The use of biochemical markers in the diagnosis of pelvic endometriosis
Abstract
The aim of this study was to evaluate CA 125 II, C-reactive protein (CRP) and serum amyloid A (SAA) and anticardiolipin antibody (aCL) concentrations for the diagnosis of pelvic endometriosis. The study population consisted of 15 women without endometriosis, as confirmed by laparoscopy (group A), and 35 patients with pelvic endometriosis diagnosed by laparoscopy or laparotomy (group B). Group B patients were divided into those at stages I and II of the disease (BI/II) and those at stages III and IV (BIII/IV). Blood samples were obtained twice during the menstrual cycle: on day 1, 2 or 3 of the cycle and on day 8, 9 or 10 of the cycle. CA 125 II and CRP concentrations were higher in group III/IV patients compared with healthy controls, mainly during the first 3 days of the menstrual cycle; SAA concentrations were also higher in this group of patients compared with healthy controls, but only during the first 3 days of the menstrual cycle. Immunoglobulin (Ig) M aCL concentrations were higher in all patients with endometriosis compared with healthy controls, mainly during the first 3 days of the menstrual cycle. It is concluded that these determinations may contribute to the diagnosis and the indication of treatment for pelvic endometriosis. Determination of CA 125 II concentrations at the beginning of the menstrual cycle may aid the diagnosis of stage III and IV endometriosis. IgM aCL appears to be associated with the presence of all stages of the disease, while SAA values are elevated in severe situations. Measurement of these molecules may therefore provide a valuable tool in the diagnosis and management of endometriosis.
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“Comparison of our results with those from other studies reporting CRP levels in women with endometriosis is difficult (Table 5) due to differences in patient phenotype, patient number, type of peripheral blood (serum or plasma) and CRP methodology (variety of assays manufactured by a variety of companies) [11-14,36].”
BackgroundResultCopeptin is associated with the severity of endometriosis
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Evaluation of CA-125 and soluble CD-23 in patients with pelvic endometriosis: a case-control study
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Self-citationSerum YKL-40 levels are altered in endometriosis
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- Authors
- Abrao, M. S., Podgaec, S., Filho, B. M., Ramos, L. O., Pinotti, J. A., & de Oliveira, R. M.
- Affiliations
- Universidade de São Paulo (BR)
- ORCID
- Podgaec, S.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-11-01
- Volume
- 12
- Issue
- 11
- Pages
- 2523-2527
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2081381796
- Cited by
- 100
- References
- 16
- Citations by year
- 2024: 1 · 2022: 5 · 2021: 4 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 7 · 2013: 5 · 2012: 9
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- pelvic endometriosis, C-reactive protein, serum amyloid A, anticardiolipin antibodies, biochemical markers, endometriosis diagnosis, endometriosis stage, menstrual cycle, immunoglobulin M
- MeSH terms
- Adult, Serum Amyloid A Protein, Endometriosis, Female, Humans, Pelvis, Predictive Value of Tests, Protein C, Biomarkers, Antibodies, Anticardiolipin
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