Regulation of the expression of inducible nitric oxide synthase

Kleinert, Hartmut; Pautz, Andrea; Linker, Katrin; Schwarz, Petra M.

doi:10.1016/j.ejphar.2004.07.030

Cited by 705Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stress

Regulation of the expression of inducible nitric oxide synthase

Kleinert, Hartmut, Pautz, Andrea, Linker, Katrin, Schwarz, Petra M.·2004·European Journal of Pharmacology

DOI 10.1016/j.ejphar.2004.07.030

Open this paper in CoChat — free account

Abstract

The role of nitric oxide (NO) generated by the inducible isoform of nitric oxide synthase (iNOS) is very complex. Induction of iNOS expression and hence NO production has been described to have beneficial antiviral, antiparasital, microbicidal, immunomodulatory, and antitumoral effects. However, induced at the wrong place or at the wrong time, iNOS has detrimental consequences and seems to be involved in the pathophysiology of different human diseases. The pathways regulating iNOS expression seem to vary in different cells or different species. In general, activation of the transcription factors nuclear factor (NF)-kappaB and signal transducer and activator of transcription (STAT)-1alpha and thereby activation of the iNOS promoter seems to be an essential step in the regulation of iNOS expression in most cells. Also, post-transcriptional mechanisms are critically involved in the regulation of iNOS expression.

Integrity signals

Registry

Crossref · 10.1016/j.ejphar.2004.07.030

Cites

125 of 125 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Inducible NOS is expressed in multiple cell types in response to inflammatory stimuli such as endotoxin and cytokines.
“This isoform is expressed in multiple cell types in response to inflammatory stimuli such as that induced by endotoxin and cytokines, e.g. interleukin-1 and -2, tumor necrosis factor-α, and interferon-γ (27, 32).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [32]
For inducible NOS to kill microbes, parasites, or cancer cells, high levels of NO are needed to destroy FeS centers and respiratory proteins in the target organism.
“At the extreme of this spectrum, it is known that for inducible NOS to kill microbes, parasites, or cancer cells, high levels of NO are needed to destroy FeS centers and respiratory proteins in the target organism (28, 31, 32, 46).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [32]
NOS2 has the highest capacity to generate NO and is expressed in multiple cell types in response to inflammatory stimuli.
“NOS2 (also termed inducible NOS or iNOS), which has the highest capacity to generate NO, is expressed in multiple cell types in response to inflammatory stimuli [75, 76].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [76]

1 retracted

Hepatocyte Nuclear Factor-4α Mediates Redox Sensitivity of Inducible Nitric-oxide Synthase Gene Transcription
Guo, H., Cai, C. Q., & Kuo, P. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109017200 · Cited by 22 · see citing works
Retracted
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
Ghosh, S., May, M. J., & Kopp, E. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.225 · Cited by 5,182 · see citing works
NITRIC OXIDE AND MACROPHAGE FUNCTION
MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,184 · see citing works
Nitric oxide and the immune response
Bogdan, C. (2001) · Nature Immunology · doi:10.1038/ni1001-907 · Cited by 3,447 · see citing works
Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.
Xie, Q. W., Kashiwabara, Y., & Nathan, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37600-7 · Cited by 2,212 · see citing works
TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway
Schindler, C., & Darnell, J. E. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003201 · Cited by 1,808 · see citing works
Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656 · see citing works
Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.
Caput, D., Beutler, B., Hartog, K., Thayer, R. M., Brown-Shimer, S. L., & Cerami, A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.6.1670 · Cited by 1,516 · see citing works
Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide.
Xie, Q. W., Whisnant, R., & Nathan, C. F. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.6.1779 · Cited by 1,118 · see citing works
HuR and mRNA stability
Brennan, C. M., & Steitz*, J. A. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000854 · Cited by 1,095 · see citing works
Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.
Lowenstein, C. J., Alley, E. W., Raval, P., Snowman, A. M., Snyder, S. H., Russell, S. W., & Murphy, W. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9730 · Cited by 1,066 · see citing works
Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.
Lyons, C., Orloff, G. J., & Cunningham, J. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42704-4 · Cited by 866 · see citing works
Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages
Kamijo, R., Harada, H., Matsuyama, T., Bosland, M. C., Gerecitano, J. F., Shapiro, D., Le, J., Koh, S. I., Kimura, T., Green, S. J., et al. (1994) · Science · doi:10.1126/science.7510419 · Cited by 843 · see citing works
Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.
Geller, D. A., Lowenstein, C. J., Shapiro, R. A., Nussler, A. K., Silvio, M. D., Wang, S. C., Nakayama, D. K., Simmons, R. L., Snyder, S. H., & Billiar, T. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3491 · Cited by 821 · see citing works
Evidence that Tristetraprolin Binds to AU-Rich Elements and Promotes the Deadenylation and Destabilization of Tumor Necrosis Factor Alpha mRNA
Lai, W. S., Carballo, E., Strum, J. R., Kennington, E. A., Phillips, R. S., & Blackshear, P. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4311 · Cited by 730 · see citing works
Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta.
Yoram Vodovotz, B., Bogdan, C., Paik, J., Xie, Q. W., & Nathan, C. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.2.605 · Cited by 649 · see citing works
A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.
Melillo, G., Musso, T., Sica, A., Taylor, L. S., Cox, G. W., & Varesio, L. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.6.1683 · Cited by 626 · see citing works
Inducible nitric oxide synthase in human diseases
Kröncke, K.-D., Fehsel, K., & Kolb‐Bachofen, V. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00648.x · Cited by 585 · see citing works
Role of interferon regulatory factor 1 in induction of nitric oxide synthase.
Martin, E., Nathan, C. F., & Xie, Q. W. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.3.977 · Cited by 477 · see citing works
Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.
Forrester, K., Ambs, S., Lupold, S. E., Kapust, R. B., Spillare, E. A., Weinberg, W. C., Felley‐Bosco, E., Wang, X. W., Geller, D. A., Tzeng, E., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2442 · Cited by 463 · see citing works
Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability
Carballo, E., Lai, W. S., & Blackshear, P. J. (2000) · Blood · doi:10.1182/blood.v95.6.1891 · Cited by 442 · see citing works
Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression.
Mukaida, N., Morita, M., Ishikawa, Y., Rice, N. R., Okamoto, S., Kasahara, T., & Matsushima, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36831-x · Cited by 425 · see citing works
Regulation of the Expression of Inducible Nitric Oxide Synthase
Kleinert, H., Schwarz, P. M., & Förstermann, U. (2003) · Biological Chemistry · doi:10.1515/bc.2003.152 · Cited by 422 · see citing works
Self-citation
Multiple NF-κB Enhancer Elements Regulate Cytokine Induction of the Human Inducible Nitric Oxide Synthase Gene
Taylor, B. S., de Vera, M. E., Ganster, R. W., Wang, Q., Shapiro, R. A., Morris, S. M., Billiar, T. R., & Geller, D. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.24.15148 · Cited by 413 · see citing works
Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter.
de Vera, M. E., Shapiro, R. A., Nussler, A. K., Mudgett, J. S., Simmons, R. L., Morris, S. M., Billiar, T. R., & Geller, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1054 · Cited by 399 · see citing works
Peroxisome Proliferator-Activated Receptor γ-Dependent Repression of the Inducible Nitric Oxide Synthase Gene
Li, M., Pascual, G., & Glass, C. K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4699-4707.2000 · Cited by 377 · see citing works
Regulation of Nitric Oxide Production by Arginine Metabolic Enzymes
Mori, M., & Gotoh, T. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3169 · Cited by 346 · see citing works
Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-κB
Ganster, R. W., Taylor, B. S., Shao, L., & Geller, D. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151239498 · Cited by 321 · see citing works
Hypoxic Regulation of Inducible Nitric Oxide Synthase via Hypoxia Inducible Factor-1 in Cardiac Myocytes
Jung, F., Palmer, L. A., Zhou, N., & Johns, R. A. (2000) · Circulation Research · doi:10.1161/01.res.86.3.319 · Cited by 317 · see citing works
Cytokine-mediated Transcriptional Induction of the Human Inducible Nitric Oxide Synthase Gene Requires Both Activator Protein 1 and Nuclear Factor κB-binding Sites
Marks-Kończalik, J., Chu, S. C., & Moss, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.35.22201 · Cited by 311 · see citing works
An Interferon-γ-activated Site (GAS) Is Necessary for Full Expression of the Mouse iNOS Gene in Response to Interferon-γ and Lipopolysaccharide
Gao, J., Morrison, D. C., Parmely, T. J., Russell, S. W., & Murphy, W. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.2.1226 · Cited by 303 · see citing works
mRNA stability in eukaryotes
Mitchell, P., & Tollervey, D. W. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00063-0 · Cited by 278 · see citing works
Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor κB
YU, Z., ZHANG, W., & KONE, B. C. (2002) · Biochemical Journal · doi:10.1042/bj20020588 · Cited by 255 · see citing works
Identification of TIAR as a Protein Binding to the Translational Regulatory AU-rich Element of Tumor Necrosis Factor α mRNA
Gueydan, C., Droogmans, L., Chalon, P., Huez, G. A., Caput, D., & Kruys, V. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2322 · Cited by 253 · see citing works
Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-kappa B.
Kleinert, H., Euchenhofer, C., Ihrig‐Biedert, I., et al. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08682-1 · Cited by 234 · see citing works
Self-citation
Substrate Supply for Nitric-Oxide Synthase in Macrophages and Endothelial Cells: Role of Cationic Amino Acid Transporters
Closs, E. I., Scheld, J.-S., Sharafi, M., & Förstermann, U. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)26443-9 · Cited by 228 · see citing works
Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells
Darville, M. I., & Eizirik, D. L. (1998) · Diabetologia · doi:10.1007/s001250051036 · Cited by 218 · see citing works
Cloning and expression of inducible nitric oxide synthase from rat astrocytes
Galea, E., Reis, D. J., & Feinstein, D. L. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490370313 · Cited by 198 · see citing works
MOLECULAR REGULATION OF THE HUMAN INDUCIBLE NITRIC OXIDE SYNTHASE (iNOS) GENE
Taylor, B. S., & Geller, D. A. (2000) · Shock · doi:10.1097/00024382-200006000-00001 · Cited by 186 · see citing works
Complex Contribution of the 3′-Untranslated Region to the Expressional Regulation of the Human Inducible Nitric-oxide Synthase Gene
Rodríguez‐Pascual, F., Hausding, M., Ihrig‐Biedert, I., Furneaux, H., Levy, A. P., Förstermann, U., & Kleinert, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910460199 · Cited by 182 · see citing works
Self-citation
p38 MAPK-mediated Transcriptional Activation of Inducible Nitric-oxide Synthase in Glial Cells
Bhat, N. R., Feinstein, D. L., Shen, Q., & Bhat, A. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204994200 · Cited by 181 · see citing works
Transforming Growth Factor-β1 Inhibition of Macrophage Activation Is Mediated via Smad3
Werner, F., Jain, M. K., Feinberg, M. W., Sibinga, N. E. S., Pellacani, A. U. E., Wiesel, P., Chin, M. T., Topper, J. N., Perrella, M. A., & Lee, M.-E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004536200 · Cited by 180 · see citing works
Central role of transcription factor NF‐IL6 for cytokine and iron‐mediated regulation of murine inducible nitric oxide synthase expression
Dlaska, M., & Weiss, G. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.10.6171 · Cited by 176 · see citing works
Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice
Ambs, S., Ogunfusika, M. O., Merriam, W. G., Bennett, W. P., Billiar, T. R., & Harris, C. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8823 · Cited by 170 · see citing works
Mitogen-activated Protein Kinases Mediate Activator Protein-1-dependent Human Inducible Nitric-oxide Synthase Promoter Activation
Kristof, A. S., Marks-Kończalik, J., & Moss, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009563200 · Cited by 169 · see citing works
Regulation of Cytokine-inducible Nitric Oxide Synthase in Cardiac Myocytes and Microvascular Endothelial Cells
Singh, K., Balligand, J., Fischer, T. A., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.2.1111 · Cited by 168 · see citing works
Analysis of the Cytokine-Stimulated Human Inducible Nitric Oxide Synthase (iNOS) Gene: Characterization of Differences between Human and Mouse iNOS Promoters
Chu, S. C., Marks-Kończalik, J., Wu, H.-P., Banks, T. C., & Moss, J. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9062 · Cited by 166 · see citing works
Arginase 1 Overexpression in Psoriasis
Bruch‐Gerharz, D., Schnorr, O., Suschek, C. V., Beck, K., Pfeilschifter, J. M., Ruzicka, T., & Kolb-Bachofen, V. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63811-4 · Cited by 163 · see citing works
Inducible Nitric-oxide Synthase Is Regulated by the Proteasome Degradation Pathway
Musial, A., & Eissa, N. T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100725200 · Cited by 157 · see citing works
Molecular mechanisms of dexamethasone inhibition of nitric oxide synthase expression in interleukin 1 beta-stimulated mesangial cells: evidence for the involvement of transcriptional and posttranscriptional regulation.
Kunz, D., Walker, G., Eberhardt, W., & Pfeilschifter, J. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.255 · Cited by 147 · see citing works
Signalling events involved in interferon‐γ‐inducible macrophage nitric oxide generation
Blanchette, J., Jaramillo, M., & Olivier, M. (2003) · Immunology · doi:10.1046/j.1365-2567.2003.01620.x · Cited by 145 · see citing works
Cytokine induction of NO synthase II in human DLD‐1 cells: roles of the JAK‐STAT, AP‐1 and NF‐κB‐signaling pathways
Kleinert, H., Wallerath, T., Fritz, G., Ihrig‐Biedert, I., Rodríguez‐Pascual, F., Geller, D. A., & Förstermann, U. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702039 · Cited by 143 · see citing works
Self-citation
Molecular Cloning and Expression of an Avian Macrophage Nitric-oxide Synthase cDNA and the Analysis of the Genomic 5′-Flanking Region
Lin, A., Chang, C. C., & McCormick, C. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.20.11911 · Cited by 134 · see citing works
Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells
Felley‐Bosco, E., Bender, F. C., Courjault, F., Bron, C., & Quest, A. F. G. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250406797 · Cited by 134 · see citing works
Molecular mechanisms of inducible nitric oxide synthase gene expression by IL-1beta and cAMP in rat mesangial cells.
Eberhardt, W., Plüss, C., Hummel, R., & Pfeilschifter, J. M. (1998) · PubMed · Cited by 131 · see citing works
Activation of Retinoic X Receptor and Peroxisome Proliferator-Activated Receptor–γ Inhibits Nitric Oxide and Tumor Necrosis Factor–α Production in Rat Kupffer Cells
Uchimura, K., Nakamuta, M., Enjoji, M., Irie, T., Sugimoto, R., Muta, T., Iwamoto, H., & Nawata, H. (2001) · Hepatology · doi:10.1053/jhep.2001.21145 · Cited by 126 · see citing works
Kalirin Inhibition of Inducible Nitric-oxide Synthase
Ratovitski, E. A., Alam, M. R., Quick, R. A., McMillan, A., Bao, C., Kozlovsky, C., Hand, T. A., Johnson, R. C., Mains, R. E., Eipper, B. A., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.993 · Cited by 121 · see citing works
Green Tea Inhibits Human Inducible Nitric-Oxide Synthase Expression by Down-Regulating Signal Transducer and Activator of Transcription-1α Activation
Tedeschi, E., Menegazzi, M., Yao, Y., et al. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.1.111 · Cited by 116 · see citing works
Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: The role of NF-κB-repressing factor (NRF) in basal repression of the hiNOS gene
Feng, X., Guo, Z., Nourbakhsh, M., Häuser, H., Ganster, R. W., Shao, L., & Geller, D. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212306199 · Cited by 112 · see citing works
Molecular Mechanisms of Inducible Nitric Oxide Synthase Gene Expression by IL-1β and cAMP in Rat Mesangial Cells
Eberhardt, W., Plüss, C., Hummel, R., & Pfeilschifter, J. M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.10.4961 · Cited by 111 · see citing works
Modulation of AUUUA Response Element Binding by Heterogeneous Nuclear Ribonucleoprotein A1 in Human T Lymphocytes
Hamilton, B. J., Burns, C. M., Nichols, R. C., & Rigby, W. F. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.45.28732 · Cited by 109 · see citing works
Dexamethasone suppresses iNOS gene expression by upregulating I-κBα and inhibiting NF-κB
de Vera, M. E., Taylor, B. S., Wang, Q., Shapiro, R. A., Billiar, T. R., & Geller, D. A. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.6.g1290 · Cited by 108 · see citing works
Activation of estrogen receptor β is a prerequisite for estrogen‐dependent upregulation of nitric oxide synthases in neonatal rat cardiac myocytes
Nuedling, S., Karas, R. H., Mendelsohn, M. E., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Meyer, R., Vetter, H., & Grohé, C. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02675-8 · Cited by 107 · see citing works
The role of 3′-untranslated region (3′-UTR) mediated mRNA stability in cardiovascular pathophysiology
Misquitta, C., Iyer, V. R., Werstiuk, E. S., & Grover, A. K. (2001) · Molecular and Cellular Biochemistry · doi:10.1023/a:1011982932645 · Cited by 104 · see citing works
ESE-1 Is a Novel Transcriptional Mediator of Inflammation That Interacts with NF-κB to Regulate the Inducible Nitric-oxide Synthase Gene
Rudders, S. A., Gaspar, J., Madore, R., Voland, C., Grall, F. T., Patel, A. P., Pellacani, A. U. E., Perrella, M. A., Libermann, T. A., & Oettgen, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006507200 · Cited by 101 · see citing works
In vivo Footprinting of the Mouse Inducible Nitric Oxide Synthase Gene: Inducible Protein Occupation of Numerous Sites Including Oct and NF-IL6
Goldring, C. E., Reveneau, S., Algarté-Génin, M., et al. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.9.1682 · Cited by 95 · see citing works
15‐Deoxy‐Δ12,14‐PGJ2, but not troglitazone, modulates IL‐1β effects in human chondrocytes by inhibiting NF‐κB and AP‐1 activation pathways
Boyault, S., Simonin, M.-A., Bianchi, A., Compe, E., Liagre, B., Mainard, D., Bécuwe, P., Dauça, M., Netter, P., Terlain, B. L., et al. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02614-x · Cited by 94 · see citing works
Molecular mechanisms of iNOS induction by IL-1β and IFN-γ in rat aortic smooth muscle cells
Teng, X., Zhang, H., Snead, C. M., & Catravas, J. D. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2002.282.1.c144 · Cited by 94 · see citing works
Human Inducible Nitric Oxide Synthase Gene Is Transcriptionally Regulated by Nuclear Factor-κB Dependent Mechanism
Nunokawa, Y., Oikawa, S., & Tanaka, S. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0897 · Cited by 93 · see citing works
Anti-Inflammatory Actions of St. John’s Wort: Inhibition of Human Inducible Nitric-Oxide Synthase Expression by Down-Regulating Signal Transducer and Activator of Transcription-1α (STAT-1α) Activation
Tedeschi, E., Menegazzi, M., Margotto, D., Suzuki, H., Förstermann, U., & Kleinert, H. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.054460 · Cited by 92 · see citing works
Self-citation
Regulation of Inducible Nitric Oxide Synthase Expression by p300 and p50 Acetylation
Deng, W., & Wu, K. K. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.12.6581 · Cited by 91 · see citing works
c-Jun NH2-Terminal Kinase Inhibitor Anthra(1,9-cd)pyrazol-6(2H)-one Reduces Inducible Nitric-Oxide Synthase Expression by Destabilizing mRNA in Activated Macrophages
Lahti, A., Jalonen, U., Kankaanranta, H., & Moilanen, E. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.2.308 · Cited by 89 · see citing works
An Inducible Nitric-oxide Synthase (NOS)-associated Protein Inhibits NOS Dimerization and Activity
Ratovitski, E. A., Bao, C., Quick, R. A., McMillan, A., Kozlovsky, C., & Lowenstein, C. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30250 · Cited by 86 · see citing works
Transcriptional regulation of human inducible nitric oxide synthase gene in an intestinal epithelial cell line
Linn, S. C., Morelli, P. J., Edry, I., Cottongim, S., Szabó, C., & Salzman, A. L. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.272.6.g1499 · Cited by 84 · see citing works
Cloning and characterization of human inducible nitric oxide synthase splice variants: A domain, encoded by exons 8 and 9, is critical for dimerization
Eissa, N. T., Yuan, J. W., Haggerty, C. M., Choo, E. K., Palmer, C. D., & Moss, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7625 · Cited by 83 · see citing works
Binding of the Transcription Factor Interferon Regulatory Factor-1 to the Inducible Nitric-oxide Synthase Promoter
Spink, J. M., & Evans, T. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24417 · Cited by 81 · see citing works
Molecular Cloning and Analysis of the Rat Inducible Nitric Oxide Synthase Gene Promoter in Aortic Smooth Muscle Cells 11The nucleotide sequence data reported in this paper have been submitted to the GenBank with the accession number AF042085.
Zhang, H., Chen, X., Teng, X., Snead, C. M., & Catravas, J. D. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00078-1 · Cited by 78 · see citing works
Transcriptional Activation of the Human Inducible Nitric-oxide Synthase Promoter by Krüppel-like Factor 6
Warke, V. G., Nambiar, M. P., Krishnan, S. K., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300787200 · Cited by 75 · see citing works
Molecular cloning, gene organization and expression of rainbow trout (Oncorhynchus mykiss) inducible nitric oxide synthase (iNOS) gene
Wang, T., Mike, W. A. R. D., Grabowski, P., & Secombes, C. J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3580747 · Cited by 73 · see citing works
17β-Estradiol increases inducible nitric oxide synthase expression in macrophages
You, H. J., Kim, J. Y., & Jeong, H. G. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00477-7 · Cited by 70 · see citing works
Transcriptional Regulation of the Human iNOS Gene in Vascular-Smooth-Muscle Cells and Macrophages: Evidence for Tissue Specificity
Kolyada, A. Y., Savikovsky, N., & Madias, N. E. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0449 · Cited by 69 · see citing works
Structural Diversity in the 5’-Untranslated Region of Cytokine-stimulated Human Inducible Nitric Oxide Synthase mRNA
Chu, S. C., Wu, H.-P., Banks, T. C., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10625 · Cited by 68 · see citing works
Hypoxia Inactivates Inducible Nitric Oxide Synthase in Mouse Macrophages by Disrupting Its Interaction with α-Actinin 4
Daniliuc, S., Bitterman, H., Rahat, M. A., Kinarty, A., Rosenzweig, D., & Lahat, N. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.6.3225 · Cited by 67 · see citing works
N-Acetyl-cysteine modulates inducible nitric oxide synthase gene expression in human hepatocytes
Majano, P. L., Medina, J., Zubı́a, I., Sunyer, L., Lara‐Pezzi, E., Maldonado-Rodrı́guez, A., López‐Cabrera, M., & Moreno‐Otero, R. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2003.12.009 · Cited by 65 · see citing works
Activation of Stat1 and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is independent of interferon‐γ‐induced MAPK activation that is mediated by p21ras
Nishiya, T., Uehara, T., Edamatsu, H., et al. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00383-9 · Cited by 65 · see citing works
Complex Formation of the Interferon (IFN) Consensus Sequence-binding Protein with IRF-1 Is Essential for Murine Macrophage IFN-γ-induced iNOS Gene Expression
Xiong, H., Zhu, C. Y., Li, H., Chen, F., Mayer, L., Ozato, K., Unkeless, J. C., & Plevy, S. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209583200 · Cited by 64 · see citing works
Inhibition of small G proteins of the Rho family by statins or Clostridium difficile toxin B enhances cytokine‐mediated induction of NO synthase II
Hausding, M., Witteck, A., Rodríguez‐Pascual, F., von Eichel-Streiber, C., Förstermann, U., & Kleinert, H. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703607 · Cited by 63 · see citing works
Self-citation
Synergistic regulation of inducible nitric oxide synthase gene by CCAAT/enhancer‐binding protein β and nuclear factor‐κB in hepatocytes
Sakitani, K., Nishizawa, M., Inoue, K., Masu, Y., Okumura, T., & Ito, S. (1998) · Genes to Cells · doi:10.1046/j.1365-2443.1998.00193.x · Cited by 62 · see citing works
A Novel Lipopolysaccharide-response Element Contributes to Induction of Nitric Oxide Synthase
Xie, Q. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.23.14867 · Cited by 61 · see citing works
STAT-1 and c-Fos interaction in nitric oxide synthase-2 gene activation
Xu, W., COMHAIR, S. A. A., Zheng, S., Chu, S. C., Marks-Kończalik, J., Moss, J., Haque, S. J., & ERZURUM, S. C. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00441.2002 · Cited by 60 · see citing works
Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands
Toell, A., Kröncke, K., Kleinert, H., & Carlberg, C. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10104 · Cited by 57 · see citing works
Self-citation
Dedifferentiated Human Ventricular Cardiac Myocytes Express Inducible Nitric Oxide Synthase mRNA But Not Protein in Response to IL-1, TNF, IFNγ, and LPS
Lüss, H., Li, R., Shapiro, R. A., Tzeng, E., McGowan, F. X. J., Yoneyama, T., Hatakeyama, K., Geller, D. A., Mickle, D. A. G., Simmons, R. L., et al. (1997) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0349 · Cited by 53 · see citing works
Cytokine-induced nitric oxide synthase gene transcription is blocked by the heat shock response in human liver cells
de Vera, M. E., Wong, J. M., Zhou, J.-Y., Tzeng, E., Wong, H. R., Billiar, T. R., & Geller, D. A. (1996) · Surgery · doi:10.1016/s0039-6060(96)80281-9 · Cited by 50 · see citing works
Superoxide enhances interleukin 1β–mediated transcription of the hepatocyte-inducible nitric oxide synthase gene
Kuo, P. C., Abe, K. Y., & Schroeder, R. A. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70268-x · Cited by 49 · see citing works
Inflammation Modulates the Interaction of Heterogeneous Nuclear Ribonucleoprotein (hnRNP) I/Polypyrimidine Tract Binding Protein and hnRNP L with the 3′Untranslated Region of the Murine Inducible Nitric-Oxide Synthase mRNA
Söderberg, M., Raffalli‐Mathieu, F., & Lang, M. A. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.2.423 · Cited by 49 · see citing works
Transcriptional Regulation of the Human iNOS Gene by IL-1β in Endothelial Cells
Kolyada, A. Y., & Madias, N. E. (2001) · Molecular Medicine · doi:10.1007/bf03402216 · Cited by 48 · see citing works
Sporogen, S14-95, and S-Curvularin, Three Inhibitors of Human Inducible Nitric-Oxide Synthase Expression Isolated from Fungi
Yao, Y., Hausding, M., Erkel, G., et al. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.2.383 · Cited by 48 · see citing works
Potentiation of nitric oxide synthase expression by superoxide in interleukin 1β‐stimulated rat mesangial cells
Beck, K., Eberhardt, W., Walpen, S., Apel, M., & Pfeilschifter, J. M. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01035-7 · Cited by 47 · see citing works
Role of Tetrahydrobiopterin Availability in the Regulation of Nitric-oxide Synthase Expression in Human Mesangial Cells
Saura, M., Pérez‐Sala, D., Cañada, F. J., & Lamas, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.24.14290 · Cited by 46 · see citing works
Elk-3 Is a Transcriptional Repressor of Nitric-oxide Synthase 2
Chen, Y., Layne, M. D., Chung, S. W., 江島, 邦., Baron, R. M., Yet, S., & Perrella, M. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308179200 · Cited by 46 · see citing works
Retinoic Acid Inhibits Nitric Oxide Synthase-2 Expression through the Retinoic Acid Receptor-α
Sirsjö, A., Gidlöf, A. C., Olsson, A., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2535 · Cited by 45 · see citing works
Oxidative Stress Increases Hepatocyte iNOS Gene Transcription and Promoter Activity
Kuo, P. C., Abe, K. Y., & Schroeder, R. A. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6562 · Cited by 44 · see citing works
Modulation of Inducible Nitric Oxide Synthase mRNA Stability by Tetrahydrobiopterin in Vascular Smooth Muscle Cells
Linscheid, P., Schaffner, A., & Schoedon, G. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8072 · Cited by 43 · see citing works
Inhibition of NF‐κB/Rel nuclear translocation by dexamethasone: Mechanism for the inhibition of iNOS gene expression
Jeon, Y. J., Han, S. H., Lee, Y. W., et al. (1998) · IUBMB Life · doi:10.1080/15216549800202822 · Cited by 42 · see citing works
Tetrahydrobiopterin is a limiting factor of nitric oxide generation in interleukin 1β-stimulated rat glomerular mesangial cells
Mühl, H., & Pfeilschifter, J. M. (1994) · Kidney International · doi:10.1038/ki.1994.398 · Cited by 42 · see citing works
Down-regulation of High Mobility Group-I(Y) Protein Contributes to the Inhibition of Nitric-oxide Synthase 2 by Transforming Growth Factor-β1
Pellacani, A. U. E., Wiesel, P., Razavi, S., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008170200 · Cited by 40 · see citing works
A critical role for C/EBPβ binding to the AABS promoter response element in the human iNOS gene
Guo, Z., Shao, L., Feng, X., Reid, K. M., Marderstein, E. L., Nakao, A., & Geller, D. A. (2003) · The FASEB Journal · doi:10.1096/fj.02-1172fje · Cited by 39 · see citing works
The role of IFN regulatory factor-1 in synovitis and nitric oxide production
Shiraishi, A., Dudler, J., & Lotz, M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.7.3549 · Cited by 37 · see citing works
Involvement of protein kinases in the induction of NO synthase II in human DLD‐1 cells
Kleinert, H., Euchenhofer, C., Fritz, G., Ihrig‐Biedert, I., & Förstermann, U. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701782 · Cited by 37 · see citing works
Self-citation
C/EBP-β Mediates iNOS Induction by Hypoxia in Rat Pulmonary Microvascular Smooth Muscle Cells
Teng, X., Li, D., Catravas, J. D., & Johns, R. A. (2002) · Circulation Research · doi:10.1161/hh0202.103647 · Cited by 37 · see citing works
Involvement of transcriptional mechanisms in the inhibition of NOS2 expression by dexamethasone in rat mesangial cells
Saura, M., Zaragoza, C., Dı́az-Cazorla, M., Hernández‐Perera, O., Eng, E., Lowenstein, C. J., Pérez‐Sala, D., & Lamas, S. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00725.x · Cited by 36 · see citing works
Possible involvement of Janus kinase Jak2 in interferon-γ induction of nitric oxide synthase in rat glial cells
Kitamura, Y., Takahashi, H., Nomura, Y., & Taniguchi, T. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00212-9 · Cited by 35 · see citing works
Role of Interferon Regulatory Factor-1 in Double-stranded RNA-induced iNOS Expression by Mouse Islets
Blair, L. A., Maggi, L. B., Scarim, A. L., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109819200 · Cited by 35 · see citing works
Octamer Motif is Required for the NF-κB-mediated Induction of the Inducible Nitric Oxide Synthase Gene Expression in RAW 264.7 Macrophages
Kim, Y., Ko, C.-B., Park, Y.-P., et al. (1999) · Molecules and Cells · doi:10.1016/s1016-8478(23)13515-1 · Cited by 35 · see citing works
Octamer motif is required for the NF-kappaB-mediated induction of the inducible nitric oxide synthase gene expression in RAW 264.7 macrophages.
Kim, Y.-M., Ko, C. B., Park, Y.-P., et al. (1999) · PubMed · Cited by 30 · see citing works
Serine/threonine phosphorylation regulates HNF-4α-dependent redox-mediated iNOS expression in hepatocytes
Guo, H., Wei, J., Inoue, Y., et al. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00394.2002 · Cited by 27 · see citing works
Attenuation of nitric oxide synthase induction in IRF-1-deficient glial cells
Fujimura, M., Teiji, T., Kato, I., Takasawa, S., 川瀬, 誠., Taniguchi, T., Okamoto, H., & Yoshimoto, T. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00264-3 · Cited by 26 · see citing works
Post-transcriptional regulation of inducible nitric oxide synthase in chronic lymphocytic leukemia B cells in pro- and antiapoptotic culture conditions
Tiscornia, A., Cayota, A., Landoni, A. I., et al. (2003) · Leukemia · doi:10.1038/sj.leu.2403169 · Cited by 26 · see citing works
Cytokine-activated Jak-2 is involved in inducible nitric oxide synthase expression independent from NF-κB activation in vascular smooth muscle cells
Doi, M., Shichiri, M., Katsuyama, K., et al. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00578-0 · Cited by 25 · see citing works
Transcriptional Regulation of the Human Inducible Nitric Oxide Synthase Gene in an Intestinal Epithelial Cell Line † 127
Morelli, P. J., Linn, S. C., Edry, I., Cottingim, S. E., Szabó, C., & Salzman, A. L. (1997) · Pediatric Research · doi:10.1203/00006450-199704001-00147 · Cited by 22 · see citing works
Negative Regulation of LPS-Stimulated Expression of Inducible Nitric Oxide Synthase by AP-1 in Macrophage Cell Line J774A.1
Kizaki, T., SUZUKI, K. S., Hitomi, Y., et al. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6123 · Cited by 20 · see citing works
Strain Dependent Rat iNOS Promoter Activity—Correlation to Identified WT1 Transcription Factor Binding Site
Johannesen, J., Karlsen, A. E., Pociot, F., et al. (2003) · Autoimmunity · doi:10.1080/0891693031000101288 · Cited by 13 · see citing works
NO Synthesis and NOS Regulation
Förstermann, U., Li, H., Schwarz, P. M., & Kleinert, H. (2003) · Springer eBooks · doi:10.1007/0-306-48412-9_7 · Cited by 12 · see citing works
Self-citation
Replacement of 198MQMDII203 of mouse IRF-1 by 197IPVEVV202 of human IRF-1 abrogates induction of IFN-β, iNOS, and COX-2 gene expression by IRF-1
Upreti, M., Kumar, S., & Rath, P. C. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.156 · Cited by 10 · see citing works
Involvement of the hypothalamic-pituitary-adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: Viewpoint based on a systemic pathogenetic role
Straub, R. H., & Cutolo, M. (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200103)44:3

Flagged first, then by citations

Sorted by citations

Nitric oxide synthase in innate and adaptive immunity: an update
Bogdan, C. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.01.003 · Cited by 862 · see citing works
What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology
Hill, B. G., Dranka, B. P., Bailey, S. M., Lancaster, J. R., & Darley-Usmar, V. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.101618 · Cited by 310 · see citing works
Regulation of obesity and insulin resistance by nitric oxide
Sansbury, B. E., & Hill, B. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.016 · Cited by 274 · see citing works
Endothelial dysfunction in obesity
Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_15 · Cited by 255 · see citing works
Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity
Yuskaitis, C. J., & Jope, R. S. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2008.10.014 · Cited by 240 · see citing works
N-Docosahexaenoylethanolamine ameliorates LPS-induced neuroinflammation via cAMP/PKA-dependent signaling
Park, T., Chen, H., Kevala, K., Lee, J.-W., & Kim, H.-Y. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0751-z · Cited by 131 · see citing works
Peroxynitrite, a potent macrophage‐derived oxidizing cytotoxin to combat invading pathogens
Prolo, C., Álvarez, M. N., & Radi, R. (2014) · BioFactors · doi:10.1002/biof.1150 · Cited by 123 · see citing works
Nanocosmetics and Nanomedicines
(2011) · doi:10.1007/978-3-642-19792-5 · Cited by 116 · see citing works
Inducible Nitric Oxide Synthase in the Carcinogenesis of Gastrointestinal Cancers
de Oliveira, G. A., Cheng, R. Y. S., Ridnour, L. A., Basudhar, D., Somasundaram, V., McVicar, D. W., Monteiro, H. P., & Wink, D. A. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6850 · Cited by 91 · see citing works
Exendin‐4 inhibits iNOS expression at the protein level in LPS‐stimulated Raw264.7 macrophage by the activation of cAMP/PKA pathway
Chang, S., Kim, D., Ryu, G. R., Ko, S., Jeong, I., Ahn, Y., Jo, Y., & Kim, M. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24425 · Cited by 44 · see citing works
Exendin-4 inhibits interleukin-1β-induced iNOS expression at the protein level, but not at the transcriptional and posttranscriptional levels, in RINm5F β-cells
Kang, J.-H., Chang, S.-Y., Jang, H.-J., Kim, D.-B., Ryu, G. R., Ko, S. H., Jeong, I.-K., Jo, Y.-H., & Kim, M.-J. (2009) · Journal of Endocrinology · doi:10.1677/joe-08-0507 · Cited by 30 · see citing works
Protein Never in Mitosis Gene A Interacting-1 (PIN1) regulates degradation of inducible nitric oxide synthase in endothelial cells
Liu, T., Huang, Y., Likhotvorik, R. I., Keshvara, L., & Hoyt, D. G. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00366.2007 · Cited by 25 · see citing works
Effects of nitric oxide on magnocellular neurons of the supraoptic nucleus involve multiple mechanisms
Silva, M. P. D., Cedraz-Mercez, P. L., & Varanda, W. A. (2014) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20133326 · Cited by 16 · see citing works

Physiological Role of Na,K‐ATPase Isoforms
Lingrel, J. B., Neumann, J. C., Dostanic, I., et al. (2004) · doi:10.1002/3527606122.ch16
No mediator is an island: A mediator supports others, but who supports the mediator?
Keys, B. (2006) · e-publications@bond (Bond University)
Classification of FABP isoforms and tissues based on quantitative evaluation of transcript levels of these isoforms in various rat tissues
Yamamoto, T., Yamamoto, A., Watanabe, M., Matsuo, T., Yamazaki, N., Kataoka, M., Terada, H., & Shinohara, Y. (2009) · Biotechnology Letters · doi:10.1007/s10529-009-0065-7 · Cited by 39 · see citing works
Transcriptional regulation of transcriptional Mediator complexes in cardiovascular development and disease.
Zhang, Y., Zhao, Y., Zhuang, L., et al. (2022) · PubMed · doi:10.16288/j.yczz.21-411
Functional Roles of the α Isoforms of the Na,K‐ATPase
Lingrel, J. B., Moseley, A. E., Dostanic, I., et al. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07214.x · Cited by 100 · see citing works

Authors: Kleinert, H., Pautz, A., Linker, K., & Schwarz, P. M.
Affiliations: Johannes Gutenberg University Mainz (DE)
Corresponding author: Kleinert, Hartmut
ORCID: Kleinert, Hartmut
Pautz, Andrea
Venue: European Journal of Pharmacology
Publisher: Elsevier BV
Published: 2004-10
Volume: 500
Issue: 1-3
Pages: 255-266
ISSN: 0014-2999 (ISSN-L)
DOI: 10.1016/j.ejphar.2004.07.030
OpenAlex: W2096015727
Cited by: 705
References: 125
Citations by year: 2026: 5 · 2025: 4 · 2024: 15 · 2023: 14 · 2022: 18 · 2021: 15 · 2020: 10 · 2019: 25 · 2018: 36 · 2017: 33 · 2016: 36 · 2015: 40 · 2014: 40 · 2013: 53 · 2012: 75
FWCI: 3.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: inducible nitric oxide synthase, nitric oxide, NF-κB, STAT1, iNOS promoter, transcription factors, post-transcriptional regulation
MeSH terms: Animals, Humans, Promoter Regions, Genetic, RNA, Messenger, Transcription Factors, Transcription, Genetic, Protein Biosynthesis, Signal Transduction, Gene Expression Regulation, Enzymologic, Nitric Oxide Synthase, Nitric Oxide Synthase Type II

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regulation of the expression of inducible nitric oxide synthase

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks