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Cited by 8Neurotransmitter Receptor Influence on BehaviorGenetic Associations and EpidemiologySchizophrenia research and treatment

Association between serotonin 2C receptor gene (HTR2C) polymorphisms and psychopathological symptoms in children and adolescents

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Paes, L.A., Torre, O.H. Della, Henriques, T.B., de Mello, M.P., Celeri, E.H.R.V., Dalgalarrondo, P., Guerra Júnior, G., dos Santos Júnior, A.·2018·Brazilian Journal of Medical and Biological Research
DOI 10.1590/1414-431x20187252PMC PMC6010321
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Abstract

Serotonin 2C receptors (5HT2C) are involved in serotonin-driven dynamic equilibrium adjustments responsible for homeostatic stability in brain structures that modulate behavior and emotions. Single nucleotide polymorphisms (SNPs) from the serotonin 2C receptor gene (HTR2C) have been associated with several neurological and mental disorders, including abnormalities in cognitive and emotional processes. The aim of this study was to evaluate the association between the rs6318 SNP of the HTR2C gene and behavioral characteristics exhibited by children and adolescents based on the Child Behavior Checklist (CBCL/6-18) inventory. Eighty-five psychiatric outpatients between 8 and 18 years of age underwent genotyping of the rs6318 SNP. The CBCL/6-18 scale was administered to their caregivers. The chi-squared test was used to assess differences in the frequency of C and G alleles of the rs6318 SNP relative to the grouped CBCL/6-18 scores; significance level was 5%. The presence of the G allele of rs6318 was found to be associated with characteristics of aggressive behavior and social problems, and aggressive behavior was found to be associated with heterozygosis in females. These findings contribute to the identification of mental and behavioral phenotypes associated with gene expression.

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  • Other serotonin receptor encoding gene polymorphisms, including 5-hydroxytryptamine receptor 1B, 1E and 2C, demonstrated significant effects on childhood aggression.

    “Other serotonin receptor encoding gene polymorphisms, including 5-hydroxytryptamine receptor 1B [93, 94], 1E [95] and 2 C [96] further demonstrated significant effects on childhood aggression”

    From Genetics of child aggression, a systematic review (2024) · cites this paper as [96]

    For the 2C citation, the Discussion reports a statistically significant association between the HTR2C rs6318 polymorphism and aggressive behavior in children and adolescents. It also says longitudinal studies are needed to examine a possible causal relationship, so the paper supports an association, not a demonstrated causal effect. The 1B and 1E claims are attributed to other citations. (LLM, conf=0.84)

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  • The presence of the G allele was found to be associated with aggressive behavior (p = 0.033), and aggressive behavior was found to be associated with heterozygosis in females.

    “The presence of the G allele was found to be associated with aggressive behavior (p = 0.033), and aggressive behavior was found to be associated with heterozygosis in females.”

    From Genetics of child aggression, a systematic review (2024) · cites this paper as Paes [96]

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Research works printed but not linked: 2

  1. [6]Bordin IA Rocha MM Paula CS Teixeira MCTV Achenbach TM Rescorla LA Child behavior checklist (CBCL), youth self-report (YSR) and teacher's report form (TRF): an overview of the development of the original and Brazilian versions Cad Saude Publica 2013 29 13 28 10.1590/S0102-311X2013000500004 23370021 · DOI
  2. [10]Nature education Scitable Accessed October 18 2016 http://www.nature.com/scitable/definition/single-nucleotide-polymorphism-snp-295

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Authors
Paes, L. A., Torre, O. H. D., Henriques, T. B., de Mello, M. P., Celeri, E. H. R. V., Dalgalarrondo, P., Guerra Júnior, G., & dos Santos Júnior, A.
Affiliations
  • Universidade Estadual de Campinas (UNICAMP) (BR)
  • Universidade Estadual de Campinas, Brasil
ORCID
Venue
Brazilian Journal of Medical and Biological Research
Publisher
FapUNIFESP (SciELO)
Published
2018
Volume
51
Issue
8
Pages
e7252-e7252
ISSN
  • 0100-879X (ISSN-L)
  • 1414-431X
DOI
10.1590/1414-431x20187252
PMC
PMC6010321
OpenAlex
W2810664661
Cited by
8
References
31
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1
FWCI
0.34
Type
journal article
Language
en
Open access
Licence
Locations
  • Brazilian Journal of Medical and Biological Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Americanae (AECID Library) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Fundação de Amparo à Pesquisa do Estado de São Paulo (12/14005-1)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
5-HT2C receptor, single nucleotide polymorphisms, aggression, social problems, psychiatric symptoms, children and adolescents, Child Behavior Checklist, genetic association, sex differences, heterozygosity
MeSH terms
Adolescent, Alleles, Mental Disorders, Child, Child Behavior Disorders, Cross-Sectional Studies, Female, Gene Frequency, Genotype, Humans, Male, Psychiatric Status Rating Scales, Surveys and Questionnaires, Sex Factors, Chi-Square Distribution, Polymorphism, Single Nucleotide, Receptor, Serotonin, 5-HT2C, Checklist, Gene-Environment Interaction

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