Aumento da utilização de benzodiazepínicos entre idosos mais velhos: Projeto Bambuí
Open accessAbstract
BACKGROUND: Benzodiazepines are the most widely used psychoactive drugs, despite the risks associated with their prolonged use, especially among older adults. OBJECTIVE: To investigate the use of benzodiazepines among community-dwelling people aged ≥ 75 years. METHODS: The study was conducted among members of the baseline (in 1997) and survivors (in 2012) of the Bambuí Project cohort. The prevalence of benzodiazepine use was estimated separately for each year, and the comparison between them was performed using the Poisson regression model with robust variance. RESULTS: The prevalence of benzodiazepine use was higher in 2012 (33.9%) compared to 1997 (24.9%). After multiple adjustments, the difference in prevalence did not remain significant in study population (PR = 1.25; 95%CI 0.99 - 1.60), unlike that observed in the female stratum (PR = 1.38; 95%CI 1.04 - 1.84). Clonazepam was the strongest-growing drug between the two years (PR = 4.94; 95%CI 2.54 - 9.62). CONCLUSION: This study showed an important increase in benzodiazepine use in an older adult population. These results are concerning as these drugs are contraindicated for use in older adults, mainly if used chronically, and are available in the national list of essential medicines. Health professionals should be aware of the risks involved in its use regarding this population.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
While some studies have shown a decrease in the prescribing of some drug classes, such as benzodiazepines over time, these decreases have been small and inconsistent across different countries.
“While some studies have shown a decrease in the prescribing of some drug classes, such as benzodiazepines over time [83, 84], these decreases have been small and inconsistent across different countries [85, 86].”
From Stakeholders' views on the use of psychotropic medication in older people: a systematic review (2022) · cites this paper as [85]
The Discussion (page not supplied) reports declining benzodiazepine use in several countries but increasing use in others, supporting the claim that trends differ across countries. It does not characterize the decreases as small; the reported decline in Canada, from 23.2% to 14.8%, makes that blanket description uncertain. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A scaled version of the General Health Questionnaire
Goldberg, D. P., & Hillier, V. F. (1979) · Psychological Medicine · doi:10.1017/s0033291700021644 · Cited by 5,494 · see citing works
European guideline for the diagnosis and treatment of insomnia
Riemann, D., Baglioni, C., Bassetti, C., Bjorvatn, B., Dolenc Groselj, L., Ellis, J. G., Espie, C. A., Garcia‐Borreguero, D., Gjerstad, M., Gonçalves, M., et al. (2017) · Journal of Sleep Research · doi:10.1111/jsr.12594 · Cited by 2,049 · see citing works
Bandelow, B., Sher, L., Bunevicius, R., Hollander, E., Kasper, S., Zohar, J., Möller, H.-J., WFSBP Task Force on Mental Disorders in Primary Care, & WFSBP Task Force on Anxiety Disorders, O. A. P. (2012) · International Journal of Psychiatry in Clinical Practice · doi:10.3109/13651501.2012.667114 · Cited by 428 · see citing works
The ESEMeD/MHEDEA 2000 investigators, Alonso, J., Angermeyer, M. C., Bernert, S., Bruffaerts, R., Brugha, T. S., Bryson, H., de Girolamo, G., de Graaf, R., Demyttenaere, K., et al. (2004) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0047.2004.00331.x · Cited by 313 · see citing works
Psychoactive drug abuse in older adults
Simoni, J. M., & Yang, H.-W. K. (2006) · The American Journal of Geriatric Pharmacotherapy · doi:10.1016/j.amjopharm.2006.10.002 · Cited by 307 · see citing works
Deprescribing benzodiazepine receptor agonists: Evidence-based clinical practice guideline.
(2018) · Europe PMC (PubMed Central) · Cited by 250 · see citing works
Assessment of Attitudes Toward Deprescribing in Older Medicare Beneficiaries in the United States
Reeve, E., Wolff, J. L., Skehan, M. E., Bayliss, E. A., Hilmer, S. N., & Boyd, C. M. (2018) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2018.4720 · Cited by 201 · see citing works
Benzodiazepine Misuse in the Elderly: Risk Factors, Consequences, and Management
Airagnes, G., Pélissolo, A., Lavallée, M., Flament, M. F., & Limosin, F. (2016) · Current Psychiatry Reports · doi:10.1007/s11920-016-0727-9 · Cited by 176 · see citing works
Usage of benzodiazepines: A review
Donoghue, J., & Lader, M. (2010) · International Journal of Psychiatry in Clinical Practice · doi:10.3109/13651500903447810 · Cited by 156 · see citing works
Lopez-Munoz, F. J., Álamo, C., & García‐García, P. (2011) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2011.01.002 · Cited by 145 · see citing works
Ng, B. J., Le Couteur, D. G., & Hilmer, S. N. (2018) · Drugs & Aging · doi:10.1007/s40266-018-0544-4 · Cited by 118 · see citing works
Cohort Profile: The Bambui (Brazil) Cohort Study of Ageing
Lima‐Costa, M. F., Firmo, J. O., & Uchôa, E. (2010) · International Journal of Epidemiology · doi:10.1093/ije/dyq143 · Cited by 104 · see citing works
Self-citationMaust, D. T., Blow, F. C., Wiechers, I. R., Kales, H. C., & Marcus, S. C. (2017) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.16m10713 · Cited by 93 · see citing works
Rocha, F. L., Guerra, H. L., & Lima‐Costa, M. F. (2002) · Sleep Medicine · doi:10.1016/s1389-9457(01)00119-8 · Cited by 80 · see citing works
Self-citationBrunoni, A. R., Nunes, M. A., de Figueiredo, R. C., Barreto, S. M., da Fonseca, M. D. J. M., Lotufo, P. A., & Benseñor, I. M. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.05.054 · Cited by 64 · see citing works
Cognitive behavioral therapy for anorexia nervosa: an update
Dalle Grave, R., El Ghoch, M., Sartirana, M., & Calugi, S. (2016) · Current Psychiatry Reports · doi:10.1007/s11920-015-0643-4 · Cited by 60 · see citing works
Prescrição de benzodiazepínicos para adultos e idosos de um ambulatório de saúde mental
Naloto, D. C. C., Lopes, F. C., Barberato-Filho, S., Lopes, L. C., Fiol, F. D. S. D., & Bergamaschi, C. D. C. (2016) · Ciência & Saúde Coletiva · doi:10.1590/1413-81232015214.10292015 · Cited by 52 · see citing works
Alvarenga, J. M., Filho, A. I. D. L., Firmo, J. O. A., et al. (2007) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462006005000062 · Cited by 51 · see citing works
Self-citationBenzodiazepine Use in Older Adults in the United States, Ontario, and Australia from 2010 to 2016
Brett, J., Maust, D. T., Bouck, Z., Ignacio, R. V., Mecredy, G. C., Kerr, E. A., Bhatia, S., Elshaug, A. G., & Pearson, S. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15292 · Cited by 49 · see citing works
Carrasco‐Garrido, P., López‐de‐Andrés, A., Hernández‐Barrera, V., Jiménez‐Trujillo, I., & Jiménez‐García, R. (2012) · International Psychogeriatrics · doi:10.1017/s104161021200169x · Cited by 35 · see citing works
Is Drug Utilization in Greece Sex dependent? A Population‐based Study
Athanasopoulos, C., Pitychoutis, P. M., Messari, I., Lionis, C. D., & Papadopoulou‐Daifoti, Z. (2012) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2012.00920.x · Cited by 32 · see citing works
Davies, S., Jacob, B. J., Rudoler, D., Zaheer, J., de Oliveira, C., & Kurdyak, P. A. (2017) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125317743651 · Cited by 30 · see citing works
Wolf, I.-K., Du, Y., & Knopf, H. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1254-x · Cited by 28 · see citing works
Fatores associados ao uso de psicotrópicos por idosos residentes no Município de São Paulo
Noia, A. S., Secoli, S. R., Duarte, Y. A. D. O., et al. (2012) · Revista da Escola de Enfermagem da USP · doi:10.1590/s0080-62342012000700006 · Cited by 26 · see citing works
Blumstein, T., Benyamini, Y., Chetrit, A., Mizrahi, E. H., & Lerner‐Geva, L. (2012) · Aging & Mental Health · doi:10.1080/13607863.2011.644262 · Cited by 24 · see citing works
Chronic use of benzodiazepines among older adults
Alvarenga, J. M., Giacomin, K. C., Filho, A. I. D. L., Uchôa, E., & Firmo, J. O. A. (2014) · Revista de Saúde Pública · doi:10.1590/s0034-8910.2014048004986 · Cited by 22 · see citing works
Self-citationUso de psicofármacos entre idosos residentes em comunidade: prevalência e fatores associados
Abi-Ackel, M. M., Lima‐Costa, M. F., Costa, E., & Filho, A. I. D. L. (2017) · Revista Brasileira de Epidemiologia · doi:10.1590/1980-5497201700010005 · Cited by 21 · see citing works
Self-citationUso de benzodiazepínicos entre idosos: o alívio de "jogar água no fogo", não pensar e dormir
Alvarenga, J. M., Filho, A. I. D. L., Giacomin, K. C., Uchôa, E., & Firmo, J. O. A. (2015) · Revista Brasileira de Geriatria e Gerontologia · doi:10.1590/1809-9823.2015.14045 · Cited by 19 · see citing works
Self-citationAn association between benzodiazepine use and occurrence of benign brain tumors
Harnod, T., Lin, C., Sung, F., et al. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.11.009 · Cited by 17 · see citing works
Desplenter, S., Caenen, C., Meelberghs, J., Hartikainen, S. A., Sulkava, R. O., & Bell, J. S. (2011) · International Psychogeriatrics · doi:10.1017/s1041610211000718 · Cited by 17 · see citing works
Benzodiazepine use and associated factors in elderly in the city of Dourados, MS, Brazil
Cunha, C. D. D. A., de Souza, M. C. C., Cattanio, G. A. A., Iahnn, S. R., & Lima, R. D. C. (2015) · Jornal Brasileiro de Psiquiatria · doi:10.1590/0047-2085000000080 · Cited by 6 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- REV BRAS EPIDEMIOL 2020; 23: E200029
- American Geriatrics Society 2019 Updated AGS Beers Criteria® for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc 2019; 67(4): 674-94. https://doi.org/10.1111/jgs.15767 · DOI · Paper page
Cited by
Sorted by citations
Stakeholders' views on the use of psychotropic medication in older people: a systematic review
Bednarczyk, E., Cook, S., Brauer, R., & Garfield, S. (2022) · Age and Ageing · doi:10.1093/ageing/afac060 · Cited by 22 · see citing works
- Authors
- Oliveira, A. L. M. L., Nascimento, M. M. G. D., Castro-Costa, É., Firmo, J. O. A., Lima-Costa, M. F., & Loyola Filho, A. I. D.
- Affiliations
- Fiocruz Minas (BR)
- Universidade Federal de Minas Gerais (BR)
- Fundação Oswaldo Cruz, Brazil
- Fundação Oswaldo Cruz, Brazil; Universidade Federal de Minas Gerais, Brasil
- ORCID
- Venue
- Revista Brasileira de Epidemiologia
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2020
- Volume
- 23
- Pages
- e200029-e200029
- ISSN
- 1415-790X (ISSN-L)
- 1980-5497
- OpenAlex
- W3022437052
- Cited by
- 17
- References
- 31
- Citations by year
- 2026: 2 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 1
- FWCI
- 1.32
- Type
- journal article
- Language
- pt
- Open access
- diamond
- doi.org
- Licence
- Locations
- Revista Brasileira de Epidemiologia (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- benzodiazepines, older adults, prevalence trends, clonazepam, community-dwelling older adults, drug use in older adults, sex differences in drug use, essential medicines
- MeSH terms
- Aged, Aged, 80 and over, Benzodiazepines, Brazil, Drug Utilization, Female, Humans, Income, Male, Psychotropic Drugs, Risk Factors, Time Factors, Cohort Studies, Multivariate Analysis, Age Distribution, Sex Distribution, Independent Living
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
