Frequency of endometriotic lesions in peritoneum samples from asymptomatic fertile women and correlation with CA125 values
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CONTEXT AND OBJECTIVE: Serological testing for CA125 has been widely used to detect endometriosis and to monitor its progression. However, controversy still exists regarding the usefulness of the plasma CA125 assay for diagnosing endometriosis. Furthermore, some authors have described superficial endometriosis as a cyclical and normal phenomenon in women's lives, and have indicated that development and progression of this disease would only occur in some women as a result of immunological changes. This study aimed to determine the frequency of endometriosis and the correlation between serum CA125 levels and the presence of endometriotic lesions in the peritoneum of asymptomatic fertile patients. DESIGN AND SETTING: Cross-sectional study at the Family Planning outpatient clinic of Faculdade de Medicina do ABC. METHODS: Eighty asymptomatic fertile patients who underwent tubal sterilization surgery were studied. Blood and peritoneum samples were collected. CA125 levels were measured from blood samples, and peritoneum biopsies were studied using histopathological tests. RESULTS: Histopathological evaluation of the peritoneum revealed that 16.25% of the patients had minimal or mild endometriosis. There was no statistically significant difference in CA125 levels between patients with and without endometriosis. CONCLUSION: The presence of endometriotic lesions in the peritoneum of fertile patients supports the hypothesis that incidental findings of minimal or mild endometriosis may not be of clinical significance, and that the progression of the disease probably occurs as a result of immunological and genetic abnormalities. Serum CA125 levels did not show any diagnostic significance with regard to detecting the disease.
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Studies looking for asymptomatic endometriosis among women undergoing tubal ligation yielded rates of endometriosis centering around 19%.
“These studies yielded rates of endometriosis that center around 19% (Barbosa et al., 2009; Rawson, 1991; Tissot et al., 2017).”
From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Barbosa et al., 2009
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“…ndometriosis is a common gynecological disease, de-fined as the growth of endometrial tissue outside the uterine cavity that often results in a vast array of gynecological problems including dyspareunia, dysmenorrhea, pelvic pain, and infertility (Giudice and Kao, 2004; Barbosa et al. , 2009, 2010).”
Self-citationBarbosa, C. P., Mafra, F., Cordts, E. B., Peluso, C., Christofolini, D. M., & Bianco, B. A. V. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.07.793
Self-citationde Oliveira, R., Cunha, L. L. G., Canto, B. E. S., Magalhães, M. B., Barbosa, C. P., & Vilariño, F. L. (2015) · International Journal of Reproduction Fertility & Sexual Health · doi:10.19070/2377-1887-150008
“However, it is worth noting that 16% of patients are asymptomatic [5].”
BackgroundSelf-citationManejo del cáncer de ovario durante el embarazo
Reyna‐Villasmil, E. (2020) · Revista de Obstetricia y Ginecología de Venezuela · doi:10.51288/00800410
Outcomes of Using Hormonal Therapy after Surgical Excision of Abdominal Wall Endometriomas
Saadi, R. K., Naiem, N. I., & Habash, M. M. (2022) · Journal of Pharmaceutical Negative Results · doi:10.47750/pnr.2022.13.03.161
Taş, E. E., Halilzade, M. İ., Doğanay, M., & Yavuz, A. F. (2025) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.70399
“22,23 In summary, this study evaluated the clinical characteristics of”
International Trends in Endometriosis Delay to Diagnosis Data
Ellis, K. B., & Wood, R. (2026) · Health & Social Care in the Community · doi:10.1155/hsc/7911605
- Authors
- Barbosa, C. P., Souza, Â. M. B. D., Bianco, B., Christofolini, D., Bach, F. A. M., & Lima, G. R. D.
- Affiliations
- Faculdade de Medicina do ABC (BR)
- Faculdade de Medicina do ABC, Brazil
- Universidade Federal de São Paulo (BR)
- Corresponding author
- Barbosa, Caio Parente
- Venue
- Sao Paulo Medical Journal
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2009-11
- Volume
- 127
- Issue
- 6
- Pages
- 342-345
- ISSN
- 0035-0362 (ISSN-L)
- 1516-3180
- PMC
- PMC11149680
- OpenAlex
- W2005210975
- Cited by
- 58
- References
- 31
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 8 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 7 · 2013: 4 · 2012: 7
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Sao Paulo Medical Journal (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, CA125, serum biomarkers, tubal ligation, diagnostic sensitivity, disease progression
- MeSH terms
- Adult, Brazil, Endometriosis, Female, Fertility, Humans, Peritoneal Diseases, Biomarkers, CA-125 Antigen
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