Depression rather than liver impairment reduces quality of life in patients with hepatitis C
Open accessAbstract
OBJECTIVE: Patients with chronic hepatitis C (CHC) have a poorer quality of life than those with other chronic liver diseases. However, some of the factors that determine health-related quality of life (HRQOL) in these patients, such as the degree of liver fibrosis, are still controversial. Therefore, the aim of the present study was to investigate the impact of CHC on HRQOL by conducting clinical, psychiatric, and sociodemographic evaluations. METHODS: One hundred and twenty-four consecutive patients attending a referral center for hepatitis were evaluated using the Mini-International Neuropsychiatry Interview, the Hamilton Depression Rating Scale, the Hospital Anxiety and Depression Scale, and the Medical Outcomes Study 36-Item Short-Form Health Survey. Multiple linear regression analyses were used to quantify independent associations between HRQOL and the clinical, psychiatric, and sociodemographic variables of interest. RESULTS: Reduced HRQOL was independently associated with major depressive disorder (MDD) and with elevated levels of alanine aminotransferase, but was not associated with hepatic cirrhosis. CONCLUSIONS: MDD rather than the grade of liver fibrosis was strongly associated with HRQOL impairment in patients with CHC. These findings highlight that, in patients with CHC, the psychological effects of the disease deserve more attention and the implementation of integrated medical, psychiatric, and psychological care may be helpful.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Research shows that deploying and offering behavioral health services at the point of care reduces the stigma against seeking behavioral health care and improves the patient experience.
“Research shows that deploying and offering behavioral health services at the point of care reduces the stigma against seeking behavioral health care and improves the patient experience.29”
From A Behavioral Health Program for Alcohol Use Disorder, Substance Abuse, and Depression in Chronic Liver Disease (2019) · cites this paper as [29]
The Discussion (page unavailable) suggests that integrated medical, psychiatric, and psychological care may help patients with chronic hepatitis C. It does not report whether offering behavioral health services at the point of care reduces stigma about seeking care or improves patient experience; searches for those outcomes found no supporting passage. (LLM, conf=0.72)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,638 · see citing works
Diagnosis and classification of diabetes mellitus
American Diabetes Association (2014) · Diabetes Care · doi:10.2337/dc14-s081 · Cited by 5,974 · see citing works
Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T., Cifkova, R., De Backer, G., Dominiczak, A., et al. (2013) · Journal of Hypertension · doi:10.1097/01.hjh.0000431740.32696.cc · Cited by 5,655 · see citing works
(1994) · Medical Entomology and Zoology · Cited by 4,156 · see citing works
The Natural History of Community-Acquired Hepatitis C in the United States
Alter, M. J., Margolis, H. S., Krawczynski, K., Judson, F. N., Mares, A., Alexander, W. J., Hu, P. Y., Miller, J. K., Gerber, M. A., Sampliner, R. E., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212313272702 · Cited by 1,592 · see citing works
Mancia, G., Fagard, R. H., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T. C., Cífková, R., Backer, G. D., Dominiczak, A. F., et al. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e328364ca4c · Cited by 1,187 · see citing works
Amorim, P. (2000) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462000000300003 · Cited by 1,075 · see citing works
Younossi, Z. M., Guyatt, G. H., Kiwi, M. L., Boparai, N., & King, D. (1999) · Gut · doi:10.1136/gut.45.2.295 · Cited by 670 · see citing works
Factors associated with poor health-related quality of life of patients with cirrhosis
Marchesini, G., Bianchi, G. P., Amodio, P., Salerno, F., Merli, M., Panella, C., Loguercio, C., Apolone, G., Niero, M., & Abbiati, R. A. (2001) · Gastroenterology · doi:10.1053/gast.2001.21193 · Cited by 500 · see citing works
Bonkovsky, H. L., & Woolley, M. J. (1999) · Hepatology · doi:10.1002/hep.510290124 · Cited by 397 · see citing works
Do SF-36 summary component scores accurately summarize subscale scores?
Taft, C., Karlsson, J., & Sullivan, M. (2001) · Quality of Life Research · doi:10.1023/a:1012552211996 · Cited by 392 · see citing works
Psychiatric disorders among veterans with hepatitis C infection
El‐Serag, H. B., Kunik, M. E., Richardson, P., & Rabeneck, L. (2002) · Gastroenterology · doi:10.1053/gast.2002.34750 · Cited by 283 · see citing works
Hepatitis C Virus Infects the Endothelial Cells of the Blood-Brain Barrier
Fletcher, N. F., Wilson, G. K., Murray, J., Hu, K., Lewis, A., Reynolds, G. M., Stamataki, Z., Meredith, L. W., Rowe, I. A. C., Luo, G. G., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.11.028 · Cited by 248 · see citing works
Depression and anxiety in patients with hepatitis C: prevalence, detection rates and risk factors
Golden, J., O'Dwyer, A. M., & Conroy, R. M. (2005) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2005.06.006 · Cited by 211 · see citing works
Psychological status and depression in patients with liver cirrhosis
Bianchi, G., Marchesini, G., Nicolino, F., Graziani, R., Sgarbi, D., Loguercio, C., Abbiati, R., & Zoli, M. (2005) · Digestive and Liver Disease · doi:10.1016/j.dld.2005.01.020 · Cited by 187 · see citing works
Loftis, J. M., Huckans, M. S., Ruimy, S., Hinrichs, D. J., & Hauser, P. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.11.001 · Cited by 117 · see citing works
Overview of research on health-related quality of life in patients with chronic liver disease.
Gutteling, J. J., de Man, R. A., Busschbach, J. J. V., & Darlington, A.-S. E. (2007) · PubMed · Cited by 111 · see citing works
Association of chronic liver disease with depression: A population-based study
Lee, K., Otgonsuren, M., Younoszai, Z., Mir, H. M., & Younossi, Z. M. (2013) · Psychosomatics · doi:10.1016/j.psym.2012.09.005 · Cited by 104 · see citing works
A psychometric comparison of health-related quality of life measures in chronic liver disease
Ünal, G., de Boer, J. B., Borsboom, G., Brouwer, J. T., Essink‐Bot, M., & de Man, R. A. (2001) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(00)00372-3 · Cited by 103 · see citing works
Uncertainty, Symptoms, and Quality of Life in Persons With Chronic Hepatitis C
Bailey, D. E., Landerman, L. R., Barroso, J. V., Bixby, P., Mishel, M. H., Muir, A. J., Strickland, L. E., & Clipp, E. C. (2009) · Psychosomatics · doi:10.1176/appi.psy.50.2.138 · Cited by 96 · see citing works
Anxiety Comorbidity and Quality of Life in Bipolar Disorder Patients
Kauer‐Sant’Anna, M., Frey, B. N., Andreazza, A. C., Ceresér, K. M. M., Gazalle, F. K., Tramontina, J., da Costa, S. C., Santin, A. M. P., & Kapczinski, F. P. (2007) · The Canadian Journal of Psychiatry · doi:10.1177/070674370705200309 · Cited by 86 · see citing works
Biopsychosocial Predictors of Health-Related Quality of Life in Patients With Chronic Hepatitis C
Häuser, W., Zimmer, C., Schiedermaier, P., & Grandt, D. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000145824.82125.a8 · Cited by 85 · see citing works
The quality of life of HIV-infected women is associated with psychiatric morbidity
Tostes, M. A., Chalub, M., & Botega, N. J. (2003) · AIDS Care · doi:10.1080/09540120410001641020 · Cited by 78 · see citing works
Laguardia, J., Campos, M. R., Travassos, C., Najar, A. L., dos Anjos, L. A., & Vasconcellos, M. M. (2011) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-9-61 · Cited by 73 · see citing works
Karaivazoglou, K., Iconomou, G., Triantos, C. K., Hyphantis, T. N., Thomopoulos, K., Lagadinou, M., Gogos, C. A., Labropoulou‐Karatza, C., & Assimakopoulos, K. (2010) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31618-7 · Cited by 71 · see citing works
Rowan, P., Al-Jurdi, R., Tavakoli-Tabasi, S., Kunik, M., Satrom, S. L., & El-Serag, H. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000173860.08478.a6 · Cited by 53 · see citing works
Helbling, B., Overbeck, K., Gonvers, J., Malinverni, R., Dufour, J.-F., Borovicka, J., Heim, M. H., Cerny, A., Negro, F., Bucher, S. E., et al. (2008) · Gut · doi:10.1136/gut.2007.142844 · Cited by 51 · see citing works
Is there a measurement overlap between depressive symptoms and quality of life?
da Rocha, N. S., Power, M., Bushnell, D. M., & Fleck, M. P. D. A. (2009) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2008.11.015 · Cited by 46 · see citing works
Fábregas, B. C., de Ávila, R. E., Faria, M. N., Moura, A. S., Carmo, R. A., & Teixeira, A. L. (2013) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2013.03.008 · Cited by 40 · see citing works
Kalman, D., Lee, A. F., Chan, E., Miller, D. R., Spiro, A., Ren, X. S., & Kazis, L. E. (2004) · The American Journal of Drug and Alcohol Abuse · doi:10.1081/ada-120037389 · Cited by 38 · see citing works
Depression and quality of life of hemodialysis patients living in a poor region of Brazil
Santos, P. R. (2011) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462011000400005 · Cited by 37 · see citing works
Wagner, M., Lee, J.-H., Kronenberger, B., Friedl, R., Sarrazin, C., Teuber, G., Herrmann, E. M., & Zeuzem, S. (2006) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2006.00772.x · Cited by 31 · see citing works
Does cirrhosis affect quality of life in hepatitis C virus‐infected patients?
Hsu, P. C., Krajden, M., Yoshida, E. M., Anderson, F., TOMLINSON, G. A., & Krahn, M. D. (2009) · Liver International · doi:10.1111/j.1478-3231.2008.01865.x · Cited by 31 · see citing works
Psychosocial Issues and Mental Health Treatment Recommendations for Patients With Hepatitis C
Silberbogen, A. K., Ulloa, E. W., Janke, E. A., & Mori, D. L. (2009) · Psychosomatics · doi:10.1176/appi.psy.50.2.114 · Cited by 25 · see citing works
da Rocha, N. S., & Fleck, M. P. (2010) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462010000200005 · Cited by 25 · see citing works
The impact of chronic hepatitis C and co-morbid illnesses on health-related quality of life
Kwan, J. W., Cronkite, R. C., Yiu, A., Goldstein, M. K., Kazis, L. E., & Cheung, R. C. (2008) · Quality of Life Research · doi:10.1007/s11136-008-9344-3 · Cited by 21 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Nunnally J, Bernstein I. Psychometric theory. 3rd ed. New York: McGraw-Hill; 1994.
- da Cunha LR. Decreased health-related quality of life (HRQOL) in chronic hepatitis C (CHC): association with major depressive disorder (MDD), anxiety disorders, clinical comorbidities and socio- demographic factors [dissertation]. Belo Horizonte: Universidade Federal de Minas Gerais; 2012.
Cited by
Sorted by citations
Bering, T., Diniz, K. G. D., Coelho, M. P. P., Vieira, D. A., Soares, M. M. S., Kakehasi, A. M., Correia, M. I. T. D., Teixeira, R., Queiroz, D. M. M., Rocha, G. A., et al. (2018) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12269 · Cited by 73 · see citing works
Self-citationCombined Healthy Lifestyle Is Inversely Associated with Psychological Disorders among Adults
Saneei, P., Esmaillzadeh, A., Keshteli, A. H., Roohafza, H., Afshar, H., Feizi, A., & Adibi, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146888 · Cited by 69 · see citing works
Verma, M., Horrow, J., & Navarro, V. (2019) · Hepatology Communications · doi:10.1002/hep4.1328 · Cited by 23 · see citing works
“Depression is known to be more strongly associated with reduced QOL than to liver disease severity.(31)”
BackgroundGutiérrez-Rojas, L., Martín, J. J. D. L. G., Buey, L. G., Otano, J. I. U., Mena, Á., & Roncero, C. (2022) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2022.06.001 · Cited by 18 · see citing works
The impact of nutrition on quality of life of patients with hepatitis C
Silva, L. D., Bering, T., & Rocha, G. A. (2017) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000396 · Cited by 15 · see citing works
Self-citationSahoo, S., Mishra, E., & Premkumar, M. (2024) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2024.101390 · Cited by 12 · see citing works
Biopsychosocial predictors of interferon-related depression in patients with Hepatitis C
Murri, M. B., Cecere, A. C., Masotti, M., Sammito, G., la Marca, A., Torres, G. V., Bonfitto, I., Cuozzo, E., Rossi, L., Serviddio, G., et al. (2017) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2017.01.001 · Cited by 9 · see citing works
Vieira, D. A., da Cunha, L. R., da Silva, C. B., Almeida, M. T. B., Gomes, A. D., de Faria, C. L. L., Teixeira, R., Neves, F. S., Rocha, G. A., de Melo, F. F., et al. (2019) · Quality of Life Research · doi:10.1007/s11136-019-02129-5 · Cited by 9 · see citing works
Self-citationEffect of hepatitis C infection on the quality of life
Horváth, G., Keleti, T., Makara, M., Ungvari, G. S., & Gazdag, G. (2018) · Perspectives In Psychiatric Care · doi:10.1111/ppc.12269 · Cited by 7 · see citing works
Coelho, M. P. P., de Vries, T. P., Pires, A. M., Parreira, M. P., de Alvarenga, É. R., Cambraia, R. D., dos Santos, R. R., Bezerra, J. M. T., Colosimo, E. A., Rocha, G. A., et al. (2024) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.17950 · Cited by 6 · see citing works
Self-citationPreston, R., Christmass, M. A., Lim, E., McGough, S., & Heslop, K. (2024) · International Journal of Mental Health Nursing · doi:10.1111/inm.13396 · Cited by 6 · see citing works
da Silva, C. B., Vieira, D. A., de Melo, L. F., Chagas, A. L. S., Gomes, A. D., de Faria, C. L. L., Teixeira, R., Queiroz, D. M. M., Rocha, G. A., Soares, M. M. S., et al. (2020) · World Journal of Hepatology · doi:10.4254/wjh.v12.i4.137 · Cited by 6 · see citing works
Self-citationDiniz, K. G. D., Vieira, D. A., Colosimo, E. A., Coelho, M. P. P., Bering, T., Teixeira, R., Correia, M. I. T. D., Rocha, G. A., & Silva, L. D. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.08.011 · Cited by 6 · see citing works
Self-citationda Cunha, L. R., Vieira, D. A., Giampietro, Y. G., Gomes, A. D., de Faria, C. L. L., de Melo, F. F., Teixeira, R., Teixeira‐Carvalho, A., de Oliveira, L. M., Martins‐Filho, O. A., et al. (2018) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2018.11.015 · Cited by 6 · see citing works
Self-citationKacavenda-Babovic, D. (2021) · Acta Clinica Croatica · doi:10.20471/acc.2021.60.04.03 · Cited by 4 · see citing works
Souza, G. H. D. P. E., Silva, L. D., Vieira, D. A., Rocha, G. A., Lima, A. S., & Vidigal, P. V. T. (2023) · Arquivos de Gastroenterologia · doi:10.1590/s0004-2803.230302023-03 · Cited by 4 · see citing works
Self-citationGutiérrez-Rojas, L., Martín, J. J. D. L. G., Buey, L. G., Otano, J. I. U., Mena, Á., & Roncero, C. (2023) · Gastroenterología y Hepatología (English Edition) · doi:10.1016/j.gastre.2022.06.009 · Cited by 3 · see citing works
da Cunha, L. R., Castro, M., DUARTE, G. S., NASCIMENTO, G. C. E., Rocha, G. A., & Silva, L. D. (2021) · Arquivos de Gastroenterologia · doi:10.1590/s0004-2803.202100000-86 · Cited by 2 · see citing works
Self-citationNagi, M. L. F., Manan, S., Shaheen, A., Amjad, M., Farooq, M., & Kazmi, S. T. H. (2018) · The Professional Medical Journal · doi:10.29309/tpmj/18.4824 · Cited by 1 · see citing works
Mugada, V., Veera, K. C., & Paravada, J. (2020) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2020.104010 · Cited by 1 · see citing works
Early Intervention and Health Promotion in the Management of Chronic Liver Disease
Hussain, S. (2018) · International Journal of User-Driven Healthcare · doi:10.4018/ijudh.2018010102
Spotlight on some psychiatric aspects of hepatitis-C virus patients
Elkholy, M. G., Shama, G., Enaba, M. E., & Eldeeb, F. A. (2021) · Tanta Medical Journal · doi:10.4103/tmj.tmj_34_18
TNF-α is associated with low phase angle in male patients with chronic hepatitis C
de Vries, T. P., Pires, A. M., Camilo, F. G., de Alvarenga, É. R., Martins‐Filho, O. A., Gomes, K. B., Rocha, G. A., & Silva, L. D. (2026) · Nutrition · doi:10.1016/j.nut.2026.113349
Self-citation
- Authors
- Silva, L. D., da Cunha, C. C., da Cunha, L. R., Araújo, R. F., Barcelos, V. M., Menta, P. L., Neves, F. S., Teixeira, R., Rocha, G. A., & Gontijo, E. D.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- Universidade Federal de Minas Gerais (UFMG), Brazil
- Universidade Federal de Minas Gerais (UFMG), Brazil; UFMG, Brazil
- ORCID
- Venue
- Revista Brasileira de Psiquiatria
- Publisher
- EDITORA SCIENTIFIC
- Published
- 2015-03
- Volume
- 37
- Issue
- 1
- Pages
- 21-30
- ISSN
- 1516-4446 (ISSN-L)
- OpenAlex
- W2110251967
- Cited by
- 24
- References
- 38
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 1
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Brazilian Journal of Psychiatry (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Universidade Federal de Minas Gerais
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- chronic hepatitis C, health-related quality of life, major depressive disorder, liver fibrosis, alanine aminotransferase, liver cirrhosis, depression, anxiety
- MeSH terms
- Adult, Aged, Anxiety Disorders, Brazil, Depressive Disorder, Major, Major Depressive Disorder, Enzyme-Linked Immunosorbent Assay, Epidemiologic Methods, Female, Health Status, Humans, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Quality of Life, Socioeconomic Factors, Hepatitis C, Chronic, Hepatic Insufficiency, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
