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Cited by 256Nonmelanoma Skin Cancer StudiesPhotodynamic Therapy Research StudiesSkin Protection and Aging

Comparison of Topical Methyl Aminolevulinate Photodynamic Therapy With Cryotherapy or Fluorouracil for Treatment of Squamous Cell Carcinoma In Situ: Results of a Multicenter Randomized Trial

Morton, Colin, Horn, Michael, Leman, Joyce, Tack, Brigitte, Bedane, Christophe, Tjioe, Milan, Ibbotson, Sally, Khemis, Abdallah +1 more·2006·Archives of Dermatology
DOI 10.1001/archderm.142.6.729
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Abstract

OBJECTIVE: To compare the efficacy, tolerability, and cosmetic outcome of photodynamic therapy (PDT) using topical methyl aminolevulinate with cryotherapy or topical fluorouracil for treatment of squamous cell carcinoma in situ. DESIGN: Randomized, placebo-controlled study, with follow-up at 3 and 12 months after last treatment. SETTING: Forty outpatient dermatology centers in 11 European countries. PATIENTS: Random sample of 225 patients with histologically confirmed squamous cell carcinoma in situ (lesion size, 6-40 mm) and no evidence of progression. INTERVENTIONS: Treatment with PDT with methyl aminolevulinate (160 mg/g; n = 96) or matching placebo cream (n = 17), cryotherapy (n = 82), or topical fluorouracil (5% cream; n = 30). Methyl aminolevulinate or placebo cream was applied for 3 hours before illumination with broadband red light (75 J/cm2, 570-670 nm). Treatment was repeated 1 week later. Cryotherapy was performed with liquid nitrogen spray. Fluorouracil was applied for 4 weeks. Lesions with a partial response at 3 months were re-treated. MAIN OUTCOME MEASURES: Clinically verified complete response of lesions; blinded and on-site assessment of cosmetic outcome (4-point rating scale). RESULTS: At 12 months, the estimated sustained lesion complete response rate with methyl aminolevulinate PDT was superior to that with cryotherapy (80% vs 67%; odds ratio, 1.77; 95% confidence interval, 1.01-3.12; P = .047), and better than that with fluorouracil (80% vs 69%; odds ratio, 1.64; 95% confidence interval, 0.78-3.45; P = .19). Cosmetic outcome at 3 months was good or excellent in 94% of patients treated with methyl aminolevulinate PDT vs 66% with cryotherapy and 76% with fluorouracil, and was maintained at 12 months. CONCLUSION: Methyl aminolevulinate PDT is an effective treatment option for squamous cell carcinoma in situ, with excellent cosmesis.

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  • Comparing MAL/PDT to cryotherapy and 5-fluorouracil showed similar response rates with all treatments used against SCC in situ at the 12 month follow-up point.

    “Comparing MAL/PDT to cryotherapy and 5-fluorouracil showed similar response rates with all treatments used against SCC in situ at the 12 month follow-up point [58].”

    From Photodynamic Therapy for Non-Melanoma Skin Cancers (2016) · cites this paper as [58]

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Authors
Morton, C., Horn, M., Leman, J., Tack, B., Bedane, C., Tjioe, M., Ibbotson, S., Khemis, A., & Wolf, P.
ORCID
Venue
Archives of Dermatology
Publisher
American Medical Association (AMA)
Published
2006-06-01
Volume
142
Issue
6
Pages
729-35
ISSN
0003-987X (ISSN-L)
DOI
10.1001/archderm.142.6.729
OpenAlex
W2125566133
Cited by
256
References
17
Citations by year
2026: 6 · 2025: 11 · 2024: 15 · 2023: 12 · 2022: 12 · 2021: 12 · 2020: 7 · 2019: 10 · 2018: 16 · 2017: 12 · 2016: 13 · 2015: 15 · 2014: 8 · 2013: 15 · 2012: 12
FWCI
9.27
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Dermatology (publishedVersion)
  • PubMed (publishedVersion)
  • Discovery Research Portal (University of Dundee) (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords
methyl aminolevulinate, photodynamic therapy, Bowen's disease, cryotherapy, topical fluorouracil, cosmetic outcome, treatment efficacy, actinic keratosis, tolerability, recurrence prevention, liquid nitrogen cryotherapy, topical chemotherapy
MeSH terms
Administration, Cutaneous, Adult, Aged, Aged, 80 and over, Aminolevulinic Acid, Antimetabolites, Antineoplastic, Carcinoma, Squamous Cell, Double-Blind Method, Europe, Female, Fluorouracil, Humans, Male, Middle Aged, Photochemotherapy, Skin Neoplasms, Treatment Outcome, Photosensitizing Agents, Cryotherapy

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