Glucagon-like Peptide 1 Improves Insulin Resistance in Vitro through Anti-Inflammation of Macrophages
Open accessAbstract
Glucagon-like peptide 1 (GLP-1), a kind of gut hormone, is used in the treatment of type 2 diabetes (T2D). Emerging evidence indicates that GLP-1 has anti-inflammatory activity. Chronic inflammation in the adipose tissue of obese individuals is a cause of insulin resistance and T2D. We hypothesized that GLP-1 analogue therapy in patients with T2D could suppress the inflammatory response of macrophages, and therefore inhibit insulin resistance. Our results showed that GLP-1 agonist (exendin-4) not only attenuated macrophage infiltration, but also inhibited the macrophage secretion of inflammatory cytokines including TNF-β, IL-6, and IL-1β. Furthermore, we observed that lipopolysaccharide (LPS)-induced macrophage conditioned media could impair insulin-stimulated glucose uptake. This effect was compensated by treatment with the conditioned media from macrophages treated with the combination of LPS and exendin-4. It was also observed that exendin-4 directly inhibited the activation of NF-κB in macrophages. In conclusion, our results indicated that GLP-1 improved inflammatory macrophage-derived insulin resistance by inhibiting NF-κB pathway and secretion of inflammatory cytokines in macrophages. Furthermore, our observations suggested that the anti-inflammatory effect of GLP-1 on macrophages can contribute to GLP-1 analogue therapy of T2D.
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GLP-1 and its analogs have anti-inflammatory properties.
“Studies have shown that GLP-1 and its analogs have anti-inflammatory properties.”
From The Role of Glp-1 Receptor Agonists in Insulin Resistance with Concomitant Obesity Treatment in Polycystic Ovary Syndrome (2022) · cites this paper as [102]
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“T2D represents a significant threat to global health and human life (31).”
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- Authors
- Guo, C., Huang, T., Chen, A., Chen, X., Wang, L., Shen, F., & Gu, X.
- Affiliations
- Wenzhou Medical University (CN)
- Venue
- Brazilian Journal of Medical and Biological Research
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2016
- Volume
- 49
- Issue
- 12
- Pages
- e5826-e5826
- ISSN
- 0100-879X (ISSN-L)
- 1414-431X
- PMC
- PMC5188858
- OpenAlex
- W2554228598
- Cited by
- 112
- References
- 42
- Citations by year
- 2026: 18 · 2025: 18 · 2024: 10 · 2023: 15 · 2022: 7 · 2021: 13 · 2020: 6 · 2019: 10 · 2018: 11 · 2017: 4
- FWCI
- 7.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brazilian Journal of Medical and Biological Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81000356)
- Natural Science Foundation of Zhejiang Province (LY16H070006)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- glucagon-like peptide-1, exendin-4, insulin resistance, macrophages, inflammation, type 2 diabetes, adipose tissue, NF-κB signaling, inflammatory cytokines, lipopolysaccharide, insulin-stimulated glucose uptake, gastrointestinal hormones
- MeSH terms
- Exenatide, Adipose Tissue, Animals, Humans, Inflammation, Insulin Resistance, Macrophages, Peptides, Venoms, Inflammation Mediators, Mice, Glucagon-Like Peptide 1, Cell Migration Assays
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