573 · see citing works
Vasopressin: Behavioral roles of an “original” neuropeptide
Caldwell, H. K., Lee, H.-J., Macbeth, A. H., & Young, W. S. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.007 · Cited by 504 · see citing works
Oxytocin in general anxiety and social fear: a translational approach
Neumann, I. D., & Slattery, D. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.004 · Cited by 468 · see citing works
Short-Term interaction between dogs and their owners: effects on oxytocin, cortisol, insulin and heart rate an exploratory study
Handlin, L., Hydbring-Sandberg, E., Nilsson, A., Ejdebäck, M., Jansson, A., & Uvnäs-Moberg, K. (2011) · Anthrozoös · doi:10.2752/175303711x13045914865385 · Cited by 373 · see citing works
Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation
UvnÃ¤s-Moberg, K., Handlin, L., & Petersson, M. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01529 · Cited by 351 · see citing works
Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications
Ring, R. H., Malberg, J. E., Potestio, L., Ping, J., Boikess, S., Luo, B., Schechter, L. E., Rizzo, S., Rahman, Z., & Rosenzweig-Lipson, S. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0293-z · Cited by 319 · see citing works
Oxytocin receptors in the nucleus accumbens facilitate “spontaneous” maternal behavior in adult female prairie voles
Olazábal, D. E., & Young, L. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.017 · Cited by 289 · see citing works
Mother–infant bonding and the evolution of mammalian social relationships
Broad, K. D., Curley, J. P., & Keverne, E. B. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1940 · Cited by 283 · see citing works
Neuroanatomical evidence for reciprocal regulation of the corticotrophin-releasing factor and oxytocin systems in the hypothalamus and the bed nucleus of the stria terminalis of the rat: Implications for balancing stress and affect
Dabrowska, J., Hazra, R., Ahern, T. H., Guo, J.-D., McDonald, A. J., Mascagni, F., Muller, J. F., Young, L. J., & Rainnie, D. G. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.003 · Cited by 274 · see citing works
The animal and human neuroendocrinology of social cognition, motivation and behavior
McCall, C., & Singer, T. (2012) · Nature Neuroscience · doi:10.1038/nn.3084 · Cited by 273 · see citing works
The psychobiology of emotion: the role of the oxytocinergic system
Uvnäs-Moberg, K., Arn, I., & Magnusson, D. (2005) · International Journal of Behavioral Medicine · doi:10.1207/s15327558ijbm1202_3 · Cited by 238 · see citing works
Genes, brains and mammalian social bonds
Curley, J. P., & Keverne, E. B. (2005) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2005.05.018 · Cited by 214 · see citing works
Cerebrospinal fluid and plasma oxytocin concentrations are positively correlated and negatively predict anxiety in children
Carson, D. S., Berquist, S. W., Trujillo, T. H., Garner, J. P., Hannah, S. L., Hyde, S. A., Sumiyoshi, R. D., Jackson, L. P., Moss, J. K., Strehlow, M. C., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.132 · Cited by 196 · see citing works
Intranasal oxytocin administration attenuates the ACTH stress response in monkeys
Parker, K. J., Buckmaster, C. L., Schatzberg, A. F., & Lyons, D. M. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.04.002 · Cited by 204 · see citing works
Maternal behavior deficits in nulliparous oxytocin knockout mice
Pedersen, C. A., Vadlamudi, S. V., Boccia, M. L., & Amico, J. A. (2006) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00162.x · Cited by 190 · see citing works
Intranasal oxytocin blocks alcohol withdrawal in human subjects
Pedersen, C. A., Smedley, K. L., Leserman, J., Jarskog, L. F., Rau, S. W., Kampov‐Polevoi, A., Casey, R. L., Fender, T., & Garbutt, J. C. (2013) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01958.x · Cited by 196 · see citing works
Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats
Slattery, D. A., & Neumann, I. D. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.038 · Cited by 195 · see citing works
Impact of early adversity on glucocorticoid regulation and later mental disorders
Strüber, N., Strüber, D., & Roth, G. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.10.015 · Cited by 173 · see citing works
The advantage of social living: Brain neuropeptides mediate the beneficial consequences of sex and motherhood
Neumann, I. D. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.012 · Cited by 162 · see citing works
Preliminary evidence that plasma oxytocin levels are elevated in major depression
Parker, K. J., Kenna, H. A., Zeitzer, J. M., Keller, J., Blasey, C. M., Amico, J. A., & Schatzberg, A. F. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.09.017 · Cited by 163 · see citing works
Optogenetic insights on the relationship between anxiety-related behaviors and social deficits
Allsop, S. A., Vander Weele, C. M., Wichmann, R., & Tye, K. M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00241 · Cited by 150 · see citing works
Oxytocin and vasopressin receptor distributions in a solitary and a social species of tuco‐tuco ( Ctenomys haigi and Ctenomys sociabilis )
Beery, A. K., Lacey, E. A., & Francis, D. D. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21638 · Cited by 144 · see citing works
Oxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139 · see citing works
Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome
Hall, S. S., Lightbody, A. A., McCarthy, B. E., Parker, K. J., & Reiss, A. L. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.020 · Cited by 143 · see citing works
A psychobiological rationale for oxytocin in the treatment of posttraumatic stress disorder
Olff, M., Langeland, W., Witteveen, A., & Denys, D. (2010) · CNS Spectrums · doi:10.1017/s109285290000047x · Cited by 135 · see citing works
The role of oxytocin in cardiovascular regulation
Gutkowska, J., Jankowski, M., & Antunes-Rodrigues, J. (2014) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20133309 · Cited by 131 · see citing works
Oxytocin and Social Adaptation: Insights from Neuroimaging Studies of Healthy and Clinical Populations
Ma, Y., Shamay-Tsoory, S., Han, S., & Zink, C. F. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.10.009 · Cited by 131 · see citing works
Roles of Oxytocin Neurones in the Control of Stress, Energy Metabolism, and Social Behaviour
Onaka, T., Takayanagi, Y., & Yoshida, M. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02300.x · Cited by 123 · see citing works
Oxytocin and Estrogen Receptor β in the Brain: An Overview
Acevedo-Rodriguez, A., Mani, S. K., & Handa, R. J. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00160 · Cited by 124 · see citing works
Oxytocin Protects Hippocampal Memory and Plasticity from Uncontrollable Stress
Lee, S.-Y., Park, S.-H., Chung, C., Kim, J. J., Choi, S.-Y., & Han, J.-S. (2015) · Scientific Reports · doi:10.1038/srep18540 · Cited by 119 · see citing works
The influence of depressive symptomatology and perceived stress on plasma and salivary oxytocin before, during and after a support enhancement intervention
Holt-Lunstad, J., Birmingham, W., & Light, K. C. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.007 · Cited by 103 · see citing works
Hydration State Controls Stress Responsiveness and Social Behavior
Krause, E. G., de Kloet, A. D., Flak, J. N., Smeltzer, M. D., Solomon, M. B., Evanson, N. K., Woods, S. C., Sakai, R. R., & Herman, J. P. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6078-10.2011 · Cited by 85 · see citing works
Estrogen receptor β and oxytocin interact to modulate anxiety-like behavior and neuroendocrine stress reactivity in adult male and female rats
Kudwa, A. E., McGivern, R. F., & Handa, R. J. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.03.004 · Cited by 73 · see citing works
Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology
Chang, S. W. C., & Platt, M. L. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.006 · Cited by 71 · see citing works
Oxytocin modulates behavioral and physiological responses to a stressor in marmoset monkeys
Cavanaugh, J., Carp, S. B., Rock, C. M., & French, J. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.12.027 · Cited by 64 · see citing works
Non-invasive measurement of small peptides in the common marmoset (Callithrix jacchus): A radiolabeled clearance study and endogenous excretion under varying social conditions
Seltzer, L. J., & Ziegler, T. E. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.12.012 · Cited by 58 · see citing works
Helping behavior in prairie voles: a model of empathy and the importance of oxytocin
Kitano, K., Yamagishi, A., Horie, K., Nishimori, K., & Sato, N. (2022) · iScience · doi:10.1016/j.isci.2022.103991 · Cited by 31 · see citing works
Anxiolytic drug discovery: What are the novel approaches and how can we improve them?
Stewart, A. M., & Kalueff, A. V. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.857309 · Cited by 22 · see citing works
Autism‐relevant behaviors are minimally impacted by conditional deletion of Pten in oxytocinergic neurons
Clipperton‐Allen, A. E., Chen, Y., & Page, D. T. (2016) · Autism Research · doi:10.1002/aur.1641 · Cited by 18 · see citing works
The role of D2 dopamine receptors in oxytocin induced place preference and anxiolytic effect
László, K., Péczely, L., Géczi, F., Kovács, A., Zagoracz, O., Ollmann, T., Kertes, E., Kállai, V., László, B., Berta, B., et al. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104777 · Cited by 18 · see citing works
Behavioral and endocrine effects of chronic exposure to low doses of chlorobenzenes in Wistar rats
Nagyeri, G., Valkusz, Z., Radacs, M., Ocsko, T., Hausinger, P., Laszlo, M., Laszlo, F. A., Juhasz, A., Julesz, J., & Galfi, M. (2012) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2011.09.011 · Cited by 17 · see citing works

Anxiolytic effects of ethanol and phenobarbital are abolished in test-experienced rats submitted to the elevated plus maze
Bertoglio, L. J., & Carobrez, A. P. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00958-9 · Cited by 74 · see citing works
Involvement of GABAA Receptors in the Anxiolytic‐Like Effect of Hydroxycitronellal
Andrade, J., Monteiro, Á. B., de Andrade, H. H. N., et al. (2021) · BioMed Research International · doi:10.1155/2021/9929805 · Cited by 19 · see citing works
Anxiolytic activity of Azadirachta indica leaf extract in rats.
Jaiswal, A., Sk, B., & Sb, A. (1994) · PubMed · Cited by 60 · see citing works
Intranasal administration of NAP, a neuroprotective peptide, decreases anxiety-like behavior in aging mice in the elevated plus maze*1
Alcalay, R. N. (2004) · Neuroscience Letters · doi:10.1016/s0304-3940(03)01385-5
Comparative study of anxiolytic-like effect of a novel herbal treatment with Diazepam on Balb/c mice
Doukkali, Z. (2016) · Journal of Addiction and Dependence · doi:10.15436/2471-061x-16-022

Authors: Amico, J. A., Mantella, R. C., Vollmer, R. R., & Li, X.
Affiliations: University of Pittsburgh (US)
Corresponding author: Amico, J. A.
Venue: Journal of Neuroendocrinology
Publisher: Wiley
Published: 2004-04
Volume: 16
Issue: 4
Pages: 319-324
ISSN: 0953-8194 (ISSN-L)
1365-2826
DOI: 10.1111/j.0953-8194.2004.01161.x
OpenAlex: W2070460280
Cited by: 327
References: 45
Citations by year: 2026: 7 · 2025: 11 · 2024: 9 · 2023: 12 · 2022: 9 · 2021: 16 · 2020: 30 · 2019: 9 · 2018: 18 · 2017: 11 · 2016: 14 · 2015: 15 · 2014: 17 · 2013: 14 · 2012: 18
FWCI: 2.54
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 15 d)
Locations: Journal of Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01hd037268-04)
National Institute of Mental Health
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD37268)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, anxiety, psychogenic stress, stress response, corticosterone, stress-induced hyperthermia, hypothalamic-pituitary-adrenal axis, medial amygdala, Fos expression, elevated plus maze, female mice, oxytocin receptor
MeSH terms: Animals, Anxiety, Female, Mice, Mutant Strains, Oxytocin, Stress, Physiological, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Anxiety and stress responses in female oxytocin deficient mice

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks