Effects of nitric oxide on magnocellular neurons of the supraoptic nucleus involve multiple mechanisms

Silva, M.P. da; Cedraz-Mercez, P.L.; Varanda, W.A.

doi:10.1590/1414-431x20133326

Cited by 16Neuroendocrine regulation and behaviorNitric Oxide and Endothelin EffectsNeuropeptides and Animal Physiology

Effects of nitric oxide on magnocellular neurons of the supraoptic nucleus involve multiple mechanisms

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Silva, M.P. da, Cedraz-Mercez, P.L., Varanda, W.A.·2014·Brazilian Journal of Medical and Biological Research

DOI 10.1590/1414-431x20133326PMC PMC4051181

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Abstract

Physiological evidence indicates that the supraoptic nucleus (SON) is an important region for integrating information related to homeostasis of body fluids. Located bilaterally to the optic chiasm, this nucleus is composed of magnocellular neurosecretory cells (MNCs) responsible for the synthesis and release of vasopressin and oxytocin to the neurohypophysis. At the cellular level, the control of vasopressin and oxytocin release is directly linked to the firing frequency of MNCs. In general, we can say that the excitability of these cells can be controlled via two distinct mechanisms: 1) the intrinsic membrane properties of the MNCs themselves and 2) synaptic input from circumventricular organs that contain osmosensitive neurons. It has also been demonstrated that MNCs are sensitive to osmotic stimuli in the physiological range. Therefore, the study of their intrinsic membrane properties became imperative to explain the osmosensitivity of MNCs. In addition to this, the discovery that several neurotransmitters and neuropeptides can modulate their electrical activity greatly increased our knowledge about the role played by the MNCs in fluid homeostasis. In particular, nitric oxide (NO) may be an important player in fluid balance homeostasis, because it has been demonstrated that the enzyme responsible for its production has an increased activity following a hypertonic stimulation of the system. At the cellular level, NO has been shown to change the electrical excitability of MNCs. Therefore, in this review, we focus on some important points concerning nitrergic modulation of the neuroendocrine system, particularly the effects of NO on the SON.

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These AVP neurons receive osmosensitive inputs from the organum vasculosum lamina terminalis via glutamatergic synapses and are modulated by nitric oxide (NO) signaling pathways.
“These AVP neurons receive osmosensitive inputs from the organum vasculosum lamina terminalis via glutamatergic synapses and are modulated by nitric oxide (NO) signaling pathways (146–148).”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [147]
The Abstract (page not provided) says vasopressin-producing supraoptic neurons receive synaptic input from circumventricular organs containing osmosensitive neurons. The Concluding remarks (page not provided) describe NO modulation of these neurons and a role for glutamatergic neurotransmission during osmotic stress. Our copy does not identify the organum vasculosum of the lamina terminalis as the input source or establish that its inputs use glutamatergic synapses. (LLM, conf=0.87)
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Hypertonicity increases NO production to modulate the firing rate of magnocellular neurons of the supraoptic nucleus of rats
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\n Modulação nitrérgica de canais para cátions ativados por hiperpolarização e nucleotídeo cíclico em neurônios do núcleo supraóptico\n
da Silva, M. P. (2015) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
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Authors: Silva, M. P. D., Cedraz-Mercez, P. L., & Varanda, W. A.
Affiliations: Universidade de São Paulo (BR)
ORCID: Varanda, W.A.
Venue: Brazilian Journal of Medical and Biological Research
Publisher: FapUNIFESP (SciELO)
Published: 2014-02
Volume: 47
Issue: 2
Pages: 90-100
ISSN: 0100-879X (ISSN-L)
DOI: 10.1590/1414-431x20133326
PMC: PMC4051181
OpenAlex: W1998066696
Cited by: 16
References: 90
Citations by year: 2025: 2 · 2023: 2 · 2021: 2 · 2020: 3 · 2019: 3 · 2017: 2 · 2016: 1
FWCI: 0.14
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Brazilian Journal of Medical and Biological Research (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
Americanae (AECID Library) (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo (12/19750-7)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (23038)
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: nitric oxide, supraoptic nucleus, magnocellular neurons, vasopressin, oxytocin, neuronal excitability, osmotic sensitivity, fluid homeostasis, neuroendocrine system, circumventricular organs, neuropeptides
MeSH terms: Action Potentials, Animals, Guanylate Cyclase, Humans, Neurons, Neurosecretory Systems, Nitric Oxide, Oxytocin, Supraoptic Nucleus, Vasopressins, Water-Electrolyte Balance, Nitric Oxide Synthase, Nitric Oxide Donors, Rats

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Effects of nitric oxide on magnocellular neurons of the supraoptic nucleus involve multiple mechanisms

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