Cortisol Responses to Emotional Stress in Men: Association with a Functional Polymorphism in the 5HTR2C Gene
Open accessAbstract
The serotonin 5HTR2C receptor has been shown to mediate HPA axis activation during stress. We hypothesized that a functional polymorphism (rs6318) of the 5HTR2C gene would be associated with HPA axis response to a laboratory stress protocol. The present sample consisted of 41 men (22 African Americans, 19 Caucasians). We found that at rest men with the more active rs6318 Ser23 C allele had similar cortisol values compared to those with the less active Cys23 G allele. During laboratory stress, however, men with the Ser23 C allele exhibited the predicted significantly higher cortisol levels (p<0.001), as well as larger increases in anger (p=0.08) and depressive mood (p=0.006) ratings, compared to the Cys23 G carriers. The increase in cortisol was significantly related to the increases in ratings of anger and depression assessed before and after the emotion induction, and these correlations became nonsignificant when rs6318 genotype was covaried. We conclude that genetic variation in 5HTR2C may be associated with HPA axis activation and stimulated by emotional stress, and also with both psychological and physiological endophenotypes that increase the risk of cardiovascular disease and type-2 diabetes.
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Genetic variation in 5HTR2C is associated with HPA axis activation and emotional stress responses, which may increase the risk of cardiovascular disease and type-2 diabetes.
“These findings suggest that genetic variation in 5HTR2C is associated with HPA axis activation and emotional stress responses, which may increase the risk of cardiovascular disease and type-2 diabetes, linking the mechanisms of stress with multiple health outcomes [12].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [12]
In a study of 41 men, individuals with the more active Ser23 C allele of the 5HTR2C gene exhibited significantly higher cortisol levels and greater increases in anger and depressive mood during laboratory stress compared to those with the less active Cys23 G allele.
“A study investigating the functional polymorphism (rs6318) of the 5HTR2C gene in 41 men found that individuals with the more active Ser23 C allele exhibited significantly higher cortisol levels and greater increases in anger and depressive mood during laboratory stress compared to those with the less active Cys23 G allele.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [12]
The serotonin 5HTR2C receptor plays a crucial role in mediating HPA axis activation during stress.
“The serotonin 5HTR2C receptor plays a crucial role in mediating HPA axis activation during stress, which can have broader implications for other stress-related conditions such as diabetes.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [12]
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- Authors
- Brummett, B. H., Kuhn, C. M., Boyle, S. H., Babyak, M. A., Siegler, I. C., & Williams, R. B.
- Affiliations
- Duke Medical Center (US)
- Corresponding author
- Brummett, Beverly H.
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 89
- Issue
- 1
- Pages
- 94-98
- ISSN
- 0301-0511 (ISSN-L)
- PMC
- PMC3245751
- OpenAlex
- W2007136524
- Cited by
- 50
- References
- 32
- Citations by year
- 2024: 4 · 2023: 1 · 2022: 3 · 2021: 1 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 8 · 2013: 9 · 2012: 1
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Update notices
- erratum (2020-11-01)
- Open access
- green
- europepmc.org
- Locations
- Biological Psychology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL036587)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- cortisol, emotional stress, serotonin receptors, hypothalamic-pituitary-adrenal axis, anger, depressive mood, genetic polymorphism, men, African Americans, cardiovascular risk, type 2 diabetes risk
- MeSH terms
- Adolescent, Adult, Cysteine, Genotype, Humans, Hydrocortisone, Male, Middle Aged, Psychiatric Status Rating Scales, Radioimmunoassay, Serine, Statistics as Topic, Stress, Psychological, Polymorphism, Single Nucleotide, Receptor, Serotonin, 5-HT2C, Young Adult, Genetic Association Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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